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The map label for this gene is yfjR [H]

Identifier: 186477625

GI number: 186477625

Start: 3231935

End: 3232804

Strand: Reverse

Name: yfjR [H]

Synonym: Bphy_2877

Alternate gene names: 186477625

Gene position: 3232804-3231935 (Counterclockwise)

Preceding gene: 186477628

Following gene: 186477624

Centisome position: 92.92

GC content: 66.21

Gene sequence:

>870_bases
ATGGACATCGGTTTTATCGGTCTCGGCGAAATGGGTGCGGCGATGGTCGCAAACATGTTGAAAGCGGGGCATAGCGTGCG
CGTCTGGAACCGCTCGGCGGAGAAGGCACAGCCGCTCGTCGGGCTGGGTGCGCAGGTGGTCGGTTCGCCCGCGGAAGCCT
TCACGGGCGACGCCGTCTTTTCGATGCTCGCCGACGATGCCGCGTTGCACGATGTCATCAGCGCGTCGCTGCTCGAACAT
GCGCCGCGCGGACTGATTCACGTGAACATGGCGACGATTTCCGTGTCGCTCGCGGAACAACTGGCGACGGCGCACGCCAG
CCGCGGCGTGCACTACGTGGCGGCGCCCGTCATGGGCCGACCCGACGTCGCCGCGGCAGGGAAGCTGACGATTGTCGCCG
CCGGGCCCGCCGAGGCGATCGACCGTGTGCAGCCCGTCTTCGATTCGATCGGCCAGAAAACCTGGCGTATCGGCTCGCTG
CCGCAGCAGGCGAATGTCGTGAAACTGGCGGCGAATTTCATGCTTGCAGCCGCCGTCGAGTCGCTTGGCGAGGCGTCGGC
TCTGCTCGGCGGTCATGGCGTCGCGATGCAGGACTTTCTCGACGTGATCACGAACAGCGTATTTCCCGGCCCCGTTTATC
AGGGCTACGGCAAGATGATCGCGGAACAACGCTACGAGCCGGCGCTCTTCAAGGCGCGTCTCGGTCTGAAGGACGTACGT
CTCGCGCTGGCGGCCGCCGAGCTGGTCTCGACGCCGCTGCCGGTGGCGAGCGTCGTGCGCGACAGTCTCATCGAAGCCGT
CGCTCACGGCGACGGTGAAAAGGATTTCGCGGTGCTGGGCCAGGTCGCGTCGCGTCGCGCAGGGCGCTGA

Upstream 100 bases:

>100_bases
ACGTCAGTATCGCACCGCAAGAAGCGCCGCGCCGATGGGCAATTACCTGCACGACGCGCGCGGCTGTGCTCTACTTCGGG
TTCTTCAACAGGAGCTAGTG

Downstream 100 bases:

>100_bases
CGCATCGGCATCGCCCGTCGCCTGCCGGGTCGATTGCCGATGCTTGCGGTCATTTCATCGGCGGACGGCGCGAACCGGCG
TCGAAACGGGCGGGGCGGGC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MDIGFIGLGEMGAAMVANMLKAGHSVRVWNRSAEKAQPLVGLGAQVVGSPAEAFTGDAVFSMLADDAALHDVISASLLEH
APRGLIHVNMATISVSLAEQLATAHASRGVHYVAAPVMGRPDVAAAGKLTIVAAGPAEAIDRVQPVFDSIGQKTWRIGSL
PQQANVVKLAANFMLAAAVESLGEASALLGGHGVAMQDFLDVITNSVFPGPVYQGYGKMIAEQRYEPALFKARLGLKDVR
LALAAAELVSTPLPVASVVRDSLIEAVAHGDGEKDFAVLGQVASRRAGR

Sequences:

>Translated_289_residues
MDIGFIGLGEMGAAMVANMLKAGHSVRVWNRSAEKAQPLVGLGAQVVGSPAEAFTGDAVFSMLADDAALHDVISASLLEH
APRGLIHVNMATISVSLAEQLATAHASRGVHYVAAPVMGRPDVAAAGKLTIVAAGPAEAIDRVQPVFDSIGQKTWRIGSL
PQQANVVKLAANFMLAAAVESLGEASALLGGHGVAMQDFLDVITNSVFPGPVYQGYGKMIAEQRYEPALFKARLGLKDVR
LALAAAELVSTPLPVASVVRDSLIEAVAHGDGEKDFAVLGQVASRRAGR
>Mature_289_residues
MDIGFIGLGEMGAAMVANMLKAGHSVRVWNRSAEKAQPLVGLGAQVVGSPAEAFTGDAVFSMLADDAALHDVISASLLEH
APRGLIHVNMATISVSLAEQLATAHASRGVHYVAAPVMGRPDVAAAGKLTIVAAGPAEAIDRVQPVFDSIGQKTWRIGSL
PQQANVVKLAANFMLAAAVESLGEASALLGGHGVAMQDFLDVITNSVFPGPVYQGYGKMIAEQRYEPALFKARLGLKDVR
LALAAAELVSTPLPVASVVRDSLIEAVAHGDGEKDFAVLGQVASRRAGR

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=280, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=24.3055555555556, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790315, Length=286, Percent_Identity=28.6713286713287, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693186, Length=282, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=26.056338028169, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789092, Length=277, Percent_Identity=26.3537906137184, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574115, Length=277, Percent_Identity=26.3537906137184, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24655230, Length=298, Percent_Identity=28.5234899328859, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19922568, Length=298, Percent_Identity=28.5234899328859, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.-.- [C]

Molecular weight: Translated: 29960; Mature: 29960

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIGFIGLGEMGAAMVANMLKAGHSVRVWNRSAEKAQPLVGLGAQVVGSPAEAFTGDAVF
CCCCEECCCHHHHHHHHHHHHCCCEEEEECCCHHHCCCHHHCCHHHHCCCHHHHHHHHHH
SMLADDAALHDVISASLLEHAPRGLIHVNMATISVSLAEQLATAHASRGVHYVAAPVMGR
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
PDVAAAGKLTIVAAGPAEAIDRVQPVFDSIGQKTWRIGSLPQQANVVKLAANFMLAAAVE
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHCHHHEECCCCCCHHHHHHHHHHHHHHHHHH
SLGEASALLGGHGVAMQDFLDVITNSVFPGPVYQGYGKMIAEQRYEPALFKARLGLKDVR
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
LALAAAELVSTPLPVASVVRDSLIEAVAHGDGEKDFAVLGQVASRRAGR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDIGFIGLGEMGAAMVANMLKAGHSVRVWNRSAEKAQPLVGLGAQVVGSPAEAFTGDAVF
CCCCEECCCHHHHHHHHHHHHCCCEEEEECCCHHHCCCHHHCCHHHHCCCHHHHHHHHHH
SMLADDAALHDVISASLLEHAPRGLIHVNMATISVSLAEQLATAHASRGVHYVAAPVMGR
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
PDVAAAGKLTIVAAGPAEAIDRVQPVFDSIGQKTWRIGSLPQQANVVKLAANFMLAAAVE
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHCHHHEECCCCCCHHHHHHHHHHHHHHHHHH
SLGEASALLGGHGVAMQDFLDVITNSVFPGPVYQGYGKMIAEQRYEPALFKARLGLKDVR
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
LALAAAELVSTPLPVASVVRDSLIEAVAHGDGEKDFAVLGQVASRRAGR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]