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The map label for this gene is metC [H]

Identifier: 186475742

GI number: 186475742

Start: 1092001

End: 1093185

Strand: Direct

Name: metC [H]

Synonym: Bphy_0977

Alternate gene names: 186475742

Gene position: 1092001-1093185 (Clockwise)

Preceding gene: 186475741

Following gene: 186475744

Centisome position: 31.39

GC content: 64.14

Gene sequence:

>1185_bases
ATGACTCCAAAGACTCCGAAGCACGGCTTGCAGACCCGTATTGTCCAGCCGACCGATCAGATGACACCCGGTTGGGAATC
GTTTTCTGTGCCCGTGGCGCGGGCGTCGACGGTCGTGTTTCCCGACCTCGCGACCATGCGTGCGCTCGACTGGAAGAACG
ACGCGCAATGGCGCTACGGCCTGCACGCGACGCCGACGTCGATCGCGCTCGCGCAGCGGCTCGCGGCGCTCGAAGGCGGC
AATCACGCGCTGTTGCAGCCGTCCGGCCTGTCGTCGATCTCGAACGTCTACTTCGGCCTCGTCAAATCGGGCGACGACGT
GCTGATTCCCGACAACGTTTACTCGCCGAACCGCGATCACGCGGAATGGCTCGCGAAAGACTTCGGCATCAGCGCGCGCT
ACTACGATCCGATGATCGGCGCGGGCATCGCCGATCTGATCCAGCCGAACACGAAGCTGATCTGGCTCGAAGCGCCCGGC
TCGGTGACGATGGAAGTGTCGGATATTCCCGCCATCACGGCCGTCGCCCGTGCGCGCGGCGTGGTCACGGCGATCGACAA
CACGTGGTCGGCGGGTCTCGCATTCCGTCCGTTCGATCACGGCGTCGACATTTCGATGCAGGCGCTCACGAAGTATCAGT
CGGGCGGCAGCGACGTGCTGATGGGCGCGACCATCACCGTGGACCGCGAACTGCATCTGAAGCTGAAGCTGGCGCGCATG
CGCATGGGCATCGGCGTGTCGGCGGACGATTGCTCGCTGATCCTGCGCAGCCTGCCGTCGATGAAAGTGCGCTTCGAGCA
GCACGACAGAAGCGCACTCGAACTCGCCACCTGGCTGAAAACGCGGCCCGAAATCGCCACCGTGCTGCATCCGGCGTTGC
CGGACTGTCCGGGGCACGCATTCTACAAGCGCGACTTCACGGGCGCGGGCGGACTCTTTTCGGTCGTGTTCGACGCGCGT
TACACGCCGGAGCAGATCGACACGTTTTGCGAATCGCTGGAACTGTTCTCGCTGGGCTGGAGCTGGGGCGGCGCGCAAAG
TCTCGCGATGCCGTACAACGTCGCGTCGATGCGCACCGAATCGAAATGGCCGCATCGCGGCACGCTGGTGCGCTTCTACG
TCGGTCTTGAGGACGAAGCGGATCTGCGCAAAGATATCGAGCGCTGTCTCGTCGCGCTGGGCTGA

Upstream 100 bases:

>100_bases
CCCGCCCCGTCTCGCGGGCAGCCCGTCAATGGTGTGAGCAATCTGACGATAGGCGAATAAGCGCCGCGCTTATCACTGAC
GAATCCAACTTTATCTGACC

Downstream 100 bases:

>100_bases
ACGCGTCACACTTCATCGAAGCACGAACAACAAGCCCGCTCGATATCGAGCGGGCTTTTTCACCTGTGCCGTCGCAGCAA
GCTGCGATCAGAACAGCCGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTPKTPKHGLQTRIVQPTDQMTPGWESFSVPVARASTVVFPDLATMRALDWKNDAQWRYGLHATPTSIALAQRLAALEGG
NHALLQPSGLSSISNVYFGLVKSGDDVLIPDNVYSPNRDHAEWLAKDFGISARYYDPMIGAGIADLIQPNTKLIWLEAPG
SVTMEVSDIPAITAVARARGVVTAIDNTWSAGLAFRPFDHGVDISMQALTKYQSGGSDVLMGATITVDRELHLKLKLARM
RMGIGVSADDCSLILRSLPSMKVRFEQHDRSALELATWLKTRPEIATVLHPALPDCPGHAFYKRDFTGAGGLFSVVFDAR
YTPEQIDTFCESLELFSLGWSWGGAQSLAMPYNVASMRTESKWPHRGTLVRFYVGLEDEADLRKDIERCLVALG

Sequences:

>Translated_394_residues
MTPKTPKHGLQTRIVQPTDQMTPGWESFSVPVARASTVVFPDLATMRALDWKNDAQWRYGLHATPTSIALAQRLAALEGG
NHALLQPSGLSSISNVYFGLVKSGDDVLIPDNVYSPNRDHAEWLAKDFGISARYYDPMIGAGIADLIQPNTKLIWLEAPG
SVTMEVSDIPAITAVARARGVVTAIDNTWSAGLAFRPFDHGVDISMQALTKYQSGGSDVLMGATITVDRELHLKLKLARM
RMGIGVSADDCSLILRSLPSMKVRFEQHDRSALELATWLKTRPEIATVLHPALPDCPGHAFYKRDFTGAGGLFSVVFDAR
YTPEQIDTFCESLELFSLGWSWGGAQSLAMPYNVASMRTESKWPHRGTLVRFYVGLEDEADLRKDIERCLVALG
>Mature_393_residues
TPKTPKHGLQTRIVQPTDQMTPGWESFSVPVARASTVVFPDLATMRALDWKNDAQWRYGLHATPTSIALAQRLAALEGGN
HALLQPSGLSSISNVYFGLVKSGDDVLIPDNVYSPNRDHAEWLAKDFGISARYYDPMIGAGIADLIQPNTKLIWLEAPGS
VTMEVSDIPAITAVARARGVVTAIDNTWSAGLAFRPFDHGVDISMQALTKYQSGGSDVLMGATITVDRELHLKLKLARMR
MGIGVSADDCSLILRSLPSMKVRFEQHDRSALELATWLKTRPEIATVLHPALPDCPGHAFYKRDFTGAGGLFSVVFDARY
TPEQIDTFCESLELFSLGWSWGGAQSLAMPYNVASMRTESKWPHRGTLVRFYVGLEDEADLRKDIERCLVALG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=294, Percent_Identity=32.9931972789116, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI299473759, Length=237, Percent_Identity=34.1772151898734, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI25453487, Length=293, Percent_Identity=30.0341296928328, Blast_Score=129, Evalue=7e-30,
Organism=Escherichia coli, GI1789383, Length=362, Percent_Identity=38.6740331491713, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1790375, Length=362, Percent_Identity=30.1104972375691, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17560056, Length=330, Percent_Identity=31.8181818181818, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=330, Percent_Identity=31.2121212121212, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=377, Percent_Identity=28.1167108753316, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=314, Percent_Identity=40.4458598726115, Blast_Score=243, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6319307, Length=347, Percent_Identity=27.9538904899135, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323333, Length=423, Percent_Identity=26.0047281323877, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321254, Length=380, Percent_Identity=25.7894736842105, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321904, Length=341, Percent_Identity=24.9266862170088, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922554, Length=391, Percent_Identity=33.7595907928389, Blast_Score=194, Evalue=9e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43306; Mature: 43175

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKTPKHGLQTRIVQPTDQMTPGWESFSVPVARASTVVFPDLATMRALDWKNDAQWRYG
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHCCEEECCCHHHHHHCCCCCCCCEEEC
LHATPTSIALAQRLAALEGGNHALLQPSGLSSISNVYFGLVKSGDDVLIPDNVYSPNRDH
CCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHEEEEECCCCEEECCCCCCCCCHH
AEWLAKDFGISARYYDPMIGAGIADLIQPNTKLIWLEAPGSVTMEVSDIPAITAVARARG
HHHHHHHHCCCCEECCCHHHCCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCC
VVTAIDNTWSAGLAFRPFDHGVDISMQALTKYQSGGSDVLMGATITVDRELHLKLKLARM
EEEEECCCCCCCEEECCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEECCEEEEEEEEEHH
RMGIGVSADDCSLILRSLPSMKVRFEQHDRSALELATWLKTRPEIATVLHPALPDCPGHA
HHCCCCCCHHHHHHHHCCCCCEEEEHHCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
FYKRDFTGAGGLFSVVFDARYTPEQIDTFCESLELFSLGWSWGGAQSLAMPYNVASMRTE
EEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEEECCCCCCCCCEECCCCHHHHCCC
SKWPHRGTLVRFYVGLEDEADLRKDIERCLVALG
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPKTPKHGLQTRIVQPTDQMTPGWESFSVPVARASTVVFPDLATMRALDWKNDAQWRYG
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHCCEEECCCHHHHHHCCCCCCCCEEEC
LHATPTSIALAQRLAALEGGNHALLQPSGLSSISNVYFGLVKSGDDVLIPDNVYSPNRDH
CCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHEEEEECCCCEEECCCCCCCCCHH
AEWLAKDFGISARYYDPMIGAGIADLIQPNTKLIWLEAPGSVTMEVSDIPAITAVARARG
HHHHHHHHCCCCEECCCHHHCCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCC
VVTAIDNTWSAGLAFRPFDHGVDISMQALTKYQSGGSDVLMGATITVDRELHLKLKLARM
EEEEECCCCCCCEEECCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEECCEEEEEEEEEHH
RMGIGVSADDCSLILRSLPSMKVRFEQHDRSALELATWLKTRPEIATVLHPALPDCPGHA
HHCCCCCCHHHHHHHHCCCCCEEEEHHCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
FYKRDFTGAGGLFSVVFDARYTPEQIDTFCESLELFSLGWSWGGAQSLAMPYNVASMRTE
EEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEEECCCCCCCCCEECCCCHHHHCCC
SKWPHRGTLVRFYVGLEDEADLRKDIERCLVALG
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]