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The map label for this gene is envZ [H]

Identifier: 186475954

GI number: 186475954

Start: 1335765

End: 1337120

Strand: Reverse

Name: envZ [H]

Synonym: Bphy_1189

Alternate gene names: 186475954

Gene position: 1337120-1335765 (Counterclockwise)

Preceding gene: 186475955

Following gene: 186475952

Centisome position: 38.43

GC content: 66.37

Gene sequence:

>1356_bases
ATGAGCACGCCAACGGTTCATATGCAGGATCGCATGACGGGCCTTTTACGCGGCCTGTGGCGACCGCGCACGCTGTTCGT
GCGGCTGTCGCTGATCTTCGTCGCGGGATTGCTGGCCGCGCAGACGCTGTCGTTCTGGCTGACGATGACCGAGCGCAACG
AGGCGACCATGCACCTGATGGTCGGCTACATCGGCCAGGAAGTGACCAGTTCCGTCGCGCTGCTGGACCGTCTGACCCCC
GCTGAGCGCGAGGAATGGCTGCCGAAGCTCGGACGGCGCAGTTACCGGTTCACCCTGGGCACGGGCACGCGCGGCATGCC
GCCGGACGCGAAGCTGTCGCAGGAAATCGGCACGTCGATCGCGAAGGACATCGGGCAGCAATACAAGGTGACGGCCAACG
CGGTGCCGGGCGAGGGCGAGCATCTGGAAGTGCATCTGACACTGAGCGACGGCACGCCGCTCACCATCGACATGCATCCG
ATGCATGGCATTCCGCTGTCGCCTTGGCTGCCGCTCGTGCTGATCGCGCAACTCGCGCTGCTCGCCGGCTGTGCGTGGCT
CGCGGTGCGCCTCGCGACGCGGCCGCTCGAGCGTCTCGCGCGCGCTGCCGATACGCTCGGCCCCGATCTCGCGCCCGCTA
CGCTGCCCGAAGACGGCCCGGAAGAAGTGGCGCGCGCGTCGAAGGCCTTCAATGCGATGCAGGCGCGCATCGGCATCTAT
ATGCGCGAACGGCTGCAGATACTCGCCGCGATTTCGCACGATCTGCAAACACCCATCACGCGGATGCGGCTGCGCGCCGA
CATGCTCGACGACGAGGCGGAGCGCGGGCGTCTGCAAAAGGATCTGAAGGAGATGGAACTGCTTGTGCGCGAAGGCGTCG
CTTATGCGCGCACGCTGCACGGCGCCGACGAAAAACCCGTCCGCGTGAATCCGGACGCGCTGATCGAGAGCATCGTCAAC
GACTATGCCGACGCGGGCAACCGCGTGACGCTTGCGGGGCGCGTCGGTACGGCCGTGACCACGCGTCCGCAGGCGCTGCG
CCGCATTCTCGGCAATCTGGTCGATAACGCGCTGAAGTACTCGGGTGGCGACGAGGTGAACGTCGAAGTGTCCGTCGACG
GGACGGCCGCGCCGCACTGGTCGATCGTCGTGCTCGATCGCGGCCCGGGCATTCCGCAGGAGCAGCTCGACGCCGTGTTC
CAGCCGTTCTATCGCGTCGAAAATTCGCGCAATCGCGAGACGGGCGGGACGGGGTTGGGGCTCGCCATTGCAAAACAGCT
CGCGCAGTCGATAAACGCGACGCTCACGCTGCGCAATCGCGAAGGCGGCGGACTCGAAGCGCGACTCACACTCTGA

Upstream 100 bases:

>100_bases
AGCGCCTCGGCGACGACGCACGGGAGCCGCGCTACATCAAGACGCTGCGCAACGAGGGCTATGTATTCTCGTCGCTCGTG
ACAGCCGAGGAAAACGGCGG

Downstream 100 bases:

>100_bases
CGTCCGCGCCTGCCGTGTGCCTGGTCGCGGCCCGCACGTAATCGACGAAGCGCTTCACGACGGCGTCGTCGCGCGCCGTC
TGCCACGCGAGGCCGACACG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSTPTVHMQDRMTGLLRGLWRPRTLFVRLSLIFVAGLLAAQTLSFWLTMTERNEATMHLMVGYIGQEVTSSVALLDRLTP
AEREEWLPKLGRRSYRFTLGTGTRGMPPDAKLSQEIGTSIAKDIGQQYKVTANAVPGEGEHLEVHLTLSDGTPLTIDMHP
MHGIPLSPWLPLVLIAQLALLAGCAWLAVRLATRPLERLARAADTLGPDLAPATLPEDGPEEVARASKAFNAMQARIGIY
MRERLQILAAISHDLQTPITRMRLRADMLDDEAERGRLQKDLKEMELLVREGVAYARTLHGADEKPVRVNPDALIESIVN
DYADAGNRVTLAGRVGTAVTTRPQALRRILGNLVDNALKYSGGDEVNVEVSVDGTAAPHWSIVVLDRGPGIPQEQLDAVF
QPFYRVENSRNRETGGTGLGLAIAKQLAQSINATLTLRNREGGGLEARLTL

Sequences:

>Translated_451_residues
MSTPTVHMQDRMTGLLRGLWRPRTLFVRLSLIFVAGLLAAQTLSFWLTMTERNEATMHLMVGYIGQEVTSSVALLDRLTP
AEREEWLPKLGRRSYRFTLGTGTRGMPPDAKLSQEIGTSIAKDIGQQYKVTANAVPGEGEHLEVHLTLSDGTPLTIDMHP
MHGIPLSPWLPLVLIAQLALLAGCAWLAVRLATRPLERLARAADTLGPDLAPATLPEDGPEEVARASKAFNAMQARIGIY
MRERLQILAAISHDLQTPITRMRLRADMLDDEAERGRLQKDLKEMELLVREGVAYARTLHGADEKPVRVNPDALIESIVN
DYADAGNRVTLAGRVGTAVTTRPQALRRILGNLVDNALKYSGGDEVNVEVSVDGTAAPHWSIVVLDRGPGIPQEQLDAVF
QPFYRVENSRNRETGGTGLGLAIAKQLAQSINATLTLRNREGGGLEARLTL
>Mature_450_residues
STPTVHMQDRMTGLLRGLWRPRTLFVRLSLIFVAGLLAAQTLSFWLTMTERNEATMHLMVGYIGQEVTSSVALLDRLTPA
EREEWLPKLGRRSYRFTLGTGTRGMPPDAKLSQEIGTSIAKDIGQQYKVTANAVPGEGEHLEVHLTLSDGTPLTIDMHPM
HGIPLSPWLPLVLIAQLALLAGCAWLAVRLATRPLERLARAADTLGPDLAPATLPEDGPEEVARASKAFNAMQARIGIYM
RERLQILAAISHDLQTPITRMRLRADMLDDEAERGRLQKDLKEMELLVREGVAYARTLHGADEKPVRVNPDALIESIVND
YADAGNRVTLAGRVGTAVTTRPQALRRILGNLVDNALKYSGGDEVNVEVSVDGTAAPHWSIVVLDRGPGIPQEQLDAVFQ
PFYRVENSRNRETGGTGLGLAIAKQLAQSINATLTLRNREGGGLEARLTL

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=307, Percent_Identity=32.5732899022801, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1787894, Length=304, Percent_Identity=29.6052631578947, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790346, Length=263, Percent_Identity=29.6577946768061, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=28.1879194630872, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=25.4480286738351, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=280, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=322, Percent_Identity=26.7080745341615, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI48994928, Length=114, Percent_Identity=36.8421052631579, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=26.7281105990783, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=295, Percent_Identity=26.1016949152542, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=212, Percent_Identity=25.4716981132075, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=325, Percent_Identity=25.2307692307692, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=24.2009132420091, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789403, Length=307, Percent_Identity=27.3615635179153, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=206, Percent_Identity=27.6699029126214, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=28.1746031746032, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49395; Mature: 49263

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTVHMQDRMTGLLRGLWRPRTLFVRLSLIFVAGLLAAQTLSFWLTMTERNEATMHLM
CCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHH
VGYIGQEVTSSVALLDRLTPAEREEWLPKLGRRSYRFTLGTGTRGMPPDAKLSQEIGTSI
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
AKDIGQQYKVTANAVPGEGEHLEVHLTLSDGTPLTIDMHPMHGIPLSPWLPLVLIAQLAL
HHHCCHHEEEEECCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
LAGCAWLAVRLATRPLERLARAADTLGPDLAPATLPEDGPEEVARASKAFNAMQARIGIY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MRERLQILAAISHDLQTPITRMRLRADMLDDEAERGRLQKDLKEMELLVREGVAYARTLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHC
GADEKPVRVNPDALIESIVNDYADAGNRVTLAGRVGTAVTTRPQALRRILGNLVDNALKY
CCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHC
SGGDEVNVEVSVDGTAAPHWSIVVLDRGPGIPQEQLDAVFQPFYRVENSRNRETGGTGLG
CCCCEEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHH
LAIAKQLAQSINATLTLRNREGGGLEARLTL
HHHHHHHHHHCCEEEEEEECCCCCCEEEEEC
>Mature Secondary Structure 
STPTVHMQDRMTGLLRGLWRPRTLFVRLSLIFVAGLLAAQTLSFWLTMTERNEATMHLM
CCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHH
VGYIGQEVTSSVALLDRLTPAEREEWLPKLGRRSYRFTLGTGTRGMPPDAKLSQEIGTSI
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
AKDIGQQYKVTANAVPGEGEHLEVHLTLSDGTPLTIDMHPMHGIPLSPWLPLVLIAQLAL
HHHCCHHEEEEECCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
LAGCAWLAVRLATRPLERLARAADTLGPDLAPATLPEDGPEEVARASKAFNAMQARIGIY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MRERLQILAAISHDLQTPITRMRLRADMLDDEAERGRLQKDLKEMELLVREGVAYARTLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHC
GADEKPVRVNPDALIESIVNDYADAGNRVTLAGRVGTAVTTRPQALRRILGNLVDNALKY
CCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHC
SGGDEVNVEVSVDGTAAPHWSIVVLDRGPGIPQEQLDAVFQPFYRVENSRNRETGGTGLG
CCCCEEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHH
LAIAKQLAQSINATLTLRNREGGGLEARLTL
HHHHHHHHHHCCEEEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]