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The map label for this gene is maeB [H]

Identifier: 186477352

GI number: 186477352

Start: 2942108

End: 2944402

Strand: Reverse

Name: maeB [H]

Synonym: Bphy_2604

Alternate gene names: 186477352

Gene position: 2944402-2942108 (Counterclockwise)

Preceding gene: 186477357

Following gene: 186477351

Centisome position: 84.63

GC content: 63.75

Gene sequence:

>2295_bases
ATGTCGACGCCCGTCAATACCAAACTCCGTGAAGCCGCTCTCGATTACCACGAATTCCCGACCCCCGGGAAGATCGCGAT
CGCCCCGACGAAGCAGATGATCAACCAGCGCGACCTCGCACTGGCGTACTCGCCGGGCGTTGCGTTCGCGTGCGAGGCGA
TCGTCGAGAATCCGCTGAATGCCGCGCGCTTCACCGCGCGCAGCAACCTGGTCGGCGTCGTGTCGAACGGCACGGCAGTG
CTCGGTCTCGGCAACATCGGGCCGCTCGCGTCGAAGCCGGTCATGGAAGGCAAGGCCGTGCTGTTCAAGAAGTTCGCCGG
CATCGACGTGTTCGACATCGAGTTGAACGAATCGGACCCGCACAAGCTGGTCGAGGTGATCGCCGCGCTGGAGCCGACGT
TCGGCGGCATCAACCTGGAAGATATCAAGGCGCCGGACTGCTTTATCGTCGAGCGCGAGTGCCGCAAGCGCATGAAGATC
CCCGTCTTCCACGACGACCAGCACGGCACGGCAATCGTCGTCGCGGCGGCGATCTCGAACGGCCTGAAGGTGGTCGGCAA
GAGCATCAAGGAAGTGAAGCTGGTGGCGTCGGGCGCGGGCGCGGCGTCGCTCGCGTGTCTGAACCTGCTGGTCGACCTCG
GCATGCCGCTCGAAAACATCTACGTGACGGACCTGGCCGGCGTGGTCTACAAGGGCCGCACGGAACTGATGGATCCGGAC
AAGGAGCGTTTTGCGCGTGAGACGGACGCCCGCACGCTGGCGGAAGTGATGGACGGCGCGGACGTGTTCCTCGGCCTCTC
GGCAGGCGGCGTGCTCAAGCAGGACATGGTCAAGCAGATGGCCGGGAAGCCGCTGATCCTGGCGCTTGCCAATCCGACGC
CGGAAATCCTGCCGGAACTGGCGCTCGAAGTGCGTCCGGATGCCGTGCTGGCAACGGGTCGCACCGACTACCCGAATCAG
GTCAACAACGTCCTGTGCTTCCCGTTCATCTTCCGTGGCGCGCTGGATGTCGGCGCAACCGTCATTACGAAGGAAATGGA
AATCGCCGCGGTCAACGCGATCGCGGAACTGGCGCGTCAGGAGCAGTCGGACATCGTCGCGACGGCGTACGGCATTCAGG
ATCTGTCGTTCGGACCGGAATACCTGATTCCGAAGCCCTTCGATCCGCGCCTGATCGTGCAGATCGCGCCCGCCGTTGCG
CAGGCGGCGATGGATTCGGGCGTCGCGACGCGTCCGATCGAGGACATGGAGGCGTACAAGCAGCATTTGCAGCAGTTCGT
GTACCACAGCGGCACGACGATGAAGCCGATCTTCCAGCTGGCGCGCGGCGTCGAGCCGGAGAAGAAGCGCATCGTGTTTG
CGGAAGGCGAGGAAGAGCGCGTGCTGCGCGCGGTGCAGATCGTGGTCGACGAAAAGCTCGCGAAGCCGATCCTGATCGGC
CGTCCGGCCGTGATCGAGCAGCGCATCGCGAAGTTCGGGCTGCGTCTGGTGAACGGCCAGGACTACACGATCGTCAACAC
GGACCACGACGAGCGTTATCGTGACTTCTGGCAGACGTACCACAAGATGATGTGTCGCAAGGGCTTCACCGAGCAGATGG
CGAAGCTGGAAATGCGCCGCCGTACGACGCTGATCGGCTCGATGCTGGTCACGAAGGGGCACGCCGACGGCATGATCTGC
GGCACGGTCAGCACGACCCATCGCCACTTGCACTTCATCGACCAGGTGATCGGCAAGAAGGACGGCGCCAAGGTCTACGC
GGCGATGAATGCGCTCGTGCTGCCGAATCGCCAGATTTTTCTCGTCGATACCCACGTGAACGTCGATCCGACGGCCGAAG
AACTCGCGGAAATCACGATCATGGCGGCGGAGGAAGTGCGCCGTTTCGGCATCGAGCCGAAGATCGCGCTGCTGTCGCAT
TCGAACTTTGGCACGAGCAATGCGCCGTCCGCGCAGAAGATGCGCGACGTGCTGGCGCTGCTGCAGGAGCGCGCGCCGCA
TCTGCAGGTGGACGGCGAAATGCACGGCGACCTCGCGCTCGACGCGAACCTGCGCAAGGAAATTCTGGCCGAGTCGACGC
TGGAAGGCGACGCGAACCTGCTGGTGCTGCCCAATATCGACGCCGCGAACATCTCGTACAACCTGCTGAAGACGGCGGCG
GGCAACAACATCGCTATCGGGCCGATCCTGCTCGGCGCGGCCAAGCCCGTGCACGTGCTGACCCCGTCGGCAACGGTTCG
CCGGATCGTCAACATGACGGCGCTGCTGGTGGCAGACGTCAACGCGTCGCGTTAA

Upstream 100 bases:

>100_bases
CGGTCGCGGGACCTGCACCCGGATTGCAGGCTTCGACTTTTGGGATTGGCGCTACAATGCCGTCGAACATCTATTCTAAT
CCGCACTTCCAAGTCCGCTT

Downstream 100 bases:

>100_bases
GCTGTCCCTTTCTCTGCGCGAGTCGGTGAATTCCAGTTCGCGCGGGCAAAAAAAAGGCGTGCCCGCAATGGGCACGCCTT
CGAGCAATGGCTGGGGATTA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MSTPVNTKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEAIVENPLNAARFTARSNLVGVVSNGTAV
LGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVEVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKI
PVFHDDQHGTAIVVAAAISNGLKVVGKSIKEVKLVASGAGAASLACLNLLVDLGMPLENIYVTDLAGVVYKGRTELMDPD
KERFARETDARTLAEVMDGADVFLGLSAGGVLKQDMVKQMAGKPLILALANPTPEILPELALEVRPDAVLATGRTDYPNQ
VNNVLCFPFIFRGALDVGATVITKEMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVQIAPAVA
QAAMDSGVATRPIEDMEAYKQHLQQFVYHSGTTMKPIFQLARGVEPEKKRIVFAEGEEERVLRAVQIVVDEKLAKPILIG
RPAVIEQRIAKFGLRLVNGQDYTIVNTDHDERYRDFWQTYHKMMCRKGFTEQMAKLEMRRRTTLIGSMLVTKGHADGMIC
GTVSTTHRHLHFIDQVIGKKDGAKVYAAMNALVLPNRQIFLVDTHVNVDPTAEELAEITIMAAEEVRRFGIEPKIALLSH
SNFGTSNAPSAQKMRDVLALLQERAPHLQVDGEMHGDLALDANLRKEILAESTLEGDANLLVLPNIDAANISYNLLKTAA
GNNIAIGPILLGAAKPVHVLTPSATVRRIVNMTALLVADVNASR

Sequences:

>Translated_764_residues
MSTPVNTKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEAIVENPLNAARFTARSNLVGVVSNGTAV
LGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVEVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKI
PVFHDDQHGTAIVVAAAISNGLKVVGKSIKEVKLVASGAGAASLACLNLLVDLGMPLENIYVTDLAGVVYKGRTELMDPD
KERFARETDARTLAEVMDGADVFLGLSAGGVLKQDMVKQMAGKPLILALANPTPEILPELALEVRPDAVLATGRTDYPNQ
VNNVLCFPFIFRGALDVGATVITKEMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVQIAPAVA
QAAMDSGVATRPIEDMEAYKQHLQQFVYHSGTTMKPIFQLARGVEPEKKRIVFAEGEEERVLRAVQIVVDEKLAKPILIG
RPAVIEQRIAKFGLRLVNGQDYTIVNTDHDERYRDFWQTYHKMMCRKGFTEQMAKLEMRRRTTLIGSMLVTKGHADGMIC
GTVSTTHRHLHFIDQVIGKKDGAKVYAAMNALVLPNRQIFLVDTHVNVDPTAEELAEITIMAAEEVRRFGIEPKIALLSH
SNFGTSNAPSAQKMRDVLALLQERAPHLQVDGEMHGDLALDANLRKEILAESTLEGDANLLVLPNIDAANISYNLLKTAA
GNNIAIGPILLGAAKPVHVLTPSATVRRIVNMTALLVADVNASR
>Mature_763_residues
STPVNTKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEAIVENPLNAARFTARSNLVGVVSNGTAVL
GLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVEVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIP
VFHDDQHGTAIVVAAAISNGLKVVGKSIKEVKLVASGAGAASLACLNLLVDLGMPLENIYVTDLAGVVYKGRTELMDPDK
ERFARETDARTLAEVMDGADVFLGLSAGGVLKQDMVKQMAGKPLILALANPTPEILPELALEVRPDAVLATGRTDYPNQV
NNVLCFPFIFRGALDVGATVITKEMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVQIAPAVAQ
AAMDSGVATRPIEDMEAYKQHLQQFVYHSGTTMKPIFQLARGVEPEKKRIVFAEGEEERVLRAVQIVVDEKLAKPILIGR
PAVIEQRIAKFGLRLVNGQDYTIVNTDHDERYRDFWQTYHKMMCRKGFTEQMAKLEMRRRTTLIGSMLVTKGHADGMICG
TVSTTHRHLHFIDQVIGKKDGAKVYAAMNALVLPNRQIFLVDTHVNVDPTAEELAEITIMAAEEVRRFGIEPKIALLSHS
NFGTSNAPSAQKMRDVLALLQERAPHLQVDGEMHGDLALDANLRKEILAESTLEGDANLLVLPNIDAANISYNLLKTAAG
NNIAIGPILLGAAKPVHVLTPSATVRRIVNMTALLVADVNASR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=25.6559766763848, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI62420882, Length=352, Percent_Identity=27.5568181818182, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI62420880, Length=352, Percent_Identity=27.5568181818182, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI239049447, Length=352, Percent_Identity=27.5568181818182, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4505145, Length=370, Percent_Identity=26.2162162162162, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI270265879, Length=319, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788806, Length=756, Percent_Identity=61.7724867724868, Blast_Score=962, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=319, Percent_Identity=33.2288401253918, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=30.4761904761905, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17537199, Length=474, Percent_Identity=24.4725738396624, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=29.2887029288703, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281362672, Length=474, Percent_Identity=26.3713080168776, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281362674, Length=474, Percent_Identity=26.3713080168776, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356279, Length=474, Percent_Identity=26.3713080168776, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI78707242, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI78707238, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=27.1428571428571, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=27.1428571428571, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=24.9283667621776, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83073; Mature: 82942

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPVNTKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEAIVENPLN
CCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCEEEEECCCHHHHHHHHHHCCCH
AARFTARSNLVGVVSNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDP
HHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCH
HKLVEVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHDDQHGTAIVVAAAISN
HHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHCCCCCEEECCCCCCEEEEEEHHHC
GLKVVGKSIKEVKLVASGAGAASLACLNLLVDLGMPLENIYVTDLAGVVYKGRTELMDPD
CHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCHHHEEHHHHHHHHCCCCHHCCCCC
KERFARETDARTLAEVMDGADVFLGLSAGGVLKQDMVKQMAGKPLILALANPTPEILPEL
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
ALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATVITKEMEIAAVNAIAELARQ
HHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHHCHHHEEHHHHHHHHHHHHHHHHH
EQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVQIAPAVAQAAMDSGVATRPIEDMEAYK
HHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHH
QHLQQFVYHSGTTMKPIFQLARGVEPEKKRIVFAEGEEERVLRAVQIVVDEKLAKPILIG
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEC
RPAVIEQRIAKFGLRLVNGQDYTIVNTDHDERYRDFWQTYHKMMCRKGFTEQMAKLEMRR
CHHHHHHHHHHHCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RTTLIGSMLVTKGHADGMICGTVSTTHRHLHFIDQVIGKKDGAKVYAAMNALVLPNRQIF
HHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEHHEEEECCCEEE
LVDTHVNVDPTAEELAEITIMAAEEVRRFGIEPKIALLSHSNFGTSNAPSAQKMRDVLAL
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
LQERAPHLQVDGEMHGDLALDANLRKEILAESTLEGDANLLVLPNIDAANISYNLLKTAA
HHHCCCCEEECCCCCCCEEECCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHCC
GNNIAIGPILLGAAKPVHVLTPSATVRRIVNMTALLVADVNASR
CCCEEECCEEECCCCCEEEECCCHHHHHHHHHHHHEEECCCCCC
>Mature Secondary Structure 
STPVNTKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEAIVENPLN
CCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCEEEEECCCHHHHHHHHHHCCCH
AARFTARSNLVGVVSNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDP
HHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCH
HKLVEVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHDDQHGTAIVVAAAISN
HHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHCCCCCEEECCCCCCEEEEEEHHHC
GLKVVGKSIKEVKLVASGAGAASLACLNLLVDLGMPLENIYVTDLAGVVYKGRTELMDPD
CHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCHHHEEHHHHHHHHCCCCHHCCCCC
KERFARETDARTLAEVMDGADVFLGLSAGGVLKQDMVKQMAGKPLILALANPTPEILPEL
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
ALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATVITKEMEIAAVNAIAELARQ
HHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHHCHHHEEHHHHHHHHHHHHHHHHH
EQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVQIAPAVAQAAMDSGVATRPIEDMEAYK
HHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHH
QHLQQFVYHSGTTMKPIFQLARGVEPEKKRIVFAEGEEERVLRAVQIVVDEKLAKPILIG
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEC
RPAVIEQRIAKFGLRLVNGQDYTIVNTDHDERYRDFWQTYHKMMCRKGFTEQMAKLEMRR
CHHHHHHHHHHHCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RTTLIGSMLVTKGHADGMICGTVSTTHRHLHFIDQVIGKKDGAKVYAAMNALVLPNRQIF
HHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEHHEEEECCCEEE
LVDTHVNVDPTAEELAEITIMAAEEVRRFGIEPKIALLSHSNFGTSNAPSAQKMRDVLAL
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
LQERAPHLQVDGEMHGDLALDANLRKEILAESTLEGDANLLVLPNIDAANISYNLLKTAA
HHHCCCCEEECCCCCCCEEECCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHCC
GNNIAIGPILLGAAKPVHVLTPSATVRRIVNMTALLVADVNASR
CCCEEECCEEECCCCCEEEECCCHHHHHHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]