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The map label for this gene is aceE [H]

Identifier: 186476603

GI number: 186476603

Start: 2111627

End: 2114362

Strand: Reverse

Name: aceE [H]

Synonym: Bphy_1848

Alternate gene names: 186476603

Gene position: 2114362-2111627 (Counterclockwise)

Preceding gene: 186476605

Following gene: 186476600

Centisome position: 60.77

GC content: 65.5

Gene sequence:

>2736_bases
ATGACGGATTTATCGAGCGGTGCCCGCCCCGTTGTTGCCTTGACCCAGGCTCGCATCGACAGCGATCCGCAGGAGACGGC
CGAATGGCTCGCCGCGCTGGATGGCGTCGTGCAACATGTCGGCCTCGAGCGCGCGCAGTACCTGTTCGACCGGCTGGCGG
CGCACGCGCTCGGCAATGGGGTCGCGACGGCGCGCGCGAACGTCACGCCCTACGCAAACACGATATCCGTCGATCAGCAG
CCGCCTTATCCCGGCGACCTCGACACGGAAGAAAAGCTCGCCGCCGCGTTGCGCTGGAACGCGCTCGCGATGGTGGTGCG
CGCCAATCGCGCGTACGGCGAATTGGGCGGCCACATTGCGAGCTATGCTTCGGCGGCTGATCTGTTCGAAGTCGGCTTCA
ATCACTTCTTCCGCGCCGCGAGCACTAGGCAAGACGGCAACGATGCGCGCGGCGGCGATCTCGTCTACTTCCAGCCGCAT
TCGTCGCCGGGCGTGTACGCGCGCGCGTTCCTCGAAGGCTTTCTGGACGAGACGCATCTGGAACACTATCGCCGCGAAAT
CGCCGGGCCGGGCTTGTGTTCGTATCCGCATCCGTGGCTGATGCCCGACTTCTGGCAGTTCCCGACGGGCTCGATGGGCA
TCGGTCCCATCAACGCGATCTACCAGGCGCGCTTCATGCGCTATCTGCAGAACCGCGGCCTCCTGAAGACGGAGGGCCGC
AAGGTGTGGGGCTTCTTCGGCGACGGCGAGATGGACGAGCCGGAGTCGATCGGTGCGCTGTCGCTCGCGGCGCGCGAAGG
GCTCGACAACCTCGTGTTCGTGATCAATTGCAATTTGCAGCGGCTCGACGGCCCCGTGCGCAGCAACGGCCGCATCATCG
ACGAACTCGAAGCGCAGTTCACGGGCGCCGGCTGGAACGTGATCAAGGTGCTGTGGGGCTCGGACTGGGATGCGCTGTTC
GCACGCGACCGCACGGGCGCCTTGCTGCGCGCGTTTGCCCATACCGTCGACGGCCAGTTCCAGACCTTCTCGGCCAACGA
CGGCGCGTATAACCGCGAGCGCTTCTTCGGCCAGAATCCCGAGCTCGAGGCGCTCGCCGCGCATCTGAGCAACGACGATA
TCGACCGCTTGCGGCGCGGCGGCCACGACGTGCGCAAGCTGCACGCCGCGTATGACCGTGCGTTGAAGCATCGCGGCCAG
CCCACGGTGATACTCGCGAAGACGATGAAGGGCTTCGGCATGGGCTCCATCGGCCAGGGGCGCATGACGACGCATCAGCA
GAAGAAGCTCGACGTCGAGCAGCTGAAGGCGTTCCGCGACCGCTTCCGCCTGCCGTTGTCGGACGAGGACGTCGAGCAAC
TCAGGTTTTACAAGCCAGCAGAAAACAGCCCGGAAATGCAGTACCTGCATGCACGCCGGGTTGCCCTCGGAGGCTATCTG
CCCAGAAGGCGGGCGGCGGCATCGCGGACACCGACCGTGCCCGCGCTGCCATCCTGGGGGCAATTCGCGCTGGAGGCGAA
CGGCAAGGAGATGTCGACCACGATGGCCGTCGTGCGCATGCTCGGCAGTCTGCTGAAGGACGCGTCGCTGGGCCCGCGTG
TCGTGCCTGTCGTCGCCGATGAAGCGCGGACCTTCGGCATGGCGAACCTGTTCCGCCAGGTGGGCATCTATTCGCCGCTC
GGCCAGTTGTATGAGCCGGAAGACATGGGCTCGATGCTGTACTACCGCGAAGACACGGGCGGCCAGATACTCGAAGAGGG
TATTTCCGAAGCAGGGGCCGTGTCGTCGTGGATCGCCGCGGCCACGTCGTATAGCGTGCACGATCTCGCCATGCTGCCGT
TCTACATCTACTACTCGATGTTCGGCTTCCAGCGCATCGGCGACCTGATCTGGGCGGCAGCGGACCAGCGCGCGCGAGGC
TTCCTGATCGGCGCGACGGCGGGCAAGACGACGCTCGGCGGCGAAGGGCTTCAGCATCAGGACGGCACGAGTCATCTCGC
GGCATCGACGGTGCCGAACTGCCGTTCATACGATCCCGCGTTTGCCTTCGAAGTCGCGCTGATCGTCGATGAAGGCATGC
GGGAGATGCTCGAACGTCAGCGCGATGTGTTCTATTACCTGACCGTCACGAACGAGAACTACGCACAGCCTTCGCTGCCT
GCAGCTGTGTCTGTCGATACCGTGCGGGAAGGCGTGCTGAAGGGGATGTATCCGCTCGATCAGGCATCGCTGGAAACGGC
GCAGGTGCAATTGCTCGGCGCGGGCGCGATTCTCGGCGAAGTGCAGGCAGCCGCGCGCATGCTGAGGGACGACTGGAACA
TCCCGGCTGCCGTATGGAGCGTGACGAGCTTCACCGAACTGCATCGTAACGGCGTTGCAGCGGAACGTGCGGAGCGCCTC
TTCGACGACGCGCAACACGCGTTGCCGTATGTGACGTCCGCGCTCGCTGCAGTGCGCGGCCCGGTGATCGCCGCGACCGA
CTATGTGCGCGCCGTGCCCGAACTGATCCGCGCGTATGTGCCGCGCCGCTACGTGACGCTCGGCACCGACGGCTTCGGGC
GCAGCGACACGCGCGCTGCGCTGCGCGCGTTCTTCGAAGTGGATCGCGCGTCGATCGCGATTGCCGCGTTGAAGGCGCTC
GCCGACGAGGGGGCGAGCGAACGCGACATCGTCAGGCAGGCGATCGACCGTTATGGCAAACGCGATGGGGACAACGGCGC
GCCCTGGGAGAGGTGA

Upstream 100 bases:

>100_bases
CTGCGCAAGCAAAAGAGACGCACATTTTCCGGACGCATGGGTAAGCTGATGAGACCTTTTCGAGTCGCCTTTCACCCACG
CTTTCTGCCGGAGTTGCGCC

Downstream 100 bases:

>100_bases
TGCGCGTCACATTTGCGGAGTTTGCGGAGTTTGCGCATGTTGCGCAGGTTGCGGCACGAGCAGATTGGCATCGCGCGCGA
GCAGCCAGCGGCCGTCGGCC

Product: 2-oxoacid dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 911; Mature: 910

Protein sequence:

>911_residues
MTDLSSGARPVVALTQARIDSDPQETAEWLAALDGVVQHVGLERAQYLFDRLAAHALGNGVATARANVTPYANTISVDQQ
PPYPGDLDTEEKLAAALRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRAASTRQDGNDARGGDLVYFQPH
SSPGVYARAFLEGFLDETHLEHYRREIAGPGLCSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQNRGLLKTEGR
KVWGFFGDGEMDEPESIGALSLAAREGLDNLVFVINCNLQRLDGPVRSNGRIIDELEAQFTGAGWNVIKVLWGSDWDALF
ARDRTGALLRAFAHTVDGQFQTFSANDGAYNRERFFGQNPELEALAAHLSNDDIDRLRRGGHDVRKLHAAYDRALKHRGQ
PTVILAKTMKGFGMGSIGQGRMTTHQQKKLDVEQLKAFRDRFRLPLSDEDVEQLRFYKPAENSPEMQYLHARRVALGGYL
PRRRAAASRTPTVPALPSWGQFALEANGKEMSTTMAVVRMLGSLLKDASLGPRVVPVVADEARTFGMANLFRQVGIYSPL
GQLYEPEDMGSMLYYREDTGGQILEEGISEAGAVSSWIAAATSYSVHDLAMLPFYIYYSMFGFQRIGDLIWAAADQRARG
FLIGATAGKTTLGGEGLQHQDGTSHLAASTVPNCRSYDPAFAFEVALIVDEGMREMLERQRDVFYYLTVTNENYAQPSLP
AAVSVDTVREGVLKGMYPLDQASLETAQVQLLGAGAILGEVQAAARMLRDDWNIPAAVWSVTSFTELHRNGVAAERAERL
FDDAQHALPYVTSALAAVRGPVIAATDYVRAVPELIRAYVPRRYVTLGTDGFGRSDTRAALRAFFEVDRASIAIAALKAL
ADEGASERDIVRQAIDRYGKRDGDNGAPWER

Sequences:

>Translated_911_residues
MTDLSSGARPVVALTQARIDSDPQETAEWLAALDGVVQHVGLERAQYLFDRLAAHALGNGVATARANVTPYANTISVDQQ
PPYPGDLDTEEKLAAALRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRAASTRQDGNDARGGDLVYFQPH
SSPGVYARAFLEGFLDETHLEHYRREIAGPGLCSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQNRGLLKTEGR
KVWGFFGDGEMDEPESIGALSLAAREGLDNLVFVINCNLQRLDGPVRSNGRIIDELEAQFTGAGWNVIKVLWGSDWDALF
ARDRTGALLRAFAHTVDGQFQTFSANDGAYNRERFFGQNPELEALAAHLSNDDIDRLRRGGHDVRKLHAAYDRALKHRGQ
PTVILAKTMKGFGMGSIGQGRMTTHQQKKLDVEQLKAFRDRFRLPLSDEDVEQLRFYKPAENSPEMQYLHARRVALGGYL
PRRRAAASRTPTVPALPSWGQFALEANGKEMSTTMAVVRMLGSLLKDASLGPRVVPVVADEARTFGMANLFRQVGIYSPL
GQLYEPEDMGSMLYYREDTGGQILEEGISEAGAVSSWIAAATSYSVHDLAMLPFYIYYSMFGFQRIGDLIWAAADQRARG
FLIGATAGKTTLGGEGLQHQDGTSHLAASTVPNCRSYDPAFAFEVALIVDEGMREMLERQRDVFYYLTVTNENYAQPSLP
AAVSVDTVREGVLKGMYPLDQASLETAQVQLLGAGAILGEVQAAARMLRDDWNIPAAVWSVTSFTELHRNGVAAERAERL
FDDAQHALPYVTSALAAVRGPVIAATDYVRAVPELIRAYVPRRYVTLGTDGFGRSDTRAALRAFFEVDRASIAIAALKAL
ADEGASERDIVRQAIDRYGKRDGDNGAPWER
>Mature_910_residues
TDLSSGARPVVALTQARIDSDPQETAEWLAALDGVVQHVGLERAQYLFDRLAAHALGNGVATARANVTPYANTISVDQQP
PYPGDLDTEEKLAAALRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRAASTRQDGNDARGGDLVYFQPHS
SPGVYARAFLEGFLDETHLEHYRREIAGPGLCSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQNRGLLKTEGRK
VWGFFGDGEMDEPESIGALSLAAREGLDNLVFVINCNLQRLDGPVRSNGRIIDELEAQFTGAGWNVIKVLWGSDWDALFA
RDRTGALLRAFAHTVDGQFQTFSANDGAYNRERFFGQNPELEALAAHLSNDDIDRLRRGGHDVRKLHAAYDRALKHRGQP
TVILAKTMKGFGMGSIGQGRMTTHQQKKLDVEQLKAFRDRFRLPLSDEDVEQLRFYKPAENSPEMQYLHARRVALGGYLP
RRRAAASRTPTVPALPSWGQFALEANGKEMSTTMAVVRMLGSLLKDASLGPRVVPVVADEARTFGMANLFRQVGIYSPLG
QLYEPEDMGSMLYYREDTGGQILEEGISEAGAVSSWIAAATSYSVHDLAMLPFYIYYSMFGFQRIGDLIWAAADQRARGF
LIGATAGKTTLGGEGLQHQDGTSHLAASTVPNCRSYDPAFAFEVALIVDEGMREMLERQRDVFYYLTVTNENYAQPSLPA
AVSVDTVREGVLKGMYPLDQASLETAQVQLLGAGAILGEVQAAARMLRDDWNIPAAVWSVTSFTELHRNGVAAERAERLF
DDAQHALPYVTSALAAVRGPVIAATDYVRAVPELIRAYVPRRYVTLGTDGFGRSDTRAALRAFFEVDRASIAIAALKALA
DEGASERDIVRQAIDRYGKRDGDNGAPWER

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=882, Percent_Identity=53.0612244897959, Blast_Score=956, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 100329; Mature: 100198

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLSSGARPVVALTQARIDSDPQETAEWLAALDGVVQHVGLERAQYLFDRLAAHALGNG
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VATARANVTPYANTISVDQQPPYPGDLDTEEKLAAALRWNALAMVVRANRAYGELGGHIA
CEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SYASAADLFEVGFNHFFRAASTRQDGNDARGGDLVYFQPHSSPGVYARAFLEGFLDETHL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
EHYRREIAGPGLCSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQNRGLLKTEGR
HHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCC
KVWGFFGDGEMDEPESIGALSLAAREGLDNLVFVINCNLQRLDGPVRSNGRIIDELEAQF
EEEEEECCCCCCCCHHCCHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCCCCHHHHHHHH
TGAGWNVIKVLWGSDWDALFARDRTGALLRAFAHTVDGQFQTFSANDGAYNRERFFGQNP
CCCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCCC
ELEALAAHLSNDDIDRLRRGGHDVRKLHAAYDRALKHRGQPTVILAKTMKGFGMGSIGQG
CHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
RMTTHQQKKLDVEQLKAFRDRFRLPLSDEDVEQLRFYKPAENSPEMQYLHARRVALGGYL
CCCCCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
PRRRAAASRTPTVPALPSWGQFALEANGKEMSTTMAVVRMLGSLLKDASLGPRVVPVVAD
CHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
EARTFGMANLFRQVGIYSPLGQLYEPEDMGSMLYYREDTGGQILEEGISEAGAVSSWIAA
HHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
ATSYSVHDLAMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATAGKTTLGGEGLQHQ
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCC
DGTSHLAASTVPNCRSYDPAFAFEVALIVDEGMREMLERQRDVFYYLTVTNENYAQPSLP
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCC
AAVSVDTVREGVLKGMYPLDQASLETAQVQLLGAGAILGEVQAAARMLRDDWNIPAAVWS
CCEEHHHHHHHHHHCCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHHCCCCCHHHHH
VTSFTELHRNGVAAERAERLFDDAQHALPYVTSALAAVRGPVIAATDYVRAVPELIRAYV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHC
PRRYVTLGTDGFGRSDTRAALRAFFEVDRASIAIAALKALADEGASERDIVRQAIDRYGK
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
RDGDNGAPWER
CCCCCCCCCCC
>Mature Secondary Structure 
TDLSSGARPVVALTQARIDSDPQETAEWLAALDGVVQHVGLERAQYLFDRLAAHALGNG
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VATARANVTPYANTISVDQQPPYPGDLDTEEKLAAALRWNALAMVVRANRAYGELGGHIA
CEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SYASAADLFEVGFNHFFRAASTRQDGNDARGGDLVYFQPHSSPGVYARAFLEGFLDETHL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
EHYRREIAGPGLCSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQNRGLLKTEGR
HHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCC
KVWGFFGDGEMDEPESIGALSLAAREGLDNLVFVINCNLQRLDGPVRSNGRIIDELEAQF
EEEEEECCCCCCCCHHCCHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCCCCHHHHHHHH
TGAGWNVIKVLWGSDWDALFARDRTGALLRAFAHTVDGQFQTFSANDGAYNRERFFGQNP
CCCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCCC
ELEALAAHLSNDDIDRLRRGGHDVRKLHAAYDRALKHRGQPTVILAKTMKGFGMGSIGQG
CHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
RMTTHQQKKLDVEQLKAFRDRFRLPLSDEDVEQLRFYKPAENSPEMQYLHARRVALGGYL
CCCCCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
PRRRAAASRTPTVPALPSWGQFALEANGKEMSTTMAVVRMLGSLLKDASLGPRVVPVVAD
CHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
EARTFGMANLFRQVGIYSPLGQLYEPEDMGSMLYYREDTGGQILEEGISEAGAVSSWIAA
HHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
ATSYSVHDLAMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATAGKTTLGGEGLQHQ
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCC
DGTSHLAASTVPNCRSYDPAFAFEVALIVDEGMREMLERQRDVFYYLTVTNENYAQPSLP
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCC
AAVSVDTVREGVLKGMYPLDQASLETAQVQLLGAGAILGEVQAAARMLRDDWNIPAAVWS
CCEEHHHHHHHHHHCCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHHCCCCCHHHHH
VTSFTELHRNGVAAERAERLFDDAQHALPYVTSALAAVRGPVIAATDYVRAVPELIRAYV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHC
PRRYVTLGTDGFGRSDTRAALRAFFEVDRASIAIAALKALADEGASERDIVRQAIDRYGK
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
RDGDNGAPWER
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171401; 10984043 [H]