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The map label for this gene is recQ [H]

Identifier: 186477594

GI number: 186477594

Start: 3186259

End: 3188106

Strand: Reverse

Name: recQ [H]

Synonym: Bphy_2846

Alternate gene names: 186477594

Gene position: 3188106-3186259 (Counterclockwise)

Preceding gene: 186477595

Following gene: 186477593

Centisome position: 91.63

GC content: 62.66

Gene sequence:

>1848_bases
ATGTCCCGTCCGCTCCAGATCCTCAACGAAGTTTTCGGTTATCCCGCGTTTCGAGGGCAGCAAGGCGAAATCGTCGAACA
TGTTTCGGCGGGCGGCGACTGTCTGGTGCTGATGCCGACGGGCGGCGGCAAGTCGCTGTGTTATCAGATTCCATCTCTGG
TGAGGCGTGAGGCGGGGTTGGGGGCGGGCATCGTCGTGTCGCCGCTGATCGCACTGATGCAGGATCAGGTGGCGGCGCTG
ACGGAAGTTGGCGTCCGCGCGGCGTACCTGAATTCGACCCTGTCGGGCGCCGAAGCCGCTGCGACGGAACGTGCACTGCG
CGAGGGCGAAATCGATTTGCTGTATGTGGCGCCAGAGCGTCTGATGACGCCGCGCTTTCTCGATCTGCTCGAGCGCACGC
GCATCGGCCTGTTCGCGATCGACGAAGCACATTGCGTGTCGCAATGGGGGCACGATTTCCGCCCCGAATACATTCAGCTT
TCCGTCCTGCACGAACGTTTTCCATCGGTGCCGCGCATCGCGCTCACCGCGACCGCCGACGCGATTACGCGCGACGAAAT
CATTCACAGGCTCGCACTCGACGCCGCGCGTGTGTTTGTGTCGAGCTTCGACCGGCCGAACATCCGCTATCGGATCGTCG
AAAAGGACAATGCACGCTCGCAACTGCTCGACTTCATCCGCGCGGAACACTCGCGTGCAGACGGCACGACCGACGCAGGC
GTCGTGTATTGCCTGTCGCGCCGCAAGGTCGAAGAGACGGCTGACTGGTTGAAGACGCAGGGCGTGCGTGCGCTGCCGTA
TCACGCGGGAATGGAATTCGAGGTGCGTCAAAAGCACCAGGAAATGTTCCAGCGCGAAGAAGGCATCGTGATGTGCGCGA
CGATTGCGTTCGGCATGGGCATCGACAAACCGGACGTGCGTTTCGTCGCGCACCTTGACTTGCCGAAGAGCGTCGAAGGC
TATTACCAGGAGACCGGTCGCGCAGGCCGCGATGGTTTACCTGCAAACGCGTGGATGACTTACGGACTCGGCGACGTCGT
GCAGCAGCGCAAGATGATCGACGAATCCGAAGCCGACGACGCGCACAAGCGCGTGCAAACGGGCAAGCTCGATGCGTTGC
TCGGCCTGTGCGAAACGGCTTCGTGCCGGCGCGTGCGGCTGCTCGCCTACTTCGGCGAAGAAGGCAAGCCGTGCGGCAAC
TGCGATACGTGCCTCGAGCCGCCAGCGTCGTGGGACGCGACGCGCGAATCGCAAATGGCGCTCTCGTGCGTATTCCGCGC
GCAGCGCGCGAGCGGAATCCACTTTGGCGCAGGACACCTGATCGACATTCTCCGCGGCAATCGCACCGAGAAGATTCTGC
AGCGCGGTCACGAGAAGCTGAGTACGTTTGGAATTGGCGCGGCTTTGTCCGAGCATGAATGGCGCGCAGTGTTTCGCCAG
TTGGTGGCATTCGGATTTCTCACCGTCGATCACGAGGGATTCGGCTCGCTTGTGCTGACAGAAATTAGCAAGTCGGTCCT
GAAGGGCGAACAGACCGTGACCATGCGCCGTTACGTGAAGCCTGTGCGGACGCGACAGTCGTCCGGTCGCACCAGCGAGC
GCGCCGACCCGACGGCTGGCATGAACGCGCGCGAGCGCGCTCGGTGGGATCGGCTGCGCACATGGCGCACCGAGACGGCG
AAAAGCGATGGCGTCCCGGCCTACGTCATCTTCCACGACGCGACCTTGGCGGAAATTGCGCGGAATTGCCCTGAATCGCT
CGACGATCTGCGGCACATTCCCGGCATGGGCGCGCGTAAGCTCGACCGTTTCGGCGACGAACTGCTTGAAGTCGTCGCCG
CGGATTGA

Upstream 100 bases:

>100_bases
GACTCTGAAGATTGGCCGGTTGCACGACAAAGACAGGGCGAAACGCGATGGGGTTGGTAAAATTCGACTCACCCGTTACG
CGCTCTTCTCGCTCTCCTTC

Downstream 100 bases:

