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The map label for this gene is yciC [H]

Identifier: 186477812

GI number: 186477812

Start: 3446348

End: 3447607

Strand: Reverse

Name: yciC [H]

Synonym: Bphy_3068

Alternate gene names: 186477812

Gene position: 3447607-3446348 (Counterclockwise)

Preceding gene: 186477813

Following gene: 186477810

Centisome position: 99.09

GC content: 63.89

Gene sequence:

>1260_bases
ATGAATCAGCCGCTTTTGCCCGTCACCGTGATCTCCGGTTTTGTGGGCGCCGGTAAGACCGCGCTCGTCGAACAGATTCT
GTCGAACCGCAACGGGCCGCGCGTCGCCGCGATCGTCACCGATCTTGCCGCCGTGCGCCTCGATATCGACAATGCGGCAC
CCCCGTCCTCCTCCCCGACGTTGCGCGTCGATTTGCCGAATGGTTGTGTTTGCGTCGAGGCCGCTGAAGACCTGCACGAA
CAGTTGGCGGGCCTCGCGTCCGAAGGTCGATTCGACGCGATCGTCATCGAAGCCGCCGCGACCGACGAGCCGATGAACGT
CGTCGAATCGATCCTCGAGGAGGAATCCCTGGCAACGCTCGTGCGTGTCGACACAGCCTTGACGGTGGTCGATGCCGCCG
GTTTCCTGCGCGACTACGCGTCGACCGATGCGCTGGCCGAGCGCGGCCTCGCCGGTTACGAAGACGACGATCGCACGATC
GTGGAAGTGCTGATCGACCAGGTCGAGTTCTGCGACGTGTTCGTCATCAACAAGGCGGATCTCGTTTCCGCTGACGATCT
CGCGCATCTGCAAGCTGTGCTGGCCGCGCTGAATCCGCGTGCAGCGCAGATCGTCAGCAGCTACGGCAATGCGCCCGTCG
AGGAAGTGCTCGGCACTGCGCGCTTCGATTACGACGTAACGTCGAACGCGGCGGGCTGGCTTGCGCTGCTGCACGACTCG
TCGAGCGATGCGGACGAAGGCGGCAGGCGAGGTGTGGGGCATGTCGTGTATCGCGCGCGGCGTCCGTTCCATCCCGAGCG
TTTCTGGGCGTTGCTGCACGAAGAGTGGAAGGGCGTGCTGCGCGGCAAAGGTTTTTTCTGGCTCGCGACGCGCAACGAGA
TCGGCGGCTCGCTGTCGCAAGCGGGCGGTGCTTGCCGACCCGCGCCTGCGGGCACCTGGTGGGCCGCCCAGGATCGCAGC
GAATGGCCCGCGGGCGACGACGAGCTGCTCGAAGAGATCGCCGCCGACTGGTATGGCGATGCCGACGACTTCACGATCGG
CGATCGTCGCCAGGAACTCGTTCTGATCGGCGTCGATATCGATCCGGCGCAATGGCGCGCGAAGTTCGACGCCTGTCTTC
TGACCGATGGCGAATATGCGTTGGGTGTACAAGGCTGGCTCGCACTCGCCGATCCGTTCCCCGCATGGGACCTCGAAGAC
GACGATCACGAACATCATCATCATGACCATGACGACGGCCATCATCATCACCATCACTGA

Upstream 100 bases:

>100_bases
CAGTTGATGCACAATGCGGCTTCGTGCTGCCGTCGTCTCGCGTTGATTCCAACGTTCGCCGCGCGCATGCGTCATTCACC
TTCAAGCTTTCCGTACCGCG

Downstream 100 bases:

>100_bases
GTGCGGCGAATGCCTGCTTGCGCGACCGCGATAGAAAACGCAGACGAAAAAAAACCCGCCAACGGCGGGTGTCAACAACT
CAAGCTGCTGATGCTTAGCG

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MNQPLLPVTVISGFVGAGKTALVEQILSNRNGPRVAAIVTDLAAVRLDIDNAAPPSSSPTLRVDLPNGCVCVEAAEDLHE
QLAGLASEGRFDAIVIEAAATDEPMNVVESILEEESLATLVRVDTALTVVDAAGFLRDYASTDALAERGLAGYEDDDRTI
VEVLIDQVEFCDVFVINKADLVSADDLAHLQAVLAALNPRAAQIVSSYGNAPVEEVLGTARFDYDVTSNAAGWLALLHDS
SSDADEGGRRGVGHVVYRARRPFHPERFWALLHEEWKGVLRGKGFFWLATRNEIGGSLSQAGGACRPAPAGTWWAAQDRS
EWPAGDDELLEEIAADWYGDADDFTIGDRRQELVLIGVDIDPAQWRAKFDACLLTDGEYALGVQGWLALADPFPAWDLED
DDHEHHHHDHDDGHHHHHH

Sequences:

