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The map label for this gene is trpE [H]

Identifier: 186477446

GI number: 186477446

Start: 3051384

End: 3052877

Strand: Direct

Name: trpE [H]

Synonym: Bphy_2698

Alternate gene names: 186477446

Gene position: 3051384-3052877 (Clockwise)

Preceding gene: 186477445

Following gene: 186477447

Centisome position: 87.7

GC content: 63.59

Gene sequence:

>1494_bases
ATGACCGAACTCGAATTTCAGTCCCTCGCAAACGAGGGCTTCAATCGCATCCCGATGATCGCCGAAGCGCTGGCCGATCT
TGAGACGCCGCTCTCGCTGTATCTGAAGCTCGCGCAAACCGAGCGCAACGGCGCGAACTCTTTTCTGCTCGAATCGGTGG
TGGGGGGCGAACGCTTCGGCCGCTACTCATTCATCGGGCTGCCGGCGCGCACGCTGATCCGCACGAATAACGGCGTGACG
GAAGTGGTCAAGGACGGCAAGGTCGTCGAGACGCATGAAGGCGATCCGCTCGAATTCATCCAGCAGTTCCAGAGTCGCTT
CAAGATCGCGCTGCGCCCGGGCCTGCCGCGTTTCGCGGGCGGTCTCGCCGGCTACTTCGGCTACGACGCTGTGCGCTACA
TCGAAAAGAAGCTCGCGCACACGGCCCCGCCCGACGACCTGCATCTCCCGGACATCCAGCTGCTGCTGACGGAAGAAGTC
GCCGTCATCGACAACCTCGCGGGCAAGCTGTACCTCGTGATCTACGCCGACCCGACCACGCCCGAAGCGTACACGCGCGC
CAAGCAGCGTCTGCGCGAACTCAAGCAACGCCTGCGCACGACCGTGCAGCCGCCCGTCACGTCGGCGAGCGTGCGGACCG
AAATCTTCCGCGAGTTCAAGAAGGACGACTATCTGGCCGCCGTGCGCAAGGCGAAGGAATACATCGCAGCAGGCGAACTG
ATGCAGGTGCAGGTGGGCCAGCGCCTCACCAAGCCCTATCGCGACAATCCCCTCTCGCTGTATCGCGCGCTGCGTTCGCT
GAATCCGTCGCCGTATATGTACTACTACAACTTCGGCGACTTCCACGTGGTCGGCGCGTCGCCGGAAATTCTCGTGCGTC
AGGAAAAGCGCAACGACGACCGCATCGTCACGATCCGGCCGCTCGCGGGCACGCGTCCGCGTGGCAACACGCCTGAGCGC
GACGCCGAACTCGCCACCGAACTGCTGAACGATCCGAAGGAGATCGCCGAACACGTGATGCTGATCGACCTCGCGCGCAA
CGACGTGGGCCGCATCGCGGAAATCGGCTCTGTGGCCGTGACCGACAAGATGGTGATCGAAAAATACTCGCACGTGCAGC
ACATCGTGAGTTCCGTCGAGGGCAAGCTGAAGCCGGGCATGACCAATTTCGACGTGCTGCGCGCGACGTTCCCGGCGGGC
ACGCTGTCGGGTGCGCCGAAGGTTCGCGCAATGGAACTGATCGACGAACTCGAACCCGTGAAGCGCGGCCTGTACGGCGG
CGCCGTCGGCTACCTGTCGTTCACGGGCGAGATGGACCTCGCAATCACGATCCGCACGGGTGTGATCTGCAACGGCAATC
TGTATGTACAGGCGGCAGCGGGCGTGGTCGCCGACTCGGTGCCCGAATCCGAATGGCAAGAGACGGAGAACAAGGCGCGC
GCCGTGCTGCGCGCCGCCGAGCAGGTCCAAGACGGCCTCGATAGCGACTTCTGA

Upstream 100 bases:

>100_bases
CGCGCGCCGGTCTCTTACCTGTGACGAGCACATTCGACCGGTAACGCAGCCATGCCATGTCCGAGCACCACACCGCCGGA
CACACGAACAGGATCGGAAC

Downstream 100 bases:

>100_bases
CGGAGACTGACCATGCTGCTGATGATCGACAACTACGACTCGTTCACCTATAACCTGGTCCAGTACTTCGGCGAACTCGG
CGAAGACGTTCGGACTTATC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTELEFQSLANEGFNRIPMIAEALADLETPLSLYLKLAQTERNGANSFLLESVVGGERFGRYSFIGLPARTLIRTNNGVT
EVVKDGKVVETHEGDPLEFIQQFQSRFKIALRPGLPRFAGGLAGYFGYDAVRYIEKKLAHTAPPDDLHLPDIQLLLTEEV
AVIDNLAGKLYLVIYADPTTPEAYTRAKQRLRELKQRLRTTVQPPVTSASVRTEIFREFKKDDYLAAVRKAKEYIAAGEL
MQVQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRNDDRIVTIRPLAGTRPRGNTPER
DAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVAVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAG
TLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFTGEMDLAITIRTGVICNGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDSDF

Sequences:

>Translated_497_residues
MTELEFQSLANEGFNRIPMIAEALADLETPLSLYLKLAQTERNGANSFLLESVVGGERFGRYSFIGLPARTLIRTNNGVT
EVVKDGKVVETHEGDPLEFIQQFQSRFKIALRPGLPRFAGGLAGYFGYDAVRYIEKKLAHTAPPDDLHLPDIQLLLTEEV
AVIDNLAGKLYLVIYADPTTPEAYTRAKQRLRELKQRLRTTVQPPVTSASVRTEIFREFKKDDYLAAVRKAKEYIAAGEL
MQVQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRNDDRIVTIRPLAGTRPRGNTPER
DAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVAVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAG
TLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFTGEMDLAITIRTGVICNGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDSDF
>Mature_496_residues
TELEFQSLANEGFNRIPMIAEALADLETPLSLYLKLAQTERNGANSFLLESVVGGERFGRYSFIGLPARTLIRTNNGVTE
VVKDGKVVETHEGDPLEFIQQFQSRFKIALRPGLPRFAGGLAGYFGYDAVRYIEKKLAHTAPPDDLHLPDIQLLLTEEVA
VIDNLAGKLYLVIYADPTTPEAYTRAKQRLRELKQRLRTTVQPPVTSASVRTEIFREFKKDDYLAAVRKAKEYIAAGELM
QVQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRNDDRIVTIRPLAGTRPRGNTPERD
AELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVAVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAGT
LSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFTGEMDLAITIRTGVICNGNLYVQAAAGVVADSVPESEWQETENKARA
VLRAAEQVQDGLDSDF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=377, Percent_Identity=41.6445623342175, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788114, Length=447, Percent_Identity=33.3333333333333, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI87082077, Length=275, Percent_Identity=28.3636363636364, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786809, Length=225, Percent_Identity=29.3333333333333, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=465, Percent_Identity=41.9354838709677, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324361, Length=494, Percent_Identity=25.7085020242915, Blast_Score=136, Evalue=9e-33,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55290; Mature: 55159

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELEFQSLANEGFNRIPMIAEALADLETPLSLYLKLAQTERNGANSFLLESVVGGERFG
CCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHCC
RYSFIGLPARTLIRTNNGVTEVVKDGKVVETHEGDPLEFIQQFQSRFKIALRPGLPRFAG
CEEEECCCHHHEEECCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHCEEEECCCCCHHHH
GLAGYFGYDAVRYIEKKLAHTAPPDDLHLPDIQLLLTEEVAVIDNLAGKLYLVIYADPTT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHCCCEEEEEEEECCCC
PEAYTRAKQRLRELKQRLRTTVQPPVTSASVRTEIFREFKKDDYLAAVRKAKEYIAAGEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCH
MQVQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRNDD
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEECCCCCC
RIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVAV
EEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHCCHHH
TDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAGTLSGAPKVRAMELIDELEPV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHH
KRGLYGGAVGYLSFTGEMDLAITIRTGVICNGNLYVQAAAGVVADSVPESEWQETENKAR
HHHHCCCEEEEEEEECCEEEEEEEEECEEECCCEEEEECCCHHHCCCCCHHHHHHHHHHH
AVLRAAEQVQDGLDSDF
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TELEFQSLANEGFNRIPMIAEALADLETPLSLYLKLAQTERNGANSFLLESVVGGERFG
CCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHCC
RYSFIGLPARTLIRTNNGVTEVVKDGKVVETHEGDPLEFIQQFQSRFKIALRPGLPRFAG
CEEEECCCHHHEEECCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHCEEEECCCCCHHHH
GLAGYFGYDAVRYIEKKLAHTAPPDDLHLPDIQLLLTEEVAVIDNLAGKLYLVIYADPTT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHCCCEEEEEEEECCCC
PEAYTRAKQRLRELKQRLRTTVQPPVTSASVRTEIFREFKKDDYLAAVRKAKEYIAAGEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCH
MQVQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRNDD
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEECCCCCC
RIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVAV
EEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHCCHHH
TDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAGTLSGAPKVRAMELIDELEPV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHH
KRGLYGGAVGYLSFTGEMDLAITIRTGVICNGNLYVQAAAGVVADSVPESEWQETENKAR
HHHHCCCEEEEEEEECCEEEEEEEEECEEECCCEEEEECCCHHHCCCCCHHHHHHHHHHH
AVLRAAEQVQDGLDSDF
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]