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The map label for this gene is guaA

Identifier: 186476070

GI number: 186476070

Start: 1470105

End: 1471688

Strand: Reverse

Name: guaA

Synonym: Bphy_1312

Alternate gene names: 186476070

Gene position: 1471688-1470105 (Counterclockwise)

Preceding gene: 186476071

Following gene: 186476064

Centisome position: 42.3

GC content: 61.81

Gene sequence:

>1584_bases
ATGCATGACAAGATCCTGATTCTCGACTTTGGTTCGCAAGTCACCCAACTGATCGCACGCCGCATTCGCGAAGCGCACGT
GCTGTCGGAAATCCATCCGCACGACGTCAGCGACGAATTCATTCGCGACTTCAAGCCGACGGGCATCATCCTGTCGGGTG
GCCCGAACTCGGTCACCGAGACGGACACGCCGCGCGCGCCGCAGGCGGTGTTCGAGGCTGGCGTGCCCGTGCTAGGCATC
TGCTACGGCATGCAGACGATGGCCGAGCAGCTGGGCGGCAAGGTCGACAGCGGCCACCTGCGCGAATTCGGCTACGCGGA
AGTGCGCGCGCGCAATCACACGAGCTTCCTCGACGGCATTCAGGACTTCGCGACGCCCGAAGGCCACGGCATGCTGAAGG
TGTGGATGAGCCACGGCGACAAGGTGCTGGAAATGCCGCAAGGCTTCCAGCTGATGGCATCGACGGAATCGTGCCCGATT
GCTGCGATGGCTGACGAGACGCGCCATTTCTACGGCGTGCAGTGGCACCCGGAAGTCACGCATACGGTGCAGGGCCGCGC
GATGCTCGAACGCTTCGTGCTGAAGATTTGCGGCGCGAAGCCCGACTGGGAAATGGGCAACTACATCGACGAAGCGGTTG
AAAACATCCGCAAACAGGTCGGCGACGAGCATGTGATTCTCGGTCTGTCGGGCGGCGTCGATTCGTCGGTGGCGGCGGCG
CTGTTGCATCGCGCGATCGGCGATCAGCTGACCTGCGTGTTCGTCGATCACGGTTTGCTGCGCCTGAATGAAGCCGAGCA
GGTGATGTCGATGTTCGCGGACAACCTCGGCGTGAAGGTGATCCATGTCGACGCCAGCGAAGCGTTCATGTCGAAGCTCA
AGGGTGTGACGGATCCGGAAGCGAAGCGCAAGATCATCGGCGCGGAATTCGTCGAAGTGTTCCAGACGGAAGCGGGCAAG
CTGACGGACGCGAAATGGCTCGCGCAAGGGACGATCTATCCGGACGTGATCGAATCGGCGGGCAAGGGCAAGAAGGCCGC
GCACACGATCAAGAGCCATCACAACGTCGGCGGCCTGCCGGAAACGCTGAACCTCAAGCTGCTCGAACCGCTGCGCGAAC
TCTTCAAGGACGAAGTGCGGGAACTGGGCGTGAAGTTGGGTTTGCCGCCTTCGATGGTGTATCGCCATCCGTTCCCGGGC
CCTGGCCTCGGCGTGCGGATTCTTGGCGAAGTGAAGCGCGAATACGCCGATCTGCTGCGCCGCGCGGACGCGATCTTCAT
CGAATCCCTGCGCACGTTTATCGACAAGGACACGGACAAGTCGTGGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCC
TGCCTGTGAAGAGCGTCGGTGTGATGGGCGACGGACGCACGTATGAATATGTTGTCGCGCTGCGCGCCGTCCAGACGCTC
GACTTCATGACGGCGCACTGGGCGCATCTGCCGCACGATCTGCTCGGCCATGTGTCGAATCGGATCATTAATGAGGTGCG
CGGCATCAATCGTGTCGTGTACGACATCTCGGGCAAGCCGCCTGCGACGATTGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
TGCGGCGCCTGCACGTCCGTTTTAATGACAACGCCGTCCTGTCGCACATGCGACACGCGCGGCTTTCCCTATCCGTTCTT
TTTAGATTCCGTCCGCTGCC

Downstream 100 bases:

>100_bases
GGCCGGGTTGAAAAGAGGGCGCTGCGGCGCCCTTTTTCATTGCCGGTGCCTACCATCTCTCCAGCACATACGTCGCCGCC
AGCGTCCCGTAGTAACGCTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MHDKILILDFGSQVTQLIARRIREAHVLSEIHPHDVSDEFIRDFKPTGIILSGGPNSVTETDTPRAPQAVFEAGVPVLGI
CYGMQTMAEQLGGKVDSGHLREFGYAEVRARNHTSFLDGIQDFATPEGHGMLKVWMSHGDKVLEMPQGFQLMASTESCPI
AAMADETRHFYGVQWHPEVTHTVQGRAMLERFVLKICGAKPDWEMGNYIDEAVENIRKQVGDEHVILGLSGGVDSSVAAA
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMSMFADNLGVKVIHVDASEAFMSKLKGVTDPEAKRKIIGAEFVEVFQTEAGK
LTDAKWLAQGTIYPDVIESAGKGKKAAHTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRELGVKLGLPPSMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIESLRTFIDKDTDKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
DFMTAHWAHLPHDLLGHVSNRIINEVRGINRVVYDISGKPPATIEWE

