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The map label for this gene is pntAA [H]

Identifier: 186477291

GI number: 186477291

Start: 2863609

End: 2864751

Strand: Reverse

Name: pntAA [H]

Synonym: Bphy_2543

Alternate gene names: 186477291

Gene position: 2864751-2863609 (Counterclockwise)

Preceding gene: 186477295

Following gene: 186477290

Centisome position: 82.34

GC content: 65.0

Gene sequence:

>1143_bases
ATGCACATCGGAGTGCCAGCCGAGACGCGGCCGTACGAAACACGCGTCGCCGCGACGCCCGAGACGGTCAAGAAGTACGT
GTCGCAGGGCCACAGGGTTAGCGTACAGCGCGGCGCAGGGACGGCCGCAAGTTATCTGGACGACGCGTACGCAGCTGCGG
GCGCAGAGCTCGTCGATGCGCCAGCCGCATTCGGCGCAGAGCTCGTTCTCAAGGTTCAAAGCCCGACCGATTCAGAACTC
CCGCTTCTCAAACGCGGCTCGGTACTGGTCGGCATGCTCGAGCCGTTTAATGCTGAAAACGCATCGAAGCTAGCAACTGC
CGGCATCACTGCGTTCGCGCTCGAAGCCGCGCCGCGCACGACGCGTGCGCAAAGCCTCGACGTACTGTCGTCTCAAGCCA
ACATTGCGGGTTATAAAGCGGTGCTGCTCGCCGCCGACCTGTATCCGCGTTTCATGCCGATGCTGATGACGGCGGCGGGC
ACGGTGAAAGCCGCGCGCGTGCTGATTCTCGGCGCGGGCGTGGCGGGCTTGCAGGCGATTGCGACTGCAAAGCGCCTGGG
TGCCGTGATCGAAGCCTCAGACGTGCGGCCTGCCGTGAAAGAGCAGATCGAATCGCTCGGGGCGAAATTCCTCGACGTGC
CTTACGAAACCGATGAGGAGCGCGAAGCGGCGCAAGGCGTCGGCGGCTACGCGCGGCCGATGCCGCCTTCGTGGCTCGCA
CGCCAGTCGGCGCTCGTCCATGAACGCGCGAAGCAGGCCGACGTGATCATCTCCACCGCGCTGATTCCGGGGCGTCCCGC
GCCGACGCTGCTTTCCGTGGAAACGGTGCAGGCGATGAAGCCGGGCTCCGTGGTGATCGACCTCGCGGCGGGACGCGGGC
CGGAGTACGAAGGCCAGCGCGGCGGCAACTGTCCGCTGACGGAAGCGGACAAGGTCGTCGTCAAGCACGGCGTGACGATC
GCGGGATATACGAATCTCGCGTCGATGGTCGCATCCGATGCTTCGGCGCTGTATGCGCGCAACCTGCTCGACTTCATGAA
GCTGATCGTCACGAAGGAAGGCACGCTCAATATCGATCTCGCGGACGACATCGTCGCGGCCACGCTGCTGGCCCGCGACG
GCGAAGTCACGCGCAAGGCATAA

Upstream 100 bases:

>100_bases
AGCCGTGCGTAGCCGTTGCACTTGCCTTTTGCATTGCCGGCGTTGCCCTTCGTCGGCGATTCCAGATTTTCATAACAGGA
TGGTCGAAGGAGGATTTACG

Downstream 100 bases:

>100_bases
GCGCACTCACGTGCATGGGACCAGAGTAAAGCGCTGAAGCGCCGGCTCTGACCGACAGGAGAGAGGAAGATGGAAGTCAT
CAACCATACCGTGATCAATC

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MHIGVPAETRPYETRVAATPETVKKYVSQGHRVSVQRGAGTAASYLDDAYAAAGAELVDAPAAFGAELVLKVQSPTDSEL
PLLKRGSVLVGMLEPFNAENASKLATAGITAFALEAAPRTTRAQSLDVLSSQANIAGYKAVLLAADLYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEEREAAQGVGGYARPMPPSWLA
RQSALVHERAKQADVIISTALIPGRPAPTLLSVETVQAMKPGSVVIDLAAGRGPEYEGQRGGNCPLTEADKVVVKHGVTI
AGYTNLASMVASDASALYARNLLDFMKLIVTKEGTLNIDLADDIVAATLLARDGEVTRKA

Sequences:

>Translated_380_residues
MHIGVPAETRPYETRVAATPETVKKYVSQGHRVSVQRGAGTAASYLDDAYAAAGAELVDAPAAFGAELVLKVQSPTDSEL
PLLKRGSVLVGMLEPFNAENASKLATAGITAFALEAAPRTTRAQSLDVLSSQANIAGYKAVLLAADLYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEEREAAQGVGGYARPMPPSWLA
RQSALVHERAKQADVIISTALIPGRPAPTLLSVETVQAMKPGSVVIDLAAGRGPEYEGQRGGNCPLTEADKVVVKHGVTI
AGYTNLASMVASDASALYARNLLDFMKLIVTKEGTLNIDLADDIVAATLLARDGEVTRKA
>Mature_380_residues
MHIGVPAETRPYETRVAATPETVKKYVSQGHRVSVQRGAGTAASYLDDAYAAAGAELVDAPAAFGAELVLKVQSPTDSEL
PLLKRGSVLVGMLEPFNAENASKLATAGITAFALEAAPRTTRAQSLDVLSSQANIAGYKAVLLAADLYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEEREAAQGVGGYARPMPPSWLA
RQSALVHERAKQADVIISTALIPGRPAPTLLSVETVQAMKPGSVVIDLAAGRGPEYEGQRGGNCPLTEADKVVVKHGVTI
AGYTNLASMVASDASALYARNLLDFMKLIVTKEGTLNIDLADDIVAATLLARDGEVTRKA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=391, Percent_Identity=39.386189258312, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI122939153, Length=391, Percent_Identity=39.386189258312, Blast_Score=258, Evalue=6e-69,
Organism=Escherichia coli, GI1787887, Length=383, Percent_Identity=43.8642297650131, Blast_Score=305, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17550456, Length=377, Percent_Identity=40.3183023872679, Blast_Score=271, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39742; Mature: 39742

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGVPAETRPYETRVAATPETVKKYVSQGHRVSVQRGAGTAASYLDDAYAAAGAELVDA
CCCCCCCCCCCCCEEECCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHCC
PAAFGAELVLKVQSPTDSELPLLKRGSVLVGMLEPFNAENASKLATAGITAFALEAAPRT
CHHCCCEEEEEECCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHCHHHEEEECCCCC
TRAQSLDVLSSQANIAGYKAVLLAADLYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEEREAAQGVGGYARPMPPSWLA
HHHHHHHHHHCCCCCCHHHHHHHHHHCHHEECCCCCCCHHHHHHHCCCCCCCCCCHHHHH
RQSALVHERAKQADVIISTALIPGRPAPTLLSVETVQAMKPGSVVIDLAAGRGPEYEGQR
HHHHHHHHHHHHHHEEEEEEECCCCCCCCEEEHHHHHHCCCCCEEEEEECCCCCCCCCCC
GGNCPLTEADKVVVKHGVTIAGYTNLASMVASDASALYARNLLDFMKLIVTKEGTLNIDL
CCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEH
ADDIVAATLLARDGEVTRKA
HHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHIGVPAETRPYETRVAATPETVKKYVSQGHRVSVQRGAGTAASYLDDAYAAAGAELVDA
CCCCCCCCCCCCCEEECCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHCC
PAAFGAELVLKVQSPTDSELPLLKRGSVLVGMLEPFNAENASKLATAGITAFALEAAPRT
CHHCCCEEEEEECCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHCHHHEEEECCCCC
TRAQSLDVLSSQANIAGYKAVLLAADLYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEEREAAQGVGGYARPMPPSWLA
HHHHHHHHHHCCCCCCHHHHHHHHHHCHHEECCCCCCCHHHHHHHCCCCCCCCCCHHHHH
RQSALVHERAKQADVIISTALIPGRPAPTLLSVETVQAMKPGSVVIDLAAGRGPEYEGQR
HHHHHHHHHHHHHHEEEEEEECCCCCCCCEEEHHHHHHCCCCCEEEEEECCCCCCCCCCC
GGNCPLTEADKVVVKHGVTIAGYTNLASMVASDASALYARNLLDFMKLIVTKEGTLNIDL
CCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEH
ADDIVAATLLARDGEVTRKA
HHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]