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The map label for this gene is cbl [H]

Identifier: 186476383

GI number: 186476383

Start: 1847665

End: 1848591

Strand: Reverse

Name: cbl [H]

Synonym: Bphy_1625

Alternate gene names: 186476383

Gene position: 1848591-1847665 (Counterclockwise)

Preceding gene: 186476384

Following gene: 186476382

Centisome position: 53.13

GC content: 62.57

Gene sequence:

>927_bases
ATGAATTTTCAGCAGTTGCGCTTCGTGCGCGAAGCCGTGCGGCAGAACATGAACCTGACGGAAGTCGCGAACGTGCTGTA
CACGTCGCAGTCGGGTGTGTCGAAGCAGATCAAGGATCTCGAGGACGAGCTGGGCGTCGATATTTTCATTCGACGCGGCA
AGCGCCTGACGGGGCTCACTGAGCCGGGCAAGGCCGTGCATCAGTTGATCGAGCGCATGCTGCTCGACGCCGAGAACCTG
CGCCGCGTCGCGCGCCAGTATGCGGACCAGGACAACGGCCACCTCGTCGTCGCGACGACGCACACGCAGGCGCGCTATGC
GTTGCCGAAGGTGGTGCGCCAGTTCACCGAGGTCTATCCGAAGGTGCATCTCGCGCTGCGCCAGGGCAACCCGCAGCAGA
TCGCGCAGATGATCATCAACGGCGAGGCGGACATCGGTATTTCGACGGAAGCGCTCGACCGCTATCCCGACATCGTGACG
TTCCCTTGCTATTCGTGGCATCACGTTGTGGTCGTGCCGAAGGGGCATCCGCTCGTGGGCCGCGTGAACCTGTCGCTCGA
AGAGATCGCCGAGTACCCGATCGTCACATACGACCAGGACTTCACGGGCCGCTCGCATATCGACTCGGCGTTCGCGAAGG
CGGGTGCGCTGCCCGACGTCGTGCTGACGGCCATCGATGCCGATGTGATCAAGACCTACGTCGAACTCGGCATGGGCATC
GGCATCGTCGCGGCGATGGCATTCGATCCGAAGCGCGACACGGAACTCGTCGCACTGGATACGCAGCATCTGTTCGAAGC
GAGCACGACGCGTGTCGGCTTGCGCAAGGGCGCGTTTCTGCGCGCGTATGCGTACCGTCTCATCGAAATGTTCGCACCGC
AACTCCACGAAGCGGATATCGCGAGCCAGCTGCGCGAAGCAGCCTGA

Upstream 100 bases:

>100_bases
ATGAGCGGCACAATGAGCGGCACATTGAGCCGCACACCGTGCGCATTTCGAACCAGGCATTGAACAATAAACTGACTTCG
GACGAACCGGAGACATCGAT

Downstream 100 bases:

>100_bases
CTGCGCATCGAGTCAACGCGTGCCGCGCGACAGGCTCGCGTTTTTATCGATGGCGGCGACGTGTGCTTCGCTTACAATCG
CCGCCATGAATACTTCCACT

Product: transcriptional regulator CysB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLTEPGKAVHQLIERMLLDAENL
RRVARQYADQDNGHLVVATTHTQARYALPKVVRQFTEVYPKVHLALRQGNPQQIAQMIINGEADIGISTEALDRYPDIVT
FPCYSWHHVVVVPKGHPLVGRVNLSLEEIAEYPIVTYDQDFTGRSHIDSAFAKAGALPDVVLTAIDADVIKTYVELGMGI
GIVAAMAFDPKRDTELVALDTQHLFEASTTRVGLRKGAFLRAYAYRLIEMFAPQLHEADIASQLREAA

Sequences:

>Translated_308_residues
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLTEPGKAVHQLIERMLLDAENL
RRVARQYADQDNGHLVVATTHTQARYALPKVVRQFTEVYPKVHLALRQGNPQQIAQMIINGEADIGISTEALDRYPDIVT
FPCYSWHHVVVVPKGHPLVGRVNLSLEEIAEYPIVTYDQDFTGRSHIDSAFAKAGALPDVVLTAIDADVIKTYVELGMGI
GIVAAMAFDPKRDTELVALDTQHLFEASTTRVGLRKGAFLRAYAYRLIEMFAPQLHEADIASQLREAA
>Mature_308_residues
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLTEPGKAVHQLIERMLLDAENL
RRVARQYADQDNGHLVVATTHTQARYALPKVVRQFTEVYPKVHLALRQGNPQQIAQMIINGEADIGISTEALDRYPDIVT
FPCYSWHHVVVVPKGHPLVGRVNLSLEEIAEYPIVTYDQDFTGRSHIDSAFAKAGALPDVVLTAIDADVIKTYVELGMGI
GIVAAMAFDPKRDTELVALDTQHLFEASTTRVGLRKGAFLRAYAYRLIEMFAPQLHEADIASQLREAA

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=308, Percent_Identity=53.2467532467532, Blast_Score=349, Evalue=1e-97,
Organism=Escherichia coli, GI1787530, Length=295, Percent_Identity=49.4915254237288, Blast_Score=315, Evalue=2e-87,
Organism=Escherichia coli, GI157672245, Length=225, Percent_Identity=30.6666666666667, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788887, Length=245, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788481, Length=244, Percent_Identity=26.6393442622951, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790399, Length=252, Percent_Identity=22.6190476190476, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367136, Length=241, Percent_Identity=24.4813278008299, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787806, Length=243, Percent_Identity=23.0452674897119, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082132, Length=122, Percent_Identity=34.4262295081967, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790208, Length=230, Percent_Identity=25.6521739130435, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=185, Percent_Identity=27.027027027027, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34479; Mature: 34479

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLT
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCC
EPGKAVHQLIERMLLDAENLRRVARQYADQDNGHLVVATTHTQARYALPKVVRQFTEVYP
CCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
KVHLALRQGNPQQIAQMIINGEADIGISTEALDRYPDIVTFPCYSWHHVVVVPKGHPLVG
HHEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCCCCEEEEEEECCCCEEE
RVNLSLEEIAEYPIVTYDQDFTGRSHIDSAFAKAGALPDVVLTAIDADVIKTYVELGMGI
EECCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCH
GIVAAMAFDPKRDTELVALDTQHLFEASTTRVGLRKGAFLRAYAYRLIEMFAPQLHEADI
HHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHH
ASQLREAA
HHHHHHCC
>Mature Secondary Structure
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLT
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCC
EPGKAVHQLIERMLLDAENLRRVARQYADQDNGHLVVATTHTQARYALPKVVRQFTEVYP
CCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
KVHLALRQGNPQQIAQMIINGEADIGISTEALDRYPDIVTFPCYSWHHVVVVPKGHPLVG
HHEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCCCCEEEEEEECCCCEEE
RVNLSLEEIAEYPIVTYDQDFTGRSHIDSAFAKAGALPDVVLTAIDADVIKTYVELGMGI
EECCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCH
GIVAAMAFDPKRDTELVALDTQHLFEASTTRVGLRKGAFLRAYAYRLIEMFAPQLHEADI
HHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHH
ASQLREAA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]