Sequences:

>Translated_527_residues
MHDKILILDFGSQVTQLIARRIREAHVLSEIHPHDVSDEFIRDFKPTGIILSGGPNSVTETDTPRAPQAVFEAGVPVLGI
CYGMQTMAEQLGGKVDSGHLREFGYAEVRARNHTSFLDGIQDFATPEGHGMLKVWMSHGDKVLEMPQGFQLMASTESCPI
AAMADETRHFYGVQWHPEVTHTVQGRAMLERFVLKICGAKPDWEMGNYIDEAVENIRKQVGDEHVILGLSGGVDSSVAAA
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMSMFADNLGVKVIHVDASEAFMSKLKGVTDPEAKRKIIGAEFVEVFQTEAGK
LTDAKWLAQGTIYPDVIESAGKGKKAAHTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRELGVKLGLPPSMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIESLRTFIDKDTDKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
DFMTAHWAHLPHDLLGHVSNRIINEVRGINRVVYDISGKPPATIEWE
>Mature_527_residues
MHDKILILDFGSQVTQLIARRIREAHVLSEIHPHDVSDEFIRDFKPTGIILSGGPNSVTETDTPRAPQAVFEAGVPVLGI
CYGMQTMAEQLGGKVDSGHLREFGYAEVRARNHTSFLDGIQDFATPEGHGMLKVWMSHGDKVLEMPQGFQLMASTESCPI
AAMADETRHFYGVQWHPEVTHTVQGRAMLERFVLKICGAKPDWEMGNYIDEAVENIRKQVGDEHVILGLSGGVDSSVAAA
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMSMFADNLGVKVIHVDASEAFMSKLKGVTDPEAKRKIIGAEFVEVFQTEAGK
LTDAKWLAQGTIYPDVIESAGKGKKAAHTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRELGVKLGLPPSMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIESLRTFIDKDTDKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
DFMTAHWAHLPHDLLGHVSNRIINEVRGINRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.9911190053286, Blast_Score=288, Evalue=7e-78,
Organism=Escherichia coli, GI1788854, Length=524, Percent_Identity=67.5572519083969, Blast_Score=726, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=36.159169550173, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=36.159169550173, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=36.159169550173, Blast_Score=299, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=536, Percent_Identity=49.6268656716418, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=36.3475177304965, Blast_Score=299, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_BURP8 (B2JIA0)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857540.1
- ProteinModelPortal:   B2JIA0
- SMR:   B2JIA0
- GeneID:   6242803
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1312
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 58395; Mature: 58395

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 81-81 ACT_SITE 176-176 ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRIREAHVLSEIHPHDVSDEFIRDFKPTGIILSGGPNSVTE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCCCCCCC
TDTPRAPQAVFEAGVPVLGICYGMQTMAEQLGGKVDSGHLREFGYAEVRARNHTSFLDGI
CCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHCCCHHHHHHH
QDFATPEGHGMLKVWMSHGDKVLEMPQGFQLMASTESCPIAAMADETRHFYGVQWHPEVT
HHHCCCCCCCEEEEEECCCCCEECCCCCCEEEECCCCCCEEHEHHCCHHEECEEECCCHH
HTVQGRAMLERFVLKICGAKPDWEMGNYIDEAVENIRKQVGDEHVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMSMFADNLGVKVIHVDASEAFMSKLKGVTDPE
HHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCCCH
AKRKIIGAEFVEVFQTEAGKLTDAKWLAQGTIYPDVIESAGKGKKAAHTIKSHHNVGGLP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCC
ETLNLKLLEPLRELFKDEVRELGVKLGLPPSMVYRHPFPGPGLGVRILGEVKREYADLLR
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIESLRTFIDKDTDKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHH
DFMTAHWAHLPHDLLGHVSNRIINEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRIREAHVLSEIHPHDVSDEFIRDFKPTGIILSGGPNSVTE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCCCCCCC
TDTPRAPQAVFEAGVPVLGICYGMQTMAEQLGGKVDSGHLREFGYAEVRARNHTSFLDGI
CCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHCCCHHHHHHH
QDFATPEGHGMLKVWMSHGDKVLEMPQGFQLMASTESCPIAAMADETRHFYGVQWHPEVT
HHHCCCCCCCEEEEEECCCCCEECCCCCCEEEECCCCCCEEHEHHCCHHEECEEECCCHH
HTVQGRAMLERFVLKICGAKPDWEMGNYIDEAVENIRKQVGDEHVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMSMFADNLGVKVIHVDASEAFMSKLKGVTDPE
HHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCCCH
AKRKIIGAEFVEVFQTEAGKLTDAKWLAQGTIYPDVIESAGKGKKAAHTIKSHHNVGGLP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCC
ETLNLKLLEPLRELFKDEVRELGVKLGLPPSMVYRHPFPGPGLGVRILGEVKREYADLLR
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIESLRTFIDKDTDKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHH
DFMTAHWAHLPHDLLGHVSNRIINEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA