BacMap

Definition	Shigella boydii CDC 3083-94 chromosome, complete genome.
Accession	NC_010658
Length	4,615,997

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The map label for this gene is kduD

Identifier: 187730969

GI number: 187730969

Start: 2815451

End: 2816137

Strand: Direct

Name: kduD

Synonym: SbBS512_E3020

Alternate gene names: 187730969

Gene position: 2815451-2816137 (Clockwise)

Preceding gene: 187732461

Following gene: 187730497

Centisome position: 60.99

GC content: 52.4

Gene sequence:

>687_bases
ATGGCGTTGGGGCTGGCGCAAGCGGGCTGTGACATTGTTGGCATTAACATCGTTGAACCGACTGAAACCATCGAGCAGGT
CACGGCGCTGGGGCGTCGTTTTTTAAGCCTGACCGCCGATCTGCGAAAGATTGATGGCATTCCTGGACTGCTGGATCGCG
CGGTAGCTGAATTTGGTCATATTGATATCCTGGTGAATAACGCCGGATTGATTCGCCGCGAAGACGCTCTCGAGTTCAGC
GAAAAAGACTGGGACGATGTCATGAACCTGAATATCAAGAGCGTATTCTTCATGTCTCAGGCAGCGGCGAAACACTTTAT
CGCGCAAGGCAATGGCGGCAAGATTATCAATATCGCGTCAATGCTCTCCTTCCAGGGCGGGATCCGTGTGCCTTCTTATA
CCGCATCAAAAAGCGGCGTGATGGGTGTGACGCGATTGATGGCGAACGAATGGGCTAAACACAACATTAATGTTAATGCG
ATAGCTCCGGGTTACATGGCGACCAACAATACTCAACAACTACGGGCAGATGAACAACGTAGCGCGGAAATTCTCGACCG
CATTCCAGCTGGTCGTTGGGGACTGCCGAGTGACCTGATGGGGCCGATAGTGTTCCTTGCCTCCAGCGCTTCAGATTATG
TGAATGGTTATACCATTGCCGTGGATGGCGGTTGGCTGGCGCGTTAA

Upstream 100 bases:

>100_bases
CTGTGTTGTTCTGAGGTGAGCATATCACCTCTGTTCAGGTGGCCAAATTCAGTGTGCCACTTCAGTCGTCACTGGTTGTG
ATACTGGGCTGGGCCAGGGG

Downstream 100 bases:

>100_bases
TTCATTCTTCTTACTTTTATGACCCTGCCGCATGGCAGGGTTTTTTATACCTGTAGATCATCATAATCCATATCATGGTT
ATGAAATAATCCATATTAAT

Product: 2-deoxy-D-gluconate 3-dehydrogenase

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPGLLDRAVAEFGHIDILVNNAGLIRREDALEFS
EKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHNINVNA
IAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVNGYTIAVDGGWLAR

Sequences:

>Translated_228_residues
MALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPGLLDRAVAEFGHIDILVNNAGLIRREDALEFS
EKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHNINVNA
IAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVNGYTIAVDGGWLAR
>Mature_227_residues
ALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPGLLDRAVAEFGHIDILVNNAGLIRREDALEFSE
KDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHNINVNAI
APGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVNGYTIAVDGGWLAR

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=192, Percent_Identity=35.4166666666667, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI66933014, Length=229, Percent_Identity=30.5676855895196, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI7705925, Length=211, Percent_Identity=30.8056872037915, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI32483357, Length=180, Percent_Identity=31.1111111111111, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI40254992, Length=198, Percent_Identity=31.8181818181818, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI10190704, Length=202, Percent_Identity=31.6831683168317, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI19923817, Length=195, Percent_Identity=28.2051282051282, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4503301, Length=205, Percent_Identity=27.3170731707317, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI126723750, Length=152, Percent_Identity=30.2631578947368, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI5031737, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI4504505, Length=202, Percent_Identity=27.2277227722772, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI59889578, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI31542939, Length=151, Percent_Identity=29.1390728476821, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789208, Length=228, Percent_Identity=99.5614035087719, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI87082160, Length=234, Percent_Identity=41.8803418803419, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1790717, Length=228, Percent_Identity=41.2280701754386, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI1787335, Length=179, Percent_Identity=37.4301675977654, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1788459, Length=229, Percent_Identity=34.061135371179, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87082100, Length=235, Percent_Identity=31.063829787234, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787905, Length=226, Percent_Identity=30.9734513274336, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786812, Length=231, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789057, Length=188, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789378, Length=199, Percent_Identity=25.1256281407035, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI2367365, Length=176, Percent_Identity=28.9772727272727, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI2367175, Length=237, Percent_Identity=27.8481012658228, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=191, Percent_Identity=35.6020942408377, Blast_Score=116, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17555706, Length=167, Percent_Identity=37.7245508982036, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17561402, Length=202, Percent_Identity=35.6435643564356, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560676, Length=180, Percent_Identity=31.6666666666667, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71994600, Length=219, Percent_Identity=31.0502283105023, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=179, Percent_Identity=32.9608938547486, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17559104, Length=219, Percent_Identity=31.9634703196347, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=227, Percent_Identity=26.431718061674, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=198, Percent_Identity=31.3131313131313, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=231, Percent_Identity=29.4372294372294, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17563726, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=204, Percent_Identity=29.9019607843137, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=205, Percent_Identity=30.2439024390244, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=241, Percent_Identity=29.045643153527, Blast_Score=83, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=241, Percent_Identity=29.045643153527, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=210, Percent_Identity=30, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=205, Percent_Identity=29.7560975609756, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=233, Percent_Identity=27.8969957081545, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17531453, Length=241, Percent_Identity=29.8755186721992, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=189, Percent_Identity=31.7460317460317, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=207, Percent_Identity=29.4685990338164, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=199, Percent_Identity=29.6482412060301, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17561272, Length=191, Percent_Identity=28.2722513089005, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=203, Percent_Identity=32.0197044334975, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=244, Percent_Identity=28.6885245901639, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=205, Percent_Identity=29.7560975609756, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=170, Percent_Identity=26.4705882352941, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=188, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=189, Percent_Identity=25.3968253968254, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=175, Percent_Identity=29.1428571428571, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=175, Percent_Identity=29.1428571428571, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=158, Percent_Identity=30.379746835443, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=176, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=114, Percent_Identity=35.9649122807018, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=187, Percent_Identity=26.2032085561497, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639444, Length=225, Percent_Identity=32.4444444444444, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21355319, Length=180, Percent_Identity=30.5555555555556, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357041, Length=221, Percent_Identity=30.316742081448, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28571526, Length=221, Percent_Identity=30.316742081448, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI23397609, Length=179, Percent_Identity=27.9329608938547, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644339, Length=172, Percent_Identity=30.2325581395349, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644337, Length=206, Percent_Identity=27.6699029126214, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24643142, Length=222, Percent_Identity=27.4774774774775, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI18859837, Length=185, Percent_Identity=32.4324324324324, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737361, Length=214, Percent_Identity=28.0373831775701, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 24620; Mature: 24489

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPGLLDRAVAEFGH
CCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
IDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIAS
EEEEECCCCCEECCCHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCEEEHHH
MLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQR
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCHHHHCCHHH
SAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVNGYTIAVDGGWLAR
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHCCEEEEECCCEECC
>Mature Secondary Structure 
ALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPGLLDRAVAEFGH
CCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
IDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIAS
EEEEECCCCCEECCCHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCEEEHHH
MLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQR
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCHHHHCCHHH
SAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVNGYTIAVDGGWLAR
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHCCEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 2836407; 1766386 [H]