Click here to switch to the map view.

The map label for this gene is hipA [C]

Identifier: 186475833

GI number: 186475833

Start: 1200463

End: 1201824

Strand: Direct

Name: hipA [C]

Synonym: Bphy_1068

Alternate gene names: 186475833

Gene position: 1200463-1201824 (Clockwise)

Preceding gene: 186475832

Following gene: 186475837

Centisome position: 34.5

GC content: 65.57

Gene sequence:

>1362_bases
ATGCTGCACACCCTGCATGTCACGACGCACGAAGGTGCCGTGGGCCGTCTGGACTTCGACGCGAGGCAAACCCTCTATCG
TTTCGCATACGACGGAAACTGGACGGCACGCCGGAATGCGTTCCCGTTGTCACCGCACATTCCGCTGTCGGGTGCAGAAC
CGGCTGGCGGCGCAGTGCATCGCTTCATCGCGAATCTGCTGCCGGAGGGGCGGGCGCTGGACGTGGCGTCCGTCGTCTAT
CAGGTGTCGAAGGACAACATCTATGGCCTCATCCGCATGCTCGGCAAGGAGCCCGTCGGCGCGCTGAGTTTTCTCGCTTC
CGGCGAAGCGGGCGAGCCCATCGAGCGGGGCGCCGGCGAACAACCGCCGGCGCGCAGGGCAATTTCGCCCGACGAACTGA
GCCAGCGCATCCGCGAGCGCGACGCGATTCCGTTTCCTGTGTGGGACGGCAAAGTGCGTCTGTCGGTGGCGGGCTATCAG
GACAAGCTGCAGGTGCTGCTGGAGGGCGATCGCATCGCGCTCGCCGACGGGCCGCTGAGTTCGACGCATATTCTCAAGCC
GGAATCGCGCAGTCCCGTGACGCCGTGCATGGTCGCCAACGAGCATTACTGCATGACGCTCGCGTCGCGCATGGGCTTGC
AGACCGCGCCCGTGGCGATCCGGCGCATTCCCGAGCCGATCCTGCTGATCCAGCGCTTCGACCGCAGCGTCGTGCTCGAC
GCCGCGGATGGCGAGTCGGTCGAAGCCGTGCGCCGCCGGCATGTGATCGACGGCTGCCAGGCGCTCGACTTGCCCGTGTC
GTTCAAATACGAACGCAATTTCGGCAATACGCAGGACGTGCGCAACATCCGCGAAGGCGTCAGCTTCGAGAAGCTGTTTT
CGCTCCAGCGGCATCTGGACAACCCGGCTGCGGCGCGTACCTTCATGATCCGCTGGGCGCTCTTTCAGCTGCTGATCGGC
AACAGCGATGCGCACGGCAAGAACCTGTCGTTCTTCGTGCATGGCGGCGGCCTCGATCCCGCGCCGCTGTACGACCTCGT
CTCTGTCAATGCATACGGAGAGCAGGTCGAGCAGGACATGGCGATGGGCTACGGCGAGGCATTCCGCCTCGAAGAGATCA
CGCCGTTCGCGCTCGCGGATTTTGCGCAGCGCACGGGCACGGCGCCGCGCTTTCTCGCGCGCGAAATGGCGCGGATGGCG
CAGGCCGCGAAGGCGCTTGCGCCTGAACTCGCGCGCTCGCACGTCTACATTGCCGACGAGCGCGCGCTGGTGCAGACGAT
CGCCAGGTTCATCGGCGCACAGGCCGACCGTCTGCTGCAATTCGCGCCGATGGTGCCGCAGGTCGACCGCAAGCTACTCT
AG

Upstream 100 bases:

>100_bases
TCGGCCTGAACCTGCTGGTGTTCACGAACCAGCAGACCAGCGCGGTGCTCGATGCCGTGGAACCGCTTGCCGGCGCGAGC
CCGACGCGGGAGCAGTCCTG

Downstream 100 bases:

>100_bases
CAATCGGGTCAATCGGGTAAAACAAAGGGCGCTTTACGTGCCCCTTGCTCGTCGACGGATGTCAGCATGACACGCCGTTC
TGGTTCCGCGCGATATCCGC

Product: HipA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MLHTLHVTTHEGAVGRLDFDARQTLYRFAYDGNWTARRNAFPLSPHIPLSGAEPAGGAVHRFIANLLPEGRALDVASVVY
QVSKDNIYGLIRMLGKEPVGALSFLASGEAGEPIERGAGEQPPARRAISPDELSQRIRERDAIPFPVWDGKVRLSVAGYQ
DKLQVLLEGDRIALADGPLSSTHILKPESRSPVTPCMVANEHYCMTLASRMGLQTAPVAIRRIPEPILLIQRFDRSVVLD
AADGESVEAVRRRHVIDGCQALDLPVSFKYERNFGNTQDVRNIREGVSFEKLFSLQRHLDNPAAARTFMIRWALFQLLIG
NSDAHGKNLSFFVHGGGLDPAPLYDLVSVNAYGEQVEQDMAMGYGEAFRLEEITPFALADFAQRTGTAPRFLAREMARMA
QAAKALAPELARSHVYIADERALVQTIARFIGAQADRLLQFAPMVPQVDRKLL

Sequences:

>Translated_453_residues
MLHTLHVTTHEGAVGRLDFDARQTLYRFAYDGNWTARRNAFPLSPHIPLSGAEPAGGAVHRFIANLLPEGRALDVASVVY
QVSKDNIYGLIRMLGKEPVGALSFLASGEAGEPIERGAGEQPPARRAISPDELSQRIRERDAIPFPVWDGKVRLSVAGYQ
DKLQVLLEGDRIALADGPLSSTHILKPESRSPVTPCMVANEHYCMTLASRMGLQTAPVAIRRIPEPILLIQRFDRSVVLD
AADGESVEAVRRRHVIDGCQALDLPVSFKYERNFGNTQDVRNIREGVSFEKLFSLQRHLDNPAAARTFMIRWALFQLLIG
NSDAHGKNLSFFVHGGGLDPAPLYDLVSVNAYGEQVEQDMAMGYGEAFRLEEITPFALADFAQRTGTAPRFLAREMARMA
QAAKALAPELARSHVYIADERALVQTIARFIGAQADRLLQFAPMVPQVDRKLL
>Mature_453_residues
MLHTLHVTTHEGAVGRLDFDARQTLYRFAYDGNWTARRNAFPLSPHIPLSGAEPAGGAVHRFIANLLPEGRALDVASVVY
QVSKDNIYGLIRMLGKEPVGALSFLASGEAGEPIERGAGEQPPARRAISPDELSQRIRERDAIPFPVWDGKVRLSVAGYQ
DKLQVLLEGDRIALADGPLSSTHILKPESRSPVTPCMVANEHYCMTLASRMGLQTAPVAIRRIPEPILLIQRFDRSVVLD
AADGESVEAVRRRHVIDGCQALDLPVSFKYERNFGNTQDVRNIREGVSFEKLFSLQRHLDNPAAARTFMIRWALFQLLIG
NSDAHGKNLSFFVHGGGLDPAPLYDLVSVNAYGEQVEQDMAMGYGEAFRLEEITPFALADFAQRTGTAPRFLAREMARMA
QAAKALAPELARSHVYIADERALVQTIARFIGAQADRLLQFAPMVPQVDRKLL

Specific function: Unbalanced Or Excessive Expression Of Hipa Is Toxic To The Cell. [C]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hipA, H.influenzae HI_0665 and y4dM [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=340, Percent_Identity=28.5294117647059, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 50053; Mature: 50053

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHTLHVTTHEGAVGRLDFDARQTLYRFAYDGNWTARRNAFPLSPHIPLSGAEPAGGAVH
CEEEEEEEECCCCCEECCHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
RFIANLLPEGRALDVASVVYQVSKDNIYGLIRMLGKEPVGALSFLASGEAGEPIERGAGE
HHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHCCCC
QPPARRAISPDELSQRIRERDAIPFPVWDGKVRLSVAGYQDKLQVLLEGDRIALADGPLS
CCCCCCCCCHHHHHHHHHHCCCCCCCEECCEEEEEECCCHHHHHEEEECCEEEEECCCCC
STHILKPESRSPVTPCMVANEHYCMTLASRMGLQTAPVAIRRIPEPILLIQRFDRSVVLD
CCEEECCCCCCCCCCEEECCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCCEEEEE
AADGESVEAVRRRHVIDGCQALDLPVSFKYERNFGNTQDVRNIREGVSFEKLFSLQRHLD
CCCCCHHHHHHHHHHHCCCCEECCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCC
NPAAARTFMIRWALFQLLIGNSDAHGKNLSFFVHGGGLDPAPLYDLVSVNAYGEQVEQDM
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCHHHHHHHHHH
AMGYGEAFRLEEITPFALADFAQRTGTAPRFLAREMARMAQAAKALAPELARSHVYIADE
HHCCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECH
RALVQTIARFIGAQADRLLQFAPMVPQVDRKLL
HHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MLHTLHVTTHEGAVGRLDFDARQTLYRFAYDGNWTARRNAFPLSPHIPLSGAEPAGGAVH
CEEEEEEEECCCCCEECCHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
RFIANLLPEGRALDVASVVYQVSKDNIYGLIRMLGKEPVGALSFLASGEAGEPIERGAGE
HHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHCCCC
QPPARRAISPDELSQRIRERDAIPFPVWDGKVRLSVAGYQDKLQVLLEGDRIALADGPLS
CCCCCCCCCHHHHHHHHHHCCCCCCCEECCEEEEEECCCHHHHHEEEECCEEEEECCCCC
STHILKPESRSPVTPCMVANEHYCMTLASRMGLQTAPVAIRRIPEPILLIQRFDRSVVLD
CCEEECCCCCCCCCCEEECCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCCEEEEE
AADGESVEAVRRRHVIDGCQALDLPVSFKYERNFGNTQDVRNIREGVSFEKLFSLQRHLD
CCCCCHHHHHHHHHHHCCCCEECCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCC
NPAAARTFMIRWALFQLLIGNSDAHGKNLSFFVHGGGLDPAPLYDLVSVNAYGEQVEQDM
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCHHHHHHHHHH
AMGYGEAFRLEEITPFALADFAQRTGTAPRFLAREMARMAQAAKALAPELARSHVYIADE
HHCCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECH
RALVQTIARFIGAQADRLLQFAPMVPQVDRKLL
HHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]