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The map label for this gene is qor [C]

Identifier: 186475749

GI number: 186475749

Start: 1101155

End: 1102171

Strand: Direct

Name: qor [C]

Synonym: Bphy_0984

Alternate gene names: 186475749

Gene position: 1101155-1102171 (Clockwise)

Preceding gene: 186475747

Following gene: 186475750

Centisome position: 31.65

GC content: 61.36

Gene sequence:

>1017_bases
ATGAAAGCCGTTGGACTGACTCATTACCTTCCCATCGACAATCCCGAGTCGCTTGTCGACATCGAGATCGACAAGCCACA
GCCGGTGGGTCATGACATTCTCGTGAAAGTCGAGGCGATTTCCGTGAACCCGGTGGACTACAAGGTCCGCGCGCCGAAGG
ACACTGTTGAGAAGACGCCGCGTGTGCTCGGTTGGGATGCGTCGGGGGTTGTCGAAGCCGTCGGACCCGACGTGACGCTT
TTCAAGCCAGGCGACCCGGTGTTCTACGCGGGCAGCATTACGCGACCGGGCGCGAACAGCGAGTTTCATCTCGTCGACGA
GCGCATTGTGGGCCGCAAGCCGGCGTCGCTGGATTTCACGCATGCTGCCGCGTTGCCGTTGACGGCGATCACCGCGTGGG
AAGCGCTGTTCGACCGTCTGGGCGTGTCGCCGCAGGGTGCGGATGCGGGCAAGACGGTGCTGATTATCGGCGGCGCGGGC
GGGGTGGGCTCGATCGGCATCCAGCTGGCTAAGCGGCTGGCGAAGCTGATGGTGATTGCGACAGCGTCGCGGCCCGAGTC
GGCGAGATGGGCGAAGGAGCTGGGCGCGGATCATATCGTCGATCACTTCGGCGACATGCCTGCGCAACTGAAGCAGATCG
GCTTCGAGGAGGTCGATTACGTGTTGATGTTCAACGACACCGATCGTCATTTTCCGGCGGCGGCTGCCGTCATCAAGCCG
CAGGGTGGAATTGCGACGATCGTGGAGAATGCGAAGCCGGTTCCTGTGGAACTGTTGAAGGCGAAGAGCGCGGCGTTTCA
TTGGGAGTTCATGTTCACGCGATCGATGTTCGGCACACCGGACATGATCGAGCAGCATAAGTTGCTGACGGAGGTTTCGC
GTCTGATCGACGCGGGGATCTTGCGGACCACGGTTGGGGAGCATCTCGGCAAGATCAATGCCGAGAATGTGCGGCGCGCG
CACAAGCTGCTCGAGGAGGGGCGGGCGATTGGGAAGTTGGTGTTGACAGGGTTTTGA

Upstream 100 bases:

>100_bases
TTCTACAGTGGAGTCAACGCGAGCGGCTTCACTTTGAACCCGTGCCATGCCGCCGTTTGCGAAACCGTTCAGGACACACC
ACACGAATCAAGGAGCCGTC

Downstream 100 bases:

>100_bases
TCCTTGTCCGCGGCGTTAGTCGCAGACAAAGAAAAAACACTGCGCTGACAAGCGGGGGAAACACCGCGCCACACACGCCA
CGCTTGGCGTTAGACTTCAC

Product: zinc-binding alcohol dehydrogenase family protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKAVGLTHYLPIDNPESLVDIEIDKPQPVGHDILVKVEAISVNPVDYKVRAPKDTVEKTPRVLGWDASGVVEAVGPDVTL
FKPGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFTHAAALPLTAITAWEALFDRLGVSPQGADAGKTVLIIGGAG
GVGSIGIQLAKRLAKLMVIATASRPESARWAKELGADHIVDHFGDMPAQLKQIGFEEVDYVLMFNDTDRHFPAAAAVIKP
QGGIATIVENAKPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVSRLIDAGILRTTVGEHLGKINAENVRRA
HKLLEEGRAIGKLVLTGF

Sequences:

>Translated_338_residues
MKAVGLTHYLPIDNPESLVDIEIDKPQPVGHDILVKVEAISVNPVDYKVRAPKDTVEKTPRVLGWDASGVVEAVGPDVTL
FKPGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFTHAAALPLTAITAWEALFDRLGVSPQGADAGKTVLIIGGAG
GVGSIGIQLAKRLAKLMVIATASRPESARWAKELGADHIVDHFGDMPAQLKQIGFEEVDYVLMFNDTDRHFPAAAAVIKP
QGGIATIVENAKPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVSRLIDAGILRTTVGEHLGKINAENVRRA
HKLLEEGRAIGKLVLTGF
>Mature_338_residues
MKAVGLTHYLPIDNPESLVDIEIDKPQPVGHDILVKVEAISVNPVDYKVRAPKDTVEKTPRVLGWDASGVVEAVGPDVTL
FKPGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFTHAAALPLTAITAWEALFDRLGVSPQGADAGKTVLIIGGAG
GVGSIGIQLAKRLAKLMVIATASRPESARWAKELGADHIVDHFGDMPAQLKQIGFEEVDYVLMFNDTDRHFPAAAAVIKP
QGGIATIVENAKPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVSRLIDAGILRTTVGEHLGKINAENVRRA
HKLLEEGRAIGKLVLTGF

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=337, Percent_Identity=30.8605341246291, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI194239674, Length=182, Percent_Identity=34.6153846153846, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI13236495, Length=182, Percent_Identity=34.6153846153846, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI194239676, Length=190, Percent_Identity=34.7368421052632, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI24308257, Length=327, Percent_Identity=26.9113149847095, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI22538446, Length=191, Percent_Identity=31.9371727748691, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI22538444, Length=191, Percent_Identity=31.9371727748691, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI18379349, Length=220, Percent_Identity=30.9090909090909, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=333, Percent_Identity=29.1291291291291, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71987554, Length=177, Percent_Identity=37.2881355932203, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17507255, Length=189, Percent_Identity=32.2751322751323, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36492; Mature: 36492

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGLTHYLPIDNPESLVDIEIDKPQPVGHDILVKVEAISVNPVDYKVRAPKDTVEKTP
CCCCCCEEEECCCCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCEEEECCHHHHHHCC
RVLGWDASGVVEAVGPDVTLFKPGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFT
CEECCCCCCHHHHCCCCEEEECCCCCEEEECCCCCCCCCCCEEEEHHHHHCCCCCCCCCH
HAAALPLTAITAWEALFDRLGVSPQGADAGKTVLIIGGAGGVGSIGIQLAKRLAKLMVIA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEEE
TASRPESARWAKELGADHIVDHFGDMPAQLKQIGFEEVDYVLMFNDTDRHFPAAAAVIKP
ECCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHCCHHHCCEEEEECCCCCCCCCEEEEEEC
QGGIATIVENAKPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVSRLIDAGI
CCCEEEEECCCCCCCHHHHHHCCHHEEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHH
LRTTVGEHLGKINAENVRRAHKLLEEGRAIGKLVLTGF
HHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHEEEECC
>Mature Secondary Structure
MKAVGLTHYLPIDNPESLVDIEIDKPQPVGHDILVKVEAISVNPVDYKVRAPKDTVEKTP
CCCCCCEEEECCCCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCEEEECCHHHHHHCC
RVLGWDASGVVEAVGPDVTLFKPGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFT
CEECCCCCCHHHHCCCCEEEECCCCCEEEECCCCCCCCCCCEEEEHHHHHCCCCCCCCCH
HAAALPLTAITAWEALFDRLGVSPQGADAGKTVLIIGGAGGVGSIGIQLAKRLAKLMVIA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEEE
TASRPESARWAKELGADHIVDHFGDMPAQLKQIGFEEVDYVLMFNDTDRHFPAAAAVIKP
ECCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHCCHHHCCEEEEECCCCCCCCCEEEEEEC
QGGIATIVENAKPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVSRLIDAGI
CCCEEEEECCCCCCCHHHHHHCCHHEEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHH
LRTTVGEHLGKINAENVRRAHKLLEEGRAIGKLVLTGF
HHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]