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The map label for this gene is fadI [H]

Identifier: 186476461

GI number: 186476461

Start: 1943152

End: 1944480

Strand: Direct

Name: fadI [H]

Synonym: Bphy_1703

Alternate gene names: 186476461

Gene position: 1943152-1944480 (Clockwise)

Preceding gene: 186476460

Following gene: 186476462

Centisome position: 55.85

GC content: 67.57

Gene sequence:

>1329_bases
ATGCCTGATGCATCACAGTCACCTGCACAGTCGGCCGCGCTGCCTGCCGGCCGCCGCGTCGCGATCCTGGGCGGCAACCG
CATCCCGTTCGCGCGCTCGAACACCGCGTACGCGACGGCGTCGAACCAGGACATGCTGACTTTCACGCTGCAAGGGCTGA
TCGACCGCTACAACCTGCACGGCGAGCGCCTCGGCGAAGTCGTGGCGGGCGCCGTCATCAAGCATTCGCGCGACTACAAC
CTGACGCGCGAAGCGCTGCTGTCGACCACGCTCGCGAAGGAAACGCCCGCGTACGACGTACAGCAGGCCTGCGGCACGGG
CCTTGAAGCGGCCATTCTGGTGGCGAACAAGATCGCGCTCGGACAGATCGACGCGGGCATCGCGGGCGGCGTCGATACGA
CGTCGGATGCGCCCATCGGCGTCAACGAAAAGCTGCGCAAGATCCTGCTCGAAGCGAACCGCGGCAAGTCGGCGGGGCAG
CGCGCCGGTGCGCTCGCGAAGCTGCGGCCCGGGATGTTCTTCAGGCCGCTCTTGCCGCGCAACAGCGAGCCGCGCACGGG
TCTGTCGATGGGCGAGCATTGCGAACTGATGGCCAAGCGCTGGGCGATTTCGCGCGAGGCTCAGGACGTGCTGGCCTACG
ACAGCCACCGCAAGCTGACGCAAGCGTATGCGCGCGGCTTCCTCAACGACCTGATGACGCCCTATCGCGGCCTGTCCCGC
GACAACACGCTGCGCAGCGACCTCACACTCGACAGGCTCGCGTCGCTGAAACCGGTGTTCGACCGCGACGCGGGCACGAT
GACGGCAGGCAACTCCACGCCCCTGACGGACGGCGCATCGGCCGTGCTGCTCGCAAGCGAGGCGTGGGCGGCCGCGCGCA
ATCTGCCTGTGCTCGCCTGGCTCACGTGGCACGAGACGGCCGCCGTCGATTTCTTCGAGAAGAAAGAGGGTCTGCTGATG
GCGCCCGCGTACGCCGTGCCGCGTATGCTTACGCGCGCGGGGCTGACGCTGCAGGATTTCGATTTCTACGAAATCCACGA
GGCGTTCGCGGCGCAGGTGCTGTGCACGCTCGCCGCGTGGCAAGACGACGAGTACTGCCGCACGCACCTGGGACTGGAAC
GCGCGCTCGGCAGCATCGACCACACGAAAATCAACGTGAACGGCGGATCGCTCGCGACGGGCCATCCGTTTGCCGCGACG
GGCGGACGTATCGTCGGGGGACTCGCGAAACAGCTCGCGCAACTCGACAAGCCGGCGGGCACCGCGCGCGGACTGATCTC
GATCTGCGCGGCGGGCGGCCAGGGTGTGGTCGCCATACTGGAACGGTAG

Upstream 100 bases:

>100_bases
GGAATCCATGCCCCGCCTGATCCGTTTCGAGCAGGTGCGGGGCGCCGCATGCGTCACCTGATCCGCCCAACCGACGGAGC
ACGCCACAGGGAGCCCATCC

Downstream 100 bases:

>100_bases
AATCACGCGCCATTGCAGGTCGCACTTAGCACGTTGCAATTAGCACGATTGATGCACGCGAGCCAGACAACGACAATGCC
GGGAGACGGAGACAAACGAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MPDASQSPAQSAALPAGRRVAILGGNRIPFARSNTAYATASNQDMLTFTLQGLIDRYNLHGERLGEVVAGAVIKHSRDYN
LTREALLSTTLAKETPAYDVQQACGTGLEAAILVANKIALGQIDAGIAGGVDTTSDAPIGVNEKLRKILLEANRGKSAGQ
RAGALAKLRPGMFFRPLLPRNSEPRTGLSMGEHCELMAKRWAISREAQDVLAYDSHRKLTQAYARGFLNDLMTPYRGLSR
DNTLRSDLTLDRLASLKPVFDRDAGTMTAGNSTPLTDGASAVLLASEAWAAARNLPVLAWLTWHETAAVDFFEKKEGLLM
APAYAVPRMLTRAGLTLQDFDFYEIHEAFAAQVLCTLAAWQDDEYCRTHLGLERALGSIDHTKINVNGGSLATGHPFAAT
GGRIVGGLAKQLAQLDKPAGTARGLISICAAGGQGVVAILER

Sequences:

>Translated_442_residues
MPDASQSPAQSAALPAGRRVAILGGNRIPFARSNTAYATASNQDMLTFTLQGLIDRYNLHGERLGEVVAGAVIKHSRDYN
LTREALLSTTLAKETPAYDVQQACGTGLEAAILVANKIALGQIDAGIAGGVDTTSDAPIGVNEKLRKILLEANRGKSAGQ
RAGALAKLRPGMFFRPLLPRNSEPRTGLSMGEHCELMAKRWAISREAQDVLAYDSHRKLTQAYARGFLNDLMTPYRGLSR
DNTLRSDLTLDRLASLKPVFDRDAGTMTAGNSTPLTDGASAVLLASEAWAAARNLPVLAWLTWHETAAVDFFEKKEGLLM
APAYAVPRMLTRAGLTLQDFDFYEIHEAFAAQVLCTLAAWQDDEYCRTHLGLERALGSIDHTKINVNGGSLATGHPFAAT
GGRIVGGLAKQLAQLDKPAGTARGLISICAAGGQGVVAILER
>Mature_441_residues
PDASQSPAQSAALPAGRRVAILGGNRIPFARSNTAYATASNQDMLTFTLQGLIDRYNLHGERLGEVVAGAVIKHSRDYNL
TREALLSTTLAKETPAYDVQQACGTGLEAAILVANKIALGQIDAGIAGGVDTTSDAPIGVNEKLRKILLEANRGKSAGQR
AGALAKLRPGMFFRPLLPRNSEPRTGLSMGEHCELMAKRWAISREAQDVLAYDSHRKLTQAYARGFLNDLMTPYRGLSRD
NTLRSDLTLDRLASLKPVFDRDAGTMTAGNSTPLTDGASAVLLASEAWAAARNLPVLAWLTWHETAAVDFFEKKEGLLMA
PAYAVPRMLTRAGLTLQDFDFYEIHEAFAAQVLCTLAAWQDDEYCRTHLGLERALGSIDHTKINVNGGSLATGHPFAATG
GRIVGGLAKQLAQLDKPAGTARGLISICAAGGQGVVAILER

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=445, Percent_Identity=36.8539325842697, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI4501853, Length=454, Percent_Identity=29.7356828193833, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI167614485, Length=433, Percent_Identity=28.6374133949192, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI148539872, Length=440, Percent_Identity=27.5, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4557237, Length=438, Percent_Identity=25.3424657534247, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1788683, Length=395, Percent_Identity=40, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI87082165, Length=435, Percent_Identity=30.3448275862069, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1788554, Length=435, Percent_Identity=31.264367816092, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787663, Length=437, Percent_Identity=31.5789473684211, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI48994986, Length=437, Percent_Identity=28.8329519450801, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17551802, Length=431, Percent_Identity=35.0348027842227, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI133906874, Length=435, Percent_Identity=28.5057471264368, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17535921, Length=444, Percent_Identity=26.5765765765766, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI25147385, Length=430, Percent_Identity=25.1162790697674, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6322031, Length=436, Percent_Identity=31.1926605504587, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=438, Percent_Identity=26.7123287671233, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=36.8909512761021, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24655093, Length=433, Percent_Identity=27.7136258660508, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24640423, Length=433, Percent_Identity=25.1732101616628, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=29.0076335877863, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 47247; Mature: 47116

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDASQSPAQSAALPAGRRVAILGGNRIPFARSNTAYATASNQDMLTFTLQGLIDRYNLH
CCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHHCCC
GERLGEVVAGAVIKHSRDYNLTREALLSTTLAKETPAYDVQQACGTGLEAAILVANKIAL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHHEE
GQIDAGIAGGVDTTSDAPIGVNEKLRKILLEANRGKSAGQRAGALAKLRPGMFFRPLLPR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCHHHCCCCCEEECCCCC
NSEPRTGLSMGEHCELMAKRWAISREAQDVLAYDSHRKLTQAYARGFLNDLMTPYRGLSR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DNTLRSDLTLDRLASLKPVFDRDAGTMTAGNSTPLTDGASAVLLASEAWAAARNLPVLAW
CCCHHHHCCHHHHHHCCCHHCCCCCCEECCCCCCCCCCCCEEEEEHHHHHHHCCCCEEEE
LTWHETAAVDFFEKKEGLLMAPAYAVPRMLTRAGLTLQDFDFYEIHEAFAAQVLCTLAAW
EEECCHHHHHHHHCCCCEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHC
QDDEYCRTHLGLERALGSIDHTKINVNGGSLATGHPFAATGGRIVGGLAKQLAQLDKPAG
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
TARGLISICAAGGQGVVAILER
HHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
PDASQSPAQSAALPAGRRVAILGGNRIPFARSNTAYATASNQDMLTFTLQGLIDRYNLH
CCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHHCCC
GERLGEVVAGAVIKHSRDYNLTREALLSTTLAKETPAYDVQQACGTGLEAAILVANKIAL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHHEE
GQIDAGIAGGVDTTSDAPIGVNEKLRKILLEANRGKSAGQRAGALAKLRPGMFFRPLLPR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCHHHCCCCCEEECCCCC
NSEPRTGLSMGEHCELMAKRWAISREAQDVLAYDSHRKLTQAYARGFLNDLMTPYRGLSR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DNTLRSDLTLDRLASLKPVFDRDAGTMTAGNSTPLTDGASAVLLASEAWAAARNLPVLAW
CCCHHHHCCHHHHHHCCCHHCCCCCCEECCCCCCCCCCCCEEEEEHHHHHHHCCCCEEEE
LTWHETAAVDFFEKKEGLLMAPAYAVPRMLTRAGLTLQDFDFYEIHEAFAAQVLCTLAAW
EEECCHHHHHHHHCCCCEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHC
QDDEYCRTHLGLERALGSIDHTKINVNGGSLATGHPFAATGGRIVGGLAKQLAQLDKPAG
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
TARGLISICAAGGQGVVAILER
HHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA