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The map label for this gene is lpxD [H]

Identifier: 187730288

GI number: 187730288

Start: 1946222

End: 1947178

Strand: Direct

Name: lpxD [H]

Synonym: SbBS512_E2138

Alternate gene names: 187730288

Gene position: 1946222-1947178 (Clockwise)

Preceding gene: 187732509

Following gene: 187731014

Centisome position: 42.16

GC content: 38.14

Gene sequence:

>957_bases
ATGTTCAGCGCACTAGATATTAAAACGTTGATGCAAGGAACTTTATATGGTGATCCATCACTCAGGGTTGATACCATTCG
GCCAATCCATAGTCCTTTAGTTGGTGGACTCTCGATTGTTATGACACCTGGAGATTTGTTGCATATACCAACGACTGGTG
CGGATATAATTATCGGACCGGAAGAGATCATTAGTTCTAATACTAAGGCAAAGATTGTAGTCGATTACCTGAACGTGAAT
AATCTTAACAAAGTTTTAAGATATTTTAAGGTACATAAGTATCGTTTGTTTGAGCAAGAAAACACTTCAACGATACCTGA
TGTATACATTGGTAAACACTGCCAGATAGGTATGAACTGCCATTTTATGCCTGGTGTTAAAATTATGAACTGTGTGACCA
TAGGTGATAATGTTGCCATTCATGCGAATACAGTGATTAAAGAAGGTACTATTATTGGCAATGACGTTATCATAGATTCT
AATAACTCCATCGGTAATTATAGTTTTGAATATATGTCGGATGAACGTGATTCATATGTCCGAGTTGATAGCATCGGTAG
AGTTATCATAGGTGATTATGTTGAAATCGGTTGTAACAACACCATTGACCGAGGGACACTTGGAGATACGATTATAGGCC
AAGGCACTCGTATTGATAATCAAGTGCAGATTGGACGTGACTGCATAATCGGTAATAAATGCCTGATTGTTTCACAATGC
GGTTTTTCAGGACACGTAGTTTTAGGCGACCATGTTATTACACATGGTCAAGTCGGAATCGCCGGTCACATATCAATTGG
TAGTTATTCGGTAATTAAGGCTAAATCAGGTGTAAGCCATTCTTGTCCTGAAAAGAGTGACCTTTTTGGTTACCCTGCCA
AAAATACGCGAGAATACAACAAAAATCTCGCTGTCCTTAATAAACTAACTAAACAGCATGGTGTATATAAACAGTGA

Upstream 100 bases:

>100_bases
CTTTTATGATCCAAGAGATGAAGAAAAATATAATGTGCTCAATCAGGATAATATTTATGTTCATGCTTTCTATCGCTTTT
GATTAAACAGAGGGAAACCT

Downstream 100 bases:

>100_bases
GTCGTTGAGAAGTATTATTTATATACATTAACATTAACATTAACATTAACATTAACATTAACATTAACATTAACATTAAC
ATTAACATTAACATTAACAT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase homolog

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MFSALDIKTLMQGTLYGDPSLRVDTIRPIHSPLVGGLSIVMTPGDLLHIPTTGADIIIGPEEIISSNTKAKIVVDYLNVN
NLNKVLRYFKVHKYRLFEQENTSTIPDVYIGKHCQIGMNCHFMPGVKIMNCVTIGDNVAIHANTVIKEGTIIGNDVIIDS
NNSIGNYSFEYMSDERDSYVRVDSIGRVIIGDYVEIGCNNTIDRGTLGDTIIGQGTRIDNQVQIGRDCIIGNKCLIVSQC
GFSGHVVLGDHVITHGQVGIAGHISIGSYSVIKAKSGVSHSCPEKSDLFGYPAKNTREYNKNLAVLNKLTKQHGVYKQ

Sequences:

>Translated_318_residues
MFSALDIKTLMQGTLYGDPSLRVDTIRPIHSPLVGGLSIVMTPGDLLHIPTTGADIIIGPEEIISSNTKAKIVVDYLNVN
NLNKVLRYFKVHKYRLFEQENTSTIPDVYIGKHCQIGMNCHFMPGVKIMNCVTIGDNVAIHANTVIKEGTIIGNDVIIDS
NNSIGNYSFEYMSDERDSYVRVDSIGRVIIGDYVEIGCNNTIDRGTLGDTIIGQGTRIDNQVQIGRDCIIGNKCLIVSQC
GFSGHVVLGDHVITHGQVGIAGHISIGSYSVIKAKSGVSHSCPEKSDLFGYPAKNTREYNKNLAVLNKLTKQHGVYKQ
>Mature_318_residues
MFSALDIKTLMQGTLYGDPSLRVDTIRPIHSPLVGGLSIVMTPGDLLHIPTTGADIIIGPEEIISSNTKAKIVVDYLNVN
NLNKVLRYFKVHKYRLFEQENTSTIPDVYIGKHCQIGMNCHFMPGVKIMNCVTIGDNVAIHANTVIKEGTIIGNDVIIDS
NNSIGNYSFEYMSDERDSYVRVDSIGRVIIGDYVEIGCNNTIDRGTLGDTIIGQGTRIDNQVQIGRDCIIGNKCLIVSQC
GFSGHVVLGDHVITHGQVGIAGHISIGSYSVIKAKSGVSHSCPEKSDLFGYPAKNTREYNKNLAVLNKLTKQHGVYKQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=280, Percent_Identity=28.2142857142857, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786378, Length=181, Percent_Identity=27.6243093922652, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 34751; Mature: 34751

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSALDIKTLMQGTLYGDPSLRVDTIRPIHSPLVGGLSIVMTPGDLLHIPTTGADIIIGP
CCCCCCHHHHHCCEEECCCCEEEEECCCHHHHHHCCEEEEECCCCEEEECCCCCEEEECH
EEIISSNTKAKIVVDYLNVNNLNKVLRYFKVHKYRLFEQENTSTIPDVYIGKHCQIGMNC
HHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHEEEEECCCCCCCCCEEECCEEEECCCE
HFMPGVKIMNCVTIGDNVAIHANTVIKEGTIIGNDVIIDSNNSIGNYSFEYMSDERDSYV
EECCCCEEEEEEEECCCEEEEECEEEECCEEECCEEEEECCCCCCCEEEEEECCCCCCEE
RVDSIGRVIIGDYVEIGCNNTIDRGTLGDTIIGQGTRIDNQVQIGRDCIIGNKCLIVSQC
EECCCCEEEEECEEEECCCCCCCCCCCCCCEECCCCCCCCEEEECCEEEECCEEEEEEEC
GFSGHVVLGDHVITHGQVGIAGHISIGSYSVIKAKSGVSHSCPEKSDLFGYPAKNTREYN
CCCCEEEECCEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHC
KNLAVLNKLTKQHGVYKQ
CHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSALDIKTLMQGTLYGDPSLRVDTIRPIHSPLVGGLSIVMTPGDLLHIPTTGADIIIGP
CCCCCCHHHHHCCEEECCCCEEEEECCCHHHHHHCCEEEEECCCCEEEECCCCCEEEECH
EEIISSNTKAKIVVDYLNVNNLNKVLRYFKVHKYRLFEQENTSTIPDVYIGKHCQIGMNC
HHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHEEEEECCCCCCCCCEEECCEEEECCCE
HFMPGVKIMNCVTIGDNVAIHANTVIKEGTIIGNDVIIDSNNSIGNYSFEYMSDERDSYV
EECCCCEEEEEEEECCCEEEEECEEEECCEEECCEEEEECCCCCCCEEEEEECCCCCCEE
RVDSIGRVIIGDYVEIGCNNTIDRGTLGDTIIGQGTRIDNQVQIGRDCIIGNKCLIVSQC
EECCCCEEEEECEEEECCCCCCCCCCCCCCEECCCCCCCCEEEECCEEEECCEEEEEEEC
GFSGHVVLGDHVITHGQVGIAGHISIGSYSVIKAKSGVSHSCPEKSDLFGYPAKNTREYN
CCCCEEEECCEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHC
KNLAVLNKLTKQHGVYKQ
CHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA