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The map label for this gene is ubiA

Identifier: 186477267

GI number: 186477267

Start: 2837477

End: 2838340

Strand: Reverse

Name: ubiA

Synonym: Bphy_2519

Alternate gene names: 186477267

Gene position: 2838340-2837477 (Counterclockwise)

Preceding gene: 186477268

Following gene: 186477260

Centisome position: 81.58

GC content: 62.96

Gene sequence:

>864_bases
ATGTTCGCCCGACTCCCGCTCTATCTGCGCCTTGTCCGCATGGACAAGCCGATCGGCAGCCTGCTGCTGCTATGGCCGAC
GCTCAACGCGTTGTGGATTGCCTCGGACGGTCATCCGTCGGTTTCGTTGCTGGTGATCTTCGCGCTCGGCACGATTCTGA
TGCGCTCGGCCGGCTGCGCGATCAACGACTACGCCGACCGCGACTTCGACCGCTATGTGAAGCGCACCGAAAACCGGCCG
ATCACGTCGGGCAAGATCAAGGCATGGGAAGCCGTGGCACTTGCGGCGGGCCTATCGCTGGTCGCGTTCCTGCTGATTCT
GCCGCTCAATGCGCTGACGAAGGAATTGTCGGTGGCGGCGCTGTTCGTCGCGGGCACCTATCCGTTCACGAAGCGCTTCT
TCGCGATTCCGCAAGCGTATCTGGGCATCGCCTTCGGCTTCGGCATTCCGATGGCGTTTGCCGCTGTGCAGAACCAGGTG
CCGCTGCTCGCGTGGGTGATGCTGATTGCGAACGTGTTCTGGTCGGTCGCCTACGACACCGAATACGCGATGGTCGATCG
CGACGACGACATCAAGATCGGCATCCGCACGTCCGCGTTGACGTTCGGCCGCTTCGACGTGCTCGCCATCATGCTGTGCT
ATGCAGTGACGCTCGGCATCTACGTCGGGATCGGTTTTACGCTGGGCTTTGGTGTGTTGTACTGGATCGGCCTGGCGGCC
GCGGCAGGCTGCGCCGTCTATCACTACACGCTGATCAAGGGCCGAGAGCGCATGCCGTGCTTCGCGGCGTTCCGGCACAA
CAACTGGCTGGGCGGCGCGCTGTTCGCAGGCATCGCCGCACATTACGCGGCGCAGGCGTTCTGA

Upstream 100 bases:

>100_bases
GTGAAGGCCCGTCGGGCTTTTTGTTTTTTGCCTGCGTACGAGAACCAGGCTGTCACGCACGCTGCACTAAAATAGCGGGA
TCGAATCTACGCGCACCGCC

Downstream 100 bases:

>100_bases
GTCTTGTTTCCCGCGGCGTTATGAGCCTCCCTTTATCGGCGCGACGAGGCCCGCATAACGCGTGCACCGTCTGCCGACCG
GTTCAGGCAAGCAACATCAT

Product: 4-hydroxybenzoate polyprenyl transferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MFARLPLYLRLVRMDKPIGSLLLLWPTLNALWIASDGHPSVSLLVIFALGTILMRSAGCAINDYADRDFDRYVKRTENRP
ITSGKIKAWEAVALAAGLSLVAFLLILPLNALTKELSVAALFVAGTYPFTKRFFAIPQAYLGIAFGFGIPMAFAAVQNQV
PLLAWVMLIANVFWSVAYDTEYAMVDRDDDIKIGIRTSALTFGRFDVLAIMLCYAVTLGIYVGIGFTLGFGVLYWIGLAA
AAGCAVYHYTLIKGRERMPCFAAFRHNNWLGGALFAGIAAHYAAQAF

Sequences:

>Translated_287_residues
MFARLPLYLRLVRMDKPIGSLLLLWPTLNALWIASDGHPSVSLLVIFALGTILMRSAGCAINDYADRDFDRYVKRTENRP
ITSGKIKAWEAVALAAGLSLVAFLLILPLNALTKELSVAALFVAGTYPFTKRFFAIPQAYLGIAFGFGIPMAFAAVQNQV
PLLAWVMLIANVFWSVAYDTEYAMVDRDDDIKIGIRTSALTFGRFDVLAIMLCYAVTLGIYVGIGFTLGFGVLYWIGLAA
AAGCAVYHYTLIKGRERMPCFAAFRHNNWLGGALFAGIAAHYAAQAF
>Mature_287_residues
MFARLPLYLRLVRMDKPIGSLLLLWPTLNALWIASDGHPSVSLLVIFALGTILMRSAGCAINDYADRDFDRYVKRTENRP
ITSGKIKAWEAVALAAGLSLVAFLLILPLNALTKELSVAALFVAGTYPFTKRFFAIPQAYLGIAFGFGIPMAFAAVQNQV
PLLAWVMLIANVFWSVAYDTEYAMVDRDDDIKIGIRTSALTFGRFDVLAIMLCYAVTLGIYVGIGFTLGFGVLYWIGLAA
AAGCAVYHYTLIKGRERMPCFAAFRHNNWLGGALFAGIAAHYAAQAF

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=275, Percent_Identity=34.5454545454545, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1790473, Length=279, Percent_Identity=52.3297491039427, Blast_Score=274, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17553718, Length=283, Percent_Identity=34.2756183745583, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI32565247, Length=282, Percent_Identity=32.9787234042553, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17553720, Length=338, Percent_Identity=29.2899408284024, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32565245, Length=137, Percent_Identity=40.8759124087591, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32565243, Length=133, Percent_Identity=40.6015037593985, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324370, Length=253, Percent_Identity=32.4110671936759, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21355567, Length=275, Percent_Identity=34.1818181818182, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_BURP8 (B2JGG3)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858737.1
- GeneID:   6244002
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2519
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   CLSK2314033
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 31471; Mature: 31471

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f95e5c4)-; HASH(0x2013fe64)-; HASH(0x201cf9fc)-; HASH(0x1f9d9e78)-; HASH(0x1fff4da0)-; HASH(0x1fa3f654)-; HASH(0x1fe5c088)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFARLPLYLRLVRMDKPIGSLLLLWPTLNALWIASDGHPSVSLLVIFALGTILMRSAGCA
CCCCHHHHHHHHHHCCCHHHHEEHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
INDYADRDFDRYVKRTENRPITSGKIKAWEAVALAAGLSLVAFLLILPLNALTKELSVAA
CCCHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVAGTYPFTKRFFAIPQAYLGIAFGFGIPMAFAAVQNQVPLLAWVMLIANVFWSVAYDT
HEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
EYAMVDRDDDIKIGIRTSALTFGRFDVLAIMLCYAVTLGIYVGIGFTLGFGVLYWIGLAA
EEEEECCCCCEEEEEEECEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGCAVYHYTLIKGRERMPCFAAFRHNNWLGGALFAGIAAHYAAQAF
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MFARLPLYLRLVRMDKPIGSLLLLWPTLNALWIASDGHPSVSLLVIFALGTILMRSAGCA
CCCCHHHHHHHHHHCCCHHHHEEHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
INDYADRDFDRYVKRTENRPITSGKIKAWEAVALAAGLSLVAFLLILPLNALTKELSVAA
CCCHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVAGTYPFTKRFFAIPQAYLGIAFGFGIPMAFAAVQNQVPLLAWVMLIANVFWSVAYDT
HEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
EYAMVDRDDDIKIGIRTSALTFGRFDVLAIMLCYAVTLGIYVGIGFTLGFGVLYWIGLAA
EEEEECCCCCEEEEEEECEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGCAVYHYTLIKGRERMPCFAAFRHNNWLGGALFAGIAAHYAAQAF
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA