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The map label for this gene is ipaH3 [H]

Identifier: 187734119

GI number: 187734119

Start: 2393355

End: 2395166

Strand: Direct

Name: ipaH3 [H]

Synonym: SbBS512_E2592

Alternate gene names: 187734119

Gene position: 2393355-2395166 (Clockwise)

Preceding gene: 187732574

Following gene: 187730153

Centisome position: 51.85

GC content: 46.58

Gene sequence:

>1812_bases
ATGCTCAGAAATATTTCATCCTGTTTATTTCCACATATCAGCACAATTACATCCCCCAACCATTATTTGTCCGAATGGGA
TGATTGGGAGAAACAGGGGTTACCGGAAGAACAGCGTACTGAGGCGGTAAGAAGACTTCGTGCATGTCTTACCTCTAAGG
GGCATAAACTGGACCTGCGAGCCTTGGCGCTTTCCTCGTTACCTGTACTCCCTGCTTGCATTAAAAAGCTTGATGTGAGC
TGTAATAAATTAACCATCCTTACTGATCTACCTGAAAATATTAAAGAACTTATTGCAAGAGATAATTTCTTAACACATAT
ATCTGCATTACCACATTATCTAATAACTTTGGATGTGTCCGAAAATCAATTAGAGAATCTGCCGTTATTACCAGACACCA
TCAAATCACTAAGCGCAGAGTATAATAGGTTATCCACACTGCCTTCATTACCCTTGAATTTAAAAAAACTTGAGGTTAGG
AACAACGAACTGCAAACTCTTCCATCTCTGCCTTCTAATCTTAAGATACTTAAGGTTGCGCACAACCATCTTACTGAACT
GCCCCCTTTACCTAGGAGACTGCAACTTCTTTTTGCATATAGCAATAGATTAAGCAACTTACCAAACATCCAAGAAAATA
TTATCATGAGAAGATTTTTTTATTTTGAAAACAACCAAATAACTACAATCCCGACAAATCTTTTTCGTTTAGATCCTCAT
ATAACTATTGAGATTGCAAATAACCCCTTATCAGATCAAACTCTGCTATTCTTAATACAGCAAACTTCGGTTCCAAATTT
TAACGGGCCTCAGTTTCGTATTTCCCTGTCAGACCAAAACAGACTGTTTTTACGCCAGATGTTGCCGCAAAATTTACATT
CGCGCCATATCAGAGTCATCACTGAAGGGGGGCAGAACTTTCAGATCCCCCCTCTTCCCGAAACTGTGGCAGCCTGGTTT
CCTGAAGCAGATCGTCGGGAGGTTTCTACACAATGGACTTCTTTTTCCACCGAGGAGAATTCCCGGGCATTCTCCGCGTT
CCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTGAACAGGTCGCTGCATGGCTGGAAAAAC
TCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCACTGTTGCTGCTGATGCCACTGAGAGCTGTGAGGACCGTGTCGCG
CTCACATGGAACAATCTCCGGAAAACCCTCCTGGTCCATCAGGCATCAGAAGGCCTTTTCGATAATGATACCGGCGCTCT
GCTCTCCCTGGGCAGGGAAATGTTCCGCCTCGAAATTCTGGAGGACATTGCCCGGGATAAAGTCAGAACTCTCCATTTTG
TGGACGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCCACTGCCGTGAAGGAAATG
CGTTTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTCAGAAGCCGTGAAGAGAATGA
ATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGCTGACCGCTGGGCGCTGGCAG
AAGAGCAGAAATATGAGATGCTGGAGAATGAGTACCCTCAGAGGGTGGCTGACCGGCTGAAAGCATCAGGTCTGAGCGGT
GATGCGGATGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTGAGACTGAACAGCAGATTTACCGTCAGCTGACTGACGA
GGTACTGGCCCTGCGATTGCCTGAAAACGGCTCACAACTGCACCATTCATAA

Upstream 100 bases:

>100_bases
CCTTATGGCGAATATTCTGAAACACCCTCCTCATTAGGAGAGATACATTAAATACAATTTATTCACAATCTAATTCCATA
TCCATATGCGAGAAATTAAT

Downstream 100 bases:

>100_bases
TCACATCGCATAAACCACAGACCGGACTGACTCCGGAAAAACAGAGGCCCGCCCCCGGGCCTCCCCGGATTCATCCGTTT
CCCTGTTCAGCCTGACAGCA

Product: invasion plasmid antigen

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGHKLDLRALALSSLPVLPACIKKLDVS
CNKLTILTDLPENIKELIARDNFLTHISALPHYLITLDVSENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLKKLEVR
NNELQTLPSLPSNLKILKVAHNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLFRLDPH
ITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSRHIRVITEGGQNFQIPPLPETVAAWF
PEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFTVAADATESCEDRVA
LTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEM
RFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSG
DADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS

Sequences:

>Translated_603_residues
MLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGHKLDLRALALSSLPVLPACIKKLDVS
CNKLTILTDLPENIKELIARDNFLTHISALPHYLITLDVSENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLKKLEVR
NNELQTLPSLPSNLKILKVAHNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLFRLDPH
ITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSRHIRVITEGGQNFQIPPLPETVAAWF
PEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFTVAADATESCEDRVA
LTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEM
RFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSG
DADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS
>Mature_603_residues
MLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGHKLDLRALALSSLPVLPACIKKLDVS
CNKLTILTDLPENIKELIARDNFLTHISALPHYLITLDVSENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLKKLEVR
NNELQTLPSLPSNLKILKVAHNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLFRLDPH
ITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSRHIRVITEGGQNFQIPPLPETVAAWF
PEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFTVAADATESCEDRVA
LTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEM
RFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSG
DADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Synthesizes a 'Lys-48'-linked ubiquitin chain, which requir

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm (By similarity). Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm (By similarity) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 9 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 69087; Mature: 69087

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGHKLDLR
CCCCHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHH
ALALSSLPVLPACIKKLDVSCNKLTILTDLPENIKELIARDNFLTHISALPHYLITLDVS
HHHHHCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCHHHHHHHHCCCEEEEEECC
ENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLKKLEVRNNELQTLPSLPSNLKILKVA
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHCCCCCCCCEEEEEH
HNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLFRLDPH
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCEEEEECCCEEEECCE
ITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSRHIRVI
EEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEE
TEGGQNFQIPPLPETVAAWFPEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTVSARNT
ECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
SGFREQVAAWLEKLSASAELRQQSFTVAADATESCEDRVALTWNNLRKTLLVHQASEGLF
CHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHCCCCC
DNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEM
HHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQL
HHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
HHS
CCC
>Mature Secondary Structure
MLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGHKLDLR
CCCCHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHH
ALALSSLPVLPACIKKLDVSCNKLTILTDLPENIKELIARDNFLTHISALPHYLITLDVS
HHHHHCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCHHHHHHHHCCCEEEEEECC
ENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLKKLEVRNNELQTLPSLPSNLKILKVA
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHCCCCCCCCEEEEEH
HNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLFRLDPH
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCEEEEECCCEEEECCE
ITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSRHIRVI
EEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEE
TEGGQNFQIPPLPETVAAWFPEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTVSARNT
ECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
SGFREQVAAWLEKLSASAELRQQSFTVAADATESCEDRVALTWNNLRKTLLVHQASEGLF
CHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHCCCCC
DNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEM
HHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQL
HHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
HHS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12384590 [H]