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The map label for this gene is aceA [H]

Identifier: 186476126

GI number: 186476126

Start: 1536281

End: 1537585

Strand: Direct

Name: aceA [H]

Synonym: Bphy_1368

Alternate gene names: 186476126

Gene position: 1536281-1537585 (Clockwise)

Preceding gene: 186476125

Following gene: 186476129

Centisome position: 44.16

GC content: 63.14

Gene sequence:

>1305_bases
ATGACGCGCAACGAACAGGCAAAGCAGCTTCAGCAACAATGGGAATCGGATAGCCGCTGGAAAGGCATCAAGCGCGGCTT
CACGGCGGAAGACGTCGTGCGTCTGCGTGGCTCGGTGCAGCCGGAGCACACGCTCGCACGCCGCGGCGCCGAAAAGCTGT
GGAGCGACATGCATCAGGAGCCGTTCGTGAATGCACTCGGCGCGCTCACGGGCAACCAGGCGATGCAGCAGGTGAAGGCG
GGCCTCAAGGCGATCTATCTGTCGGGCTGGCAAGTCGCAGGCGACGCCAACGTGGCGGGCGAAATGTATCCCGACCAGTC
GCTCTATCCGGCGAACTCGGTGCCGCTGGTCGTGAAGCGCATCAACAACACACTGACGCGCGCCGACCAGATCCAATGGT
CGGAAGGCAAGAATCCGGGCGACGAAGGTTACATCGACTACTTCGCACCCATCGTCGCGGACGCGGAAGCCGGTTTCGGC
GGCGTGCTGAACGCGTTCGAATTGATGAAAGCGATGATCGAAGCGGGCGCGGCCGGCGTGCACTTCGAAGACCAGCTGGC
GTCGGTGAAGAAGTGCGGCCACATGGGTGGCAAGGTTCTCGTGCCGACGCGCGAAAACGTCGCGAAGCTGACGGCCGCAC
GTCTGGCCGCCGACGTGCTGGGCGTGCCGACCGTGCTGATCGCCCGTACGGACGCCGAAGCAGCCGACCTGATCACGTCC
GACGTCGACGACAACGACAAGCCGTTCCTGACGGGCGAGCGCACGGTGGAAGGCTTCTTCCGCACCAAGCCGGGCCTCGA
GCAGGCCGTGTCGCGCGGTCTCGCGTACGCGCCGTATGCCGATCTGATCTGGTGCGAGACGGGCAAGCCGGACCTCGAGT
ACGCGAAGAAATTCGCCGAGGCGATCCACAAGCAATTCCCGGGCAAGATGCTGTCGTACAACTGCTCGCCGTCGTTCAAC
TGGAAGAAGAACCTCGACGACGCAACGATCGCGAAGTTCCAGAAGGAACTCGGCGCGATGGGCTACAAGTTCCAGTTCAT
CACGCTGGCCGGCTTCCACGCACTGAACTACTCGATGTTCAACCTCGCGCACGGCTATGCACGTCAGCAGATGAGCGCAT
TCGTCGAACTGCAGCAGGCGGAGTTCGCCGCTGCCGAACGTGGCTTCACGGCCGTCAAGCACCAGCGCGAAGTGGGCACG
GGCTACTTCGACGCCGTCACGCAGACGGTCGAGCGCGAAGCATCGACGACGGCACTGCATGGCTCGACGGAAGACGAGCA
ATTCTTCGACAAGAAGGTCGCCTGA

Upstream 100 bases:

>100_bases
TCTTATATAAGACTTCGCGAACCGAAACGCCTCAGGCGCCCTCGCTTCGTCGAAGCCACGAGTCCATTCGAACCTACTTC
AAGGCACAAAGGAGCACACC

Downstream 100 bases:

>100_bases
AACGGCTGAACCAGCTGGAACGACTGGCCATCTCTCGCGCGGCGCCGCCCGTCGCGAGTGGGCCCGTCCCTTCGTTTCGG
AAAACGCGCGCCAGTGATCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTRNEQAKQLQQQWESDSRWKGIKRGFTAEDVVRLRGSVQPEHTLARRGAEKLWSDMHQEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYIDYFAPIVADAEAGFG
GVLNAFELMKAMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVLGVPTVLIARTDAEAADLITS
DVDDNDKPFLTGERTVEGFFRTKPGLEQAVSRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARQQMSAFVELQQAEFAAAERGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDKKVA

Sequences:

>Translated_434_residues
MTRNEQAKQLQQQWESDSRWKGIKRGFTAEDVVRLRGSVQPEHTLARRGAEKLWSDMHQEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYIDYFAPIVADAEAGFG
GVLNAFELMKAMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVLGVPTVLIARTDAEAADLITS
DVDDNDKPFLTGERTVEGFFRTKPGLEQAVSRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARQQMSAFVELQQAEFAAAERGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDKKVA
>Mature_433_residues
TRNEQAKQLQQQWESDSRWKGIKRGFTAEDVVRLRGSVQPEHTLARRGAEKLWSDMHQEPFVNALGALTGNQAMQQVKAG
LKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYIDYFAPIVADAEAGFGG
VLNAFELMKAMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVLGVPTVLIARTDAEAADLITSD
VDDNDKPFLTGERTVEGFFRTKPGLEQAVSRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFNW
KKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARQQMSAFVELQQAEFAAAERGFTAVKHQREVGTG
YFDAVTQTVEREASTTALHGSTEDEQFFDKKVA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=69.284064665127, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1786525, Length=268, Percent_Identity=27.2388059701493, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982926, Length=418, Percent_Identity=63.3971291866029, Blast_Score=542, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17561814, Length=418, Percent_Identity=63.3971291866029, Blast_Score=542, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320908, Length=289, Percent_Identity=37.3702422145329, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6325263, Length=255, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47800; Mature: 47669

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNEQAKQLQQQWESDSRWKGIKRGFTAEDVVRLRGSVQPEHTLARRGAEKLWSDMHQE
CCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
HHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYIDYFAPIVADAEAGFGGVLNAFELMKAMIEAGAAGV
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVLGVPTVLIARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHC
DVDDNDKPFLTGERTVEGFFRTKPGLEQAVSRGLAYAPYADLIWCETGKPDLEYAKKFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPGKMLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMF
HHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHH
NLAHGYARQQMSAFVELQQAEFAAAERGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDKKVA
CCCCHHHHHHHCCC
>Mature Secondary Structure 
TRNEQAKQLQQQWESDSRWKGIKRGFTAEDVVRLRGSVQPEHTLARRGAEKLWSDMHQE
CCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
HHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYIDYFAPIVADAEAGFGGVLNAFELMKAMIEAGAAGV
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVLGVPTVLIARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHC
DVDDNDKPFLTGERTVEGFFRTKPGLEQAVSRGLAYAPYADLIWCETGKPDLEYAKKFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPGKMLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMF
HHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHH
NLAHGYARQQMSAFVELQQAEFAAAERGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDKKVA
CCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]