Click here to switch to the map view.

The map label for this gene is accD [C]

Identifier: 187734714

GI number: 187734714

Start: 250515

End: 252080

Strand: Direct

Name: accD [C]

Synonym: Amuc_0201

Alternate gene names: 187734714

Gene position: 250515-252080 (Clockwise)

Preceding gene: 187734713

Following gene: 187734715

Centisome position: 9.4

GC content: 60.15

Gene sequence:

>1566_bases
ATGGCTATTGATCCCAAATTGATTGACGATCTGAACAGCCGCCGCAAGAAGGTCATCCTCAGCGGCGGTCAGGAAAAGAT
CGACAAGAGACATGAAAAGGGCGAAATGACAGCCCGCGACCGCATGGGGTACCTCTTTGAGGAAGGCACCTTCTCGGAAA
TCGGCATGCATGTGCGCCACAACTGCCACAACTTCGGCATGGGTAAGAAGGAAATCCCCGGCGACGGCGTCGTTTCCGGT
TTCGGCCTGGTGGACGGCCGCCCGGTAGCCTGCGCGGCCTCCGATTTCCTGGCCCAGGGCGGTTCCCTCGGCTACATGCA
CGCCATGAAAATTGCGGATGCTCAGAAGTATGCGCTGAAAGCCGGCATCCCGATGGTGACCGTGAACGACTCCGGCGGCG
CGCGCCTCCAGGAAGGAGTGGCGGCCCTTTCCGGATACGCCCAGGTATTTTACAACAATGTGCTTGCCTCCGGCGTGGTT
CCGCAAATCTCCATGATCCTGGGCCCCTGCGCGGGCGGCGCGGCCTACTCCCCCGCCCTGACGGACTTCATCATCATGCG
CAATTCCGGCAACGCGGGCATGTACATCACCGGTCCCAAAGTGATTGAACAGGTCACGTATGAAAAATGCACGATGGACG
ACATCGGCTCCGCCGCCATTCACGCCACCGTGTCCGGCAACGTCCATTTCGTAGCGGACAGCGACGCGCACGCCATGGAC
ATCCTGAAGAGGCTTCTTTCCTTCCTTCCTTCCAACAACACGGAAGAACCGCCCCACAAACTGAACACTCCGCTGGACCT
GAGCGCTGACGAAGGCATGAGCGACCTGATTCCCGGCGACAACCGCACGCCGCTGGACGTCCAGCCCATCATCAGCCGTC
TGGTGGACAACGGGGACTTCCTGGAAGTACACAAGGACTTCGCCAAAAATGTCGTCGTCGGATTCGGCCGCATCTGCGGC
GTGGTGGTCGGCATCATCGCCAACCAGCCCAATGTGAAAGCCGGCTGCCTGGATATCGACTCCTCCGACAAGGCCGCACG
CTTCATCCGTTTCTGCAACGCGTTCAATATTCCGTTGGTGAACCTGGTGGACGTGCCCGGCTTCCTGCCCGGCAAGAACC
AGGAACGGGGCGGCATTATCCGCCACGGCGCCAAACTTATCTTCGCCTATTCCCAGGCCACGGTGCCCAAAGTCACCCTG
ATCATGCGGAAAGCCTACGGCGGCGCCTACATCGCCATGTGCTGCAAGGACCTGGGCGCTGACGCCGTCTTCGCCTGGCC
TGGTGCGGAAATTGCCGTTATGGGTGCGGAAGGCGCCGTCCCGGTACTCTACGGCCGCGAACTGAAGGCTGTGGAAGACC
CGGCGGAAAAAGCCAAGCGCCAGGGCGAACTTCTGGAAGAATACCGGGAAGCCTTTTACAACCCGTATGTGGCGGCCGGC
ATGGGGCAGATTACGGAAGTCATCAATCCGGAAGAAACCCGCGCCAAAATCGCCTTCGCCCTGCGCACCCTGCTGAACAA
GAAGGAAGTGCGCCCGGCCAAGAAACACGGCAACATTCCGCTCTAA

Upstream 100 bases:

>100_bases
CCCAAGTGCACCTTCGGCGTCCTGACCGAATTCTGCCAGCACCCCGGCAGCTGCGAATGCGGCAAGTAACATTCTCCCTA
TTCACCATACCACTAGACCA

Downstream 100 bases:

