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The map label for this gene is ypdF

Identifier: 187733968

GI number: 187733968

Start: 2560248

End: 2561333

Strand: Reverse

Name: ypdF

Synonym: SbBS512_E2754

Alternate gene names: 187733968

Gene position: 2561333-2560248 (Counterclockwise)

Preceding gene: 187732149

Following gene: 187732818

Centisome position: 55.49

GC content: 57.18

Gene sequence:

>1086_bases
ATGACATTACTCGCTTCGCTGCGCGACTGGCTTAAGGCGCAACAACTGGATGCAGTGCTTCTCTCCTCACGGCAGAACAA
ACAGCCGCATCTGGGGATCTCCACCGGATCAGGCTATGTGGTTATTAGCCGTGAAAGTGCGCACATTCTGGTAGATTCGC
GCTATTTCGTTGAGGTGGAAGCCCGTGCGCAAGGCTACCAGCTGCATTTGCTTGACGCGACGAACACGCTTACCACTATC
GTCAATCAAATCATTGCCGATGAGCAGTTGCAAACGCTCGGTTTTGAAGGCCAGCAGGTGAGTTGGGAAACAGCGCACCG
CTGGAAGTCTGAACTCAATGCGAAACTGGTTAGCGCCACGCCGGATGTGCTGCGGCAAATCAAAACGCCAGAGGAGGTGG
AGATAATCCGCCTCGCCTGTGGGATTGCCGATCGCGGAGCGGAGCATATTCGCCGCTTTATTCAGGCGGGGATGAGCGAG
CGCGAGATAGCCGCTGAACTGGAGTGGTTTATGCGCCAGCAGGGCGCAGAAAAAGCCTCTTTTGACACCATTGTCGCCAG
CGGCTGGCGCGGGGTGCTGCCGCACGGCAAAGCCAGCGACAAGATTGTTGCAGCGGGCGAGTTTGTCACTCTCGATTTTG
GTGCGCTGTATCAGGGCTACTGCTCTGATATGACGCGCACCTTGCTGGTGAATGGCGAAGGGGTGAGCGCCGAATCTCAC
CCGCTGTTTGACGTCTATCAGATTGTCCTGCAGGCACAGCTCGCGGCAATCTCTGCAATTCGCCCCGGCGTGCGCTGCCA
GCAGATTGACGACGCCGCGCGCCGGGTCATTACCGAGGCTGGATTTGGCGACTATTTCGGTCATAACACTGGTCACGCTA
TCGGCATTGAAGTCCATGAAGATCCGCGTTTTTCACCGCGGGGGACCAAGACGCTACAGCCAGGCATGTTGCTGACCGTG
GAGCCGGGGATTTATTTGCCAGGGCAAGGGGGCGTGCGCATCGAAGATGTTGTGCTGGTTACCCCGCAAGGCGCAGAAGT
GCTCTACGCCATGCCGAAAACAGTGTTGCTCACGGGAGAGGCATAA

Upstream 100 bases:

>100_bases
TGGGGGCAGTCATAACTGCGCTGATGGTGGTGTTCCTGCGTCTGATGATGTTCCGTAAAGGCAAATTGTTAATCGATAGC
CTGTAAGAAGGAAAATCCAG

Downstream 100 bases:

>100_bases
TGGATTTATCGCTATTAAAAGCGTTGAGCGAGGCAGATGCGATCGCCTCCTCGGAACAGGAAGTGCGGCAGATCCTGCTG
GAAGAAGCGGATCGCCTGCA

Product: aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYFVEVEARAQGYQLHLLDATNTLTTI
VNQIIADEQLQTLGFEGQQVSWETAHRWKSELNAKLVSATPDVLRQIKTPEEVEIIRLACGIADRGAEHIRRFIQAGMSE
REIAAELEWFMRQQGAEKASFDTIVASGWRGVLPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
PLFDVYQIVLQAQLAAISAIRPGVRCQQIDDAARRVITEAGFGDYFGHNTGHAIGIEVHEDPRFSPRGTKTLQPGMLLTV
EPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA

Sequences:

>Translated_361_residues
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYFVEVEARAQGYQLHLLDATNTLTTI
VNQIIADEQLQTLGFEGQQVSWETAHRWKSELNAKLVSATPDVLRQIKTPEEVEIIRLACGIADRGAEHIRRFIQAGMSE
REIAAELEWFMRQQGAEKASFDTIVASGWRGVLPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
PLFDVYQIVLQAQLAAISAIRPGVRCQQIDDAARRVITEAGFGDYFGHNTGHAIGIEVHEDPRFSPRGTKTLQPGMLLTV
EPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA
>Mature_360_residues
TLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYFVEVEARAQGYQLHLLDATNTLTTIV
NQIIADEQLQTLGFEGQQVSWETAHRWKSELNAKLVSATPDVLRQIKTPEEVEIIRLACGIADRGAEHIRRFIQAGMSER
EIAAELEWFMRQQGAEKASFDTIVASGWRGVLPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHP
LFDVYQIVLQAQLAAISAIRPGVRCQQIDDAARRVITEAGFGDYFGHNTGHAIGIEVHEDPRFSPRGTKTLQPGMLLTVE
PGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=254, Percent_Identity=30.7086614173228, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI149589008, Length=309, Percent_Identity=27.5080906148867, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI260593665, Length=309, Percent_Identity=27.5080906148867, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI260593663, Length=242, Percent_Identity=28.9256198347107, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI264681563, Length=198, Percent_Identity=32.8282828282828, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI93141226, Length=174, Percent_Identity=32.183908045977, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI264681565, Length=195, Percent_Identity=31.2820512820513, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788728, Length=361, Percent_Identity=97.2299168975069, Blast_Score=720, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=254, Percent_Identity=29.5275590551181, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790282, Length=297, Percent_Identity=25.5892255892256, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786364, Length=207, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508215, Length=312, Percent_Identity=29.1666666666667, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17509539, Length=170, Percent_Identity=32.3529411764706, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71989583, Length=247, Percent_Identity=25.1012145748988, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321118, Length=286, Percent_Identity=28.6713286713287, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320922, Length=240, Percent_Identity=25, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19920384, Length=260, Percent_Identity=27.6923076923077, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21357079, Length=294, Percent_Identity=28.2312925170068, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137632, Length=172, Percent_Identity=33.1395348837209, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39574; Mature: 39442

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYFVEVE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCEEEEECEEEEEEE
ARAQGYQLHLLDATNTLTTIVNQIIADEQLQTLGFEGQQVSWETAHRWKSELNAKLVSAT
ECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCC
PDVLRQIKTPEEVEIIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKAS
HHHHHHCCCCCHHEEEHEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHH
FDTIVASGWRGVLPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
HHHHHHCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHCCEEEEEECCCCCCCCCC
PLFDVYQIVLQAQLAAISAIRPGVRCQQIDDAARRVITEAGFGDYFGHNTGHAIGIEVHE
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEEEC
DPRFSPRGTKTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGE
CCCCCCCCCCCCCCCEEEEECCCEEECCCCCCEEEEEEEECCCCCEEEEECCCEEEEECC
A
C
>Mature Secondary Structure 
TLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYFVEVE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCEEEEECEEEEEEE
ARAQGYQLHLLDATNTLTTIVNQIIADEQLQTLGFEGQQVSWETAHRWKSELNAKLVSAT
ECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCC
PDVLRQIKTPEEVEIIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKAS
HHHHHHCCCCCHHEEEHEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHH
FDTIVASGWRGVLPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
HHHHHHCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHCCEEEEEECCCCCCCCCC
PLFDVYQIVLQAQLAAISAIRPGVRCQQIDDAARRVITEAGFGDYFGHNTGHAIGIEVHE
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEEEC
DPRFSPRGTKTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGE
CCCCCCCCCCCCCCCEEEEECCCEEECCCCCCEEEEEEEECCCCCEEEEECCCEEEEECC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]