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The map label for this gene is accC [H]

Identifier: 186477378

GI number: 186477378

Start: 2968568

End: 2969953

Strand: Direct

Name: accC [H]

Synonym: Bphy_2630

Alternate gene names: 186477378

Gene position: 2968568-2969953 (Clockwise)

Preceding gene: 186477377

Following gene: 186477379

Centisome position: 85.32

GC content: 62.34

Gene sequence:

>1386_bases
ATGAGTCGAATATCCGCTATGTTTGAAAAAATCCTCATTGCCAATCGCGGCGAAATCGCGCTCCGCATTCAGCGCGCGTG
CCGCGAACTCGGCGTCAAGACGGTCGTCGTCTATTCCGAAGCCGACAAGGAAGCCAAATACGTGAAGCTCGCCGACGAGG
CGGTCTGCATCGGACCGGCGCCGTCGAACCTGAGCTACCTCAACATGCCCGCGCTGATCAGCGCGGCGGAAGTGACGGAC
GCCGAGGCGATTCACCCCGGCTATGGCTTCCTGTCCGAGAACGCGGACTTCGCTGAGCGCGTCGAGCAATCGGGCTTCGT
GTTCATCGGCCCGCGTCCCGACACCATCCGCATGATGGGCGACAAGGTCACCGCGAAGCAGACGATGATCAAGACGGGCG
TGCCCTGCGTGCCCGGCTCGGAAGGCGCGTTGCCGGAAGATCCGAAAGAGATCGTGAAGATTGCGCGCTCGATCGGCTAC
CCGGTGATCATCAAGGCGGCAGGCGGCGGCGGTGGCCGCGGCATGCGCGTCGTCCACACGGAAGCCGCGCTCGTGAACGC
CGTCAACATGACGCGCGAGGAAGCGGGCCGGGCGTTCGGCAATCCGCAGGTCTACATGGAGAAATACCTGGAGAACCCGC
GGCACATCGAAATCCAGGTGCTGGCCGACTCGTTCAAGAACGCACTGTGGCTCGGCGAGCGCGACTGCTCGATGCAGCGT
CGCCATCAGAAGGTGATCGAAGAGGCGCCGGCGCCCGGCATCGCGCGGCGTCTGATCGAGCGTATCGGCGACCGTTGCGC
GGACGCGTGCAAGAAGATGGGCTATCTCGGCGCGGGCACGTTCGAGTTCCTGTACGAAAACGGCGAGTTCTACTTCATCG
AAATGAACACGCGCGTGCAGGTCGAGCACCCGGTCACCGAACTGATCACGGGCATCGACATCGTGCAGGAACAGATCCGC
ATCGCGGCAGGCGAAAAGCTCGCCATGCGTCAGCGCGACATCCAGTTCCGCGGACACGCGATCGAATGCCGTATCAACGC
TGAAGATCCGTTCAAGTTCACGCCGTCGCCCGGACGTCTTACGTCTTGGCACATGCCGGGCGGCCCCGGCATTCGCGTCG
ATTCGCACGCATATAACGGCTATTTCGTTCCGCCGAACTATGATTCGATGATCGGCAAGCTGATCGCTTACGGCGCGACG
CGCGAACAGGCGATCAAGCGGATGCGCATCGCACTGTCGGAAATGGTGGTCGAAGGCATCCAGACCAACATCCCGCTGCA
TCGCGAGCTGATGCTCGACGCGAAGTTCGTCGAGGGCGGCACGAGCATCCATTACCTCGAAAACCGGCTGGCCGCGAAGC
TGCAAGCCGCACCGGAAGAAGCGTAA

Upstream 100 bases:

>100_bases
GCCGTTCGCCATCCGCGCACCCTACTTCTTCGGGCGCGCCACCGATCCTCTGAGGCAGCCGCCCGCCCCTTCGAACCAAC
CGGGCCCGCGGCGCCCATCG

Downstream 100 bases:

>100_bases
GCAATGAGCTACCGGGAACTGGTCGTCGAACTCGCACGCGAGCACGCGGAAGCGTTGTCGGATGCGCTGCTCGAACTGGG
CGCGCTGTCGGTGTCCGTCG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSRISAMFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTD
AEAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRMMGDKVTAKQTMIKTGVPCVPGSEGALPEDPKEIVKIARSIGY
PVIIKAAGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADSFKNALWLGERDCSMQR
RHQKVIEEAPAPGIARRLIERIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQVEHPVTELITGIDIVQEQIR
IAAGEKLAMRQRDIQFRGHAIECRINAEDPFKFTPSPGRLTSWHMPGGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGAT
REQAIKRMRIALSEMVVEGIQTNIPLHRELMLDAKFVEGGTSIHYLENRLAAKLQAAPEEA

Sequences:

>Translated_461_residues
MSRISAMFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTD
AEAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRMMGDKVTAKQTMIKTGVPCVPGSEGALPEDPKEIVKIARSIGY
PVIIKAAGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADSFKNALWLGERDCSMQR
RHQKVIEEAPAPGIARRLIERIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQVEHPVTELITGIDIVQEQIR
IAAGEKLAMRQRDIQFRGHAIECRINAEDPFKFTPSPGRLTSWHMPGGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGAT
REQAIKRMRIALSEMVVEGIQTNIPLHRELMLDAKFVEGGTSIHYLENRLAAKLQAAPEEA
>Mature_460_residues
SRISAMFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTDA
EAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRMMGDKVTAKQTMIKTGVPCVPGSEGALPEDPKEIVKIARSIGYP
VIIKAAGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADSFKNALWLGERDCSMQRR
HQKVIEEAPAPGIARRLIERIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQVEHPVTELITGIDIVQEQIRI
AAGEKLAMRQRDIQFRGHAIECRINAEDPFKFTPSPGRLTSWHMPGGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGATR
EQAIKRMRIALSEMVVEGIQTNIPLHRELMLDAKFVEGGTSIHYLENRLAAKLQAAPEEA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=450, Percent_Identity=48.4444444444444, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=48.7640449438202, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=48.7640449438202, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.5, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=44.5190156599553, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=44.5190156599553, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=44.5190156599553, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI38679974, Length=522, Percent_Identity=31.2260536398467, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI38679960, Length=522, Percent_Identity=31.2260536398467, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI38679977, Length=522, Percent_Identity=31.2260536398467, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI38679967, Length=522, Percent_Identity=31.2260536398467, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI38679971, Length=522, Percent_Identity=31.2260536398467, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI134142062, Length=521, Percent_Identity=31.4779270633397, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=66.8918918918919, Blast_Score=602, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.5011286681716, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=45.8049886621315, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=43.8478747203579, Blast_Score=345, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=29.2929292929293, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=517, Percent_Identity=28.2398452611219, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=517, Percent_Identity=28.2398452611219, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=40.6741573033708, Blast_Score=346, Evalue=5e-96,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=44.6428571428571, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.0892857142857, Blast_Score=328, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6324343, Length=527, Percent_Identity=30.1707779886148, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=469, Percent_Identity=31.3432835820896, Blast_Score=222, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24651757, Length=431, Percent_Identity=45.707656612529, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=45.7207207207207, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24651759, Length=394, Percent_Identity=44.6700507614213, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24586458, Length=514, Percent_Identity=29.5719844357977, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI161076407, Length=514, Percent_Identity=29.5719844357977, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24586460, Length=514, Percent_Identity=29.5719844357977, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI161076409, Length=514, Percent_Identity=29.5719844357977, Blast_Score=216, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 51011; Mature: 50880

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRISAMFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPA
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCEEEECCC
PSNLSYLNMPALISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRMMG
CCCCCEECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEECC
DKVTAKQTMIKTGVPCVPGSEGALPEDPKEIVKIARSIGYPVIIKAAGGGGGRGMRVVHT
CCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEH
EAALVNAVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADSFKNALWLGERDCSMQR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEHHHHHHEECCCCCHHHHH
RHQKVIEEAPAPGIARRLIERIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQ
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCEEE
VEHPVTELITGIDIVQEQIRIAAGEKLAMRQRDIQFRGHAIECRINAEDPFKFTPSPGRL
ECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEECCEEEEEEECCCCCCEECCCCCCE
TSWHMPGGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIKRMRIALSEMVVEGI
EEEECCCCCCCEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
QTNIPLHRELMLDAKFVEGGTSIHYLENRLAAKLQAAPEEA
HCCCCCHHHHHEEEHHHCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRISAMFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCEEEECCC
PSNLSYLNMPALISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRMMG
CCCCCEECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEECC
DKVTAKQTMIKTGVPCVPGSEGALPEDPKEIVKIARSIGYPVIIKAAGGGGGRGMRVVHT
CCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEH
EAALVNAVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADSFKNALWLGERDCSMQR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEHHHHHHEECCCCCHHHHH
RHQKVIEEAPAPGIARRLIERIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQ
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCEEE
VEHPVTELITGIDIVQEQIRIAAGEKLAMRQRDIQFRGHAIECRINAEDPFKFTPSPGRL
ECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEECCEEEEEEECCCCCCEECCCCCCE
TSWHMPGGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIKRMRIALSEMVVEGI
EEEECCCCCCCEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
QTNIPLHRELMLDAKFVEGGTSIHYLENRLAAKLQAAPEEA
HCCCCCHHHHHEEEHHHCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]