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The map label for this gene is ndk [H]

Identifier: 186476181

GI number: 186476181

Start: 1604019

End: 1604444

Strand: Reverse

Name: ndk [H]

Synonym: Bphy_1423

Alternate gene names: 186476181

Gene position: 1604444-1604019 (Counterclockwise)

Preceding gene: 186476183

Following gene: 186476180

Centisome position: 46.12

GC content: 57.98

Gene sequence:

>426_bases
ATGGCGATCGAACGCACCCTGTCGATTATCAAGCCGGACGCAGTGGCCAAGAACGTGATCGGCCAGATCTACAGCCGCTT
CGAAAACGCTGGTCTGAAGATTGTGGCATCGCGCATGGTTCACCTGTCGCGCGCCGACGCAGAGAAGTTCTACGCAGTGC
ACGCAGCCCGCCCGTTTTTCAAGGATCTGGTTGAATTCATGATTTCCGGTCCGGTTCAGGTTCAGGTTCTGGAAGGCGAA
GGCGCGATCCTGAAGAACCGCGACCTGATGGGCGCAACGGATCCGAAGAAGGCTGAGAAAGGCACGATCCGCGCTGACTT
CGCTGACAGCATCGACGCCAATGCAGTCCACGGTTCGGACGCTCCGGAAACGGCAGCCGTCGAAGTCGCGTTCTTCTTCC
CGGAAGTCAACGTCTACTCGCGTTAA

Upstream 100 bases:

>100_bases
CCTTACAGTGCCGTAAGGGTTCAATCGCAATCATACACGGGAACATGCTACAATAGCGGATTCATTTAAATCTGTAACCT
CTTAATTTTCTGGAGTTTTT

Downstream 100 bases:

>100_bases
GCGCTTCGTCACACAGCAGTAACAGCAGCAGGAGCGGGCGCGAGCGGTATACGCGTTCATGCAGCTTGTTGCATGAACGC
AGTCTCGCACTGAATGGCAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAIERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVASRMVHLSRADAEKFYAVHAARPFFKDLVEFMISGPVQVQVLEGE
GAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPEVNVYSR

Sequences:

>Translated_141_residues
MAIERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVASRMVHLSRADAEKFYAVHAARPFFKDLVEFMISGPVQVQVLEGE
GAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPEVNVYSR
>Mature_140_residues
AIERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVASRMVHLSRADAEKFYAVHAARPFFKDLVEFMISGPVQVQVLEGEG
AILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPEVNVYSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=42.4242424242424, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI66392227, Length=134, Percent_Identity=38.8059701492537, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI66392205, Length=134, Percent_Identity=38.8059701492537, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4505409, Length=134, Percent_Identity=38.8059701492537, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI66392192, Length=134, Percent_Identity=38.8059701492537, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI66392203, Length=134, Percent_Identity=38.8059701492537, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI38045913, Length=134, Percent_Identity=38.8059701492537, Blast_Score=106, Evalue=8e-24,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=38.8059701492537, Blast_Score=105, Evalue=9e-24,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=36.1538461538462, Blast_Score=97, Evalue=4e-21,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=36.6906474820144, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=36.4285714285714, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=36.6906474820144, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=34.5323741007194, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI4505413, Length=139, Percent_Identity=33.8129496402878, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=33.5714285714286, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=60.2836879432624, Blast_Score=177, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=41.0071942446043, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=40.7692307692308, Blast_Score=114, Evalue=5e-27,
Organism=Drosophila melanogaster, GI45549037, Length=132, Percent_Identity=44.6969696969697, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=32.6086956521739, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15398; Mature: 15267

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVASRMVHLSRADAEKFYAVHAARPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHH
KDLVEFMISGPVQVQVLEGEGAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
APETAAVEVAFFFPEVNVYSR
CCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
AIERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVASRMVHLSRADAEKFYAVHAARPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHH
KDLVEFMISGPVQVQVLEGEGAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
APETAAVEVAFFFPEVNVYSR
CCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA