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The map label for this gene is livM [H]

Identifier: 186476364

GI number: 186476364

Start: 1824324

End: 1825583

Strand: Reverse

Name: livM [H]

Synonym: Bphy_1606

Alternate gene names: 186476364

Gene position: 1825583-1824324 (Counterclockwise)

Preceding gene: 186476365

Following gene: 186476363

Centisome position: 52.47

GC content: 69.05

Gene sequence:

>1260_bases
ATGCGTGACGACATCGACGTGCGCCCCACGCTGCCCGCTGCGCGCCACGTGTCGACATGGCGGGCGGCGCTGCCGTGGGC
CGCGTTGGGTGTGCTGCTAGTCGTGCCGCCGTGCGTCTCGACGCAAAGCTGGCTCGTCGCGTGGCTCGCGCAGACGGCCG
CGATGATCGTGTTCGCGCTGTCTTACAACCTGCTGCTGGGCGGCGCGGGGCTGCTGTCGTTCGGGCATGCCGCTTCGTCG
GGCATCGGTGCGCTGATCGCCGCGCAGCTGTTCAATCGCTTCGGGCTGCCGCTGCCCTTACTGCCGCTGCTGGGCGGCAT
CGGCGGCGCGCTGTTCGGCGCGTTGTACGGCCTCGTCGCGACACGCCGCTCGGGGACGGCCTTCGCGATGATCACGCTCG
GCATCGGCGAACTCGTCGCGGCGGCTGCCTGGACTCTGCCGGACTGGTTCGGCGGCGAAGCGGGCGTCGCGATCGACCGC
ACGGCGGGCATCGCGCTGCCCGGCTTCACGTTCGGCCCCGCGCGCGAAGCGTATGCGTTGATCGCGCTCTGGTGTGCGCT
CGCCGTGATCGCGATGTACGCGCTGTCGCGCACGCCGTTCATGCGGCTCGCGAATGCCGTGCGCGACAATCCTGTGCGCG
CGGCGGCCATCGGGTGCTATCCGCGGCGTGTGCGTTATGAGGTGGTCGTGTGGTCGTCGTTTTTTGCGGGCATCGCGGGC
ACGCTCGGGCTGATCAATGTCGAACTGGTGTCGACGGAAAGCGTCGGCATGCTGCGCTCGGGCTCGGTGCTGGTCGCGAC
GGTGATCGGCGGAAGCGGGGCGTTTTTCGGGCCGGTCGCGGGCGCCGTGGTGCTGGTGTTTTTCAGCGTCGTCGTGGCGA
GTGTTACGCGTGCGTGGCTGCTGTATCTCGGGCTGTTCTTCATGGCCGTCGTGATGATGTCGCCGGACGGTATCGCGGGA
TGGCTGCGGCGCGAGACCGGGCGAATCGCGCGTGACGGCTGGCGTGGCTATCTGCCGTGGTTCGCCTGCCGCATGGCGGG
CGCGTGCGCGTGGTCGCTTGCCATCGTGCTCGCGGTGCAATGGGCGTACGCACAGCGTTTCGGCACGCAGGAGCGCACGA
GTTTTTTTGCGTCGATGAACGCTGCGTGGATCGCGGTGGCCGTGCTGTGTCTGGCCGCCATCGGCTGGTTGACGATGAAC
GCTGCGACGCGCCTGGCGGGCGCGCTCATCGCGGATGTCCGAGCGGGAGTGGGCGAATGA

Upstream 100 bases:

>100_bases
GCGCTGACGCTCGCACAACTCGCGCCGCTCATGCCGTATCTGCTGCTCGTCGCGATGCTCGCCGTGCGTGCACGCGGCTT
CTTCGGGCAGCGCGACGACG

Downstream 100 bases:

>100_bases
TCCCCGCGATTGCCGTGCGGCGCCTTCACAAGCGCTTCGGCGCGACGCGCGTTCTGCGCGGCGTCGATCTGTATGTCGAA
CCGCATGAGCGACACGCGCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRDDIDVRPTLPAARHVSTWRAALPWAALGVLLVVPPCVSTQSWLVAWLAQTAAMIVFALSYNLLLGGAGLLSFGHAASS
GIGALIAAQLFNRFGLPLPLLPLLGGIGGALFGALYGLVATRRSGTAFAMITLGIGELVAAAAWTLPDWFGGEAGVAIDR
TAGIALPGFTFGPAREAYALIALWCALAVIAMYALSRTPFMRLANAVRDNPVRAAAIGCYPRRVRYEVVVWSSFFAGIAG
TLGLINVELVSTESVGMLRSGSVLVATVIGGSGAFFGPVAGAVVLVFFSVVVASVTRAWLLYLGLFFMAVVMMSPDGIAG
WLRRETGRIARDGWRGYLPWFACRMAGACAWSLAIVLAVQWAYAQRFGTQERTSFFASMNAAWIAVAVLCLAAIGWLTMN
AATRLAGALIADVRAGVGE

Sequences:

>Translated_419_residues
MRDDIDVRPTLPAARHVSTWRAALPWAALGVLLVVPPCVSTQSWLVAWLAQTAAMIVFALSYNLLLGGAGLLSFGHAASS
GIGALIAAQLFNRFGLPLPLLPLLGGIGGALFGALYGLVATRRSGTAFAMITLGIGELVAAAAWTLPDWFGGEAGVAIDR
TAGIALPGFTFGPAREAYALIALWCALAVIAMYALSRTPFMRLANAVRDNPVRAAAIGCYPRRVRYEVVVWSSFFAGIAG
TLGLINVELVSTESVGMLRSGSVLVATVIGGSGAFFGPVAGAVVLVFFSVVVASVTRAWLLYLGLFFMAVVMMSPDGIAG
WLRRETGRIARDGWRGYLPWFACRMAGACAWSLAIVLAVQWAYAQRFGTQERTSFFASMNAAWIAVAVLCLAAIGWLTMN
AATRLAGALIADVRAGVGE
>Mature_419_residues
MRDDIDVRPTLPAARHVSTWRAALPWAALGVLLVVPPCVSTQSWLVAWLAQTAAMIVFALSYNLLLGGAGLLSFGHAASS
GIGALIAAQLFNRFGLPLPLLPLLGGIGGALFGALYGLVATRRSGTAFAMITLGIGELVAAAAWTLPDWFGGEAGVAIDR
TAGIALPGFTFGPAREAYALIALWCALAVIAMYALSRTPFMRLANAVRDNPVRAAAIGCYPRRVRYEVVVWSSFFAGIAG
TLGLINVELVSTESVGMLRSGSVLVATVIGGSGAFFGPVAGAVVLVFFSVVVASVTRAWLLYLGLFFMAVVMMSPDGIAG
WLRRETGRIARDGWRGYLPWFACRMAGACAWSLAIVLAVQWAYAQRFGTQERTSFFASMNAAWIAVAVLCLAAIGWLTMN
AATRLAGALIADVRAGVGE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=296, Percent_Identity=27.7027027027027, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 44080; Mature: 44080

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDDIDVRPTLPAARHVSTWRAALPWAALGVLLVVPPCVSTQSWLVAWLAQTAAMIVFAL
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SYNLLLGGAGLLSFGHAASSGIGALIAAQLFNRFGLPLPLLPLLGGIGGALFGALYGLVA
HHHHHHCCHHHHHHCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
TRRSGTAFAMITLGIGELVAAAAWTLPDWFGGEAGVAIDRTAGIALPGFTFGPAREAYAL
HCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEECCCCCCCCHHHHHHH
IALWCALAVIAMYALSRTPFMRLANAVRDNPVRAAAIGCYPRRVRYEVVVWSSFFAGIAG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCHHEEEEEEEHHHHHHHHHH
TLGLINVELVSTESVGMLRSGSVLVATVIGGSGAFFGPVAGAVVLVFFSVVVASVTRAWL
HHHEEEEEEECCCCCCCEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLGLFFMAVVMMSPDGIAGWLRRETGRIARDGWRGYLPWFACRMAGACAWSLAIVLAVQ
HHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
WAYAQRFGTQERTSFFASMNAAWIAVAVLCLAAIGWLTMNAATRLAGALIADVRAGVGE
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRDDIDVRPTLPAARHVSTWRAALPWAALGVLLVVPPCVSTQSWLVAWLAQTAAMIVFAL
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SYNLLLGGAGLLSFGHAASSGIGALIAAQLFNRFGLPLPLLPLLGGIGGALFGALYGLVA
HHHHHHCCHHHHHHCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
TRRSGTAFAMITLGIGELVAAAAWTLPDWFGGEAGVAIDRTAGIALPGFTFGPAREAYAL
HCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEECCCCCCCCHHHHHHH
IALWCALAVIAMYALSRTPFMRLANAVRDNPVRAAAIGCYPRRVRYEVVVWSSFFAGIAG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCHHEEEEEEEHHHHHHHHHH
TLGLINVELVSTESVGMLRSGSVLVATVIGGSGAFFGPVAGAVVLVFFSVVVASVTRAWL
HHHEEEEEEECCCCCCCEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLGLFFMAVVMMSPDGIAGWLRRETGRIARDGWRGYLPWFACRMAGACAWSLAIVLAVQ
HHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
WAYAQRFGTQERTSFFASMNAAWIAVAVLCLAAIGWLTMNAATRLAGALIADVRAGVGE
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]