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The map label for this gene is neuA [H]

Identifier: 186477755

GI number: 186477755

Start: 3376631

End: 3377332

Strand: Reverse

Name: neuA [H]

Synonym: Bphy_3009

Alternate gene names: 186477755

Gene position: 3377332-3376631 (Counterclockwise)

Preceding gene: 186477756

Following gene: 186477754

Centisome position: 97.07

GC content: 64.25

Gene sequence:

>702_bases
ATGAGCCGCGTCGCCATCATTCCCGCACGCGGCGGCAGCAAGCGCATCCCGCACAAGAACATTCGCCTGTTCGACGGCGT
GCCCATCATCGCGCATTCGATTCGCGCCGCGCTGGATAGCGCGCTGTTCGATCGCGTCGTGGTCAGCACGGACAGCGAGG
AGATCGCGGCCGTCGCCCGCGAGTACGGTGCCCAGACGCCGTTCATGCGTCCCGCCGATCTGTCGAACGATCACGCCGGC
ACGCTCGAAGTCGTTCAGCATGCACTGCGCGCGCTCGGCGAATCTTATGGCTACGCGTGCTGCATTTACGCTACGGCGCC
ATTCATCGACGTTCGCTATTTGCGTGAAGGCATTGCGATGCTCGAACAGCATCGCGAGAAGTCGTACGCGTTTTCCGTGA
CGACCTTTGCGTTTCCGGTTCAGCGCGCATTGCGGCTGACGGCGGATGGCGGACTCGATGCCGTGTATCCCGAGCACCGG
CTCACGCGTTCGCAGGACCTGCCGGAAACCTGGCATGACGCCGGCCAGTTTTATTGGGGCCGCGCCGAAGCGTGGCAGCG
CGGCGACACGCTCTTTTCGCCGCTGTCGATGCCCGTCGTATTGCCGCGTCATCTGGTACAGGACATCGACACGCCCGAAG
ACTGGCGGCGAGCGGAACTGATGTTCGCGGCGCTGCGCGGGCTCGCGCAATCGAACGGCTGA

Upstream 100 bases:

>100_bases
CGGAGCAGTATTACCGCGAGGCGATCAGCCTGCCGCTCTACGCGACGCTCACGGACGCCGAGCAAGATCGCGTCGTCGCA
CAACTGAAGCGGGTGCTGGG

Downstream 100 bases:

>100_bases
CAAATAGACGCGCAAAACGATCCATATCAGGGACCCGCGAGTCCCAATAACGGAAGACGCGGGACGGCGTGAGGAAACAA
CCGATGAAAGAAATCAGAAT

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSRVAIIPARGGSKRIPHKNIRLFDGVPIIAHSIRAALDSALFDRVVVSTDSEEIAAVAREYGAQTPFMRPADLSNDHAG
TLEVVQHALRALGESYGYACCIYATAPFIDVRYLREGIAMLEQHREKSYAFSVTTFAFPVQRALRLTADGGLDAVYPEHR
LTRSQDLPETWHDAGQFYWGRAEAWQRGDTLFSPLSMPVVLPRHLVQDIDTPEDWRRAELMFAALRGLAQSNG

Sequences:

>Translated_233_residues
MSRVAIIPARGGSKRIPHKNIRLFDGVPIIAHSIRAALDSALFDRVVVSTDSEEIAAVAREYGAQTPFMRPADLSNDHAG
TLEVVQHALRALGESYGYACCIYATAPFIDVRYLREGIAMLEQHREKSYAFSVTTFAFPVQRALRLTADGGLDAVYPEHR
LTRSQDLPETWHDAGQFYWGRAEAWQRGDTLFSPLSMPVVLPRHLVQDIDTPEDWRRAELMFAALRGLAQSNG
>Mature_232_residues
SRVAIIPARGGSKRIPHKNIRLFDGVPIIAHSIRAALDSALFDRVVVSTDSEEIAAVAREYGAQTPFMRPADLSNDHAGT
LEVVQHALRALGESYGYACCIYATAPFIDVRYLREGIAMLEQHREKSYAFSVTTFAFPVQRALRLTADGGLDAVYPEHRL
TRSQDLPETWHDAGQFYWGRAEAWQRGDTLFSPLSMPVVLPRHLVQDIDTPEDWRRAELMFAALRGLAQSNG

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=222, Percent_Identity=34.6846846846847, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26024; Mature: 25893

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVAIIPARGGSKRIPHKNIRLFDGVPIIAHSIRAALDSALFDRVVVSTDSEEIAAVAR
CCCEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EYGAQTPFMRPADLSNDHAGTLEVVQHALRALGESYGYACCIYATAPFIDVRYLREGIAM
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHH
LEQHREKSYAFSVTTFAFPVQRALRLTADGGLDAVYPEHRLTRSQDLPETWHDAGQFYWG
HHHHHHHHHEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHCCEECC
RAEAWQRGDTLFSPLSMPVVLPRHLVQDIDTPEDWRRAELMFAALRGLAQSNG
HHHHHHCCCCHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRVAIIPARGGSKRIPHKNIRLFDGVPIIAHSIRAALDSALFDRVVVSTDSEEIAAVAR
CCEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EYGAQTPFMRPADLSNDHAGTLEVVQHALRALGESYGYACCIYATAPFIDVRYLREGIAM
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHH
LEQHREKSYAFSVTTFAFPVQRALRLTADGGLDAVYPEHRLTRSQDLPETWHDAGQFYWG
HHHHHHHHHEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHCCEECC
RAEAWQRGDTLFSPLSMPVVLPRHLVQDIDTPEDWRRAELMFAALRGLAQSNG
HHHHHHCCCCHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]