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The map label for this gene is envZ [H]

Identifier: 186477532

GI number: 186477532

Start: 3131363

End: 3132676

Strand: Direct

Name: envZ [H]

Synonym: Bphy_2784

Alternate gene names: 186477532

Gene position: 3131363-3132676 (Clockwise)

Preceding gene: 186477531

Following gene: 186477538

Centisome position: 90.0

GC content: 65.83

Gene sequence:

>1314_bases
GTGACCCGTATCAGGAATCCGCTGAATACGCTGTTCGGCCGGATGGCATTGCTTTCGTCGGCGGTGCTGTTTGCGATTCA
GGCCGGCTGGTTCGTGCTCGTCGTGATGCAGCCGCCGCATCATGAAGTGGACGGTTACGCACGCGGCATCCTGCTCGCAT
TGCAGGCCGCGAACGGCGAGCCCGTCAACGGCGCCGACGTTGCGCCTGCGCTGCGCGTGCATCTCGTGCCGACATGGAAC
ATGCCCGCCACCGTGCATCTCGAACCGCCGACGCGCCGCCCGTTCATCGACCTCACGCGACGCCTGCGCGCAAGCCTGCC
GTCCGGCACCGACATCGCCGTCGACGACACACATATGCCGCGCCTGTGGGTGCGCTTTCCGCGCAAGTCGATGTGGGTCG
TCATTCCCGTCGACGTGCCACCGCGCCCGCGCTTCGTGATCGAATCCGTTTCGATGCTGCTTGCCGCATTGCTGTTGTCG
CTGCTCGCGGTCTGGCAGATGCAGAGGCCGCTCACGCGCGTCGCCCATGCCGCTCGCGCGTTCGGTTCGGGCGGCCGGCC
CGAGCCCGTCTCCGAGCAGGGGCCGCGCGAGTTGCGCGACCTGATCGGTTCGTTCAACGACATGATGCGGCGCCTGAACG
AAGCGGGCGACGATCAGGCCGTGATGCTCGCGGGCGTCGCGCACGATCTGAAGGCGCCCCTTACGCGCCTGAAGCTGCGC
GCGAGCGTGCTCACCGACGAGAACGAACGAGCGGGCCTGATTCGCGATGTCGATTCGCTGACGAATATCGTGCAGCAGTT
CCTGGAATTCGCGGGACAGTCTGCGGAATCGGGACCGATGACGGAAGTCGATGGTTTCCTGCGCGAGCAGTTTTCCGCTA
CGGACGGTAATGGAACCGGCGAAGACAACGATGGCGACGACGGCGAAGCGACGCTCTTCACTCTCGATCTGCATGCGGGT
CCGCGCTTCACGCTGCCGCGCACGCTGCTGGACCGTCTCGTCACCAATCTCGTCGACAACGCCTTCGAGCACGGCGCGCC
ACCCGTCGATATCGCGACATCGCGCGACCGCGAACAATGGATCATCGACATTCGCGATCACGGCCCGGGCATTCCCGAAG
ACCGCATTGCCGCGGCGATGAAGCCATTTGTGCGGCTCGATGCGGCGCGCGGGGGAGAAGGACACTGCGGATTGGGCCTC
GCGATCGTCGTGCGGCTCACGCATCATCGCGGCGGCAACTGCACCGTGGAGAATCATCCGGAAGGCGGGCTGCACGTGCG
TATCGCGATGCCCGTCGCCGTGCCGGACGCCTGA

Upstream 100 bases:

>100_bases
CCGTGCTACGTGCAGACCGTGCGCGGCAAAGGCTATGTGTTCGTCCCCGATGCGGATCCGAACGGCGCGCCCTTCGCCGC
CGATCCCGCGTGATCGCCGC

Downstream 100 bases:

>100_bases
AGCAGCGCCGCACTTTATTACGCCCGCGGCCGTTGCGCTTACCTTGCCTTACGGTCGCCCCGTTTTGGCCAGCCAGGATC
TATAGTGCAATCCGGCGTCC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTRIRNPLNTLFGRMALLSSAVLFAIQAGWFVLVVMQPPHHEVDGYARGILLALQAANGEPVNGADVAPALRVHLVPTWN
MPATVHLEPPTRRPFIDLTRRLRASLPSGTDIAVDDTHMPRLWVRFPRKSMWVVIPVDVPPRPRFVIESVSMLLAALLLS
LLAVWQMQRPLTRVAHAARAFGSGGRPEPVSEQGPRELRDLIGSFNDMMRRLNEAGDDQAVMLAGVAHDLKAPLTRLKLR
ASVLTDENERAGLIRDVDSLTNIVQQFLEFAGQSAESGPMTEVDGFLREQFSATDGNGTGEDNDGDDGEATLFTLDLHAG
PRFTLPRTLLDRLVTNLVDNAFEHGAPPVDIATSRDREQWIIDIRDHGPGIPEDRIAAAMKPFVRLDAARGGEGHCGLGL
AIVVRLTHHRGGNCTVENHPEGGLHVRIAMPVAVPDA

Sequences:

>Translated_437_residues
MTRIRNPLNTLFGRMALLSSAVLFAIQAGWFVLVVMQPPHHEVDGYARGILLALQAANGEPVNGADVAPALRVHLVPTWN
MPATVHLEPPTRRPFIDLTRRLRASLPSGTDIAVDDTHMPRLWVRFPRKSMWVVIPVDVPPRPRFVIESVSMLLAALLLS
LLAVWQMQRPLTRVAHAARAFGSGGRPEPVSEQGPRELRDLIGSFNDMMRRLNEAGDDQAVMLAGVAHDLKAPLTRLKLR
ASVLTDENERAGLIRDVDSLTNIVQQFLEFAGQSAESGPMTEVDGFLREQFSATDGNGTGEDNDGDDGEATLFTLDLHAG
PRFTLPRTLLDRLVTNLVDNAFEHGAPPVDIATSRDREQWIIDIRDHGPGIPEDRIAAAMKPFVRLDAARGGEGHCGLGL
AIVVRLTHHRGGNCTVENHPEGGLHVRIAMPVAVPDA
>Mature_436_residues
TRIRNPLNTLFGRMALLSSAVLFAIQAGWFVLVVMQPPHHEVDGYARGILLALQAANGEPVNGADVAPALRVHLVPTWNM
PATVHLEPPTRRPFIDLTRRLRASLPSGTDIAVDDTHMPRLWVRFPRKSMWVVIPVDVPPRPRFVIESVSMLLAALLLSL
LAVWQMQRPLTRVAHAARAFGSGGRPEPVSEQGPRELRDLIGSFNDMMRRLNEAGDDQAVMLAGVAHDLKAPLTRLKLRA
SVLTDENERAGLIRDVDSLTNIVQQFLEFAGQSAESGPMTEVDGFLREQFSATDGNGTGEDNDGDDGEATLFTLDLHAGP
RFTLPRTLLDRLVTNLVDNAFEHGAPPVDIATSRDREQWIIDIRDHGPGIPEDRIAAAMKPFVRLDAARGGEGHCGLGLA
IVVRLTHHRGGNCTVENHPEGGLHVRIAMPVAVPDA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=357, Percent_Identity=27.1708683473389, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=28.0442804428044, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790551, Length=282, Percent_Identity=27.6595744680851, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787894, Length=370, Percent_Identity=26.4864864864865, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI87081816, Length=255, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=318, Percent_Identity=22.9559748427673, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47797; Mature: 47666

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIRNPLNTLFGRMALLSSAVLFAIQAGWFVLVVMQPPHHEVDGYARGILLALQAANGE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHEEEEEEECCCCC
PVNGADVAPALRVHLVPTWNMPATVHLEPPTRRPFIDLTRRLRASLPSGTDIAVDDTHMP
CCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCC
RLWVRFPRKSMWVVIPVDVPPRPRFVIESVSMLLAALLLSLLAVWQMQRPLTRVAHAARA
HHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGSGGRPEPVSEQGPRELRDLIGSFNDMMRRLNEAGDDQAVMLAGVAHDLKAPLTRLKLR
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHH
ASVLTDENERAGLIRDVDSLTNIVQQFLEFAGQSAESGPMTEVDGFLREQFSATDGNGTG
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
EDNDGDDGEATLFTLDLHAGPRFTLPRTLLDRLVTNLVDNAFEHGAPPVDIATSRDREQW
CCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IIDIRDHGPGIPEDRIAAAMKPFVRLDAARGGEGHCGLGLAIVVRLTHHRGGNCTVENHP
EEEEECCCCCCCHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCC
EGGLHVRIAMPVAVPDA
CCCEEEEEEEEEECCCC
>Mature Secondary Structure 
TRIRNPLNTLFGRMALLSSAVLFAIQAGWFVLVVMQPPHHEVDGYARGILLALQAANGE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHEEEEEEECCCCC
PVNGADVAPALRVHLVPTWNMPATVHLEPPTRRPFIDLTRRLRASLPSGTDIAVDDTHMP
CCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCC
RLWVRFPRKSMWVVIPVDVPPRPRFVIESVSMLLAALLLSLLAVWQMQRPLTRVAHAARA
HHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGSGGRPEPVSEQGPRELRDLIGSFNDMMRRLNEAGDDQAVMLAGVAHDLKAPLTRLKLR
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHH
ASVLTDENERAGLIRDVDSLTNIVQQFLEFAGQSAESGPMTEVDGFLREQFSATDGNGTG
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
EDNDGDDGEATLFTLDLHAGPRFTLPRTLLDRLVTNLVDNAFEHGAPPVDIATSRDREQW
CCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IIDIRDHGPGIPEDRIAAAMKPFVRLDAARGGEGHCGLGLAIVVRLTHHRGGNCTVENHP
EEEEECCCCCCCHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCC
EGGLHVRIAMPVAVPDA
CCCEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]