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The map label for this gene is xdhA [H]

Identifier: 186477172

GI number: 186477172

Start: 2721875

End: 2724232

Strand: Reverse

Name: xdhA [H]

Synonym: Bphy_2421

Alternate gene names: 186477172

Gene position: 2724232-2721875 (Counterclockwise)

Preceding gene: 186477173

Following gene: 186477171

Centisome position: 78.3

GC content: 63.57

Gene sequence:

>2358_bases
ATGAACCAGCAAGCCGAACCGTTCCTGAAAGACGCGAAGGAACTCGCCGACTTCACGCAAGTGCACGTGTCGCGCCCGCA
TGAATCCGCTCATCTGCACGTGAGCGGCCGCGCCACCTACACCGACGACATTCCCGAACTCGCGGGCACGCTGCACGCCG
CGCTCGGCCTGTCGCCGAAAGCGCATGCAAAGATCCTGTCGATGTCCTTCGACAAGGTGCGCGCGACGCCCGGTGTCGTC
GCGGTGTTCACGGCGGACGACATTCCCGGCCACAACGATTGCGCGCCGATCGTCAAAGGTGACGATCCGATTCTCGCGGA
CGGCGTCGTTCAGTACGTCGGCCAGCCGATGTTCATCGTCGTCGCGACGTCGCACGATGCCGCGCGACTCGGTGCGCGTC
GCGCAGACATTGAATTCGAGGAACTGCCCGCGGTGCTGACGGCGCAGCAGGCGCGCGCCGCGAACCAGAGCGTGATTCCA
CCGATGAAGCTGGCACGCGGCGATGCAGCGGCGAAGCTGCAACGCGCGGTGCATCGCGAAGCAGGCGACATGCTGCTTGG
CGGCCAGGAGCAGTTCTATTTGGAAGGACAGATCTCGTATGCGGTGCCGAAGGACGACGACGGCATGCACGTGCATTGCT
CGACGCAGCACCCGACGGAAATGCAGCATCTCGTCGCGCACATGCTGAACGTTCATTCGCACAACGTGCTGGTCGAGTGC
CGCCGGATGGGGGGCGGCTTCGGTGGCAAGGAATCGCAGTCGAGCATGTTCGCGTGCTGCGCGGCGCTCGCTGCCTGGAA
ACTGCTGTGCCCCGTGAAGCTGCGTCCGGACCGCGACGATGACATGATGGTGACGGGCAAGCGCCACGATTTTCACTATA
CGTATGACGTCGGCTACGACGACGAAGGCGTGATCGAAGGCGTGTCCGTCGACATGACGTCGCGTTGCGGCTTTTCCGCT
GACCTGTCCGGCCCCGTGATGACGCGTGCCGTGTGCCACTTCGATAACGCATATTTCCTGTCGGACGTCTCGATCGACGG
ATTCTGTGGCAAGACCAATACGCAGTCGAATACGGCGTTCCGCGGGTTCGGCGGTCCGCAGGGCGCGTTCGCGATCGAAT
ACATCATGGACAATGTCGCGCGCTCGCTCGGCAAGGATTCGCTCGACGTGCGCCGCCGCAATCTGTACGGCAAGACGGAG
CGCAATCAGACGCCGTATGGGCAGGTCGTCGAAGACAACGTGATTCATGAACTGATCGACGAACTCGAAGCGACAAGCGA
CTATCGCAGGCGCCGCGCCGAAGTGCTCGAGTTCAACCGCAATAACGAAGTGCTGAAGAAGGGCCTCGCGCTGACGCCCG
TCAAGTTCGGCATCGCGTTCAATGTCACGCACTTCAACCAGGCGGGCGCGCTCGTTCATATCTATACCGATGGCTCGGTG
CTCGTGAATCACGGTGGCACGGAAATGGGCCAGGGCCTCAATACCAAGGTCGCACAGGTGGTCGCGCATGAACTCGGCGT
GAGCTTCAGCCGCGTGCGCGTCACGGCCACGGATACGTCGAAGGTCGCGAATACGTCGGCGACGGCGGCATCGACGGGCT
CGGACCTGAACGGCAAGGCCGCGCAAGACGCCGCGCGCCAGCTGCGCGAGCGACTTGCCGAGTTCGCGGCCGACAAGTTC
GGCGCGGGCGAAGTGACGGCCGCGCAAGTGCGTTTCGCGGGCGACTGCGCGCTGGTCGGCGACGCTGTCGTGCCGTTCGA
GGAAGTAATCGCCAAGGCGTATCTGGCGCGCGTGCAGCTGTGGTCCGATGGCTTCTACGCGACGCCGAAGCTCTACTGGG
ATCAGGCGAAGCTGCAAGGCCGGCCGTTCTTCTACTACTCGTACGGTGCAGCCGTGTCGGAAGTCGTGATCGACACGCTG
ACGGGCGAAATGCGCGTGTTGCGCGCCGATGCGCTGCACGATGTGGGCGCGTCGCTGAATCCCGCGCTCGACGTGGGGCA
AGTGGAAGGCGGCTTCATTCAGGGCATGGGCTGGCTGACGACGGAAGAGCTGTGGTGGAACGCGAGCGGCAAGCTGATGA
CGCAGGCGCCGTCCACATACAAGATTCCGACCGTCAACGACACGCCGCCCGATTTCCGCGTGCGGCTGTTCAAGAACCGC
AACGCGGAGGACAGCATCCATCGCTCGAAGGCGACGGGCGAGCCGCCGTTGCTGTTGCCGTTCTCGGTGTTCTTCGCGAT
TCGCGATGCCGTGGCTGCCGTCGGCGATTACAAAGTGAACCCGCCGTTGAACGCACCTGCGACGGGCGAAGAAATCCTCA
AGGCGATTCGCGCGGTGCGCGCTTCGCGTGCGGTTTGA

Upstream 100 bases:

>100_bases
GAACGATCCGCTGCAAAAGAGTGCGCTCGATGTGCGCGCGGTGCTGGCGGCAGGCGCGGACGCCTGATAGCGAAGGGTAC
GAATACGGAGAACCTGCAGA

Downstream 100 bases:

>100_bases
CCGGAATAAGAGGCTGCCCGCGATGATGCCCGTTTCTTCTTCCGTCGACATGCCCGTTCAGATCGGCCGGCGCAGCGGCC
ACGCGACGAAGCTGCCGCCG

Product: xanthine dehydrogenase, molybdopterin binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MNQQAEPFLKDAKELADFTQVHVSRPHESAHLHVSGRATYTDDIPELAGTLHAALGLSPKAHAKILSMSFDKVRATPGVV
AVFTADDIPGHNDCAPIVKGDDPILADGVVQYVGQPMFIVVATSHDAARLGARRADIEFEELPAVLTAQQARAANQSVIP
PMKLARGDAAAKLQRAVHREAGDMLLGGQEQFYLEGQISYAVPKDDDGMHVHCSTQHPTEMQHLVAHMLNVHSHNVLVEC
RRMGGGFGGKESQSSMFACCAALAAWKLLCPVKLRPDRDDDMMVTGKRHDFHYTYDVGYDDEGVIEGVSVDMTSRCGFSA
DLSGPVMTRAVCHFDNAYFLSDVSIDGFCGKTNTQSNTAFRGFGGPQGAFAIEYIMDNVARSLGKDSLDVRRRNLYGKTE
RNQTPYGQVVEDNVIHELIDELEATSDYRRRRAEVLEFNRNNEVLKKGLALTPVKFGIAFNVTHFNQAGALVHIYTDGSV
LVNHGGTEMGQGLNTKVAQVVAHELGVSFSRVRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQLRERLAEFAADKF
GAGEVTAAQVRFAGDCALVGDAVVPFEEVIAKAYLARVQLWSDGFYATPKLYWDQAKLQGRPFFYYSYGAAVSEVVIDTL
TGEMRVLRADALHDVGASLNPALDVGQVEGGFIQGMGWLTTEELWWNASGKLMTQAPSTYKIPTVNDTPPDFRVRLFKNR
NAEDSIHRSKATGEPPLLLPFSVFFAIRDAVAAVGDYKVNPPLNAPATGEEILKAIRAVRASRAV

Sequences:

>Translated_785_residues
MNQQAEPFLKDAKELADFTQVHVSRPHESAHLHVSGRATYTDDIPELAGTLHAALGLSPKAHAKILSMSFDKVRATPGVV
AVFTADDIPGHNDCAPIVKGDDPILADGVVQYVGQPMFIVVATSHDAARLGARRADIEFEELPAVLTAQQARAANQSVIP
PMKLARGDAAAKLQRAVHREAGDMLLGGQEQFYLEGQISYAVPKDDDGMHVHCSTQHPTEMQHLVAHMLNVHSHNVLVEC
RRMGGGFGGKESQSSMFACCAALAAWKLLCPVKLRPDRDDDMMVTGKRHDFHYTYDVGYDDEGVIEGVSVDMTSRCGFSA
DLSGPVMTRAVCHFDNAYFLSDVSIDGFCGKTNTQSNTAFRGFGGPQGAFAIEYIMDNVARSLGKDSLDVRRRNLYGKTE
RNQTPYGQVVEDNVIHELIDELEATSDYRRRRAEVLEFNRNNEVLKKGLALTPVKFGIAFNVTHFNQAGALVHIYTDGSV
LVNHGGTEMGQGLNTKVAQVVAHELGVSFSRVRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQLRERLAEFAADKF
GAGEVTAAQVRFAGDCALVGDAVVPFEEVIAKAYLARVQLWSDGFYATPKLYWDQAKLQGRPFFYYSYGAAVSEVVIDTL
TGEMRVLRADALHDVGASLNPALDVGQVEGGFIQGMGWLTTEELWWNASGKLMTQAPSTYKIPTVNDTPPDFRVRLFKNR
NAEDSIHRSKATGEPPLLLPFSVFFAIRDAVAAVGDYKVNPPLNAPATGEEILKAIRAVRASRAV
>Mature_785_residues
MNQQAEPFLKDAKELADFTQVHVSRPHESAHLHVSGRATYTDDIPELAGTLHAALGLSPKAHAKILSMSFDKVRATPGVV
AVFTADDIPGHNDCAPIVKGDDPILADGVVQYVGQPMFIVVATSHDAARLGARRADIEFEELPAVLTAQQARAANQSVIP
PMKLARGDAAAKLQRAVHREAGDMLLGGQEQFYLEGQISYAVPKDDDGMHVHCSTQHPTEMQHLVAHMLNVHSHNVLVEC
RRMGGGFGGKESQSSMFACCAALAAWKLLCPVKLRPDRDDDMMVTGKRHDFHYTYDVGYDDEGVIEGVSVDMTSRCGFSA
DLSGPVMTRAVCHFDNAYFLSDVSIDGFCGKTNTQSNTAFRGFGGPQGAFAIEYIMDNVARSLGKDSLDVRRRNLYGKTE
RNQTPYGQVVEDNVIHELIDELEATSDYRRRRAEVLEFNRNNEVLKKGLALTPVKFGIAFNVTHFNQAGALVHIYTDGSV
LVNHGGTEMGQGLNTKVAQVVAHELGVSFSRVRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQLRERLAEFAADKF
GAGEVTAAQVRFAGDCALVGDAVVPFEEVIAKAYLARVQLWSDGFYATPKLYWDQAKLQGRPFFYYSYGAAVSEVVIDTL
TGEMRVLRADALHDVGASLNPALDVGQVEGGFIQGMGWLTTEELWWNASGKLMTQAPSTYKIPTVNDTPPDFRVRLFKNR
NAEDSIHRSKATGEPPLLLPFSVFFAIRDAVAAVGDYKVNPPLNAPATGEEILKAIRAVRASRAV

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=757, Percent_Identity=42.0079260237781, Blast_Score=572, Evalue=1e-163,
Organism=Homo sapiens, GI71773480, Length=751, Percent_Identity=36.884154460719, Blast_Score=444, Evalue=1e-124,
Organism=Escherichia coli, GI1789230, Length=762, Percent_Identity=28.4776902887139, Blast_Score=214, Evalue=2e-56,
Organism=Escherichia coli, GI1789246, Length=723, Percent_Identity=26.2793914246196, Blast_Score=192, Evalue=7e-50,
Organism=Escherichia coli, GI1786478, Length=732, Percent_Identity=23.9071038251366, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540638, Length=778, Percent_Identity=39.3316195372751, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI32566215, Length=709, Percent_Identity=31.4527503526093, Blast_Score=339, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17539860, Length=723, Percent_Identity=31.6735822959889, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI17737937, Length=764, Percent_Identity=41.8848167539267, Blast_Score=566, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24647193, Length=765, Percent_Identity=31.8954248366013, Blast_Score=329, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24647199, Length=734, Percent_Identity=31.1989100817439, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI24647201, Length=760, Percent_Identity=31.1842105263158, Blast_Score=295, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24647195, Length=772, Percent_Identity=29.6632124352332, Blast_Score=290, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24647197, Length=772, Percent_Identity=29.7927461139896, Blast_Score=289, Evalue=4e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 85315; Mature: 85315

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQQAEPFLKDAKELADFTQVHVSRPHESAHLHVSGRATYTDDIPELAGTLHAALGLSPK
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCH
AHAKILSMSFDKVRATPGVVAVFTADDIPGHNDCAPIVKGDDPILADGVVQYVGQPMFIV
HHHHHHHCCHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEE
VATSHDAARLGARRADIEFEELPAVLTAQQARAANQSVIPPMKLARGDAAAKLQRAVHRE
EECCCCHHHHCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHH
AGDMLLGGQEQFYLEGQISYAVPKDDDGMHVHCSTQHPTEMQHLVAHMLNVHSHNVLVEC
CCCEEECCCCEEEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHEEEH
RRMGGGFGGKESQSSMFACCAALAAWKLLCPVKLRPDRDDDMMVTGKRHDFHYTYDVGYD
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEEECCCCCEEEEEECCCC
DEGVIEGVSVDMTSRCGFSADLSGPVMTRAVCHFDNAYFLSDVSIDGFCGKTNTQSNTAF
CCCCEECCEECHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEE
RGFGGPQGAFAIEYIMDNVARSLGKDSLDVRRRNLYGKTERNQTPYGQVVEDNVIHELID
ECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
ELEATSDYRRRRAEVLEFNRNNEVLKKGLALTPVKFGIAFNVTHFNQAGALVHIYTDGSV
HHHHHHHHHHHHHHHHHCCCCHHHHHCCCEECEEEEEEEEEEEEECCCCCEEEEEECCEE
LVNHGGTEMGQGLNTKVAQVVAHELGVSFSRVRVTATDTSKVANTSATAASTGSDLNGKA
EEECCCHHHCCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHCCCCCCCCCCCCCCCCHH
AQDAARQLRERLAEFAADKFGAGEVTAAQVRFAGDCALVGDAVVPFEEVIAKAYLARVQL
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHEE
WSDGFYATPKLYWDQAKLQGRPFFYYSYGAAVSEVVIDTLTGEMRVLRADALHDVGASLN
ECCCCEECCEEEECHHHHCCCCEEEEECCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCC
PALDVGQVEGGFIQGMGWLTTEELWWNASGKLMTQAPSTYKIPTVNDTPPDFRVRLFKNR
CCCCCCCCCCCEEECCCCCEEHHHEECCCCCEEEECCCCEECCCCCCCCCCCEEEEEECC
NAEDSIHRSKATGEPPLLLPFSVFFAIRDAVAAVGDYKVNPPLNAPATGEEILKAIRAVR
CCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHH
ASRAV
HHCCC
>Mature Secondary Structure
MNQQAEPFLKDAKELADFTQVHVSRPHESAHLHVSGRATYTDDIPELAGTLHAALGLSPK
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCH
AHAKILSMSFDKVRATPGVVAVFTADDIPGHNDCAPIVKGDDPILADGVVQYVGQPMFIV
HHHHHHHCCHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEE
VATSHDAARLGARRADIEFEELPAVLTAQQARAANQSVIPPMKLARGDAAAKLQRAVHRE
EECCCCHHHHCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHH
AGDMLLGGQEQFYLEGQISYAVPKDDDGMHVHCSTQHPTEMQHLVAHMLNVHSHNVLVEC
CCCEEECCCCEEEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHEEEH
RRMGGGFGGKESQSSMFACCAALAAWKLLCPVKLRPDRDDDMMVTGKRHDFHYTYDVGYD
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEEECCCCCEEEEEECCCC
DEGVIEGVSVDMTSRCGFSADLSGPVMTRAVCHFDNAYFLSDVSIDGFCGKTNTQSNTAF
CCCCEECCEECHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEE
RGFGGPQGAFAIEYIMDNVARSLGKDSLDVRRRNLYGKTERNQTPYGQVVEDNVIHELID
ECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
ELEATSDYRRRRAEVLEFNRNNEVLKKGLALTPVKFGIAFNVTHFNQAGALVHIYTDGSV
HHHHHHHHHHHHHHHHHCCCCHHHHHCCCEECEEEEEEEEEEEEECCCCCEEEEEECCEE
LVNHGGTEMGQGLNTKVAQVVAHELGVSFSRVRVTATDTSKVANTSATAASTGSDLNGKA
EEECCCHHHCCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHCCCCCCCCCCCCCCCCHH
AQDAARQLRERLAEFAADKFGAGEVTAAQVRFAGDCALVGDAVVPFEEVIAKAYLARVQL
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHEE
WSDGFYATPKLYWDQAKLQGRPFFYYSYGAAVSEVVIDTLTGEMRVLRADALHDVGASLN
ECCCCEECCEEEECHHHHCCCCEEEEECCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCC
PALDVGQVEGGFIQGMGWLTTEELWWNASGKLMTQAPSTYKIPTVNDTPPDFRVRLFKNR
CCCCCCCCCCCEEECCCCCEEHHHEECCCCCEEEECCCCEECCCCCCCCCCCEEEEEECC
NAEDSIHRSKATGEPPLLLPFSVFFAIRDAVAAVGDYKVNPPLNAPATGEEILKAIRAVR
CCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHH
ASRAV
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]