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The map label for this gene is dapA [H]

Identifier: 186476185

GI number: 186476185

Start: 1607620

End: 1608528

Strand: Reverse

Name: dapA [H]

Synonym: Bphy_1427

Alternate gene names: 186476185

Gene position: 1608528-1607620 (Counterclockwise)

Preceding gene: 186476186

Following gene: 186476184

Centisome position: 46.23

GC content: 64.36

Gene sequence:

>909_bases
ATGGCTAACGGCACTCAGCAAGACGGCGTCGCGATTCGCGGCAGCATTCCCGCCATCATCACTCCGATGCTCGAAGACGG
CAGTCTCGATCTGCCGGCGTTCCGCAAACTGGTGGACTGGCACATCGAAGAGGGTACGAACGCGCTGGTCGTAGTCGGTA
CGAGCGGCGAGTCGGCGACGCTGTCGGTCGATGAACACGTCCTGATGGTCAAGACGGCCGTCGAGCACGCGGCGGGCCGC
ATCCCCGTGATCGCGGGCGCCGGTGCCAACTCGACCACGGAAGCAATCGAGTTGACCGAGCAGGCGAAGAAAGTGGGCGC
CGACGCCACGCTGCAGGTCGTGCCGTACTACAACAAGCCCACCCAGGAAGGCATCTATCGCCATTTCGCGAAGATTGCCG
AAGCCGTCGATCTTCCCGTGATCCTGTACAACGTGCCGGGCCGCACGGTCGCGGATATGTCGAACGAGACGATCCTGCGC
CTCGCCAACGTGCCTGGCATCATCGGCGTGAAGGAGGCGACGGGCAACATCGACCGCGCCGCGCATCTGATCAAGTCGGC
GCCCGCGCATTTCGGCATTTACAGCGGGGACGATCCCACCGCGATCGCGCTGATGCTGCTGGGCGGTCACGGCAATATCT
CGGTGACGGCGAACGTCGCGCCGCGTCTGATGAGCGAGCTGTGCAAAGCGGCGCTGGCCGCCGACGCGAAGACGGCACGC
GAAATTCACCTGAAACTGCTCTCGCTGCACAAGAACCTCTTCATCGAATCGAACCCGATTCCCGCGAAGTGGGCGTTGCA
GCAACTGGGCCGCATCAAGGGCGGCATCCGTCTGCCTCTGACGCCGCTTGACGCGCGTTACCACGACGTGGTCCGCGCTG
CGCTGCGCGAGGCAGGGCTGCTCGGCTGA

Upstream 100 bases:

>100_bases
GGGATCGGTCAAACCGAAAGATAAGGGGGTTCCCCCGCGTTACGATTTGGTCGGTTAATCCGCTACAATTGAAGTTTATC
CAACAAATTCATGACGTTTC

Downstream 100 bases:

>100_bases
GCGTCTGGTTTTTCAGGCGCCTTCCGGCATTTTTTCAACTGACGTCGATATCGCCCACGGTCCTGCACCGAATCCGGCAG
CGCGTTCTAGCTTCACGAAG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MANGTQQDGVAIRGSIPAIITPMLEDGSLDLPAFRKLVDWHIEEGTNALVVVGTSGESATLSVDEHVLMVKTAVEHAAGR
IPVIAGAGANSTTEAIELTEQAKKVGADATLQVVPYYNKPTQEGIYRHFAKIAEAVDLPVILYNVPGRTVADMSNETILR
LANVPGIIGVKEATGNIDRAAHLIKSAPAHFGIYSGDDPTAIALMLLGGHGNISVTANVAPRLMSELCKAALAADAKTAR
EIHLKLLSLHKNLFIESNPIPAKWALQQLGRIKGGIRLPLTPLDARYHDVVRAALREAGLLG

Sequences:

>Translated_302_residues
MANGTQQDGVAIRGSIPAIITPMLEDGSLDLPAFRKLVDWHIEEGTNALVVVGTSGESATLSVDEHVLMVKTAVEHAAGR
IPVIAGAGANSTTEAIELTEQAKKVGADATLQVVPYYNKPTQEGIYRHFAKIAEAVDLPVILYNVPGRTVADMSNETILR
LANVPGIIGVKEATGNIDRAAHLIKSAPAHFGIYSGDDPTAIALMLLGGHGNISVTANVAPRLMSELCKAALAADAKTAR
EIHLKLLSLHKNLFIESNPIPAKWALQQLGRIKGGIRLPLTPLDARYHDVVRAALREAGLLG
>Mature_301_residues
ANGTQQDGVAIRGSIPAIITPMLEDGSLDLPAFRKLVDWHIEEGTNALVVVGTSGESATLSVDEHVLMVKTAVEHAAGRI
PVIAGAGANSTTEAIELTEQAKKVGADATLQVVPYYNKPTQEGIYRHFAKIAEAVDLPVILYNVPGRTVADMSNETILRL
ANVPGIIGVKEATGNIDRAAHLIKSAPAHFGIYSGDDPTAIALMLLGGHGNISVTANVAPRLMSELCKAALAADAKTARE
IHLKLLSLHKNLFIESNPIPAKWALQQLGRIKGGIRLPLTPLDARYHDVVRAALREAGLLG

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=298, Percent_Identity=25.1677852348993, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=25.752508361204, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788823, Length=289, Percent_Identity=52.2491349480969, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI87082415, Length=264, Percent_Identity=33.7121212121212, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1786463, Length=280, Percent_Identity=33.5714285714286, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1789620, Length=233, Percent_Identity=29.1845493562232, Blast_Score=117, Evalue=7e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31978; Mature: 31847

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGTQQDGVAIRGSIPAIITPMLEDGSLDLPAFRKLVDWHIEEGTNALVVVGTSGESAT
CCCCCCCCCEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
LSVDEHVLMVKTAVEHAAGRIPVIAGAGANSTTEAIELTEQAKKVGADATLQVVPYYNKP
EECCCEEEHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
TQEGIYRHFAKIAEAVDLPVILYNVPGRTVADMSNETILRLANVPGIIGVKEATGNIDRA
CHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCEEEEEECCCCEEEEHHCCCCHHHH
AHLIKSAPAHFGIYSGDDPTAIALMLLGGHGNISVTANVAPRLMSELCKAALAADAKTAR
HHHHHCCCCCCCEECCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCHHHHH
EIHLKLLSLHKNLFIESNPIPAKWALQQLGRIKGGIRLPLTPLDARYHDVVRAALREAGL
HHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCC
LG
CC
>Mature Secondary Structure 
ANGTQQDGVAIRGSIPAIITPMLEDGSLDLPAFRKLVDWHIEEGTNALVVVGTSGESAT
CCCCCCCCEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
LSVDEHVLMVKTAVEHAAGRIPVIAGAGANSTTEAIELTEQAKKVGADATLQVVPYYNKP
EECCCEEEHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
TQEGIYRHFAKIAEAVDLPVILYNVPGRTVADMSNETILRLANVPGIIGVKEATGNIDRA
CHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCEEEEEECCCCEEEEHHCCCCHHHH
AHLIKSAPAHFGIYSGDDPTAIALMLLGGHGNISVTANVAPRLMSELCKAALAADAKTAR
HHHHHCCCCCCCEECCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCHHHHH
EIHLKLLSLHKNLFIESNPIPAKWALQQLGRIKGGIRLPLTPLDARYHDVVRAALREAGL
HHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCC
LG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]