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The map label for this gene is macA [H]

Identifier: 187734616

GI number: 187734616

Start: 126754

End: 128151

Strand: Direct

Name: macA [H]

Synonym: Amuc_0102

Alternate gene names: 187734616

Gene position: 126754-128151 (Clockwise)

Preceding gene: 187734615

Following gene: 187734617

Centisome position: 4.76

GC content: 58.01

Gene sequence:

>1398_bases
GTGAAGGGATTCATCAAACTCATCATCGTCATTGCCGTTCTCGGAGGCATCTGGTTTGCCTGGGAACAGTGGAAAGGAAA
TGAAGCCATCCAGGTGGACTACCAGACAGAACCTCTTGAAAAAGGAAACCTGATGATCACCATCGAAGCAACCGGCGTCA
CGGAGCCTGATGAACTGGTAGATGTAGGCGCCCAGGTCAGCGGAATCATCATGGAGTTCGGCAAGGACCTGAACGGCAAG
GTGGTGGATTATTCCAGCCCTGTAAAAGCCGGTCAGATGCTCGCGGAAATCGACAAGCTTCCCGTGCAGCTGGACGTTCA
GAGGGCGGAAGCCTCCAAAGCGCAGGCCATTGCCGGAATCGCCCGCTCCAAGGCGGACATCCAGCAGGCCAAAGCCAAGC
ACCAGCAGGCCAGACTGGACCGGGAACGCGCGGAAAAGCTGGGGCCTGGGGATGCCCTGTCCAAATCCAGCTACGACCAG
TATATTGCGGATGAAGAAACCGCCCGCGCCAACGTAGCCGTGGCGGAAGCCTCCCTGCAGGAAGCGGAAGCCTCCCTGAA
ACAGGCGGAAGCCGCGCTGAAAAAGGAAATGCGCAACCTGGAATACACCACCATCAAGTCCCCCGTGGACGGCGTCGTGG
TCAAACGCCTGGTCAACATAGGCCAAACAGTGGTTTCCAGCATGAGCGCCTCCAGCCTGTTTTACATCGCCACAGACCTT
TCCAAGCTGAAAATTTGGGCCGCTGTGAACGAGGCGGACATCGGCAGCATCCGCAAGGGGCAGGAGGTACTGTTCACCGT
GGACGCTTTCGCCGGCCGCAAATTCAAGGGAACGGTGGACAAGATACGGCTGGACGCAACCATGACGTCCAATGTGGTCA
CTTACATCGTGGACATTGATGTACCCAATCCGGACAAGCTTCTTATCCCCTATCTGACGGCAAATGTCCAATTCGTGGTG
GAGGACATACGAAACGCTTTCCTCGTTTCCAATGCGGCCCTCCGCTTCCGCCCGGAAACAGAACTGGTCAGTGCTGAACA
AAAAGCGGCCTTTGACCGGATGCAGCCGGAGCTGGCCGCCCCCGTCCGGGACGGACAAAAGAAAAAAGCCGTGGTTTGGG
AATTGCGGAACAATCTTCTTTATCCCCACCTGGTCACCAAAGGGGAAAGCAACGGCATGCTGACGGCCATTGCGGGAGAA
ACGCTCCGGGAAGGAATGGAAATCGTCTCTACGGCTCAGATACTGAACCGCTCCGACAGTTCGGGGGACGGTTCTTCCGC
CTCCGCCGGCGGGGAAAACCCGTTCGCGCCCAAAATGCCCCCGCGCCGCAAGCCGAGCACAGGCAACACGAAAACGGCAG
CCTCGGCTGGCAATGACGGGCCGCCCCCGCCTCCCTAA

Upstream 100 bases:

>100_bases
CCTTAGACATTTCCGGAAATCATGATAGGATCATGCTCCGTTGCGGAAAAGTTTTTAACATCCGTGCAACTTTTTCATTA
TTGCGAAGTATAATATAGTC

Downstream 100 bases:

>100_bases
CCCGGGGAACCGCCTTCATCCGACCGCTCAATCACTCTTTTTTACCGCATCAAGCATTCCAACAACGTGATCCGCTTACG
TGACATAACCAAGGTGTACC

Product: efflux transporter, RND family, MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKGFIKLIIVIAVLGGIWFAWEQWKGNEAIQVDYQTEPLEKGNLMITIEATGVTEPDELVDVGAQVSGIIMEFGKDLNGK
VVDYSSPVKAGQMLAEIDKLPVQLDVQRAEASKAQAIAGIARSKADIQQAKAKHQQARLDRERAEKLGPGDALSKSSYDQ
YIADEETARANVAVAEASLQEAEASLKQAEAALKKEMRNLEYTTIKSPVDGVVVKRLVNIGQTVVSSMSASSLFYIATDL
SKLKIWAAVNEADIGSIRKGQEVLFTVDAFAGRKFKGTVDKIRLDATMTSNVVTYIVDIDVPNPDKLLIPYLTANVQFVV
EDIRNAFLVSNAALRFRPETELVSAEQKAAFDRMQPELAAPVRDGQKKKAVVWELRNNLLYPHLVTKGESNGMLTAIAGE
TLREGMEIVSTAQILNRSDSSGDGSSASAGGENPFAPKMPPRRKPSTGNTKTAASAGNDGPPPPP

Sequences:

>Translated_465_residues
MKGFIKLIIVIAVLGGIWFAWEQWKGNEAIQVDYQTEPLEKGNLMITIEATGVTEPDELVDVGAQVSGIIMEFGKDLNGK
VVDYSSPVKAGQMLAEIDKLPVQLDVQRAEASKAQAIAGIARSKADIQQAKAKHQQARLDRERAEKLGPGDALSKSSYDQ
YIADEETARANVAVAEASLQEAEASLKQAEAALKKEMRNLEYTTIKSPVDGVVVKRLVNIGQTVVSSMSASSLFYIATDL
SKLKIWAAVNEADIGSIRKGQEVLFTVDAFAGRKFKGTVDKIRLDATMTSNVVTYIVDIDVPNPDKLLIPYLTANVQFVV
EDIRNAFLVSNAALRFRPETELVSAEQKAAFDRMQPELAAPVRDGQKKKAVVWELRNNLLYPHLVTKGESNGMLTAIAGE
TLREGMEIVSTAQILNRSDSSGDGSSASAGGENPFAPKMPPRRKPSTGNTKTAASAGNDGPPPPP
>Mature_465_residues
MKGFIKLIIVIAVLGGIWFAWEQWKGNEAIQVDYQTEPLEKGNLMITIEATGVTEPDELVDVGAQVSGIIMEFGKDLNGK
VVDYSSPVKAGQMLAEIDKLPVQLDVQRAEASKAQAIAGIARSKADIQQAKAKHQQARLDRERAEKLGPGDALSKSSYDQ
YIADEETARANVAVAEASLQEAEASLKQAEAALKKEMRNLEYTTIKSPVDGVVVKRLVNIGQTVVSSMSASSLFYIATDL
SKLKIWAAVNEADIGSIRKGQEVLFTVDAFAGRKFKGTVDKIRLDATMTSNVVTYIVDIDVPNPDKLLIPYLTANVQFVV
EDIRNAFLVSNAALRFRPETELVSAEQKAAFDRMQPELAAPVRDGQKKKAVVWELRNNLLYPHLVTKGESNGMLTAIAGE
TLREGMEIVSTAQILNRSDSSGDGSSASAGGENPFAPKMPPRRKPSTGNTKTAASAGNDGPPPPP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=331, Percent_Identity=29.607250755287, Blast_Score=116, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 50252; Mature: 50252

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGFIKLIIVIAVLGGIWFAWEQWKGNEAIQVDYQTEPLEKGNLMITIEATGVTEPDELV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCHHHHH
DVGAQVSGIIMEFGKDLNGKVVDYSSPVKAGQMLAEIDKLPVQLDVQRAEASKAQAIAGI
HHCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
ARSKADIQQAKAKHQQARLDRERAEKLGPGDALSKSSYDQYIADEETARANVAVAEASLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHCEEEHHHHHHH
EAEASLKQAEAALKKEMRNLEYTTIKSPVDGVVVKRLVNIGQTVVSSMSASSLFYIATDL
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
SKLKIWAAVNEADIGSIRKGQEVLFTVDAFAGRKFKGTVDKIRLDATMTSNVVTYIVDID
CCEEEEEECCCCCCCCCCCCCEEEEEEEHHCCCCCCCCHHHEEEEEEECCCEEEEEEEEC
VPNPDKLLIPYLTANVQFVVEDIRNAFLVSNAALRFRPETELVSAEQKAAFDRMQPELAA
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHC
PVRDGQKKKAVVWELRNNLLYPHLVTKGESNGMLTAIAGETLREGMEIVSTAQILNRSDS
CCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCC
SGDGSSASAGGENPFAPKMPPRRKPSTGNTKTAASAGNDGPPPPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKGFIKLIIVIAVLGGIWFAWEQWKGNEAIQVDYQTEPLEKGNLMITIEATGVTEPDELV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCHHHHH
DVGAQVSGIIMEFGKDLNGKVVDYSSPVKAGQMLAEIDKLPVQLDVQRAEASKAQAIAGI
HHCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
ARSKADIQQAKAKHQQARLDRERAEKLGPGDALSKSSYDQYIADEETARANVAVAEASLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHCEEEHHHHHHH
EAEASLKQAEAALKKEMRNLEYTTIKSPVDGVVVKRLVNIGQTVVSSMSASSLFYIATDL
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
SKLKIWAAVNEADIGSIRKGQEVLFTVDAFAGRKFKGTVDKIRLDATMTSNVVTYIVDID
CCEEEEEECCCCCCCCCCCCCEEEEEEEHHCCCCCCCCHHHEEEEEEECCCEEEEEEEEC
VPNPDKLLIPYLTANVQFVVEDIRNAFLVSNAALRFRPETELVSAEQKAAFDRMQPELAA
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHC
PVRDGQKKKAVVWELRNNLLYPHLVTKGESNGMLTAIAGETLREGMEIVSTAQILNRSDS
CCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCC
SGDGSSASAGGENPFAPKMPPRRKPSTGNTKTAASAGNDGPPPPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]