>100_bases
CATCGACATCCCGCTCAGCTCTTTCAAATCCACGCAACCTGTTGACTCGCTTACGATTTTCGGAATATGATGCTAGGTTC
CGGTTCTCGGCAGGGTTGCG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MSRPLQILNEVFGYPAFRGQQGEIVEHVSAGGDCLVLMPTGGGKSLCYQIPSLVRREAGLGAGIVVSPLIALMQDQVAAL
TEVGVRAAYLNSTLSGAEAAATERALREGEIDLLYVAPERLMTPRFLDLLERTRIGLFAIDEAHCVSQWGHDFRPEYIQL
SVLHERFPSVPRIALTATADAITRDEIIHRLALDAARVFVSSFDRPNIRYRIVEKDNARSQLLDFIRAEHSRADGTTDAG
VVYCLSRRKVEETADWLKTQGVRALPYHAGMEFEVRQKHQEMFQREEGIVMCATIAFGMGIDKPDVRFVAHLDLPKSVEG
YYQETGRAGRDGLPANAWMTYGLGDVVQQRKMIDESEADDAHKRVQTGKLDALLGLCETASCRRVRLLAYFGEEGKPCGN
CDTCLEPPASWDATRESQMALSCVFRAQRASGIHFGAGHLIDILRGNRTEKILQRGHEKLSTFGIGAALSEHEWRAVFRQ
LVAFGFLTVDHEGFGSLVLTEISKSVLKGEQTVTMRRYVKPVRTRQSSGRTSERADPTAGMNARERARWDRLRTWRTETA
KSDGVPAYVIFHDATLAEIARNCPESLDDLRHIPGMGARKLDRFGDELLEVVAAD

Sequences:

>Translated_615_residues
MSRPLQILNEVFGYPAFRGQQGEIVEHVSAGGDCLVLMPTGGGKSLCYQIPSLVRREAGLGAGIVVSPLIALMQDQVAAL
TEVGVRAAYLNSTLSGAEAAATERALREGEIDLLYVAPERLMTPRFLDLLERTRIGLFAIDEAHCVSQWGHDFRPEYIQL
SVLHERFPSVPRIALTATADAITRDEIIHRLALDAARVFVSSFDRPNIRYRIVEKDNARSQLLDFIRAEHSRADGTTDAG
VVYCLSRRKVEETADWLKTQGVRALPYHAGMEFEVRQKHQEMFQREEGIVMCATIAFGMGIDKPDVRFVAHLDLPKSVEG
YYQETGRAGRDGLPANAWMTYGLGDVVQQRKMIDESEADDAHKRVQTGKLDALLGLCETASCRRVRLLAYFGEEGKPCGN
CDTCLEPPASWDATRESQMALSCVFRAQRASGIHFGAGHLIDILRGNRTEKILQRGHEKLSTFGIGAALSEHEWRAVFRQ
LVAFGFLTVDHEGFGSLVLTEISKSVLKGEQTVTMRRYVKPVRTRQSSGRTSERADPTAGMNARERARWDRLRTWRTETA
KSDGVPAYVIFHDATLAEIARNCPESLDDLRHIPGMGARKLDRFGDELLEVVAAD
>Mature_614_residues
SRPLQILNEVFGYPAFRGQQGEIVEHVSAGGDCLVLMPTGGGKSLCYQIPSLVRREAGLGAGIVVSPLIALMQDQVAALT
EVGVRAAYLNSTLSGAEAAATERALREGEIDLLYVAPERLMTPRFLDLLERTRIGLFAIDEAHCVSQWGHDFRPEYIQLS
VLHERFPSVPRIALTATADAITRDEIIHRLALDAARVFVSSFDRPNIRYRIVEKDNARSQLLDFIRAEHSRADGTTDAGV
VYCLSRRKVEETADWLKTQGVRALPYHAGMEFEVRQKHQEMFQREEGIVMCATIAFGMGIDKPDVRFVAHLDLPKSVEGY
YQETGRAGRDGLPANAWMTYGLGDVVQQRKMIDESEADDAHKRVQTGKLDALLGLCETASCRRVRLLAYFGEEGKPCGNC
DTCLEPPASWDATRESQMALSCVFRAQRASGIHFGAGHLIDILRGNRTEKILQRGHEKLSTFGIGAALSEHEWRAVFRQL
VAFGFLTVDHEGFGSLVLTEISKSVLKGEQTVTMRRYVKPVRTRQSSGRTSERADPTAGMNARERARWDRLRTWRTETAK
SDGVPAYVIFHDATLAEIARNCPESLDDLRHIPGMGARKLDRFGDELLEVVAAD

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=650, Percent_Identity=35.6923076923077, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI14591902, Length=415, Percent_Identity=37.3493975903614, Blast_Score=281, Evalue=2e-75,
Organism=Homo sapiens, GI14591904, Length=415, Percent_Identity=37.3493975903614, Blast_Score=281, Evalue=2e-75,
Organism=Homo sapiens, GI148612816, Length=427, Percent_Identity=38.4074941451991, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI110735439, Length=510, Percent_Identity=33.7254901960784, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI169218196, Length=510, Percent_Identity=33.7254901960784, Blast_Score=252, Evalue=7e-67,
Organism=Homo sapiens, GI51242943, Length=394, Percent_Identity=38.8324873096447, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI51242947, Length=394, Percent_Identity=38.8324873096447, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI284005309, Length=344, Percent_Identity=36.046511627907, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI48994977, Length=614, Percent_Identity=43.9739413680782, Blast_Score=520, Evalue=1e-148,
Organism=Escherichia coli, GI87082221, Length=346, Percent_Identity=24.5664739884393, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25145561, Length=660, Percent_Identity=33.6363636363636, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI71987997, Length=410, Percent_Identity=39.7560975609756, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI71987993, Length=410, Percent_Identity=39.7560975609756, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI32564293, Length=673, Percent_Identity=31.3521545319465, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17552866, Length=440, Percent_Identity=37.0454545454545, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71995718, Length=225, Percent_Identity=27.5555555555556, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510309, Length=326, Percent_Identity=25.1533742331288, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17510307, Length=326, Percent_Identity=25.1533742331288, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71995514, Length=326, Percent_Identity=25.1533742331288, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115533224, Length=380, Percent_Identity=22.3684210526316, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=541, Percent_Identity=35.4898336414048, Blast_Score=345, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6324778, Length=240, Percent_Identity=28.75, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325138, Length=235, Percent_Identity=29.3617021276596, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24646066, Length=643, Percent_Identity=37.7916018662519, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24664226, Length=441, Percent_Identity=37.18820861678, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI62472181, Length=433, Percent_Identity=37.6443418013857, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24664230, Length=435, Percent_Identity=37.4712643678161, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI21358123, Length=356, Percent_Identity=35.3932584269663, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI28574962, Length=370, Percent_Identity=23.2432432432432, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 68413; Mature: 68282

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPLQILNEVFGYPAFRGQQGEIVEHVSAGGDCLVLMPTGGGKSLCYQIPSLVRREAGL
CCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
GAGIVVSPLIALMQDQVAALTEVGVRAAYLNSTLSGAEAAATERALREGEIDLLYVAPER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECHHH
LMTPRFLDLLERTRIGLFAIDEAHCVSQWGHDFRPEYIQLSVLHERFPSVPRIALTATAD
HCCHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECHH
AITRDEIIHRLALDAARVFVSSFDRPNIRYRIVEKDNARSQLLDFIRAEHSRADGTTDAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCH
VVYCLSRRKVEETADWLKTQGVRALPYHAGMEFEVRQKHQEMFQREEGIVMCATIAFGMG
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEHHHHCC
IDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLPANAWMTYGLGDVVQQRKMIDESEADD
CCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCHH
AHKRVQTGKLDALLGLCETASCRRVRLLAYFGEEGKPCGNCDTCLEPPASWDATRESQMA
HHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LSCVFRAQRASGIHFGAGHLIDILRGNRTEKILQRGHEKLSTFGIGAALSEHEWRAVFRQ
HHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LVAFGFLTVDHEGFGSLVLTEISKSVLKGEQTVTMRRYVKPVRTRQSSGRTSERADPTAG
HHHHHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
MNARERARWDRLRTWRTETAKSDGVPAYVIFHDATLAEIARNCPESLDDLRHIPGMGARK
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCHHHHHHHHHCCCCCHHH
LDRFGDELLEVVAAD
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRPLQILNEVFGYPAFRGQQGEIVEHVSAGGDCLVLMPTGGGKSLCYQIPSLVRREAGL
CCHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
GAGIVVSPLIALMQDQVAALTEVGVRAAYLNSTLSGAEAAATERALREGEIDLLYVAPER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECHHH
LMTPRFLDLLERTRIGLFAIDEAHCVSQWGHDFRPEYIQLSVLHERFPSVPRIALTATAD
HCCHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECHH
AITRDEIIHRLALDAARVFVSSFDRPNIRYRIVEKDNARSQLLDFIRAEHSRADGTTDAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCH
VVYCLSRRKVEETADWLKTQGVRALPYHAGMEFEVRQKHQEMFQREEGIVMCATIAFGMG
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEHHHHCC
IDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLPANAWMTYGLGDVVQQRKMIDESEADD
CCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCHH
AHKRVQTGKLDALLGLCETASCRRVRLLAYFGEEGKPCGNCDTCLEPPASWDATRESQMA
HHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LSCVFRAQRASGIHFGAGHLIDILRGNRTEKILQRGHEKLSTFGIGAALSEHEWRAVFRQ
HHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LVAFGFLTVDHEGFGSLVLTEISKSVLKGEQTVTMRRYVKPVRTRQSSGRTSERADPTAG
HHHHHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
MNARERARWDRLRTWRTETAKSDGVPAYVIFHDATLAEIARNCPESLDDLRHIPGMGARK
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCHHHHHHHHHCCCCCHHH
LDRFGDELLEVVAAD
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]