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The map label for this gene is pepQ [H]

Identifier: 186477465

GI number: 186477465

Start: 3072392

End: 3074206

Strand: Reverse

Name: pepQ [H]

Synonym: Bphy_2717

Alternate gene names: 186477465

Gene position: 3074206-3072392 (Counterclockwise)

Preceding gene: 186477466

Following gene: 186477464

Centisome position: 88.36

GC content: 66.34

Gene sequence:

>1815_bases
ATGAACGTACGACTCTCCGAAACTGCCTCGACGCCTGAGCGCATCGCGGCACTGCGCAGCGCGATGAAGCAGGAAGGGCT
CGCCGCCTGGCTGGTGCCCTCGGCCGATCCGCATCTTTCCGAATATCTGCCCGGCCGCTGGCAAGGGCGTGAATGGCTGT
CCGGCTTCACCGGCTCGGTCGGCACGCTGGTCGTGACGGCCGATTTCGCCGGTTTGTGGGTGGATAGCCGCTACTGGGTT
CAGGCCGAGGCGCAACTGGCGGGCACGGGCATCCAGTTGATGAAGATGTTCGGCGGCCAGCAGACGGCGCCGCATATCGA
CTGGCTCGCGCAGAACCTGCCGGCGGGCGCGACGGTCGGCGTCGACGGCGCCGTGCTCGGGGTCGCTGCGGCGCGCGCGC
TGAACGATGCGCTAAAAGCGCGCGACGTGAAGCTGCGCACCGATCTGGATCTGCTCGATACCGTGTGGCAGCAGCGTCCG
ACCCTGCCGACGGCAGCCGTGTACGAACACGTCGCGCCGCACGCGAGCGTGTCGCGCGCGAGAAAGCTCGATCAGATCCG
CCGCGCGATGCAGGAGAAGGGCGCGCAGTGGCATTTCATCTCGACGCTCGACGACCTCGCCTGGCTGCTGAATCTGCGCG
GCGCCGACGTGAACTACAACCCGGTGTTCGTCGCGCATGCGCTGATCGGGCTGGAGCGCGCTTCGCTTTTCGTGGTGGAC
GGAAAGGTGCCGCCGCAGCTGGCCGAATCGCTCGCACGCGACGGCATCAGGATCGAGCCGTACGCGAAGGCGGCTGACGC
GCTCGCCGCGCTGCCCAACGGCCAGACGCTGCTGATCGACCCGCGCCGTATCACGTTCGGGCTGCTGCAATCGGTGCCGG
CGTCGGTGGCGATCGTCGAGTCGGTGAATCCGTCGACGTTCTTCAAGTCGCGCAAGACGGAAGCGGAAGCCGAGTACGTG
CGCGCGACGATGGAGCAGGACGGCGCCGCGTTGGCTGAATTCTTCGCGTGGTTCGAAGGTGCGCTGGGCCGCGAAAAGAT
CACCGAGCTGACCATCGACGAAAAACTGACGGCGGCGCGTGCGCGCCAGGCGGGCTTCGTTACGCTGAGCTTCGCGACTA
TCGCCGGCTTCAATGCGAACGGTGCGATGCCGCATTACCGTGCGACGCCCGCGTCGCATTCGACGATCGAAGGCAACGGT
CTGCTGCTGATCGATTCCGGCGGACAGTATCTGAGCGGCACGACTGACATCACGCGCGTGGTGCCCGTCGGCACGATCAC
CGACGACCACCGCCGCGACTTCACGACCGTGTTGAAGGGCACGATGGCGCTGTCGCGCGCGAAGTTCCCGCGCGGCATCC
GTTCGCCGATGCTCGATTCGATTGCGCGTGCGCCGATCTGGGAAGCGGGCGCGGACTATGGGCACGGCACGGGCCACGGC
GTCGGCTATTTCCTGAACGTTCACGAAGGCCCGCAGGTGATCTCGCACTACGCGCCCGCCGAAAGCTGGACGGCGATGGA
AGAGGGCATGATCACGTCGATCGAGCCGGGCATCTATCGGCCGGGCAAGTGGGGCATCCGCATCGAAAACCTCGTGCTGA
ATCGCGAGGCCGAAAAGACCGAGTTCGGCGATTTCCTCGAATTCGAAACGCTGACGCTGTGCCCGATCGACACGCGCTGC
GTCGCGCTGAACCTGTTGCGCGACGACGAGCGTGCGTGGCTCAACGCGTATCACGCGACGGTGCGCGAACGCGTGTCGCC
GCGCGTGTCGGGTGACGCGAAGGCGTGGCTCGAAACGCGTACGCAGCCGGTATGA

Upstream 100 bases:

>100_bases
GACACGCTCGAGTGGCCCATATGCACCGCGATTGCGCTGGTTGCCGTTGCCGTGACGGTCGGCCTGTTTTCCCGTCGATG
AATTCTTGCAGGTGAAACCG

Downstream 100 bases:

>100_bases
GGCCGCGCTGACGAGCCGCCGCGAAACGGCGGCTCGCTCGATGCTGCCAGCTTTGCGGCAGGAAGAATCGACCAATAAAT
AGCGAGGCTCGCATGTCCCG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MNVRLSETASTPERIAALRSAMKQEGLAAWLVPSADPHLSEYLPGRWQGREWLSGFTGSVGTLVVTADFAGLWVDSRYWV
QAEAQLAGTGIQLMKMFGGQQTAPHIDWLAQNLPAGATVGVDGAVLGVAAARALNDALKARDVKLRTDLDLLDTVWQQRP
TLPTAAVYEHVAPHASVSRARKLDQIRRAMQEKGAQWHFISTLDDLAWLLNLRGADVNYNPVFVAHALIGLERASLFVVD
GKVPPQLAESLARDGIRIEPYAKAADALAALPNGQTLLIDPRRITFGLLQSVPASVAIVESVNPSTFFKSRKTEAEAEYV
RATMEQDGAALAEFFAWFEGALGREKITELTIDEKLTAARARQAGFVTLSFATIAGFNANGAMPHYRATPASHSTIEGNG
LLLIDSGGQYLSGTTDITRVVPVGTITDDHRRDFTTVLKGTMALSRAKFPRGIRSPMLDSIARAPIWEAGADYGHGTGHG
VGYFLNVHEGPQVISHYAPAESWTAMEEGMITSIEPGIYRPGKWGIRIENLVLNREAEKTEFGDFLEFETLTLCPIDTRC
VALNLLRDDERAWLNAYHATVRERVSPRVSGDAKAWLETRTQPV

Sequences:

>Translated_604_residues
MNVRLSETASTPERIAALRSAMKQEGLAAWLVPSADPHLSEYLPGRWQGREWLSGFTGSVGTLVVTADFAGLWVDSRYWV
QAEAQLAGTGIQLMKMFGGQQTAPHIDWLAQNLPAGATVGVDGAVLGVAAARALNDALKARDVKLRTDLDLLDTVWQQRP
TLPTAAVYEHVAPHASVSRARKLDQIRRAMQEKGAQWHFISTLDDLAWLLNLRGADVNYNPVFVAHALIGLERASLFVVD
GKVPPQLAESLARDGIRIEPYAKAADALAALPNGQTLLIDPRRITFGLLQSVPASVAIVESVNPSTFFKSRKTEAEAEYV
RATMEQDGAALAEFFAWFEGALGREKITELTIDEKLTAARARQAGFVTLSFATIAGFNANGAMPHYRATPASHSTIEGNG
LLLIDSGGQYLSGTTDITRVVPVGTITDDHRRDFTTVLKGTMALSRAKFPRGIRSPMLDSIARAPIWEAGADYGHGTGHG
VGYFLNVHEGPQVISHYAPAESWTAMEEGMITSIEPGIYRPGKWGIRIENLVLNREAEKTEFGDFLEFETLTLCPIDTRC
VALNLLRDDERAWLNAYHATVRERVSPRVSGDAKAWLETRTQPV
>Mature_604_residues
MNVRLSETASTPERIAALRSAMKQEGLAAWLVPSADPHLSEYLPGRWQGREWLSGFTGSVGTLVVTADFAGLWVDSRYWV
QAEAQLAGTGIQLMKMFGGQQTAPHIDWLAQNLPAGATVGVDGAVLGVAAARALNDALKARDVKLRTDLDLLDTVWQQRP
TLPTAAVYEHVAPHASVSRARKLDQIRRAMQEKGAQWHFISTLDDLAWLLNLRGADVNYNPVFVAHALIGLERASLFVVD
GKVPPQLAESLARDGIRIEPYAKAADALAALPNGQTLLIDPRRITFGLLQSVPASVAIVESVNPSTFFKSRKTEAEAEYV
RATMEQDGAALAEFFAWFEGALGREKITELTIDEKLTAARARQAGFVTLSFATIAGFNANGAMPHYRATPASHSTIEGNG
LLLIDSGGQYLSGTTDITRVVPVGTITDDHRRDFTTVLKGTMALSRAKFPRGIRSPMLDSIARAPIWEAGADYGHGTGHG
VGYFLNVHEGPQVISHYAPAESWTAMEEGMITSIEPGIYRPGKWGIRIENLVLNREAEKTEFGDFLEFETLTLCPIDTRC
VALNLLRDDERAWLNAYHATVRERVSPRVSGDAKAWLETRTQPV

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=620, Percent_Identity=37.0967741935484, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI264681565, Length=620, Percent_Identity=35.6451612903226, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI93141226, Length=609, Percent_Identity=32.512315270936, Blast_Score=340, Evalue=3e-93,
Organism=Escherichia coli, GI1788728, Length=179, Percent_Identity=36.3128491620112, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17509539, Length=606, Percent_Identity=32.8382838283828, Blast_Score=314, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI25149105, Length=600, Percent_Identity=27.3333333333333, Blast_Score=226, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322999, Length=665, Percent_Identity=31.4285714285714, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI17137632, Length=595, Percent_Identity=35.1260504201681, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI161078230, Length=611, Percent_Identity=27.1685761047463, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI21357287, Length=611, Percent_Identity=27.1685761047463, Blast_Score=236, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65972; Mature: 65972

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVRLSETASTPERIAALRSAMKQEGLAAWLVPSADPHLSEYLPGRWQGREWLSGFTGSV
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCHHHHCCCCCCC
GTLVVTADFAGLWVDSRYWVQAEAQLAGTGIQLMKMFGGQQTAPHIDWLAQNLPAGATVG
EEEEEEECCCEEEECCEEEEEEECHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEC
VDGAVLGVAAARALNDALKARDVKLRTDLDLLDTVWQQRPTLPTAAVYEHVAPHASVSRA
CCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHH
RKLDQIRRAMQEKGAQWHFISTLDDLAWLLNLRGADVNYNPVFVAHALIGLERASLFVVD
HHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEC
GKVPPQLAESLARDGIRIEPYAKAADALAALPNGQTLLIDPRRITFGLLQSVPASVAIVE
CCCCHHHHHHHHHCCEEECCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCEEEEE
SVNPSTFFKSRKTEAEAEYVRATMEQDGAALAEFFAWFEGALGREKITELTIDEKLTAAR
CCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ARQAGFVTLSFATIAGFNANGAMPHYRATPASHSTIEGNGLLLIDSGGQYLSGTTDITRV
HHHCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCEECCCCEEEEECCCCEECCCCCEEEE
VPVGTITDDHRRDFTTVLKGTMALSRAKFPRGIRSPMLDSIARAPIWEAGADYGHGTGHG
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCC
VGYFLNVHEGPQVISHYAPAESWTAMEEGMITSIEPGIYRPGKWGIRIENLVLNREAEKT
EEEEEEECCCHHHHHHCCCCHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEEECCCCCCC
EFGDFLEFETLTLCPIDTRCVALNLLRDDERAWLNAYHATVRERVSPRVSGDAKAWLETR
CCCCCCEECEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHC
TQPV
CCCC
>Mature Secondary Structure
MNVRLSETASTPERIAALRSAMKQEGLAAWLVPSADPHLSEYLPGRWQGREWLSGFTGSV
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCHHHHCCCCCCC
GTLVVTADFAGLWVDSRYWVQAEAQLAGTGIQLMKMFGGQQTAPHIDWLAQNLPAGATVG
EEEEEEECCCEEEECCEEEEEEECHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEC
VDGAVLGVAAARALNDALKARDVKLRTDLDLLDTVWQQRPTLPTAAVYEHVAPHASVSRA
CCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHH
RKLDQIRRAMQEKGAQWHFISTLDDLAWLLNLRGADVNYNPVFVAHALIGLERASLFVVD
HHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEC
GKVPPQLAESLARDGIRIEPYAKAADALAALPNGQTLLIDPRRITFGLLQSVPASVAIVE
CCCCHHHHHHHHHCCEEECCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCEEEEE
SVNPSTFFKSRKTEAEAEYVRATMEQDGAALAEFFAWFEGALGREKITELTIDEKLTAAR
CCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ARQAGFVTLSFATIAGFNANGAMPHYRATPASHSTIEGNGLLLIDSGGQYLSGTTDITRV
HHHCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCEECCCCEEEEECCCCEECCCCCEEEE
VPVGTITDDHRRDFTTVLKGTMALSRAKFPRGIRSPMLDSIARAPIWEAGADYGHGTGHG
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCC
VGYFLNVHEGPQVISHYAPAESWTAMEEGMITSIEPGIYRPGKWGIRIENLVLNREAEKT
EEEEEEECCCHHHHHHCCCCHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEEECCCCCCC
EFGDFLEFETLTLCPIDTRCVALNLLRDDERAWLNAYHATVRERVSPRVSGDAKAWLETR
CCCCCCEECEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHC
TQPV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]