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The map label for this gene is atoC [H]

Identifier: 186476899

GI number: 186476899

Start: 2409607

End: 2411118

Strand: Reverse

Name: atoC [H]

Synonym: Bphy_2148

Alternate gene names: 186476899

Gene position: 2411118-2409607 (Counterclockwise)

Preceding gene: 186476900

Following gene: 186476898

Centisome position: 69.3

GC content: 64.22

Gene sequence:

>1512_bases
ATGCTTGACTTCGCGACGCGCGGACGGCTTTTGCCGTTGTTGACTTCCCGGCGCAACGCATCCCGCGCGTACTCACTATC
AGCACTTACGAGCTTTCCAAACGCGATGCCACATGTATTGATTGTCGATGACGATCCGAGTACCCGCGACGCGCTTGCGG
CGATCATCGCGGAAGACGGGCTGACGACGGCGACGGCAGGCGACCTGCGCGAAGCCCGCATCCAGCTCGTGCGGCAGATG
CCGGACGTCGTGTTTACCGATCTGAAGCTGCCCGACGGCACGGGCGTTGACCTGTTCGAGGATCTCGATCCGCGTTCGGG
CGTCGAGTTCGTCGTGATCACGGGACACGCCACGGTGGAATCGGCCGTGAGCGCGCTCAAGATGGGCGCCGCCGACTACC
TCGTGAAGCCGATCAACATGCAGCGTGTCAAGGCGATTCTCGCCCGTCTGCCGCGTGCGGGGGACCTGAAGGCCGAAATC
GGCACGTTGCGCGGCGAGCTGCGGCGAATGGGCCGCTTCGGGCTGATGCTCGGTAATTCCGCCGTGATGCAGCAGGTCTA
CGACCAGATCAGCCGCGTTGCGCCGACGGCCGCGTCGGTGATGCTGGTCGGCGAATCGGGCACGGGCAAGGAAGTCGCCG
CGCAGACGCTGCATCAGCTGAGCCTGCGCCGCAAACATGCCTTCCTCGCCGTCAACTGCGGCGCGATCTCGCCCAACCTG
ATCGAATCCGAGATGTTCGGCCACGAGCGCGGCGCATTCACGGGCGCGGACCGCCAGCACAAGGGCTATTTCGAGCGTGC
GAACGGCGGCACGCTGTTTCTCGACGAAATCACCGAAATGCCGATCGAGCTGCAGGTGAAACTGTTACGCGTGCTGGAGA
CGGGCATGTTCATGCGCGTCGGCACGACAAAGGAAATTGAAACTGACGTCCGCCTGATCGCCGCGACCAACCGTGATCCC
GAGCAGGCCGTGCTCGAAGGCAAGCTGCGCCTCGATCTATACCACCGGCTCAACGTGTTTCCCATCAGCCTGCCGCCGTT
GCGCGAACGGGGCAAGGACGTCGAACTGCTTGCGCAGTCGTTCCTCGACGAACTGAACGAGCAGCACGGCACGAAGAAGC
ACTTCCCGCCCGCCGTGCGGGAGATGCTGCTGTCGTACCCGTGGCCCGGCAATGTGCGCGAGCTGAAAAACTATGTGCAG
CGCGCGCACATCATGTCGGGCACGGATTCGGACAGCACGGCCACGGTGCCGCTGCAGATTTCGCTGTCGAAGCCAACCGC
GGGCACCGCGATCACGATCCCGTTCGGCACGTCGCTCGCCGAGGCCGACCGCCAGCTGATTCTCGCGACGCTTGAGCAAT
GCGGCGGCGTCAAGACTCGCGCCGCCGAGATTCTGGGGATCAGCCTGAAGACGCTCTACAATCGGCTCGTCGAGTACGGC
AACGATGCGGGCCGTGCCGAAGGCGACGATGTCAGCGACGAGCCGCAGGCGCTCGGTAAAGCCGACGCCTGA

Upstream 100 bases:

