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The map label for this gene is alsR [H]

Identifier: 186475953

GI number: 186475953

Start: 1334879

End: 1335775

Strand: Direct

Name: alsR [H]

Synonym: Bphy_1188

Alternate gene names: 186475953

Gene position: 1334879-1335775 (Clockwise)

Preceding gene: 186475950

Following gene: 186475959

Centisome position: 38.37

GC content: 68.56

Gene sequence:

>897_bases
ATGGAAATCCGCCTGCTGCGTGCGTTCCTGACGGTGACGAGCCTGCGCCATTTCGGCCGTGCCGCCGATTCATTACATCT
GAGCCAGCCCGCGCTGAGCAAGCAGATCGTCGCGCTCGAAGAAAGTGTCGGCGGACGGCTCTTCGAGCGGGGCCGGCACG
GCGCGGAACTGACCGCGTTCGGCGAAGCGTTCCTGCCCGATGCCGAGGCGCTCGTGCGCGATGCCGACGACATCCTCGCC
CGCGCGCGCGAGGCGAGCAGCGGGCGGCGCGGTCATCTGCGCATTGGATTGTGTCTGTCGACGCTCACGCTCGCCCCGCC
GCTGATCGCCGCCTACCGCGCGGCCAATCCGCAGATCGGCGTCACGCTGAACGATCTGTCGTCGGCGGAACAGACGCGAC
GCATGTTTGCGGGCAAGCTCGATGTCGGCTTCGTGCGCCTGCCCGTTGCCGACGGGTTGTCGGCGTTCCCCGTGATCGAT
GAGTCGCTGGGGCTCGCGCTGCCGCCGCACGCGAAGTGGAAGCGGCTGCCCGCGAAGCTGGATGAATTCAACGAGCTGGG
CTTCGTCGCGCTCGCGCGCAGCCGCGGGCCGGGCACGGCGGCCATGATCGACGCATGGTGCGCGGAACGGGGCTTCGTGC
CGCGCGTGATCCAGCAGGCTGACGATATCCAGTCGGTGCTCGCTGCCGTCGCGGCGGGTGTCGGCGTCGCATTCGTGCCG
TCGCGCGCTGAACATCTGCTGCGCGACGCGAAGGTATTGCGGCTGAAAAATGCATCCGCACAATGGCGTGTCGGCCTCGC
GTGGCAGACGGCGCGCGACGACGCCGTCGTGAAGCGCTTCGTCGATTACGTGCGGGCCGCGACCAGGCACACGGCAGGCG
CGGACGTCAGAGTGTGA

Upstream 100 bases:

>100_bases
ATGGCAGGCATGGAGACGATAGCAACGGAATGTCGCCATTGGACCGCCCGCTCGTCGATTAGTAAAATGAATAATCCGAT
CGATACGATAACTGGTAAGA

Downstream 100 bases:

>100_bases
GTCGCGCTTCGAGTCCGCCGCCTTCGCGATTGCGCAGCGTGAGCGTCGCGTTTATCGACTGCGCGAGCTGTTTTGCAATG
GCGAGCCCCAACCCCGTCCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MEIRLLRAFLTVTSLRHFGRAADSLHLSQPALSKQIVALEESVGGRLFERGRHGAELTAFGEAFLPDAEALVRDADDILA
RAREASSGRRGHLRIGLCLSTLTLAPPLIAAYRAANPQIGVTLNDLSSAEQTRRMFAGKLDVGFVRLPVADGLSAFPVID
ESLGLALPPHAKWKRLPAKLDEFNELGFVALARSRGPGTAAMIDAWCAERGFVPRVIQQADDIQSVLAAVAAGVGVAFVP
SRAEHLLRDAKVLRLKNASAQWRVGLAWQTARDDAVVKRFVDYVRAATRHTAGADVRV

Sequences:

>Translated_298_residues
MEIRLLRAFLTVTSLRHFGRAADSLHLSQPALSKQIVALEESVGGRLFERGRHGAELTAFGEAFLPDAEALVRDADDILA
RAREASSGRRGHLRIGLCLSTLTLAPPLIAAYRAANPQIGVTLNDLSSAEQTRRMFAGKLDVGFVRLPVADGLSAFPVID
ESLGLALPPHAKWKRLPAKLDEFNELGFVALARSRGPGTAAMIDAWCAERGFVPRVIQQADDIQSVLAAVAAGVGVAFVP
SRAEHLLRDAKVLRLKNASAQWRVGLAWQTARDDAVVKRFVDYVRAATRHTAGADVRV
>Mature_298_residues
MEIRLLRAFLTVTSLRHFGRAADSLHLSQPALSKQIVALEESVGGRLFERGRHGAELTAFGEAFLPDAEALVRDADDILA
RAREASSGRRGHLRIGLCLSTLTLAPPLIAAYRAANPQIGVTLNDLSSAEQTRRMFAGKLDVGFVRLPVADGLSAFPVID
ESLGLALPPHAKWKRLPAKLDEFNELGFVALARSRGPGTAAMIDAWCAERGFVPRVIQQADDIQSVLAAVAAGVGVAFVP
SRAEHLLRDAKVLRLKNASAQWRVGLAWQTARDDAVVKRFVDYVRAATRHTAGADVRV

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=292, Percent_Identity=31.8493150684932, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787879, Length=245, Percent_Identity=30.6122448979592, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI2367136, Length=247, Percent_Identity=27.1255060728745, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI157672245, Length=299, Percent_Identity=30.1003344481605, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=27.0916334661355, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693105, Length=249, Percent_Identity=25.3012048192771, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081904, Length=175, Percent_Identity=33.7142857142857, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=27.2357723577236, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48994962, Length=96, Percent_Identity=44.7916666666667, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790208, Length=285, Percent_Identity=24.2105263157895, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32221; Mature: 32221

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRLLRAFLTVTSLRHFGRAADSLHLSQPALSKQIVALEESVGGRLFERGRHGAELTAF
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHCCCCCCEEEEC
GEAFLPDAEALVRDADDILARAREASSGRRGHLRIGLCLSTLTLAPPLIAAYRAANPQIG
CHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCHHHHHHHHCCCCCEE
VTLNDLSSAEQTRRMFAGKLDVGFVRLPVADGLSAFPVIDESLGLALPPHAKWKRLPAKL
EEEHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCHHCCCCCCCCCCHHHHHCCHHH
DEFNELGFVALARSRGPGTAAMIDAWCAERGFVPRVIQQADDIQSVLAAVAAGVGVAFVP
HHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEECC
SRAEHLLRDAKVLRLKNASAQWRVGLAWQTARDDAVVKRFVDYVRAATRHTAGADVRV
HHHHHHHHHHHHHHEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEIRLLRAFLTVTSLRHFGRAADSLHLSQPALSKQIVALEESVGGRLFERGRHGAELTAF
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHCCCCCCEEEEC
GEAFLPDAEALVRDADDILARAREASSGRRGHLRIGLCLSTLTLAPPLIAAYRAANPQIG
CHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCHHHHHHHHCCCCCEE
VTLNDLSSAEQTRRMFAGKLDVGFVRLPVADGLSAFPVIDESLGLALPPHAKWKRLPAKL
EEEHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCHHCCCCCCCCCCHHHHHCCHHH
DEFNELGFVALARSRGPGTAAMIDAWCAERGFVPRVIQQADDIQSVLAAVAAGVGVAFVP
HHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEECC
SRAEHLLRDAKVLRLKNASAQWRVGLAWQTARDDAVVKRFVDYVRAATRHTAGADVRV
HHHHHHHHHHHHHHEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]