>100_bases
CATCCATCCCAACGGATTCATATGTTACTTACAACACTCGCTTTTGCCTTCGCACAGGGCATCGCCAACGTTATGAACAA
TCTGAACTATCAGGTTGTCG

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYLFEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSG
FGLVDGRPVACAASDFLAQGGSLGYMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVV
PQISMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHATVSGNVHFVADSDAHAMD
ILKRLLSFLPSNNTEEPPHKLNTPLDLSADEGMSDLIPGDNRTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICG
VVVGIIANQPNVKAGCLDIDSSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVTL
IMRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKAKRQGELLEEYREAFYNPYVAAG
MGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHGNIPL

Sequences:

>Translated_521_residues
MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYLFEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSG
FGLVDGRPVACAASDFLAQGGSLGYMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVV
PQISMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHATVSGNVHFVADSDAHAMD
ILKRLLSFLPSNNTEEPPHKLNTPLDLSADEGMSDLIPGDNRTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICG
VVVGIIANQPNVKAGCLDIDSSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVTL
IMRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKAKRQGELLEEYREAFYNPYVAAG
MGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHGNIPL
>Mature_520_residues
AIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYLFEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSGF
GLVDGRPVACAASDFLAQGGSLGYMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVP
QISMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHATVSGNVHFVADSDAHAMDI
LKRLLSFLPSNNTEEPPHKLNTPLDLSADEGMSDLIPGDNRTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICGV
VVGIIANQPNVKAGCLDIDSSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVTLI
MRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKAKRQGELLEEYREAFYNPYVAAGM
GQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHGNIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=516, Percent_Identity=47.6744186046512, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI295821216, Length=536, Percent_Identity=46.0820895522388, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI11545863, Length=517, Percent_Identity=29.5938104448743, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1788655, Length=190, Percent_Identity=31.5789473684211, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=517, Percent_Identity=47.9690522243714, Blast_Score=496, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI25147359, Length=517, Percent_Identity=47.9690522243714, Blast_Score=495, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17552936, Length=512, Percent_Identity=31.0546875, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71997163, Length=312, Percent_Identity=24.3589743589744, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24586065, Length=530, Percent_Identity=30.377358490566, Blast_Score=225, Evalue=5e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 56009; Mature: 55878

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYLFEEGTFSEIGMHVRH
CCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCHHHHCCHHCCCCCHHHHHHHHHH
NCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLGYMHAMKIADAQKYALK
CCHHCCCCCCCCCCCCCEECCCCCCCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQISMILGPCAGGAAYSPAL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCC
TDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHATVSGNVHFVADSDAHAMD
EEEEEEECCCCCCEEEECHHHHHHHHHHHCCHHHCCCEEEEEEECCCEEEEECCCCHHHH
ILKRLLSFLPSNNTEEPPHKLNTPLDLSADEGMSDLIPGDNRTPLDVQPIISRLVDNGDF
HHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCH
LEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDIDSSDKAARFIRFCNAFNIPLV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEE
NLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVTLIMRKAYGGAYIAMCCKDLGA
EEECCCCCCCCCCCCCCCEECCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCC
DAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKAKRQGELLEEYREAFYNPYVAAG
CEEEECCCCCEEEECCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHC
MGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHGNIPL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure 
AIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYLFEEGTFSEIGMHVRH
CCCCHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCHHHHCCHHCCCCCHHHHHHHHHH
NCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLGYMHAMKIADAQKYALK
CCHHCCCCCCCCCCCCCEECCCCCCCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQISMILGPCAGGAAYSPAL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCC
TDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHATVSGNVHFVADSDAHAMD
EEEEEEECCCCCCEEEECHHHHHHHHHHHCCHHHCCCEEEEEEECCCEEEEECCCCHHHH
ILKRLLSFLPSNNTEEPPHKLNTPLDLSADEGMSDLIPGDNRTPLDVQPIISRLVDNGDF
HHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCH
LEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDIDSSDKAARFIRFCNAFNIPLV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEE
NLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVTLIMRKAYGGAYIAMCCKDLGA
EEECCCCCCCCCCCCCCCEECCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCC
DAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKAKRQGELLEEYREAFYNPYVAAG
CEEEECCCCCEEEECCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHC
MGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHGNIPL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]