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The map label for this gene is hpd [H]

Identifier: 186477614

GI number: 186477614

Start: 3216746

End: 3217843

Strand: Direct

Name: hpd [H]

Synonym: Bphy_2866

Alternate gene names: 186477614

Gene position: 3216746-3217843 (Clockwise)

Preceding gene: 186477612

Following gene: 186477616

Centisome position: 92.46

GC content: 59.38

Gene sequence:

>1098_bases
ATGAAGGTTTCAACCTGGGAGAATCCCGTCGGCACCGACGGCTTCGAATTCATCGAATACACTGCGCCGGACCCCGTGGC
GCTCGGCAAGTTGTTCGAGCAGATGGGCTTCACGGCGATCGCGAAGCATCGGCACAAGGACGTGACGTTGTACCGCCAGG
GCGACATCAACTTCATCGTGAACGCCGAGCCGGACTCGTTCGCGCAACGTTTTGCCCGCCTGCACGGCCCGTCGATCTGC
GCGATCGCGTTCCGCGTGCAGGACGCGGCGAAGGCCTACAGGCGAGCACTCGACCTCGGCGCTTGGGGATTCGATAACAA
GACGGGCCCGATGGAACTGAACATTCCCGCCATCAAGGGCATCGGCGATTCGCTGATCTATTTCGTCGACCGCTGGCGCG
GCAAGAACGGCGCGGCGCCGAACAGCATCGGCAACATCAGCATCTATGATGTCGATTTCGAGCCAATCCCGGGCGCGAAT
GCTAATCCGACCGGGCACGGCCTCACCTATATCGATCACCTCACGCACAACGTCCATCGCGGCCGTATGCACGAGTGGGC
CGAGTTCTACGAGCGCCTGTTCAATTTCCGCGAAGTGCGCTACTTCGATATCGAAGGCAAGGTGACGGGCGTGAAGTCGA
AGGCAATGACGTCGCCGTGCGGCAAGATCCGCATTCCGATCAACGAGGAAGGCTCGGAAACAGCCGGCCAGATTCAGGAA
TATCTCGACGCGTATCATGGCGAGGGCATCCAGCACATCGCGCTCGGTACGAACGACATCTACCGGACGGTCGACGGCCT
GCGCAACTCGAAGATCACGCTGCTCGACACCATCGACACGTACTATGAGCTCGTCGACCGCCGCGTGCCGAACCACGGCG
AGCCGCTCGAAGAACTGCGCAAGCGCAAAATCCTGATCGACGGCGCACGCGAAGACCTGTTACTGCAGATATTCACTGAG
AACCAGATCGGACCGATCTTCTTCGAGATCATCCAGCGCAAGGGTAATCAGGGATTCGGCGAAGGCAACTTCAAGGCGCT
GTTCGAATCGATCGATCTGGATCAGATTCGTCGCGGTGTCGTGCAAGACAAGGCTTAA

Upstream 100 bases:

>100_bases
ACGCGAGAAAATTCGCAAGTTTTCTTCCCGAACCGGCAACTACACTGTTCTTCATCGGCTCGCGCAAAGCGAAGCGGACC
TCGCCATTCAGGAGACAGAC

Downstream 100 bases:

>100_bases
CGCGCGCCAGGACGCGCGCCAGGACGTTTAAGGTGGCAAAGAAAAAGGCGAGGACCGATTCGATCCTCGCCTTTTCTGTT
CGGAAGAGCGCTCCTTGGTG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKVSTWENPVGTDGFEFIEYTAPDPVALGKLFEQMGFTAIAKHRHKDVTLYRQGDINFIVNAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYRRALDLGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAAPNSIGNISIYDVDFEPIPGAN
ANPTGHGLTYIDHLTHNVHRGRMHEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSETAGQIQE
YLDAYHGEGIQHIALGTNDIYRTVDGLRNSKITLLDTIDTYYELVDRRVPNHGEPLEELRKRKILIDGAREDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIDLDQIRRGVVQDKA

Sequences:

>Translated_365_residues
MKVSTWENPVGTDGFEFIEYTAPDPVALGKLFEQMGFTAIAKHRHKDVTLYRQGDINFIVNAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYRRALDLGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAAPNSIGNISIYDVDFEPIPGAN
ANPTGHGLTYIDHLTHNVHRGRMHEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSETAGQIQE
YLDAYHGEGIQHIALGTNDIYRTVDGLRNSKITLLDTIDTYYELVDRRVPNHGEPLEELRKRKILIDGAREDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIDLDQIRRGVVQDKA
>Mature_365_residues
MKVSTWENPVGTDGFEFIEYTAPDPVALGKLFEQMGFTAIAKHRHKDVTLYRQGDINFIVNAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYRRALDLGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAAPNSIGNISIYDVDFEPIPGAN
ANPTGHGLTYIDHLTHNVHRGRMHEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSETAGQIQE
YLDAYHGEGIQHIALGTNDIYRTVDGLRNSKITLLDTIDTYYELVDRRVPNHGEPLEELRKRKILIDGAREDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIDLDQIRRGVVQDKA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=355, Percent_Identity=27.3239436619718, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI285002264, Length=355, Percent_Identity=27.3239436619718, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI14249394, Length=339, Percent_Identity=23.598820058997, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17555220, Length=225, Percent_Identity=36, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17550752, Length=204, Percent_Identity=30.8823529411765, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667510, Length=303, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21356105, Length=303, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41235; Mature: 41235

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSTWENPVGTDGFEFIEYTAPDPVALGKLFEQMGFTAIAKHRHKDVTLYRQGDINFIV
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYRRALDLGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAAPNSIGNISIYDVDFEPIPGANANPTGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GRMHEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSETAGQIQE
CHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCHHHHHHHH
YLDAYHGEGIQHIALGTNDIYRTVDGLRNSKITLLDTIDTYYELVDRRVPNHGEPLEELR
HHHHHCCCCEEEEEECCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHH
KRKILIDGAREDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIDLDQIRRGV
HCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHH
VQDKA
HCCCC
>Mature Secondary Structure
MKVSTWENPVGTDGFEFIEYTAPDPVALGKLFEQMGFTAIAKHRHKDVTLYRQGDINFIV
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYRRALDLGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAAPNSIGNISIYDVDFEPIPGANANPTGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GRMHEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSETAGQIQE
CHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCHHHHHHHH
YLDAYHGEGIQHIALGTNDIYRTVDGLRNSKITLLDTIDTYYELVDRRVPNHGEPLEELR
HHHHHCCCCEEEEEECCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHH
KRKILIDGAREDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIDLDQIRRGV
HCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHH
VQDKA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]