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The map label for this gene is maeB [H]

Identifier: 186477617

GI number: 186477617

Start: 3222188

End: 3224473

Strand: Reverse

Name: maeB [H]

Synonym: Bphy_2869

Alternate gene names: 186477617

Gene position: 3224473-3222188 (Counterclockwise)

Preceding gene: 186477618

Following gene: 186477615

Centisome position: 92.68

GC content: 62.47

Gene sequence:

>2286_bases
ATGGACGAACAACTGAAGCAAAGCGCTCTCGCATATCACCAGAATCCGAAGCCTGGCAAGATTTCGGTCACCCCGACCAA
GCCGCTTTCGAACCAGCTGGACCTGTCGCTGGCATATTCGCCGGGTGTCGCGGCGGCGTGCATGGCCATCTACGACGAAC
CGCTCGACGCGCAAAAGTACACCTCGCGCGGCAACCTGGTTGGCGTGATCACGAACGGCACGGCTGTGCTGGGCCTTGGC
AACATCGGGCCGCTCGCCGCGAAGCCGGTGATGGAAGGCAAGGGCTGTCTCTTCAAGAAATTTGCCGGCATCGACGTGTT
CGATATCGAACTAAGCGAGTCGGATCCCGACAAGCTCGTCGAAGCGATCGCGATGCTGGAGCCGACGCTCGGCGGCATCA
ATCTCGAAGACATCAAGGCGCCCGAATGCTTCTACATCGAAAAGAAGCTGCGCGAGCGCATGAAGATCCCCGTTTTCCAC
GACGATCAGCACGGTACGGCGATCATCGCCTCGGCGGCGATTCTCAACGGGCTGAAGGTGGTCGGCAAGAAGCTGGAAGA
CATCAAGCTGGTGTGCTCGGGCGCGGGTGCCGCGGCCATCGCGTGTCTGGACCTGCTCGTGCATCTGGGCCTGAAGAAGT
CGAACACGCTGGTGGTCGATTCGAAGGGCGTAATCTACGAAGGCCGCGGAAATCTTGACGCGTCGAAAGAGCGCTACCAG
GCGAGCACCGACGCGCGCACACTCGGCGACGCAATGCACGGCTGCGACGTGTTCCTCGGCTGTTCGAGCGCTGGCGTGCT
GAAGCCGGAAATGGTCACGACGATGGCCGACAAACCGCTGATTCTCGCGCTTGCGAACCCCGAGCCGGAAATCCGCCCGG
AAGAAGCGAAGAAGGTGCGTCCGGATGCGATCATCGCGACGGGCCGTTCGGACTATCCGAACCAGGTCAACAACGTGCTG
TGCTTCCCGTTCATCTTCCGCGGCGCGCTGGACGTGGGCGCGACGACGATCACGGAAGAGATGAAGCTCGCGTGCGTGCG
CGCGATCGCCGAACTTGCGGAAGAAACCGATCAGGGCGATGAAGTCGCGAAGGCGTACGAAGGCCACTCGCTCGAATTCG
GCCCCGATTACCTGATTCCGAAGCCTTTCGACCCGCGTCTGATCATCAAGATCGCGCCCGCCGTCGCACAAGCCGCGATG
GATTCGGGCGTCGCCACGCGTCCGATTCAGGACATGGACGCGTATCGCGAGCAACTCGGTGCGACCGTCTACCGCACGGG
CATGGTGATGCGCCCCGTGTTCGCGGCAGCGAAGGCGCAACCGGCGCGCATCGTGTTCGCGGAAGGCGAAGACGAGCGCG
TGCTGCGCGCGGCGCAATTCGTGCTGCTCGAGAAGATCGCAAAGCCTATTCTCGTCGGCCGTCCGAGCGTGATTGAGATG
CGTCTGAAGAAGATGGGCTCGAAGCTCAAGTGCGGCGAGGATGTCGAGATCGTCAATCCGGAAGACGATCCGCGCTATCA
GAAGAGCTGGCAGGCGTATCACGAGATCGGCGCGCGCGAAGGCGTGACGCCGGAAGTCGCGAAGGCCGCGATGCGCAAGT
TCAACACGCTGATCGGCGCGATTCTCGTGCATCTCGGCGACGCGGACGGCATGATCTGCGGTCTGATCGATACCTATCAC
GAGCATCTGAAATTCGTCGAGCAGGTGCTGGGCAAGGCCGCGAATGTCGACAACTTCGCCGCGATGAACCTGCTGATGCT
GCCGGGCCGCAACCTGTTCATCAGCGACACCTACGTCAACGAAGTGCCGACGGCCGAACAGCTCGCCGACATGACGATTC
TCGCCGCGCGCGAAATCGAAAAGTTCGGCATCGTGCCGAAGGTCGCGCTGCTGTCTAACTCGAACTTCGGCAGCATTCCT
TCGTCCTCGGCGGCCCGCATGGCGCAGGCGCGCAAACTGATCGCCGCGCGCGCACCGCATCTCGAAGTGGACGGCGAAAT
GCACGGCGACGCGGCGCTGTCGGAAGCGGTGCGCAAGGCAGCATTCCCCGGCACGACGCTGACGGGCGAAGCGAACCTGC
TGATCATGCCGAACGTCGAAGCGGCAAACATCACCTACAACCTGCTGAAGATGATCGGCGGCGAAGGCGTGACTGTGGGT
CCCTTCCTGCTCGGCGCTGCGAAGCCGGTGCACATCCTGACGCCGGCTGCGACCGTGCGCCGGATCATCAACATGACGGC
TGTCGCTTCGGCGAACGCCAGCGTGGATCGTCAGGCCGCGAAGTGA

