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The map label for this gene is pepP [H]

Identifier: 186477297

GI number: 186477297

Start: 2870551

End: 2872095

Strand: Direct

Name: pepP [H]

Synonym: Bphy_2549

Alternate gene names: 186477297

Gene position: 2870551-2872095 (Clockwise)

Preceding gene: 186477294

Following gene: 186477298

Centisome position: 82.51

GC content: 65.5

Gene sequence:

>1545_bases
ATGGCCAGGCATGACGATGGCCAGGCGGCGAGCCGAAACGATTTTCCGTTGGGCGATACAATCGCAGCATTGAATCGCAT
CATTGCCTCGCGGCGAACGACCTTGCCTGCCGCGCCGCCGTCCACTTCGCACGATGAACCGCCGACCGAACTCATGACCG
ATCTGACTCCGGCTATCGACCTCTACCGTCAGCGCCGTGCGCGCGTGCTCGATGCGCTGCGCGCGGCGGGCGGCGGCGTC
GCAATCGTTCCGACCGCGCCCGAAGCGCTGCGCAACCGCGACGCCGATTATCCGTACCGGCACGACAGCTACTTCTACTA
TCTGACGGGCTTCAGCGAACCCGAGGCGATGCTCGTGCTGGATGCGAGCGCAAAGCAAAACGAAGCTTCGTCGACCCTCT
TCTGCCGGGCGAAGAACGCAGAGCGCGAAACGTGGGAAGGCTTCCGTTTCGGTCCCGACGGTGCGCGCGAAGCCTTCGGT
TTCGACGCGGCCTTTGCGTTCGACGAAATCGACACACAACTGCCGCGCATCATCGCCGACAAGCCGGCGCTGCACTATGC
ACTCGGTGCTTCGGAACAGTTCGACGGCAAGGTGCGTCGGTGGCTCGACGCCGTGCGCATGCAGGGCAGAAGCGGCGTCC
TCGCGCCGTCCGCCGTGCATGACCTCATGCCGTTGCTCGATGAGATGCGGCTCGTGAAGGACGAGCACGAGCTGTCGATC
ATGCGCCGCGCCGCCGCGATCTCCGCGCAGGCTCACCGTCGCGCGATGACCACGTGCCGCCCTGGCATACGCGAATTCGA
ACTCGAAGCGGAACTGCTGTATACGTTCCGCAAGCATGGCGCGCAGGCGCCAGCGTATGGCTCGATCGTGGCCGCGGGTG
CGAACGCGTGCGTGCTGCACTACCCGGCTGGCAATGCAGCTGCGCAGGACGGCGACCTGATTCTGATCGATGCGGCGTGC
GAGCTCGACGGCTACGCATCCGACATCACCCGCACCTTCCCCGCGAACGGTCGTTTCACACCTGCGCAACGCCAGATCTA
CGACATCGTGCTGGCCGCGCAGCAAGCCGCGATCGACGCGACCAAAGCCGGCGCGAGCTTCGACGCGCCGCATCAGGCCG
CCGTGCGCGTGCTCGCGCAAGGGCTGCTCGACACGGGCATCCTGAATCGCGACCTGTTCGCGAGTGTTGACGAGGTGATC
GAAGAACGCGCCTACGCGCGTTTCTACATGCATCGCACGGGTCACTGGCTCGGCATGGATGTGCACGATGCCGGCGACTA
TCGAGAGCGCGGCGCACCCGCCGACGAACACGGCGCGCTGCCATGGCGCACGTTGAAACCGGGCATGACGCTGACGATCG
AACCGGGCCTCTACATCCGCGCGGCCGACGACGTGCCAGAACAGTACTGGAACATCGGCATCCGCATCGAGGACGACGCG
ATCGTCACGGCCACGGGCTGCGAGCTGATCACGCGCGACGTGCCCGTCGACGCCGACGAAATCGAAGCGTTGATGCTCGA
CGCGCACAAGACGGGCGCAGCCTGA

Upstream 100 bases:

>100_bases
ATTTCCGTGCAACGCAGACCTTGCTTCGCCTTCGGAACGCGCGCGGCTGTCGACAGATTGCAACAATGCCGGTGGTCCGC
GCGACGGTCGACCTGGCCTG

Downstream 100 bases:

>100_bases
GCGCGCCAGGAACAGACAAGAAGATGAACGAAGCCCCACAGCCGGTTGCCGACGCGCCGCTCGTCACGTCGAATACGAAG
CCCTACGACTACGACGTGAC

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MARHDDGQAASRNDFPLGDTIAALNRIIASRRTTLPAAPPSTSHDEPPTELMTDLTPAIDLYRQRRARVLDALRAAGGGV
AIVPTAPEALRNRDADYPYRHDSYFYYLTGFSEPEAMLVLDASAKQNEASSTLFCRAKNAERETWEGFRFGPDGAREAFG
FDAAFAFDEIDTQLPRIIADKPALHYALGASEQFDGKVRRWLDAVRMQGRSGVLAPSAVHDLMPLLDEMRLVKDEHELSI
MRRAAAISAQAHRRAMTTCRPGIREFELEAELLYTFRKHGAQAPAYGSIVAAGANACVLHYPAGNAAAQDGDLILIDAAC
ELDGYASDITRTFPANGRFTPAQRQIYDIVLAAQQAAIDATKAGASFDAPHQAAVRVLAQGLLDTGILNRDLFASVDEVI
EERAYARFYMHRTGHWLGMDVHDAGDYRERGAPADEHGALPWRTLKPGMTLTIEPGLYIRAADDVPEQYWNIGIRIEDDA
IVTATGCELITRDVPVDADEIEALMLDAHKTGAA

Sequences:

>Translated_514_residues
MARHDDGQAASRNDFPLGDTIAALNRIIASRRTTLPAAPPSTSHDEPPTELMTDLTPAIDLYRQRRARVLDALRAAGGGV
AIVPTAPEALRNRDADYPYRHDSYFYYLTGFSEPEAMLVLDASAKQNEASSTLFCRAKNAERETWEGFRFGPDGAREAFG
FDAAFAFDEIDTQLPRIIADKPALHYALGASEQFDGKVRRWLDAVRMQGRSGVLAPSAVHDLMPLLDEMRLVKDEHELSI
MRRAAAISAQAHRRAMTTCRPGIREFELEAELLYTFRKHGAQAPAYGSIVAAGANACVLHYPAGNAAAQDGDLILIDAAC
ELDGYASDITRTFPANGRFTPAQRQIYDIVLAAQQAAIDATKAGASFDAPHQAAVRVLAQGLLDTGILNRDLFASVDEVI
EERAYARFYMHRTGHWLGMDVHDAGDYRERGAPADEHGALPWRTLKPGMTLTIEPGLYIRAADDVPEQYWNIGIRIEDDA
IVTATGCELITRDVPVDADEIEALMLDAHKTGAA
>Mature_513_residues
ARHDDGQAASRNDFPLGDTIAALNRIIASRRTTLPAAPPSTSHDEPPTELMTDLTPAIDLYRQRRARVLDALRAAGGGVA
IVPTAPEALRNRDADYPYRHDSYFYYLTGFSEPEAMLVLDASAKQNEASSTLFCRAKNAERETWEGFRFGPDGAREAFGF
DAAFAFDEIDTQLPRIIADKPALHYALGASEQFDGKVRRWLDAVRMQGRSGVLAPSAVHDLMPLLDEMRLVKDEHELSIM
RRAAAISAQAHRRAMTTCRPGIREFELEAELLYTFRKHGAQAPAYGSIVAAGANACVLHYPAGNAAAQDGDLILIDAACE
LDGYASDITRTFPANGRFTPAQRQIYDIVLAAQQAAIDATKAGASFDAPHQAAVRVLAQGLLDTGILNRDLFASVDEVIE
ERAYARFYMHRTGHWLGMDVHDAGDYRERGAPADEHGALPWRTLKPGMTLTIEPGLYIRAADDVPEQYWNIGIRIEDDAI
VTATGCELITRDVPVDADEIEALMLDAHKTGAA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=471, Percent_Identity=30.7855626326964, Blast_Score=232, Evalue=8e-61,
Organism=Homo sapiens, GI149589008, Length=488, Percent_Identity=32.5819672131148, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI260593665, Length=316, Percent_Identity=37.6582278481013, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI260593663, Length=487, Percent_Identity=29.9794661190965, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1789275, Length=449, Percent_Identity=44.3207126948775, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1788728, Length=329, Percent_Identity=30.3951367781155, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790282, Length=316, Percent_Identity=30.379746835443, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=478, Percent_Identity=31.7991631799163, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71989583, Length=290, Percent_Identity=29.6551724137931, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=502, Percent_Identity=28.6852589641434, Blast_Score=204, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321118, Length=487, Percent_Identity=29.1581108829569, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19920384, Length=518, Percent_Identity=32.2393822393822, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI21357079, Length=497, Percent_Identity=33.1991951710262, Blast_Score=219, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 56304; Mature: 56173

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARHDDGQAASRNDFPLGDTIAALNRIIASRRTTLPAAPPSTSHDEPPTELMTDLTPAID
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LYRQRRARVLDALRAAGGGVAIVPTAPEALRNRDADYPYRHDSYFYYLTGFSEPEAMLVL
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEE
DASAKQNEASSTLFCRAKNAERETWEGFRFGPDGAREAFGFDAAFAFDEIDTQLPRIIAD
ECCCCCCCCCCEEEEEECCCCCHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCC
KPALHYALGASEQFDGKVRRWLDAVRMQGRSGVLAPSAVHDLMPLLDEMRLVKDEHELSI
CCCCEEECCCCHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MRRAAAISAQAHRRAMTTCRPGIREFELEAELLYTFRKHGAQAPAYGSIVAAGANACVLH
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEE
YPAGNAAAQDGDLILIDAACELDGYASDITRTFPANGRFTPAQRQIYDIVLAAQQAAIDA
CCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TKAGASFDAPHQAAVRVLAQGLLDTGILNRDLFASVDEVIEERAYARFYMHRTGHWLGMD
HHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VHDAGDYRERGAPADEHGALPWRTLKPGMTLTIEPGLYIRAADDVPEQYWNIGIRIEDDA
CCCCCCHHHCCCCCCCCCCCCCEEECCCCEEEECCCEEEEECCCCCHHHHEECEEECCCE
IVTATGCELITRDVPVDADEIEALMLDAHKTGAA
EEEECCCCCEECCCCCCHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
ARHDDGQAASRNDFPLGDTIAALNRIIASRRTTLPAAPPSTSHDEPPTELMTDLTPAID
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LYRQRRARVLDALRAAGGGVAIVPTAPEALRNRDADYPYRHDSYFYYLTGFSEPEAMLVL
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEE
DASAKQNEASSTLFCRAKNAERETWEGFRFGPDGAREAFGFDAAFAFDEIDTQLPRIIAD
ECCCCCCCCCCEEEEEECCCCCHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCC
KPALHYALGASEQFDGKVRRWLDAVRMQGRSGVLAPSAVHDLMPLLDEMRLVKDEHELSI
CCCCEEECCCCHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MRRAAAISAQAHRRAMTTCRPGIREFELEAELLYTFRKHGAQAPAYGSIVAAGANACVLH
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEE
YPAGNAAAQDGDLILIDAACELDGYASDITRTFPANGRFTPAQRQIYDIVLAAQQAAIDA
CCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TKAGASFDAPHQAAVRVLAQGLLDTGILNRDLFASVDEVIEERAYARFYMHRTGHWLGMD
HHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VHDAGDYRERGAPADEHGALPWRTLKPGMTLTIEPGLYIRAADDVPEQYWNIGIRIEDDA
CCCCCCHHHCCCCCCCCCCCCCEEECCCCEEEECCCEEEEECCCCCHHHHEECEEECCCE
IVTATGCELITRDVPVDADEIEALMLDAHKTGAA
EEEECCCCCEECCCCCCHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]