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The map label for this gene is comA [H]

Identifier: 186476201

GI number: 186476201

Start: 1622460

End: 1624991

Strand: Reverse

Name: comA [H]

Synonym: Bphy_1443

Alternate gene names: 186476201

Gene position: 1624991-1622460 (Counterclockwise)

Preceding gene: 186476202

Following gene: 186476200

Centisome position: 46.71

GC content: 67.65

Gene sequence:

>2532_bases
ATGCGGGCGGTGTGGTGTGGATTTGCAGTGGGCGTCGTGTGGCTGCAGCAGCAGCCCGCGTTGCCGGGATGGCTGACGTG
GCTCGTATTGGCCGCGAGCGCCTGTGCGCTGGCCGTCGTTGCGCGGCTGTGCTTCCGGCGCGGCACCGGGTGGTTTTCGC
GTGCGGGCTGGTTTGCAGTGCTCGTCGCGGCGGCGTGCGCCGGCTTCGGTTACGGGGCGTGGCGCGCGCAGACGCGGCTC
GCGTTCGAATTGCCGCGGGAGTGGGAAGGGCGCGACATCGTCGTGCGCGGCTGGGTCAAGGGCCTGCCGACGCGCAGTGC
GGACGGCGCGCGCTTCCTGTTCGCCGTTGAAGCCGCGGACGTGCCCGTCGAACGGTTTCCACGTACGCTGCAATTGTCGT
GGATCGCGAACGATACGCCGCCGCCCGCGCTCGAGCCGGGTTCGCGCTGGCGCCTGAACGTGCGGCTCAAGCGTCCGCAC
GGCAACGCGAACTGGGGCGTGCGCGATGCCGAGGCCGCGCTGCTGGCACGCGATATCCGGGCGACGGGTTACGTGAATCT
GCCGTTGCATGCACTGCGGCTGCGGGGAAAAGCGAGCGGCGTCGGCGTGACCGTCGACGGCTTGCGGTCGGCGATCCGCA
ATCGGATTGCCGCCGTGCTGGCCGATGCGCCGCATATGGGCGTCGTCATGGCGTTAGCGATCGGCGCGCAGGACGCCGTG
AGTACCGCCGACTGGCAGTTGATGCGGCGCACGGGGACGAGCCATCTCGTCGCGATTTCGGGCTTGCATATCGGCTTCGT
CGCGGGGCTTGCAGGCTGGCTGACAGGGATGGCGTGGCGGCGCTCGTTGTTCGTCGGACGCAACTGGCCTTTGCTCGTGC
CCGCGCAGAAAGTGTCGATGGCGAGCGGCGCGCTGTTCGCTGCGTTTCACGCGGCCCTTGCGGGCTTCAACGTGCCCGCG
CAACGGACTTTGTGGATGGCGGCCATCGCTGCGCTGAGCTATCTCGGCGGACGGCGCGTCGCGCCATCGGTGGTCCTCGC
GTGGGCGCTCGGACTCGTGCTGCTGGTCGATCCCTGGGCGGTGGTATCGGCGGGATTCTGGCTGTCGTTCTGCGCGGTCG
GCGCGATCCTGTTCGCAATGTCGGGGCACGCGCGTATAGCACGGAACACGTCGCGCGATGCAGGGCTGGAAGAGGGCGAG
CGTACTTTCGTCATGCGCTGCGGCGACGCTTTGCGGTTGTGCATCGGCGGGTTGAACGAACGCATACGCAGCGGCGCCCG
TGTCCAGCTCGCCGTGACGATCGCGCTCGCACCGCTGACGGTCTGCTTTTTTTCGCAGATACCGTTGATCGGTCCATTCG
CGAATGCCTTCGCCATTCCGTGGGTGAGCGTGCTTGTGACGCCTGCCGTGATTGCCGGTGTCGCGTTGCCCGCGCCCTTC
GATGCGCTTGCTTTTCGCGCCGCACACCATCTGCTGGAATGCCTGGTGGCCGGTTTGCAACTGTTTTCGAGCGCCGCGTG
GACGCTCTGGCCGTTGCCCCAGCCGAGCGCATGGGCGCTGGCGTCGGCGGGCGTGGGTGTCGCATGGTGCCTCGCGCCGC
CTGGCTGGCCGTTGCGCTGGGCCGCGCCGCTCACGTGGCTGCCGTTGCTCGCGCCGGCCTCGGGCGCGCCCGCCGAAGGT
GCCTTCAGGCTCACAGCGCTCGATATCGGGCAAGGCTCGTCTATCGTCGTCGAGACCGCGCACCACGCATTGCTGTTCGA
CGCCGGTCCGGGTCCGGAGTCGACGCACGCGGGCGAACGCATCGTCGTGCCGTATCTGCAGGCGGCGGGTATCGACGCGC
TCGACACGTTAGTCATCAGCCACGCCGATTCCGATCATTCGGGCGGCGCTTTGGCGGTGCTGGATAGCGTCGAGGTGCGG
CAACTGCTCGCCGCTCTGCCGCCCACGCATCCGCTATGGCATGCAGCACGCGGCAAGGGCGCACAGACCGTGCGCTGCGC
AGCGGGCCAGCGCTGGCAATGGGACGGCGTCGACTTCGCGATGCTCTGGCCGAGCACGGGTCCGCTGCAAGGCAAGCCTA
ACGCGCATTGTTGTGTATTGCGAATCGGCGCCGCAGGCGTGTCGCAAAGTCAAGCACAGGTTCGAACGCACATGCAAACG
CACACGGCCGAACCACAGCCCGTGATCGCGTTGCTGGCGGCCGACATCGAAGCGCCCGTCGAACGCACGCTGCTCGCACG
CGAGCGCGCCGCGTTGCGCGCGCAGATTCTGCTCGTGCCGCATCACGGCAGCAAGACCTCATCGACCGAGCCGTTCCTCG
ACGCGATCGATCCGTCCATTGCGGTATTTCAGGTAGGCTATCGCAACCGGTTCCATCATCCTTACGCAGGCGTCTATGCG
CGTTACCAGGCACGGGGCATCGAGCTGACGCGCAGCGACGACGACGGCGCCGGACGCATCGAAGCGAGTGGTGCAGGGTT
GTCACTCGAACGCTATCGGCAGACGCATCGCCGATACTGGATGGATCGATGA

Upstream 100 bases:

>100_bases
AATCACTCTCTGGCCTGCTTCGTGCATGACCGCTGATATTGATTCGGTATCCTGATGAATATAGCGGCGATGCCGCGCGG
GCGTCGGGCGCGGAGGCGGC

Downstream 100 bases:

>100_bases
CGAAAGGCCGGCGGCCCAATCAAGAACAAATCAGAACGGAGGCAAGAGCGCTTGAAGAACATCATCCATTTCTCGCATGC
CAACGGATTTCCTGCGTCCG

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 843; Mature: 843

Protein sequence:

>843_residues
MRAVWCGFAVGVVWLQQQPALPGWLTWLVLAASACALAVVARLCFRRGTGWFSRAGWFAVLVAAACAGFGYGAWRAQTRL
AFELPREWEGRDIVVRGWVKGLPTRSADGARFLFAVEAADVPVERFPRTLQLSWIANDTPPPALEPGSRWRLNVRLKRPH
GNANWGVRDAEAALLARDIRATGYVNLPLHALRLRGKASGVGVTVDGLRSAIRNRIAAVLADAPHMGVVMALAIGAQDAV
STADWQLMRRTGTSHLVAISGLHIGFVAGLAGWLTGMAWRRSLFVGRNWPLLVPAQKVSMASGALFAAFHAALAGFNVPA
QRTLWMAAIAALSYLGGRRVAPSVVLAWALGLVLLVDPWAVVSAGFWLSFCAVGAILFAMSGHARIARNTSRDAGLEEGE
RTFVMRCGDALRLCIGGLNERIRSGARVQLAVTIALAPLTVCFFSQIPLIGPFANAFAIPWVSVLVTPAVIAGVALPAPF
DALAFRAAHHLLECLVAGLQLFSSAAWTLWPLPQPSAWALASAGVGVAWCLAPPGWPLRWAAPLTWLPLLAPASGAPAEG
AFRLTALDIGQGSSIVVETAHHALLFDAGPGPESTHAGERIVVPYLQAAGIDALDTLVISHADSDHSGGALAVLDSVEVR
QLLAALPPTHPLWHAARGKGAQTVRCAAGQRWQWDGVDFAMLWPSTGPLQGKPNAHCCVLRIGAAGVSQSQAQVRTHMQT
HTAEPQPVIALLAADIEAPVERTLLARERAALRAQILLVPHHGSKTSSTEPFLDAIDPSIAVFQVGYRNRFHHPYAGVYA
RYQARGIELTRSDDDGAGRIEASGAGLSLERYRQTHRRYWMDR

Sequences:

>Translated_843_residues
MRAVWCGFAVGVVWLQQQPALPGWLTWLVLAASACALAVVARLCFRRGTGWFSRAGWFAVLVAAACAGFGYGAWRAQTRL
AFELPREWEGRDIVVRGWVKGLPTRSADGARFLFAVEAADVPVERFPRTLQLSWIANDTPPPALEPGSRWRLNVRLKRPH
GNANWGVRDAEAALLARDIRATGYVNLPLHALRLRGKASGVGVTVDGLRSAIRNRIAAVLADAPHMGVVMALAIGAQDAV
STADWQLMRRTGTSHLVAISGLHIGFVAGLAGWLTGMAWRRSLFVGRNWPLLVPAQKVSMASGALFAAFHAALAGFNVPA
QRTLWMAAIAALSYLGGRRVAPSVVLAWALGLVLLVDPWAVVSAGFWLSFCAVGAILFAMSGHARIARNTSRDAGLEEGE
RTFVMRCGDALRLCIGGLNERIRSGARVQLAVTIALAPLTVCFFSQIPLIGPFANAFAIPWVSVLVTPAVIAGVALPAPF
DALAFRAAHHLLECLVAGLQLFSSAAWTLWPLPQPSAWALASAGVGVAWCLAPPGWPLRWAAPLTWLPLLAPASGAPAEG
AFRLTALDIGQGSSIVVETAHHALLFDAGPGPESTHAGERIVVPYLQAAGIDALDTLVISHADSDHSGGALAVLDSVEVR
QLLAALPPTHPLWHAARGKGAQTVRCAAGQRWQWDGVDFAMLWPSTGPLQGKPNAHCCVLRIGAAGVSQSQAQVRTHMQT
HTAEPQPVIALLAADIEAPVERTLLARERAALRAQILLVPHHGSKTSSTEPFLDAIDPSIAVFQVGYRNRFHHPYAGVYA
RYQARGIELTRSDDDGAGRIEASGAGLSLERYRQTHRRYWMDR
>Mature_843_residues
MRAVWCGFAVGVVWLQQQPALPGWLTWLVLAASACALAVVARLCFRRGTGWFSRAGWFAVLVAAACAGFGYGAWRAQTRL
AFELPREWEGRDIVVRGWVKGLPTRSADGARFLFAVEAADVPVERFPRTLQLSWIANDTPPPALEPGSRWRLNVRLKRPH
GNANWGVRDAEAALLARDIRATGYVNLPLHALRLRGKASGVGVTVDGLRSAIRNRIAAVLADAPHMGVVMALAIGAQDAV
STADWQLMRRTGTSHLVAISGLHIGFVAGLAGWLTGMAWRRSLFVGRNWPLLVPAQKVSMASGALFAAFHAALAGFNVPA
QRTLWMAAIAALSYLGGRRVAPSVVLAWALGLVLLVDPWAVVSAGFWLSFCAVGAILFAMSGHARIARNTSRDAGLEEGE
RTFVMRCGDALRLCIGGLNERIRSGARVQLAVTIALAPLTVCFFSQIPLIGPFANAFAIPWVSVLVTPAVIAGVALPAPF
DALAFRAAHHLLECLVAGLQLFSSAAWTLWPLPQPSAWALASAGVGVAWCLAPPGWPLRWAAPLTWLPLLAPASGAPAEG
AFRLTALDIGQGSSIVVETAHHALLFDAGPGPESTHAGERIVVPYLQAAGIDALDTLVISHADSDHSGGALAVLDSVEVR
QLLAALPPTHPLWHAARGKGAQTVRCAAGQRWQWDGVDFAMLWPSTGPLQGKPNAHCCVLRIGAAGVSQSQAQVRTHMQT
HTAEPQPVIALLAADIEAPVERTLLARERAALRAQILLVPHHGSKTSSTEPFLDAIDPSIAVFQVGYRNRFHHPYAGVYA
RYQARGIELTRSDDDGAGRIEASGAGLSLERYRQTHRRYWMDR

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=720, Percent_Identity=26.6666666666667, Blast_Score=189, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 90322; Mature: 90322

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVWCGFAVGVVWLQQQPALPGWLTWLVLAASACALAVVARLCFRRGTGWFSRAGWFAV
CCEEEHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LVAAACAGFGYGAWRAQTRLAFELPREWEGRDIVVRGWVKGLPTRSADGARFLFAVEAAD
HHHHHHHCCCCCHHHHCCEEEEECCCCCCCCEEEEEEHHCCCCCCCCCCCEEEEEEECCC
VPVERFPRTLQLSWIANDTPPPALEPGSRWRLNVRLKRPHGNANWGVRDAEAALLARDIR
CCHHHCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ATGYVNLPLHALRLRGKASGVGVTVDGLRSAIRNRIAAVLADAPHMGVVMALAIGAQDAV
HCCEEECCHHHHEECCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHC
STADWQLMRRTGTSHLVAISGLHIGFVAGLAGWLTGMAWRRSLFVGRNWPLLVPAQKVSM
CHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECHHHHHH
ASGALFAAFHAALAGFNVPAQRTLWMAAIAALSYLGGRRVAPSVVLAWALGLVLLVDPWA
HCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHH
VVSAGFWLSFCAVGAILFAMSGHARIARNTSRDAGLEEGERTFVMRCGDALRLCIGGLNE
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHH
RIRSGARVQLAVTIALAPLTVCFFSQIPLIGPFANAFAIPWVSVLVTPAVIAGVALPAPF
HHHCCCEEEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
DALAFRAAHHLLECLVAGLQLFSSAAWTLWPLPQPSAWALASAGVGVAWCLAPPGWPLRW
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCEEEEECCCCCCCEE
AAPLTWLPLLAPASGAPAEGAFRLTALDIGQGSSIVVETAHHALLFDAGPGPESTHAGER
CCCHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCEEEEEECCCCCCCCCCCCE
IVVPYLQAAGIDALDTLVISHADSDHSGGALAVLDSVEVRQLLAALPPTHPLWHAARGKG
EEEEHHHHCCCCHHHHHHEECCCCCCCCCEEEEECHHHHHHHHHHCCCCCCHHHHHCCCC
AQTVRCAAGQRWQWDGVDFAMLWPSTGPLQGKPNAHCCVLRIGAAGVSQSQAQVRTHMQT
CCEEEECCCCCEEECCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
HTAEPQPVIALLAADIEAPVERTLLARERAALRAQILLVPHHGSKTSSTEPFLDAIDPSI
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCHHHHCCCCE
AVFQVGYRNRFHHPYAGVYARYQARGIELTRSDDDGAGRIEASGAGLSLERYRQTHRRYW
EEEEECCCCCCCCCHHHHHHHEECCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHC
MDR
CCC
>Mature Secondary Structure
MRAVWCGFAVGVVWLQQQPALPGWLTWLVLAASACALAVVARLCFRRGTGWFSRAGWFAV
CCEEEHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LVAAACAGFGYGAWRAQTRLAFELPREWEGRDIVVRGWVKGLPTRSADGARFLFAVEAAD
HHHHHHHCCCCCHHHHCCEEEEECCCCCCCCEEEEEEHHCCCCCCCCCCCEEEEEEECCC
VPVERFPRTLQLSWIANDTPPPALEPGSRWRLNVRLKRPHGNANWGVRDAEAALLARDIR
CCHHHCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ATGYVNLPLHALRLRGKASGVGVTVDGLRSAIRNRIAAVLADAPHMGVVMALAIGAQDAV
HCCEEECCHHHHEECCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHC
STADWQLMRRTGTSHLVAISGLHIGFVAGLAGWLTGMAWRRSLFVGRNWPLLVPAQKVSM
CHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECHHHHHH
ASGALFAAFHAALAGFNVPAQRTLWMAAIAALSYLGGRRVAPSVVLAWALGLVLLVDPWA
HCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHH
VVSAGFWLSFCAVGAILFAMSGHARIARNTSRDAGLEEGERTFVMRCGDALRLCIGGLNE
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHH
RIRSGARVQLAVTIALAPLTVCFFSQIPLIGPFANAFAIPWVSVLVTPAVIAGVALPAPF
HHHCCCEEEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
DALAFRAAHHLLECLVAGLQLFSSAAWTLWPLPQPSAWALASAGVGVAWCLAPPGWPLRW
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCEEEEECCCCCCCEE
AAPLTWLPLLAPASGAPAEGAFRLTALDIGQGSSIVVETAHHALLFDAGPGPESTHAGER
CCCHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCEEEEEECCCCCCCCCCCCE
IVVPYLQAAGIDALDTLVISHADSDHSGGALAVLDSVEVRQLLAALPPTHPLWHAARGKG
EEEEHHHHCCCCHHHHHHEECCCCCCCCCEEEEECHHHHHHHHHHCCCCCCHHHHHCCCC
AQTVRCAAGQRWQWDGVDFAMLWPSTGPLQGKPNAHCCVLRIGAAGVSQSQAQVRTHMQT
CCEEEECCCCCEEECCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
HTAEPQPVIALLAADIEAPVERTLLARERAALRAQILLVPHHGSKTSSTEPFLDAIDPSI
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCHHHHCCCCE
AVFQVGYRNRFHHPYAGVYARYQARGIELTRSDDDGAGRIEASGAGLSLERYRQTHRRYW
EEEEECCCCCCCCCHHHHHHHEECCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHC
MDR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]