Upstream 100 bases:

>100_bases
CGCCCGCGAGAATCGCCGCCGTCGAGCATCCCGTCGACATTGGCCAGCGCAGCACGTGACATTGAGCCGGGCCCAATTAT
TAACGTCTCGCAGGTTAAAA

Downstream 100 bases:

>100_bases
GCGTGCCTCCGGCGCGATGACGTGAAAAAGGGCACCGCAAGGCGCCCTTTTTCTTTGCCACAACCAACGGCGCTATGCCA
CGTGCCGCTCGGCGCCACCC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 761; Mature: 761

Protein sequence:

>761_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACMAIYDEPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKKLEDIKLVCSGAGAAAIACLDLLVHLGLKKSNTLVVDSKGVIYEGRGNLDASKERYQ
ASTDARTLGDAMHGCDVFLGCSSAGVLKPEMVTTMADKPLILALANPEPEIRPEEAKKVRPDAIIATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQGDEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFAAAKAQPARIVFAEGEDERVLRAAQFVLLEKIAKPILVGRPSVIEM
RLKKMGSKLKCGEDVEIVNPEDDPRYQKSWQAYHEIGAREGVTPEVAKAAMRKFNTLIGAILVHLGDADGMICGLIDTYH
EHLKFVEQVLGKAANVDNFAAMNLLMLPGRNLFISDTYVNEVPTAEQLADMTILAAREIEKFGIVPKVALLSNSNFGSIP
SSSAARMAQARKLIAARAPHLEVDGEMHGDAALSEAVRKAAFPGTTLTGEANLLIMPNVEAANITYNLLKMIGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVASANASVDRQAAK

Sequences:

