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The map label for this gene is nuoL [H]

Identifier: 186476753

GI number: 186476753

Start: 2248323

End: 2250392

Strand: Reverse

Name: nuoL [H]

Synonym: Bphy_1998

Alternate gene names: 186476753

Gene position: 2250392-2248323 (Counterclockwise)

Preceding gene: 186476754

Following gene: 186476752

Centisome position: 64.68

GC content: 60.53

Gene sequence:

>2070_bases
ATGTCAACGACACTCAATGAAAACCTGTTGCTGGCGGTTGCGCTTGCACCGCTGGCCGGCTCGCTGATCGCGGGACTGTT
CGGCAATGCGATCGGGCGTGCCGGTGCGCACTCGGTCACGATCCTCGGCGTCGCGATTTCGTTCGTTCTTTCGTGCATCG
TCTTCCTCGACGTGCTGAATGGCGGCAGCTTCAACGCCACCGTCTACGAATGGATGACGGTCGGCAAGGTGAAGTTCGAG
GTGGGCTTTCTCGTCGACACGCTGACGGCGATGATGATGTGCGTCGTCACCTTCGTGTCGCTGATGGTGCACGTCTACAC
AATCGGCTACATGGCCGACGAAGAAACGGGCTACCAGCGCTTCTTCTCGTACATCTCGCTGTTCACGTTCTCGATGCTGA
TGCTCGTGATGAGCAACAACTTCCTGCAACTGTTCTTCGGCTGGGAAGCGGTGGGTCTCGTGTCGTACCTGCTGATCGGC
TTCTACTTCAAGCGTGAAAGCGCGATTTACGCCAACATGAAGGCGTTCCTCGTCAACCGCGTGGGCGACTTCGGCTTCAT
TCTCGGCATCGGCCTGATCCTCGCGTACGGCGGCTCGATGAACTACGGCGACGTGTTCGCGAAGAGCCACGAACTCGCTT
CGCTGTCGTTCCCGGGCACCGACTGGGGCCTGCTGACGGTCGCGTGTATCTGCCTGTTCATCGGCGCGATGGGTAAGTCG
GCGCAGTTCCCGCTGCATGTGTGGCTGCCCGATTCGATGGAAGGCCCGACGCCGATCTCCGCGCTGATTCACGCGGCAAC
CATGGTGACGGCCGGTATCTTCATGGTGACGCGCATGTCGCCGCTGTTCGAGTTGTCGGACTCGGCGCTGTCGTTCATCA
CGGTGATCGGCGCGATCACAGCGCTTTTCATGGGCTTCCTGGGCATCGTGCAGAACGACATCAAGCGTGTCGTCGCTTAC
TCCACGCTCTCGCAGCTTGGTTACATGACGGTCGCACTGGGCGTGTCGGCCTATCCGGTCGCCGTGTTCCACCTGATGAC
GCACGCGTTCTTCAAGGCGCTGCTGTTCCTCGGCGCAGGTTCCGTGATCATCGGCATGCACCATGACCAGGACATGCGCA
ATATGGGCGGTCTGCGCAAGTACATGCCCATCACGTGGATCACGTCGCTGATCGGTTCGCTGGCGCTGATCGGTACGCCG
TTCTTCTCGGGCTTCTACTCGAAAGATTCGATCATCGACGCGGTGAAGCTGTCGCATCTGCCGGGTTCGGGCTTCGCATA
CTTCGCGGTTGTCGCGAGCGTGTTCGTGACGGCGCTGTATTCGTTCCGCATGTACTTCCTCGTGTTCCACGGCGAAGAGC
GCTTCCGCGGTCCGAAGCATCCTGACTCGCCGATGGGTGCAGAAGCGGCTGCGCATGGTCACGGTCATGGTCACGACGAT
CACGGCCACGGTCATGACGACCACCACGCTCACGAGCCGCACGAAACGCCGTGGGTCGTCTGGGTGCCGCTGGTTCTGCT
GGCCATCCCGTCCATCGTGATCGGCGCGATCGCGGTCGGGCCGATGCTGTACGGCGATTTCTTCCAGCACGGCGTCGCAT
TCGAGAAGGTGATTTTCATCGGCGAAAACCATCCGGCGCTGCACGAAATGGCGGAAGAATTCCAGGGATGGGCCTCGATG
GGCCTGCACGCTGCATCGGGCCTGCCCGCGTGGCTGGCGCTGGCGGGTGTGGTGGTGGCGTGGTTCCTGTACCTGAAGCG
TCCGGATCTGCCCGCCGTCGTCAAGCGTGGTTTCGGTCCGATCTACACGCTGCTGGATAACAAGTACTACATGGACAAGA
TCAACGAAGTCGTGTTCGCACGCGGCGCCGTGGCCATCGGCCGCGGCCTGTGGAAGGAAGGCGATGTCGTGGTCATCGAC
GGCGTTGTCAACGGTAGCGCGCGCTTCATCGGCTGGTTTGCGAGCGTTATCCGTTTCCTGCAATCGGGTTACATCTACCA
CTACGCATTCGCCATGATTATCGGCATGCTGGGGCTCTTGACCCTGTTTGTAACGCTCGGCGGCAAATAA

Upstream 100 bases:

>100_bases
GATCGGTCTTGCAATTCTGGTGACCCTGTTCCGTAGCCTCGACACGATCAATGTCGAGGATCTCGATCAGCTCAAAGGTT
AACTTCAGGCACAGGCTGTT

Downstream 100 bases:

>100_bases
GAACAGGCTGGAGACACTTCTCATGCACACGACGTTTCCGATTCTGAGTATCGCGATCTGGATGCCGATTATTTTCGGCC
TGGTGGTCCTGGCCATCGGT

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MSTTLNENLLLAVALAPLAGSLIAGLFGNAIGRAGAHSVTILGVAISFVLSCIVFLDVLNGGSFNATVYEWMTVGKVKFE
VGFLVDTLTAMMMCVVTFVSLMVHVYTIGYMADEETGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIG
FYFKRESAIYANMKAFLVNRVGDFGFILGIGLILAYGGSMNYGDVFAKSHELASLSFPGTDWGLLTVACICLFIGAMGKS
AQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDSALSFITVIGAITALFMGFLGIVQNDIKRVVAY
STLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTP
FFSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRGPKHPDSPMGAEAAAHGHGHGHDD
HGHGHDDHHAHEPHETPWVVWVPLVLLAIPSIVIGAIAVGPMLYGDFFQHGVAFEKVIFIGENHPALHEMAEEFQGWASM
GLHAASGLPAWLALAGVVVAWFLYLKRPDLPAVVKRGFGPIYTLLDNKYYMDKINEVVFARGAVAIGRGLWKEGDVVVID
GVVNGSARFIGWFASVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Sequences:

>Translated_689_residues
MSTTLNENLLLAVALAPLAGSLIAGLFGNAIGRAGAHSVTILGVAISFVLSCIVFLDVLNGGSFNATVYEWMTVGKVKFE
VGFLVDTLTAMMMCVVTFVSLMVHVYTIGYMADEETGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIG
FYFKRESAIYANMKAFLVNRVGDFGFILGIGLILAYGGSMNYGDVFAKSHELASLSFPGTDWGLLTVACICLFIGAMGKS
AQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDSALSFITVIGAITALFMGFLGIVQNDIKRVVAY
STLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTP
FFSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRGPKHPDSPMGAEAAAHGHGHGHDD
HGHGHDDHHAHEPHETPWVVWVPLVLLAIPSIVIGAIAVGPMLYGDFFQHGVAFEKVIFIGENHPALHEMAEEFQGWASM
GLHAASGLPAWLALAGVVVAWFLYLKRPDLPAVVKRGFGPIYTLLDNKYYMDKINEVVFARGAVAIGRGLWKEGDVVVID
GVVNGSARFIGWFASVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK
>Mature_688_residues
STTLNENLLLAVALAPLAGSLIAGLFGNAIGRAGAHSVTILGVAISFVLSCIVFLDVLNGGSFNATVYEWMTVGKVKFEV
GFLVDTLTAMMMCVVTFVSLMVHVYTIGYMADEETGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFKRESAIYANMKAFLVNRVGDFGFILGIGLILAYGGSMNYGDVFAKSHELASLSFPGTDWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDSALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRGPKHPDSPMGAEAAAHGHGHGHDDH
GHGHDDHHAHEPHETPWVVWVPLVLLAIPSIVIGAIAVGPMLYGDFFQHGVAFEKVIFIGENHPALHEMAEEFQGWASMG
LHAASGLPAWLALAGVVVAWFLYLKRPDLPAVVKRGFGPIYTLLDNKYYMDKINEVVFARGAVAIGRGLWKEGDVVVIDG
VVNGSARFIGWFASVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=387, Percent_Identity=40.5684754521964, Blast_Score=286, Evalue=5e-77,
Organism=Escherichia coli, GI1788614, Length=677, Percent_Identity=35.3028064992614, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1788829, Length=414, Percent_Identity=28.2608695652174, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1788831, Length=355, Percent_Identity=29.5774647887324, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1788827, Length=466, Percent_Identity=27.8969957081545, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI2367154, Length=127, Percent_Identity=34.6456692913386, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693160, Length=403, Percent_Identity=22.8287841191067, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1788613, Length=265, Percent_Identity=27.5471698113208, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 75001; Mature: 74870

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLNENLLLAVALAPLAGSLIAGLFGNAIGRAGAHSVTILGVAISFVLSCIVFLDVLN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GGSFNATVYEWMTVGKVKFEVGFLVDTLTAMMMCVVTFVSLMVHVYTIGYMADEETGYQR
CCCCCHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFKRESAIYANMKAFLVNR
HHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VGDFGFILGIGLILAYGGSMNYGDVFAKSHELASLSFPGTDWGLLTVACICLFIGAMGKS
CCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCC
AQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDSALSFITVIGAIT
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ALFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
SVIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTPFFSGFYSKDSIIDAVKLSHL
CEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCC
PGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRGPKHPDSPMGAEAAAHGHGHGHDD
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCCHHCCCCCCCCCC
HGHGHDDHHAHEPHETPWVVWVPLVLLAIPSIVIGAIAVGPMLYGDFFQHGVAFEKVIFI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
GENHPALHEMAEEFQGWASMGLHAASGLPAWLALAGVVVAWFLYLKRPDLPAVVKRGFGP
CCCCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCH
IYTLLDNKYYMDKINEVVFARGAVAIGRGLWKEGDVVVIDGVVNGSARFIGWFASVIRFL
HHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEECEECCCHHHHHHHHHHHHHH
QSGYIYHYAFAMIIGMLGLLTLFVTLGGK
HCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STTLNENLLLAVALAPLAGSLIAGLFGNAIGRAGAHSVTILGVAISFVLSCIVFLDVLN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GGSFNATVYEWMTVGKVKFEVGFLVDTLTAMMMCVVTFVSLMVHVYTIGYMADEETGYQR
CCCCCHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFKRESAIYANMKAFLVNR
HHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VGDFGFILGIGLILAYGGSMNYGDVFAKSHELASLSFPGTDWGLLTVACICLFIGAMGKS
CCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCC
AQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDSALSFITVIGAIT
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ALFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
SVIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTPFFSGFYSKDSIIDAVKLSHL
CEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCC
PGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRGPKHPDSPMGAEAAAHGHGHGHDD
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCCHHCCCCCCCCCC
HGHGHDDHHAHEPHETPWVVWVPLVLLAIPSIVIGAIAVGPMLYGDFFQHGVAFEKVIFI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
GENHPALHEMAEEFQGWASMGLHAASGLPAWLALAGVVVAWFLYLKRPDLPAVVKRGFGP
CCCCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCH
IYTLLDNKYYMDKINEVVFARGAVAIGRGLWKEGDVVVIDGVVNGSARFIGWFASVIRFL
HHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEECEECCCHHHHHHHHHHHHHH
QSGYIYHYAFAMIIGMLGLLTLFVTLGGK
HCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]