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The map label for this gene is zwf [H]

Identifier: 186477151

GI number: 186477151

Start: 2696632

End: 2698218

Strand: Reverse

Name: zwf [H]

Synonym: Bphy_2400

Alternate gene names: 186477151

Gene position: 2698218-2696632 (Counterclockwise)

Preceding gene: 186477152

Following gene: 186477150

Centisome position: 77.55

GC content: 63.14

Gene sequence:

>1587_bases
ATGTCCAACGACGCGAAACACACGGGCGCATCATCCCCTCAGCCCGCAAGCTGCAAGATCGGCGCGGGGCCGCATGCAGC
GGGCGGCCCTGCGGGCAAGCGGCCCGCGCCGCCGTGCACGCTCGTCATTTTCGGCGCGGGCGGCGATCTCACCAGACGGC
TGTTGACGCCGTCACTCTATAACCTGAGCGTCGACGGCCTGCTCGACGACGGCATGCGTATCATCGGCGTCAATCATGGC
GAGCGCGAAACGAAAGCGTGGATCGACGATCTCGGCCAGTCGTTGAAGCAATTTGCCGCCGACAAGGCCAGCGAATCTCA
TGGGGGCAGGGTCGACGAGAAGGCGTGGAAGTGGCTGTCGTCGCGCATGACATACATGGCGGGCGAATTCGAAGCCGACG
ATGTCTTCGACAGGCTCAAAGAACGCATCGATCAAAGCTCGCATGGCAATGCGATCTTCTATCTGGCCGTCGGCGCGCGC
TTCTTCAAGCCGATCGTCGAGCGGCTCGGCAGGCATGGCCTGCTGAAAGAAGACGCACAACGGAAGGGGTGCTTCCGGCG
TCTCGTGATCGAGAAGCCGTTCGGCACGGACCTCGCGTCGGCGCGCGATCTGAATGCACACATTCTGCGCTTCGCAGCCG
AATCGCAGGTATATCGCATCGACCACTTTCTCGGCAAGGACACGGTGCAAAGCGTTCTGGCCGTGCGCTTCGCGAATGCG
ATGTTCGAGCCGGTGTGGCGGCGCGAGTACATCGACAACGTGCAGATCACGGCGTCCGAAACGCTCGGCGTGGAAGGGCG
CGGCAAGTTCTACGAGCAGACAGGTGCGTTTCGCGACATGGTGCCGAACCATCTATTCCAGCTGCTGGCGATGGTCGCGC
TGGAGCCGCCCAATTCGTTCGATGCCGAAGCGGTGCGCAACAAGAAGGCCGAACTGTTCGATGCGATCGAGCCGCTCAAG
CCATCGGACGTCGTATTCGGCCAATACGAAACGGGCGATGCGGGAGTAGGCTATCGCGACGAACCCGATGTCGCGCAAGA
CAGCACGACGGAGACCTATGCGGCGGCGCGCGTATTCATCGACAACTGGCGTTGGGCGGGCGTGCCGTTTTATCTGCGCA
CGGGCAAACGTATGGCTGCACGGCGCACGGAAATCGCCGTCCAGCTGAAGCGTGTGCCGTTCCTGCTGTTTCGCGGCACA
CCTGTCGAAGCGCTGACGCCGAACATCTTCACGCTGCGTATCGATCCCGCCCACGGCACGCGCTTCGACTTCAACGTGAA
AGTACCAGGACCGGCAATGCAGATAGGCGCGGTGCGCTCGGCCTTCAACTACAACGACTTCTTCGCCGAACGCGCCAACG
TCGGCTATGAAACGCTGTTGTACGACTGCATGCTCGGCGACGTGACGCTTTTCCAGCGGGCCGACAGCATCGAGTCGGGG
TGGTGTGCGGTTGACCGCGTACTGCATCCAGAAGGGGGCGCGCTGCCCGTTTACGGCTATCCGGCGGGCGGCAACGGGCC
GGTGCAGGCCGACGAACTGCTCGCGCGCGACGGCCGCGCATGGCGCCCGTTGCAGGACGCGGAGTAG

