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The map label for this gene is catF [H]

Identifier: 186477438

GI number: 186477438

Start: 3043567

End: 3044769

Strand: Direct

Name: catF [H]

Synonym: Bphy_2690

Alternate gene names: 186477438

Gene position: 3043567-3044769 (Clockwise)

Preceding gene: 186477437

Following gene: 186477439

Centisome position: 87.48

GC content: 63.51

Gene sequence:

>1203_bases
ATGACCGACGCTTTTATCTGTGACGCGATCCGCACTCCTTTCGGCCGCTATGGCGGCGCCTTGAAAGATGTCCGCGCGGA
CGACCTGGGCGCTGTTCCGATCAAGGCGCTCATCGAAAGAAATCCGGGCGTGGAGTGGCGCGCGCTCGACGACGTGATCT
ACGGCTGCGCCAATCAGGCCGGCGAGGACAACCGCAATGTCGCACGCATGTCGGCGCTGCTCGCAGGCTTGCCGACAGAC
GCCCCAGGTTCCACGATCAACCGGCTTTGCGGTTCGGGCATGGACGCAGTCGGCACGGCAGCCCGCGCGATCAAGGCAGG
CGAGGCTCGCCTGATGATCGCGGGTGGCGTGGAAAGCATGACGCGCGCGCCTTTCGTGATGGGCAAAGCAACGTCGGCAT
TTTCGCGCCAATCGGAGATTTATGACACGACCATCGGATGGCGCTTCGTCAATGCGCAAATGAAGCGCGTATACGGCGTC
GATTCGATGCCCGAAACGGCAGAGAATGTCGCCGTCGATTTCGAAATCAGTCGCGCCGATCAGGACGCGTTCGCACTGCG
CAGCCAGGAAAAGGCAGCGCGCGCGCAACGCGACGGCACGCTCGCGCACGAAATCGTGCCCGTCGAGATTCCGCAGAAAA
AGGGCGACCCGGTCTGCGTGACGCTAGACGAGCATCCGCGCGAAACGTCGCTCGAAGCACTGGGCAAACTGAAGGGCGTT
GTGCGTCCGGACGGTTCGGTCACGGCGGGTAATGCGTCGGGCGTCAACGACGGCGCTTGCGCTCTGCTCATCGCCAACCA
GGCAGCAACTGAACAATACGGCCTGCGTCGCCGCGCTCGTGTGATCGGTATGGCGACTGCCGGCGTCGAGCCGCGCATCA
TGGGTATCGGCCCTGCACCCGCCACGCAGAAACTGCTGAAACAGCTGAATATGACGCTCGACCAGTTCGACGTAATCGAA
CTCAACGAAGCGTTCGCGTCGCAAGGTCTGGCCGTTCTTCGGCAACTCGGCTTGCGTGACGACGACCCGCGCGTGAACCC
GAACGGCGGCGCCATCGCGCTGGGTCACCCGCTTGGCGCTTCCGGCGCGCGTCTGATTACGACAGCGCTCTATCAGCTCG
AACGCACGGGTGGCAGTTACGCCCTGTGCACCATGTGTATCGGTGTCGGCCAGGGCATCGCGCTCGCCATCGAGCGCGTC
TGA

Upstream 100 bases:

>100_bases
TATAACTTCTGCGCGACTGAAAACGCGCCAGACGTCGAACTAAGATGCAGTTCAAGGGCGCGCGCACATCCGCCCGCCCG
CTCTTCGCTGGAACTCCGAC

Downstream 100 bases:

>100_bases
GCGCCCCCCCATCCGGAACGTATGCAGACGAGGAGACATTCGATGCCCTTTGAAGCGATCCGCGTCCACATCGACGCGAC
GACGCACGTCGCCACCGTGA

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTDAFICDAIRTPFGRYGGALKDVRADDLGAVPIKALIERNPGVEWRALDDVIYGCANQAGEDNRNVARMSALLAGLPTD
APGSTINRLCGSGMDAVGTAARAIKAGEARLMIAGGVESMTRAPFVMGKATSAFSRQSEIYDTTIGWRFVNAQMKRVYGV
DSMPETAENVAVDFEISRADQDAFALRSQEKAARAQRDGTLAHEIVPVEIPQKKGDPVCVTLDEHPRETSLEALGKLKGV
VRPDGSVTAGNASGVNDGACALLIANQAATEQYGLRRRARVIGMATAGVEPRIMGIGPAPATQKLLKQLNMTLDQFDVIE
LNEAFASQGLAVLRQLGLRDDDPRVNPNGGAIALGHPLGASGARLITTALYQLERTGGSYALCTMCIGVGQGIALAIERV

Sequences:

>Translated_400_residues
MTDAFICDAIRTPFGRYGGALKDVRADDLGAVPIKALIERNPGVEWRALDDVIYGCANQAGEDNRNVARMSALLAGLPTD
APGSTINRLCGSGMDAVGTAARAIKAGEARLMIAGGVESMTRAPFVMGKATSAFSRQSEIYDTTIGWRFVNAQMKRVYGV
DSMPETAENVAVDFEISRADQDAFALRSQEKAARAQRDGTLAHEIVPVEIPQKKGDPVCVTLDEHPRETSLEALGKLKGV
VRPDGSVTAGNASGVNDGACALLIANQAATEQYGLRRRARVIGMATAGVEPRIMGIGPAPATQKLLKQLNMTLDQFDVIE
LNEAFASQGLAVLRQLGLRDDDPRVNPNGGAIALGHPLGASGARLITTALYQLERTGGSYALCTMCIGVGQGIALAIERV
>Mature_399_residues
TDAFICDAIRTPFGRYGGALKDVRADDLGAVPIKALIERNPGVEWRALDDVIYGCANQAGEDNRNVARMSALLAGLPTDA
PGSTINRLCGSGMDAVGTAARAIKAGEARLMIAGGVESMTRAPFVMGKATSAFSRQSEIYDTTIGWRFVNAQMKRVYGVD
SMPETAENVAVDFEISRADQDAFALRSQEKAARAQRDGTLAHEIVPVEIPQKKGDPVCVTLDEHPRETSLEALGKLKGVV
RPDGSVTAGNASGVNDGACALLIANQAATEQYGLRRRARVIGMATAGVEPRIMGIGPAPATQKLLKQLNMTLDQFDVIEL
NEAFASQGLAVLRQLGLRDDDPRVNPNGGAIALGHPLGASGARLITTALYQLERTGGSYALCTMCIGVGQGIALAIERV

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=42.5316455696203, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=38.7909319899244, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI4501853, Length=407, Percent_Identity=39.5577395577396, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=33.5820895522388, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=31.6279069767442, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI194353979, Length=398, Percent_Identity=30.1507537688442, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=65.8354114713217, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=43.5643564356436, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=44.139650872818, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=44.6650124069479, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1788683, Length=415, Percent_Identity=29.8795180722892, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=398, Percent_Identity=41.9597989949749, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI25147385, Length=403, Percent_Identity=33.0024813895782, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17535921, Length=410, Percent_Identity=33.6585365853659, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=32.093023255814, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=411, Percent_Identity=29.4403892944039, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=35.2357320099256, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322031, Length=403, Percent_Identity=35.7320099255583, Blast_Score=206, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=44.6384039900249, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI17648125, Length=403, Percent_Identity=38.9578163771712, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24640423, Length=402, Percent_Identity=34.0796019900498, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=30.4245283018868, Blast_Score=167, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 42278; Mature: 42147

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAFICDAIRTPFGRYGGALKDVRADDLGAVPIKALIERNPGVEWRALDDVIYGCANQA
CCCHHHHHHHHCCHHHHCCCHHHCCCCCCCCCHHHHHHHCCCCCCEEHHHHHHHHHHCCC
GEDNRNVARMSALLAGLPTDAPGSTINRLCGSGMDAVGTAARAIKAGEARLMIAGGVESM
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCHHHH
TRAPFVMGKATSAFSRQSEIYDTTIGWRFVNAQMKRVYGVDSMPETAENVAVDFEISRAD
HHCCEEECCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCCHHHEEEEEEECCCC
QDAFALRSQEKAARAQRDGTLAHEIVPVEIPQKKGDPVCVTLDEHPRETSLEALGKLKGV
CHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHCCC
VRPDGSVTAGNASGVNDGACALLIANQAATEQYGLRRRARVIGMATAGVEPRIMGIGPAP
CCCCCCEECCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHEEEEEECCCCCEEEECCCCH
ATQKLLKQLNMTLDQFDVIELNEAFASQGLAVLRQLGLRDDDPRVNPNGGAIALGHPLGA
HHHHHHHHHCCCHHHCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
SGARLITTALYQLERTGGSYALCTMCIGVGQGIALAIERV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
TDAFICDAIRTPFGRYGGALKDVRADDLGAVPIKALIERNPGVEWRALDDVIYGCANQA
CCHHHHHHHHCCHHHHCCCHHHCCCCCCCCCHHHHHHHCCCCCCEEHHHHHHHHHHCCC
GEDNRNVARMSALLAGLPTDAPGSTINRLCGSGMDAVGTAARAIKAGEARLMIAGGVESM
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCHHHH
TRAPFVMGKATSAFSRQSEIYDTTIGWRFVNAQMKRVYGVDSMPETAENVAVDFEISRAD
HHCCEEECCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCCHHHEEEEEEECCCC
QDAFALRSQEKAARAQRDGTLAHEIVPVEIPQKKGDPVCVTLDEHPRETSLEALGKLKGV
CHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHCCC
VRPDGSVTAGNASGVNDGACALLIANQAATEQYGLRRRARVIGMATAGVEPRIMGIGPAP
CCCCCCEECCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHEEEEEECCCCCEEEECCCCH
ATQKLLKQLNMTLDQFDVIELNEAFASQGLAVLRQLGLRDDDPRVNPNGGAIALGHPLGA
HHHHHHHHHCCCHHHCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
SGARLITTALYQLERTGGSYALCTMCIGVGQGIALAIERV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]