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The map label for this gene is cynR [H]

Identifier: 186475923

GI number: 186475923

Start: 1298069

End: 1298974

Strand: Reverse

Name: cynR [H]

Synonym: Bphy_1158

Alternate gene names: 186475923

Gene position: 1298974-1298069 (Counterclockwise)

Preceding gene: 186475927

Following gene: 186475922

Centisome position: 37.34

GC content: 66.56

Gene sequence:

>906_bases
ATGGACAACACGGCACTGCGTTACTTCCTGGAAGTGGCCCGCAGCGGGTCGTTGAGCAAGGCTTCGGAGCGGCTCTTCGT
GGCCGTGTCGGCGTTGAGCCGGCAGATCGGCAAGCTCGAGGAGGAACTCGGCACGCCGCTATTCGAGCGGCGCCCGCGCG
GCATGGTGCTGAGCGACGCGGGGCGCCTGCTCGCGGAGCATGCGCGGCGCAGCCTGCTCGAAGCCGAGCGCGTGGTCGGC
GAGATTCGCGGCCTCGCGGAGGAGGGGCGCGCGACGATACGCGTCGCCAGTTCGGAGGGCGTCGCGCCGCATTTTCTGCC
GCAAGTGTTCGCGCATTTTCTGAAGACGTATCCGTCGACGCATTTTCAGCTCGACGTGTCCGCGCCTTCCGTGGCGACGC
AGCGGGTGAGGGAAGGGACGGCCGATATCGCCGTCTGTTTCAGCCTCGCGCCGGAGAAGGAGATCGACGTGCACTACTCG
CAGCGCGCGCCGATCTACGCGCTGGTGCGGCGCGGACATCCGCTCGCCGCGCATCAAGCGGTGTCGCTTGGCGACCTCAC
GCCGTGGCCGCTCGCGATGGACAACCAGGGCGTGACGATCCGGCAGCTGTTCGATATTTCGTGCAGTCTGGAAGGACTGA
TCTTCGAGCCGGTATTCGTCAGCAACTATCACGCGGCGCTGCAAAGCTTCGTGCGCCTTACGGACGCCGTGACGCTGACG
GGCTATCTGACCGTGCGCAGCCGGCTCGACGCGGACGGGCTGGCGGCGATTCCGATCACGAACGCCGCGCTGCATCAGCG
CACGCTGCAGGTTCAGACGATGGCGGGGCGCACATTGCCGCAGACCGTGCAGGCGTTCGTCGATGTGTTGAAGCGGGCGA
TCGATGCGCCGGAGATCGTCGATTGA

Upstream 100 bases:

>100_bases
CCGGTTCATGGATAAGCAGTCGAACCGATGCTGCCGCCGCCGATATTTCTGCACAATTACAATATTTGCGATCAATCGTT
GCCGAAACGGCAAAGCGGAC

Downstream 100 bases:

>100_bases
TTCACCAGGTCGAAGTGTCGAAGGCCAGCGTTCACCGCGCAGCAGACAATAGCCCGAATTGGCAATCGACTATTGACGTT
TTTATCGAATACAAAATCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MDNTALRYFLEVARSGSLSKASERLFVAVSALSRQIGKLEEELGTPLFERRPRGMVLSDAGRLLAEHARRSLLEAERVVG
EIRGLAEEGRATIRVASSEGVAPHFLPQVFAHFLKTYPSTHFQLDVSAPSVATQRVREGTADIAVCFSLAPEKEIDVHYS
QRAPIYALVRRGHPLAAHQAVSLGDLTPWPLAMDNQGVTIRQLFDISCSLEGLIFEPVFVSNYHAALQSFVRLTDAVTLT
GYLTVRSRLDADGLAAIPITNAALHQRTLQVQTMAGRTLPQTVQAFVDVLKRAIDAPEIVD

Sequences:

>Translated_301_residues
MDNTALRYFLEVARSGSLSKASERLFVAVSALSRQIGKLEEELGTPLFERRPRGMVLSDAGRLLAEHARRSLLEAERVVG
EIRGLAEEGRATIRVASSEGVAPHFLPQVFAHFLKTYPSTHFQLDVSAPSVATQRVREGTADIAVCFSLAPEKEIDVHYS
QRAPIYALVRRGHPLAAHQAVSLGDLTPWPLAMDNQGVTIRQLFDISCSLEGLIFEPVFVSNYHAALQSFVRLTDAVTLT
GYLTVRSRLDADGLAAIPITNAALHQRTLQVQTMAGRTLPQTVQAFVDVLKRAIDAPEIVD
>Mature_301_residues
MDNTALRYFLEVARSGSLSKASERLFVAVSALSRQIGKLEEELGTPLFERRPRGMVLSDAGRLLAEHARRSLLEAERVVG
EIRGLAEEGRATIRVASSEGVAPHFLPQVFAHFLKTYPSTHFQLDVSAPSVATQRVREGTADIAVCFSLAPEKEIDVHYS
QRAPIYALVRRGHPLAAHQAVSLGDLTPWPLAMDNQGVTIRQLFDISCSLEGLIFEPVFVSNYHAALQSFVRLTDAVTLT
GYLTVRSRLDADGLAAIPITNAALHQRTLQVQTMAGRTLPQTVQAFVDVLKRAIDAPEIVD

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=279, Percent_Identity=30.4659498207885, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788748, Length=208, Percent_Identity=26.9230769230769, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787530, Length=257, Percent_Identity=26.0700389105058, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693105, Length=183, Percent_Identity=26.775956284153, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788296, Length=242, Percent_Identity=26.0330578512397, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790399, Length=263, Percent_Identity=25.4752851711027, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788887, Length=187, Percent_Identity=28.8770053475936, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1787601, Length=140, Percent_Identity=30, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081904, Length=260, Percent_Identity=25.7692307692308, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788481, Length=200, Percent_Identity=30, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=31.1475409836066, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788297, Length=152, Percent_Identity=26.9736842105263, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI2367136, Length=146, Percent_Identity=35.6164383561644, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790208, Length=145, Percent_Identity=31.7241379310345, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1787879, Length=188, Percent_Identity=25.531914893617, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33005; Mature: 33005

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNTALRYFLEVARSGSLSKASERLFVAVSALSRQIGKLEEELGTPLFERRPRGMVLSDA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEHHH
GRLLAEHARRSLLEAERVVGEIRGLAEEGRATIRVASSEGVAPHFLPQVFAHFLKTYPST
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
HFQLDVSAPSVATQRVREGTADIAVCFSLAPEKEIDVHYSQRAPIYALVRRGHPLAAHQA
EEEEEECCCHHHHHHHHCCCHHEEEEEECCCCCCCCEEECCCCCHHHHHHCCCCCHHHHH
VSLGDLTPWPLAMDNQGVTIRQLFDISCSLEGLIFEPVFVSNYHAALQSFVRLTDAVTLT
CCCCCCCCCCEEECCCCCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
GYLTVRSRLDADGLAAIPITNAALHQRTLQVQTMAGRTLPQTVQAFVDVLKRAIDAPEIV
EEEEEHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
D
C
>Mature Secondary Structure
MDNTALRYFLEVARSGSLSKASERLFVAVSALSRQIGKLEEELGTPLFERRPRGMVLSDA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEHHH
GRLLAEHARRSLLEAERVVGEIRGLAEEGRATIRVASSEGVAPHFLPQVFAHFLKTYPST
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
HFQLDVSAPSVATQRVREGTADIAVCFSLAPEKEIDVHYSQRAPIYALVRRGHPLAAHQA
EEEEEECCCHHHHHHHHCCCHHEEEEEECCCCCCCCEEECCCCCHHHHHHCCCCCHHHHH
VSLGDLTPWPLAMDNQGVTIRQLFDISCSLEGLIFEPVFVSNYHAALQSFVRLTDAVTLT
CCCCCCCCCCEEECCCCCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
GYLTVRSRLDADGLAAIPITNAALHQRTLQVQTMAGRTLPQTVQAFVDVLKRAIDAPEIV
EEEEEHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]