>Translated_761_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACMAIYDEPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKKLEDIKLVCSGAGAAAIACLDLLVHLGLKKSNTLVVDSKGVIYEGRGNLDASKERYQ
ASTDARTLGDAMHGCDVFLGCSSAGVLKPEMVTTMADKPLILALANPEPEIRPEEAKKVRPDAIIATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQGDEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFAAAKAQPARIVFAEGEDERVLRAAQFVLLEKIAKPILVGRPSVIEM
RLKKMGSKLKCGEDVEIVNPEDDPRYQKSWQAYHEIGAREGVTPEVAKAAMRKFNTLIGAILVHLGDADGMICGLIDTYH
EHLKFVEQVLGKAANVDNFAAMNLLMLPGRNLFISDTYVNEVPTAEQLADMTILAAREIEKFGIVPKVALLSNSNFGSIP
SSSAARMAQARKLIAARAPHLEVDGEMHGDAALSEAVRKAAFPGTTLTGEANLLIMPNVEAANITYNLLKMIGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVASANASVDRQAAK
>Mature_761_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACMAIYDEPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKKLEDIKLVCSGAGAAAIACLDLLVHLGLKKSNTLVVDSKGVIYEGRGNLDASKERYQ
ASTDARTLGDAMHGCDVFLGCSSAGVLKPEMVTTMADKPLILALANPEPEIRPEEAKKVRPDAIIATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQGDEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFAAAKAQPARIVFAEGEDERVLRAAQFVLLEKIAKPILVGRPSVIEM
RLKKMGSKLKCGEDVEIVNPEDDPRYQKSWQAYHEIGAREGVTPEVAKAAMRKFNTLIGAILVHLGDADGMICGLIDTYH
EHLKFVEQVLGKAANVDNFAAMNLLMLPGRNLFISDTYVNEVPTAEQLADMTILAAREIEKFGIVPKVALLSNSNFGSIP
SSSAARMAQARKLIAARAPHLEVDGEMHGDAALSEAVRKAAFPGTTLTGEANLLIMPNVEAANITYNLLKMIGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVASANASVDRQAAK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=27.6967930029155, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI62420882, Length=348, Percent_Identity=27.0114942528736, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI62420880, Length=348, Percent_Identity=27.0114942528736, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI239049447, Length=348, Percent_Identity=27.0114942528736, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI4505145, Length=350, Percent_Identity=26, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1788806, Length=756, Percent_Identity=63.3597883597884, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=328, Percent_Identity=31.4024390243902, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788635, Length=347, Percent_Identity=29.6829971181556, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI87081919, Length=411, Percent_Identity=22.1411192214112, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=271, Percent_Identity=28.4132841328413, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281362674, Length=404, Percent_Identity=27.4752475247525, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356279, Length=404, Percent_Identity=27.4752475247525, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362672, Length=404, Percent_Identity=27.4752475247525, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=28.8571428571429, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=28.8571428571429, Blast_Score=83, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81609; Mature: 81609

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACMAIYDEPLDAQKY
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHH
TSRGNLVGVITNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKKLEDIKLVCSGAGAAAIACLDLLVHLGLKKSNTLVVDSKGVIYEGRGNLDASKERYQ
HHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEECCCCCCCCCHHHHH
ASTDARTLGDAMHGCDVFLGCSSAGVLKPEMVTTMADKPLILALANPEPEIRPEEAKKVR
HHCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCHHHHHCC
PDAIIATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQGD
CCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
EVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIQDMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHC
ATVYRTGMVMRPVFAAAKAQPARIVFAEGEDERVLRAAQFVLLEKIAKPILVGRPSVIEM
CHHHHCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RLKKMGSKLKCGEDVEIVNPEDDPRYQKSWQAYHEIGAREGVTPEVAKAAMRKFNTLIGA
HHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
ILVHLGDADGMICGLIDTYHEHLKFVEQVLGKAANVDNFAAMNLLMLPGRNLFISDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCCEEEECCCCC
EVPTAEQLADMTILAAREIEKFGIVPKVALLSNSNFGSIPSSSAARMAQARKLIAARAPH
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEAVRKAAFPGTTLTGEANLLIMPNVEAANITYNLLKMIGGEGVTVG
EEECCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVASANASVDRQAAK
HHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCHHCCC
>Mature Secondary Structure
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACMAIYDEPLDAQKY
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHH
TSRGNLVGVITNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKKLEDIKLVCSGAGAAAIACLDLLVHLGLKKSNTLVVDSKGVIYEGRGNLDASKERYQ
HHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEECCCCCCCCCHHHHH
ASTDARTLGDAMHGCDVFLGCSSAGVLKPEMVTTMADKPLILALANPEPEIRPEEAKKVR
HHCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCHHHHHCC
PDAIIATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQGD
CCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
EVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIQDMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHC
ATVYRTGMVMRPVFAAAKAQPARIVFAEGEDERVLRAAQFVLLEKIAKPILVGRPSVIEM
CHHHHCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RLKKMGSKLKCGEDVEIVNPEDDPRYQKSWQAYHEIGAREGVTPEVAKAAMRKFNTLIGA
HHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
ILVHLGDADGMICGLIDTYHEHLKFVEQVLGKAANVDNFAAMNLLMLPGRNLFISDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCCEEEECCCCC
EVPTAEQLADMTILAAREIEKFGIVPKVALLSNSNFGSIPSSSAARMAQARKLIAARAPH
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEAVRKAAFPGTTLTGEANLLIMPNVEAANITYNLLKMIGGEGVTVG
EEECCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVASANASVDRQAAK
HHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]