>Translated_419_residues
MNQPLLPVTVISGFVGAGKTALVEQILSNRNGPRVAAIVTDLAAVRLDIDNAAPPSSSPTLRVDLPNGCVCVEAAEDLHE
QLAGLASEGRFDAIVIEAAATDEPMNVVESILEEESLATLVRVDTALTVVDAAGFLRDYASTDALAERGLAGYEDDDRTI
VEVLIDQVEFCDVFVINKADLVSADDLAHLQAVLAALNPRAAQIVSSYGNAPVEEVLGTARFDYDVTSNAAGWLALLHDS
SSDADEGGRRGVGHVVYRARRPFHPERFWALLHEEWKGVLRGKGFFWLATRNEIGGSLSQAGGACRPAPAGTWWAAQDRS
EWPAGDDELLEEIAADWYGDADDFTIGDRRQELVLIGVDIDPAQWRAKFDACLLTDGEYALGVQGWLALADPFPAWDLED
DDHEHHHHDHDDGHHHHHH
>Mature_419_residues
MNQPLLPVTVISGFVGAGKTALVEQILSNRNGPRVAAIVTDLAAVRLDIDNAAPPSSSPTLRVDLPNGCVCVEAAEDLHE
QLAGLASEGRFDAIVIEAAATDEPMNVVESILEEESLATLVRVDTALTVVDAAGFLRDYASTDALAERGLAGYEDDDRTI
VEVLIDQVEFCDVFVINKADLVSADDLAHLQAVLAALNPRAAQIVSSYGNAPVEEVLGTARFDYDVTSNAAGWLALLHDS
SSDADEGGRRGVGHVVYRARRPFHPERFWALLHEEWKGVLRGKGFFWLATRNEIGGSLSQAGGACRPAPAGTWWAAQDRS
EWPAGDDELLEEIAADWYGDADDFTIGDRRQELVLIGVDIDPAQWRAKFDACLLTDGEYALGVQGWLALADPFPAWDLED
DDHEHHHHDHDDGHHHHHH

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=222, Percent_Identity=25.6756756756757, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI146231952, Length=222, Percent_Identity=25.2252252252252, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI148727351, Length=222, Percent_Identity=24.7747747747748, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI126722884, Length=222, Percent_Identity=24.7747747747748, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI223941779, Length=197, Percent_Identity=25.8883248730964, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI87082430, Length=294, Percent_Identity=22.7891156462585, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324356, Length=232, Percent_Identity=26.7241379310345, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 45532; Mature: 45532

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPLLPVTVISGFVGAGKTALVEQILSNRNGPRVAAIVTDLAAVRLDIDNAAPPSSSPT
CCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEHHHHHHHHHEEEECCCCCCCCCCCE
LRVDLPNGCVCVEAAEDLHEQLAGLASEGRFDAIVIEAAATDEPMNVVESILEEESLATL
EEEECCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
VRVDTALTVVDAAGFLRDYASTDALAERGLAGYEDDDRTIVEVLIDQVEFCDVFVINKAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCC
LVSADDLAHLQAVLAALNPRAAQIVSSYGNAPVEEVLGTARFDYDVTSNAAGWLALLHDS
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECC
SSDADEGGRRGVGHVVYRARRPFHPERFWALLHEEWKGVLRGKGFFWLATRNEIGGSLSQ
CCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHCCCHHH
AGGACRPAPAGTWWAAQDRSEWPAGDDELLEEIAADWYGDADDFTIGDRRQELVLIGVDI
CCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECC
DPAQWRAKFDACLLTDGEYALGVQGWLALADPFPAWDLEDDDHEHHHHDHDDGHHHHHH
CHHHHHHHCCEEEEECCCEEECCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNQPLLPVTVISGFVGAGKTALVEQILSNRNGPRVAAIVTDLAAVRLDIDNAAPPSSSPT
CCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEHHHHHHHHHEEEECCCCCCCCCCCE
LRVDLPNGCVCVEAAEDLHEQLAGLASEGRFDAIVIEAAATDEPMNVVESILEEESLATL
EEEECCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
VRVDTALTVVDAAGFLRDYASTDALAERGLAGYEDDDRTIVEVLIDQVEFCDVFVINKAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCC
LVSADDLAHLQAVLAALNPRAAQIVSSYGNAPVEEVLGTARFDYDVTSNAAGWLALLHDS
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECC
SSDADEGGRRGVGHVVYRARRPFHPERFWALLHEEWKGVLRGKGFFWLATRNEIGGSLSQ
CCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHCCCHHH
AGGACRPAPAGTWWAAQDRSEWPAGDDELLEEIAADWYGDADDFTIGDRRQELVLIGVDI
CCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECC
DPAQWRAKFDACLLTDGEYALGVQGWLALADPFPAWDLEDDDHEHHHHDHDDGHHHHHH
CHHHHHHHCCEEEEECCCEEECCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]