Upstream 100 bases:

>100_bases
GCATTGCATGCCGCCGGCGTTGCCGTTCGATTGAACCACGCAGCGCGGCGGCGGGTCTTTCAGATATCGCCATTCGTGGC
TCATCGACGGAAAGCCTGCC

Downstream 100 bases:

>100_bases
ACCAGCAGATCTGTCAACAAAGACCAAAGGAGGGGACGACTTGGCCAGGACTAAAGAATCGTTGCGACGCACAGCCGCCA
GCAGCGACGAAAAGATACTC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSNDAKHTGASSPQPASCKIGAGPHAAGGPAGKRPAPPCTLVIFGAGGDLTRRLLTPSLYNLSVDGLLDDGMRIIGVNHG
ERETKAWIDDLGQSLKQFAADKASESHGGRVDEKAWKWLSSRMTYMAGEFEADDVFDRLKERIDQSSHGNAIFYLAVGAR
FFKPIVERLGRHGLLKEDAQRKGCFRRLVIEKPFGTDLASARDLNAHILRFAAESQVYRIDHFLGKDTVQSVLAVRFANA
MFEPVWRREYIDNVQITASETLGVEGRGKFYEQTGAFRDMVPNHLFQLLAMVALEPPNSFDAEAVRNKKAELFDAIEPLK
PSDVVFGQYETGDAGVGYRDEPDVAQDSTTETYAAARVFIDNWRWAGVPFYLRTGKRMAARRTEIAVQLKRVPFLLFRGT
PVEALTPNIFTLRIDPAHGTRFDFNVKVPGPAMQIGAVRSAFNYNDFFAERANVGYETLLYDCMLGDVTLFQRADSIESG
WCAVDRVLHPEGGALPVYGYPAGGNGPVQADELLARDGRAWRPLQDAE

Sequences:

>Translated_528_residues
MSNDAKHTGASSPQPASCKIGAGPHAAGGPAGKRPAPPCTLVIFGAGGDLTRRLLTPSLYNLSVDGLLDDGMRIIGVNHG
ERETKAWIDDLGQSLKQFAADKASESHGGRVDEKAWKWLSSRMTYMAGEFEADDVFDRLKERIDQSSHGNAIFYLAVGAR
FFKPIVERLGRHGLLKEDAQRKGCFRRLVIEKPFGTDLASARDLNAHILRFAAESQVYRIDHFLGKDTVQSVLAVRFANA
MFEPVWRREYIDNVQITASETLGVEGRGKFYEQTGAFRDMVPNHLFQLLAMVALEPPNSFDAEAVRNKKAELFDAIEPLK
PSDVVFGQYETGDAGVGYRDEPDVAQDSTTETYAAARVFIDNWRWAGVPFYLRTGKRMAARRTEIAVQLKRVPFLLFRGT
PVEALTPNIFTLRIDPAHGTRFDFNVKVPGPAMQIGAVRSAFNYNDFFAERANVGYETLLYDCMLGDVTLFQRADSIESG
WCAVDRVLHPEGGALPVYGYPAGGNGPVQADELLARDGRAWRPLQDAE
>Mature_527_residues
SNDAKHTGASSPQPASCKIGAGPHAAGGPAGKRPAPPCTLVIFGAGGDLTRRLLTPSLYNLSVDGLLDDGMRIIGVNHGE
RETKAWIDDLGQSLKQFAADKASESHGGRVDEKAWKWLSSRMTYMAGEFEADDVFDRLKERIDQSSHGNAIFYLAVGARF
FKPIVERLGRHGLLKEDAQRKGCFRRLVIEKPFGTDLASARDLNAHILRFAAESQVYRIDHFLGKDTVQSVLAVRFANAM
FEPVWRREYIDNVQITASETLGVEGRGKFYEQTGAFRDMVPNHLFQLLAMVALEPPNSFDAEAVRNKKAELFDAIEPLKP
SDVVFGQYETGDAGVGYRDEPDVAQDSTTETYAAARVFIDNWRWAGVPFYLRTGKRMAARRTEIAVQLKRVPFLLFRGTP
VEALTPNIFTLRIDPAHGTRFDFNVKVPGPAMQIGAVRSAFNYNDFFAERANVGYETLLYDCMLGDVTLFQRADSIESGW
CAVDRVLHPEGGALPVYGYPAGGNGPVQADELLARDGRAWRPLQDAE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=31.3524590163934, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=31.3524590163934, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI52145310, Length=355, Percent_Identity=30.9859154929577, Blast_Score=155, Evalue=9e-38,
Organism=Escherichia coli, GI1788158, Length=509, Percent_Identity=36.7387033398821, Blast_Score=307, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17538218, Length=498, Percent_Identity=32.5301204819277, Blast_Score=267, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6324088, Length=494, Percent_Identity=31.1740890688259, Blast_Score=256, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24643350, Length=485, Percent_Identity=31.340206185567, Blast_Score=252, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24643352, Length=485, Percent_Identity=31.340206185567, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI221513548, Length=500, Percent_Identity=26.2, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58412; Mature: 58280

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDAKHTGASSPQPASCKIGAGPHAAGGPAGKRPAPPCTLVIFGAGGDLTRRLLTPSLY
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCHHH
NLSVDGLLDDGMRIIGVNHGERETKAWIDDLGQSLKQFAADKASESHGGRVDEKAWKWLS
CEEECCEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
SRMTYMAGEFEADDVFDRLKERIDQSSHGNAIFYLAVGARFFKPIVERLGRHGLLKEDAQ
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHH
RKGCFRRLVIEKPFGTDLASARDLNAHILRFAAESQVYRIDHFLGKDTVQSVLAVRFANA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHH
MFEPVWRREYIDNVQITASETLGVEGRGKFYEQTGAFRDMVPNHLFQLLAMVALEPPNSF
HHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
DAEAVRNKKAELFDAIEPLKPSDVVFGQYETGDAGVGYRDEPDVAQDSTTETYAAARVFI
CHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHEEEE
DNWRWAGVPFYLRTGKRMAARRTEIAVQLKRVPFLLFRGTPVEALTPNIFTLRIDPAHGT
ECCEECCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCCEEEEEEECCCCC
RFDFNVKVPGPAMQIGAVRSAFNYNDFFAERANVGYETLLYDCMLGDVTLFQRADSIESG
EEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCC
WCAVDRVLHPEGGALPVYGYPAGGNGPVQADELLARDGRAWRPLQDAE
CHHHHHEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SNDAKHTGASSPQPASCKIGAGPHAAGGPAGKRPAPPCTLVIFGAGGDLTRRLLTPSLY
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCHHH
NLSVDGLLDDGMRIIGVNHGERETKAWIDDLGQSLKQFAADKASESHGGRVDEKAWKWLS
CEEECCEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
SRMTYMAGEFEADDVFDRLKERIDQSSHGNAIFYLAVGARFFKPIVERLGRHGLLKEDAQ
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHH
RKGCFRRLVIEKPFGTDLASARDLNAHILRFAAESQVYRIDHFLGKDTVQSVLAVRFANA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHH
MFEPVWRREYIDNVQITASETLGVEGRGKFYEQTGAFRDMVPNHLFQLLAMVALEPPNSF
HHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
DAEAVRNKKAELFDAIEPLKPSDVVFGQYETGDAGVGYRDEPDVAQDSTTETYAAARVFI
CHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHEEEE
DNWRWAGVPFYLRTGKRMAARRTEIAVQLKRVPFLLFRGTPVEALTPNIFTLRIDPAHGT
ECCEECCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCCEEEEEEECCCCC
RFDFNVKVPGPAMQIGAVRSAFNYNDFFAERANVGYETLLYDCMLGDVTLFQRADSIESG
EEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCC
WCAVDRVLHPEGGALPVYGYPAGGNGPVQADELLARDGRAWRPLQDAE
CHHHHHEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]