>100_bases
AGATGCGGTTTGCTAGCAAGAATTACGTCAATTGTTGCGTGGGTGTGGTGATTCGGGAATTTTTTCCGGGTCAGGCGTTG
GGGTGCCGGGAAGCAGGCGT

Downstream 100 bases:

>100_bases
GCGCGTCGACGGGATTCGCGCCCAGGGGCGCCGTCCGTCCCGGACGGCGGCGTCAAAAACGGCACATGCCTTGCTGATTT
CCCTTCGAGCTGTCGAACGC

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MLDFATRGRLLPLLTSRRNASRAYSLSALTSFPNAMPHVLIVDDDPSTRDALAAIIAEDGLTTATAGDLREARIQLVRQM
PDVVFTDLKLPDGTGVDLFEDLDPRSGVEFVVITGHATVESAVSALKMGAADYLVKPINMQRVKAILARLPRAGDLKAEI
GTLRGELRRMGRFGLMLGNSAVMQQVYDQISRVAPTAASVMLVGESGTGKEVAAQTLHQLSLRRKHAFLAVNCGAISPNL
IESEMFGHERGAFTGADRQHKGYFERANGGTLFLDEITEMPIELQVKLLRVLETGMFMRVGTTKEIETDVRLIAATNRDP
EQAVLEGKLRLDLYHRLNVFPISLPPLRERGKDVELLAQSFLDELNEQHGTKKHFPPAVREMLLSYPWPGNVRELKNYVQ
RAHIMSGTDSDSTATVPLQISLSKPTAGTAITIPFGTSLAEADRQLILATLEQCGGVKTRAAEILGISLKTLYNRLVEYG
NDAGRAEGDDVSDEPQALGKADA

Sequences:

>Translated_503_residues
MLDFATRGRLLPLLTSRRNASRAYSLSALTSFPNAMPHVLIVDDDPSTRDALAAIIAEDGLTTATAGDLREARIQLVRQM
PDVVFTDLKLPDGTGVDLFEDLDPRSGVEFVVITGHATVESAVSALKMGAADYLVKPINMQRVKAILARLPRAGDLKAEI
GTLRGELRRMGRFGLMLGNSAVMQQVYDQISRVAPTAASVMLVGESGTGKEVAAQTLHQLSLRRKHAFLAVNCGAISPNL
IESEMFGHERGAFTGADRQHKGYFERANGGTLFLDEITEMPIELQVKLLRVLETGMFMRVGTTKEIETDVRLIAATNRDP
EQAVLEGKLRLDLYHRLNVFPISLPPLRERGKDVELLAQSFLDELNEQHGTKKHFPPAVREMLLSYPWPGNVRELKNYVQ
RAHIMSGTDSDSTATVPLQISLSKPTAGTAITIPFGTSLAEADRQLILATLEQCGGVKTRAAEILGISLKTLYNRLVEYG
NDAGRAEGDDVSDEPQALGKADA
>Mature_503_residues
MLDFATRGRLLPLLTSRRNASRAYSLSALTSFPNAMPHVLIVDDDPSTRDALAAIIAEDGLTTATAGDLREARIQLVRQM
PDVVFTDLKLPDGTGVDLFEDLDPRSGVEFVVITGHATVESAVSALKMGAADYLVKPINMQRVKAILARLPRAGDLKAEI
GTLRGELRRMGRFGLMLGNSAVMQQVYDQISRVAPTAASVMLVGESGTGKEVAAQTLHQLSLRRKHAFLAVNCGAISPNL
IESEMFGHERGAFTGADRQHKGYFERANGGTLFLDEITEMPIELQVKLLRVLETGMFMRVGTTKEIETDVRLIAATNRDP
EQAVLEGKLRLDLYHRLNVFPISLPPLRERGKDVELLAQSFLDELNEQHGTKKHFPPAVREMLLSYPWPGNVRELKNYVQ
RAHIMSGTDSDSTATVPLQISLSKPTAGTAITIPFGTSLAEADRQLILATLEQCGGVKTRAAEILGISLKTLYNRLVEYG
NDAGRAEGDDVSDEPQALGKADA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=40.0437636761488, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=40.3587443946188, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1790299, Length=466, Percent_Identity=38.1974248927039, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1788905, Length=453, Percent_Identity=34.878587196468, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=43.8485804416404, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=43.5736677115987, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI87082117, Length=324, Percent_Identity=40.7407407407407, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI87081872, Length=305, Percent_Identity=40.655737704918, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1786524, Length=330, Percent_Identity=41.2121212121212, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=46.9827586206897, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1787583, Length=314, Percent_Identity=36.3057324840764, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1789828, Length=301, Percent_Identity=32.890365448505, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081858, Length=295, Percent_Identity=29.1525423728814, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1787229, Length=123, Percent_Identity=34.9593495934959, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786911, Length=112, Percent_Identity=33.0357142857143, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54877; Mature: 54877

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFATRGRLLPLLTSRRNASRAYSLSALTSFPNAMPHVLIVDDDPSTRDALAAIIAEDG
CCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCC
LTTATAGDLREARIQLVRQMPDVVFTDLKLPDGTGVDLFEDLDPRSGVEFVVITGHATVE
CCCCCHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCHHHCCCCCCCCEEEEEECCHHHH
SAVSALKMGAADYLVKPINMQRVKAILARLPRAGDLKAEIGTLRGELRRMGRFGLMLGNS
HHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEECCH
AVMQQVYDQISRVAPTAASVMLVGESGTGKEVAAQTLHQLSLRRKHAFLAVNCGAISPNL
HHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHH
IESEMFGHERGAFTGADRQHKGYFERANGGTLFLDEITEMPIELQVKLLRVLETGMFMRV
HHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEHHHHCCCHHHHHHHHHHHHCCCEEEE
GTTKEIETDVRLIAATNRDPEQAVLEGKLRLDLYHRLNVFPISLPPLRERGKDVELLAQS
CCCCHHCCCEEEEEECCCCHHHHHHHHHHEEEEECCCEEEECCCCCHHHCCCCHHHHHHH
FLDELNEQHGTKKHFPPAVREMLLSYPWPGNVRELKNYVQRAHIMSGTDSDSTATVPLQI
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEE
SLSKPTAGTAITIPFGTSLAEADRQLILATLEQCGGVKTRAAEILGISLKTLYNRLVEYG
EECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
NDAGRAEGDDVSDEPQALGKADA
CCCCCCCCCCCCCCHHHCCCCCC
>Mature Secondary Structure
MLDFATRGRLLPLLTSRRNASRAYSLSALTSFPNAMPHVLIVDDDPSTRDALAAIIAEDG
CCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCC
LTTATAGDLREARIQLVRQMPDVVFTDLKLPDGTGVDLFEDLDPRSGVEFVVITGHATVE
CCCCCHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCHHHCCCCCCCCEEEEEECCHHHH
SAVSALKMGAADYLVKPINMQRVKAILARLPRAGDLKAEIGTLRGELRRMGRFGLMLGNS
HHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEECCH
AVMQQVYDQISRVAPTAASVMLVGESGTGKEVAAQTLHQLSLRRKHAFLAVNCGAISPNL
HHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHH
IESEMFGHERGAFTGADRQHKGYFERANGGTLFLDEITEMPIELQVKLLRVLETGMFMRV
HHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEHHHHCCCHHHHHHHHHHHHCCCEEEE
GTTKEIETDVRLIAATNRDPEQAVLEGKLRLDLYHRLNVFPISLPPLRERGKDVELLAQS
CCCCHHCCCEEEEEECCCCHHHHHHHHHHEEEEECCCEEEECCCCCHHHCCCCHHHHHHH
FLDELNEQHGTKKHFPPAVREMLLSYPWPGNVRELKNYVQRAHIMSGTDSDSTATVPLQI
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEE
SLSKPTAGTAITIPFGTSLAEADRQLILATLEQCGGVKTRAAEILGISLKTLYNRLVEYG
EECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
NDAGRAEGDDVSDEPQALGKADA
CCCCCCCCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]