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The map label for this gene is betA [H]

Identifier: 186477795

GI number: 186477795

Start: 3426370

End: 3428064

Strand: Reverse

Name: betA [H]

Synonym: Bphy_3050

Alternate gene names: 186477795

Gene position: 3428064-3426370 (Counterclockwise)

Preceding gene: 186477798

Following gene: 186477794

Centisome position: 98.53

GC content: 59.76

Gene sequence:

>1695_bases
GTGAGCACGACAACCAGAAAGGTCGAAGGCGAGTTCGACTACATCATCATAGGCGCGGGCACGGCAGGTTGCGTGCTGGC
GAATCGCCTGACCGAAGATTCCGACGTCACAGTGCTGCTGCTCGAGGCGGGTGGCAAAGACGACTACCACTGGATTCACG
TGCCAGTTGGCTACCTCTATTGCATCGGCAATCCGCGCACCGATTGGCTCTATAAAACGCAGGCAGAACCGGGACTCAAC
GGACGCGCGTTGTCGTATCCGCGCGGCCGTGTGCTGGGCGGTTGTTCGTCGATCAACGGCATGATCTACATGCGCGGTCA
ACGCGAAGACTATGACGAATGGGCGCGCGTGACAAACGATTCGTCGTGGGCCTGGGATGCCGTGCTGCCCGTCTTCAGGC
GCAGCGAAGATCATCACGGCGGTGCGAATGAATTTCATGGCGTGGGTGGTCAATGGCGCGTTGAAAAGCAGCGGCTCAAA
TGGAAGATCCTCGAGATGTTCGCGCAAGCCGCAACGGAAACGGGCATTCCTGCCACCGACGATTTCAATCGCGGCGATAA
CACAGGCGTCGGCTACTTCGACGTGAACCAGAAGCGCGGTATACGCTGGAATGCATCGAAGGCGTTCTTGCGCCCCGCGA
TGCAAAGACCGAATCTCACGGTCATTACGGGCGCGCACACGCAACGCGTCGTGTTCGAAGGCAAGCGCTGCGTGGGTGTC
GAATATCGCGGCGACCATGTCGAGTACATCGCGAAGGCGCGTCTCGAAGTGATCATGAGTTCGGGCGCAGTGAATTCGCC
GCAACTGCTCGAACTCTCGGGTGTCGGGAATGGCGCACGTTTGCAGAAGCTCGGTATTGAAGTCGTCAACGATCTGCGCG
GTGTCGGCGAGAATCTGCAGGACCATTTGCAGTTGCGCATGGCGTATAAGGTGCACGGCGTGCGCACGCTGAACACGGCG
TCCGCGCACTGGTGGGGCAAGATGGCGATAGGCCTGCAATATCTGCTGATGCAAAGCGGACCGATGTCGATGTCGCCATC
GCAACTCGGTGCATTCGCGAAGTCAGATACGGACGACAGAACGCTGACGCGTCCCGATCTCGAATATCACGTGCAGCCGC
TTTCACTCGACAAATTTGGCGAACCGCTGCATCGCTTCAACGCGTTCACGGCGTCTGTGTGTCATTTGCGCCCCACGTCA
CGCGGCAGCGTTCATATCGAATCGCGCGATCCGCATGTTGCGCCGCTGATCGCGCCGAATTATCTGTCGACGGATTATGA
CCGTCATGTGGCCGCGAACGCATTGCGACTTACGCGTCGTATTGCAGCCGCGCCTGCATTGCAGCGATATCGGCCCGAAG
AAATCCTGCCAGGCATCCAGTTTCAGACCGAAGAAGAGTTGCAACTCGCGGCGGGAAACGTGGGCACGACTATCTTCCAT
CCTGTCGGCACGTGCCGCATGGGCACCGCCGACGATCCCGGCGCCGTCGTCGATAGCCGCTTGCGTGTGGTCGGCGTCGA
AGGTCTGCGCGTCGTGGATGCGTCGGTGATGCCGACCATCACGTCAGGCAACACGAACTCGCCGACCTTGATGATCGCGG
AGCGCGCAAGCGACATGATTCGCGTCGACCGTCGGGCGCGTGCGCACAGTCTCTCGATCGAGACACGCGTCGCATTGCCG
ATGTCGGTTGCATGA

Upstream 100 bases:

>100_bases
AGTGATTCAGGCTGCGGCATTGCATTGTTCGACTGAAGCAATGCCGCGATAGCGGGCCACACAGGAACACGAGAACAAGG
CCCATGCGAAGGAGACAACG

Downstream 100 bases:

>100_bases
CACGCAACATTCGGCGTTTTGCGCGGCGAAGGTCGCATCAAACACTAAGTGCAAATCCCAATGATTGCGCTGCATCATTG
GCGCGACAATGGCAGCCATG

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSTTTRKVEGEFDYIIIGAGTAGCVLANRLTEDSDVTVLLLEAGGKDDYHWIHVPVGYLYCIGNPRTDWLYKTQAEPGLN
GRALSYPRGRVLGGCSSINGMIYMRGQREDYDEWARVTNDSSWAWDAVLPVFRRSEDHHGGANEFHGVGGQWRVEKQRLK
WKILEMFAQAATETGIPATDDFNRGDNTGVGYFDVNQKRGIRWNASKAFLRPAMQRPNLTVITGAHTQRVVFEGKRCVGV
EYRGDHVEYIAKARLEVIMSSGAVNSPQLLELSGVGNGARLQKLGIEVVNDLRGVGENLQDHLQLRMAYKVHGVRTLNTA
SAHWWGKMAIGLQYLLMQSGPMSMSPSQLGAFAKSDTDDRTLTRPDLEYHVQPLSLDKFGEPLHRFNAFTASVCHLRPTS
RGSVHIESRDPHVAPLIAPNYLSTDYDRHVAANALRLTRRIAAAPALQRYRPEEILPGIQFQTEEELQLAAGNVGTTIFH
PVGTCRMGTADDPGAVVDSRLRVVGVEGLRVVDASVMPTITSGNTNSPTLMIAERASDMIRVDRRARAHSLSIETRVALP
MSVA

Sequences:

>Translated_564_residues
MSTTTRKVEGEFDYIIIGAGTAGCVLANRLTEDSDVTVLLLEAGGKDDYHWIHVPVGYLYCIGNPRTDWLYKTQAEPGLN
GRALSYPRGRVLGGCSSINGMIYMRGQREDYDEWARVTNDSSWAWDAVLPVFRRSEDHHGGANEFHGVGGQWRVEKQRLK
WKILEMFAQAATETGIPATDDFNRGDNTGVGYFDVNQKRGIRWNASKAFLRPAMQRPNLTVITGAHTQRVVFEGKRCVGV
EYRGDHVEYIAKARLEVIMSSGAVNSPQLLELSGVGNGARLQKLGIEVVNDLRGVGENLQDHLQLRMAYKVHGVRTLNTA
SAHWWGKMAIGLQYLLMQSGPMSMSPSQLGAFAKSDTDDRTLTRPDLEYHVQPLSLDKFGEPLHRFNAFTASVCHLRPTS
RGSVHIESRDPHVAPLIAPNYLSTDYDRHVAANALRLTRRIAAAPALQRYRPEEILPGIQFQTEEELQLAAGNVGTTIFH
PVGTCRMGTADDPGAVVDSRLRVVGVEGLRVVDASVMPTITSGNTNSPTLMIAERASDMIRVDRRARAHSLSIETRVALP
MSVA
>Mature_563_residues
STTTRKVEGEFDYIIIGAGTAGCVLANRLTEDSDVTVLLLEAGGKDDYHWIHVPVGYLYCIGNPRTDWLYKTQAEPGLNG
RALSYPRGRVLGGCSSINGMIYMRGQREDYDEWARVTNDSSWAWDAVLPVFRRSEDHHGGANEFHGVGGQWRVEKQRLKW
KILEMFAQAATETGIPATDDFNRGDNTGVGYFDVNQKRGIRWNASKAFLRPAMQRPNLTVITGAHTQRVVFEGKRCVGVE
YRGDHVEYIAKARLEVIMSSGAVNSPQLLELSGVGNGARLQKLGIEVVNDLRGVGENLQDHLQLRMAYKVHGVRTLNTAS
AHWWGKMAIGLQYLLMQSGPMSMSPSQLGAFAKSDTDDRTLTRPDLEYHVQPLSLDKFGEPLHRFNAFTASVCHLRPTSR
GSVHIESRDPHVAPLIAPNYLSTDYDRHVAANALRLTRRIAAAPALQRYRPEEILPGIQFQTEEELQLAAGNVGTTIFHP
VGTCRMGTADDPGAVVDSRLRVVGVEGLRVVDASVMPTITSGNTNSPTLMIAERASDMIRVDRRARAHSLSIETRVALPM
SVA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=538, Percent_Identity=41.4498141263941, Blast_Score=402, Evalue=1e-112,
Organism=Escherichia coli, GI1786503, Length=538, Percent_Identity=41.2639405204461, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17532301, Length=559, Percent_Identity=34.8837209302326, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24642055, Length=584, Percent_Identity=36.3013698630137, Blast_Score=335, Evalue=6e-92,
Organism=Drosophila melanogaster, GI45551458, Length=578, Percent_Identity=37.19723183391, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI45549471, Length=579, Percent_Identity=37.13298791019, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24642042, Length=568, Percent_Identity=36.7957746478873, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI24642059, Length=568, Percent_Identity=36.7957746478873, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24642048, Length=580, Percent_Identity=34.4827586206897, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24650267, Length=575, Percent_Identity=35.304347826087, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24642035, Length=574, Percent_Identity=33.6236933797909, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=34.2293906810036, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI18859995, Length=573, Percent_Identity=33.1588132635253, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24642039, Length=575, Percent_Identity=34.0869565217391, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI18859993, Length=580, Percent_Identity=31.7241379310345, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24642037, Length=574, Percent_Identity=31.8815331010453, Blast_Score=257, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24642051, Length=573, Percent_Identity=30.8900523560209, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24642057, Length=592, Percent_Identity=30.2364864864865, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24645930, Length=583, Percent_Identity=28.6449399656947, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 62343; Mature: 62211

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTTRKVEGEFDYIIIGAGTAGCVLANRLTEDSDVTVLLLEAGGKDDYHWIHVPVGYLY
CCCCCCEECCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECEEEE
CIGNPRTDWLYKTQAEPGLNGRALSYPRGRVLGGCSSINGMIYMRGQREDYDEWARVTND
ECCCCCCCCEEEECCCCCCCCCEECCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHCCC
SSWAWDAVLPVFRRSEDHHGGANEFHGVGGQWRVEKQRLKWKILEMFAQAATETGIPATD
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
DFNRGDNTGVGYFDVNQKRGIRWNASKAFLRPAMQRPNLTVITGAHTQRVVFEGKRCVGV
CCCCCCCCCEEEEECCCCCCCEECCHHHHHHHHHCCCCEEEEECCCCEEEEECCCEEEEE
EYRGDHVEYIAKARLEVIMSSGAVNSPQLLELSGVGNGARLQKLGIEVVNDLRGVGENLQ
EECCCHHHHHHHHHHHHHEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHH
DHLQLRMAYKVHGVRTLNTASAHWWGKMAIGLQYLLMQSGPMSMSPSQLGAFAKSDTDDR
HHHHEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCC
TLTRPDLEYHVQPLSLDKFGEPLHRFNAFTASVCHLRPTSRGSVHIESRDPHVAPLIAPN
EECCCCHHEEEEECCHHHHCCHHHHHHHHHEEEEEECCCCCCEEEEECCCCCEEEEECCC
YLSTDYDRHVAANALRLTRRIAAAPALQRYRPEEILPGIQFQTEEELQLAAGNVGTTIFH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHEECCCCCCEEEC
PVGTCRMGTADDPGAVVDSRLRVVGVEGLRVVDASVMPTITSGNTNSPTLMIAERASDMI
CCCCEECCCCCCCCHHHCCCEEEEECCCEEEECCCCCEEEECCCCCCCEEEEECCCCHHH
RVDRRARAHSLSIETRVALPMSVA
HHHHHHHHHEEEEEEEEECCEECC
>Mature Secondary Structure 
STTTRKVEGEFDYIIIGAGTAGCVLANRLTEDSDVTVLLLEAGGKDDYHWIHVPVGYLY
CCCCCEECCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECEEEE
CIGNPRTDWLYKTQAEPGLNGRALSYPRGRVLGGCSSINGMIYMRGQREDYDEWARVTND
ECCCCCCCCEEEECCCCCCCCCEECCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHCCC
SSWAWDAVLPVFRRSEDHHGGANEFHGVGGQWRVEKQRLKWKILEMFAQAATETGIPATD
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
DFNRGDNTGVGYFDVNQKRGIRWNASKAFLRPAMQRPNLTVITGAHTQRVVFEGKRCVGV
CCCCCCCCCEEEEECCCCCCCEECCHHHHHHHHHCCCCEEEEECCCCEEEEECCCEEEEE
EYRGDHVEYIAKARLEVIMSSGAVNSPQLLELSGVGNGARLQKLGIEVVNDLRGVGENLQ
EECCCHHHHHHHHHHHHHEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHH
DHLQLRMAYKVHGVRTLNTASAHWWGKMAIGLQYLLMQSGPMSMSPSQLGAFAKSDTDDR
HHHHEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCC
TLTRPDLEYHVQPLSLDKFGEPLHRFNAFTASVCHLRPTSRGSVHIESRDPHVAPLIAPN
EECCCCHHEEEEECCHHHHCCHHHHHHHHHEEEEEECCCCCCEEEEECCCCCEEEEECCC
YLSTDYDRHVAANALRLTRRIAAAPALQRYRPEEILPGIQFQTEEELQLAAGNVGTTIFH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHEECCCCCCEEEC
PVGTCRMGTADDPGAVVDSRLRVVGVEGLRVVDASVMPTITSGNTNSPTLMIAERASDMI
CCCCEECCCCCCCCHHHCCCEEEEECCCEEEECCCCCEEEECCCCCCCEEEEECCCCHHH
RVDRRARAHSLSIETRVALPMSVA
HHHHHHHHHEEEEEEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA