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The map label for this gene is phoR [H]

Identifier: 186475653

GI number: 186475653

Start: 992153

End: 993466

Strand: Direct

Name: phoR [H]

Synonym: Bphy_0888

Alternate gene names: 186475653

Gene position: 992153-993466 (Clockwise)

Preceding gene: 186475652

Following gene: 186475655

Centisome position: 28.52

GC content: 59.82

Gene sequence:

>1314_bases
ATGAACATCATCTGGGCACGTTCCCTGGTATCGCTTGTGCTCCTCGCTGTGCTGTGCGTGGCAATCGGCATCTTCGTCAA
CACGAAAACGGCGTTGGCGCTCGCCGTGCTCGCACTGCTCGCGCAAGGCATTTTCAGCACGTTCCACAAGCAACGCCTGT
GGCGTCTGCTCGACGCGCCTGTGTATGGCGAAGTGCCGAGCGCACCCGGCATCTGGGGCGAAATTTACTACAGGCTGCAC
AAGCTCGCGAAACGCTGGCACGCACAGGTGCGCCAGGTCGAACAGCAGCATTCGCGTTTCATTCAGGCGATTCAGGCGTC
CCCGAACGGCGTTGCGATGCTCGACGATCACGATCAGATCGAGTGGTGCAACGCGATCTCCGAAGCGCATTTCGGCCTCG
ACGCGAAACGCGATTTACGTCAGCACATCACACATCTCGTGCGTCATCCCGACTTCGTGCGCTATCTGAATTCGCATCAT
TATGAACAGATGCTGATCATGCGCGGGATGGGCGACAAGCGGCAGAACGTGCTGTCCGTGCAGGTGTTTCCGTATGGCGA
GAACCGCAAGCTGGTGCTGTCGCAGGACATTACGGAACTGGAACGCACGGATGCGATGCGCCGGGACTTCGTGGCGAATG
TATCGCACGAACTAAAGACGCCGTTGACCGTGCTGTCGGGTTTTCTCGAAACGATGCGAGAGATCCCACTCGACGAGAGC
GAGCGCGTGCGCTATCTCGATCTGATGATGCAGCAGGCGCAGCGGATGCAGCATATCGTCAGCGATCTGCTGGTGCTCGC
GACGCTCGAAGGCGACAACAAGCCGCCGAGCAACCAGATGGTCGATATGCGCGCGGTGCTACGGCATCTGGAAGATGATG
CGCAAAGCCTCTCGGGCGGACGACACCGGATTGGCTTCGAGGCCGACGAGGCATTGACGGTGACGGGAGTGGAGACGGAG
ATCATGAGCGCGTTCGGGAATCTCGTCACGAATGCGATTCGGTATACACCTGACGGCGGGTCGATCGATGTGAGTTGGCA
CGCACAGGGAGGGCAAGCCACGTTCGCAGTGACCGACAGCGGCTTGGGTATTCCTGCCGCGGATATTCCGCGATTGACTG
AGCGGTTTTATCGTGTCGATCGGAGCCGGTCTCGCGACACGGGCGGGACCGGGCTTGGGCTTGCGATCGTCAAGCATGTG
TTGCAGCGGCATGATGCGCAGCTCGAGGTGAAAAGCGAAGAAGGGCGAGGGAGCACTTTTACCGTACGGTTTCCCGTTGC
GCGGAGTGCGCGGCTTCAGTCGACCGCCGCTTGA

Upstream 100 bases:

>100_bases
ATAAGGTAAACTGATCGAAAAACACGAAGCGCGCTGCGGGCACTCGGACGCAGCGCGCTTTGTTGTCTATGAAGTCTTCA
GCTTGTCTTCAAGGTCGCAC

Downstream 100 bases:

>100_bases
TTCTGCTTTATTGTCTGCGTCGCAGTCGCCATTTTTGCCTGCGGCGCGGCGTTTGCCGTTTTTTGTTTTTCCGCTGGCAT
CCGCTTTGTGCATCTGGCAC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNIIWARSLVSLVLLAVLCVAIGIFVNTKTALALAVLALLAQGIFSTFHKQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKRWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAISEAHFGLDAKRDLRQHITHLVRHPDFVRYLNSHH
YEQMLIMRGMGDKRQNVLSVQVFPYGENRKLVLSQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMREIPLDES
ERVRYLDLMMQQAQRMQHIVSDLLVLATLEGDNKPPSNQMVDMRAVLRHLEDDAQSLSGGRHRIGFEADEALTVTGVETE
IMSAFGNLVTNAIRYTPDGGSIDVSWHAQGGQATFAVTDSGLGIPAADIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAQLEVKSEEGRGSTFTVRFPVARSARLQSTAA

Sequences:

>Translated_437_residues
MNIIWARSLVSLVLLAVLCVAIGIFVNTKTALALAVLALLAQGIFSTFHKQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKRWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAISEAHFGLDAKRDLRQHITHLVRHPDFVRYLNSHH
YEQMLIMRGMGDKRQNVLSVQVFPYGENRKLVLSQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMREIPLDES
ERVRYLDLMMQQAQRMQHIVSDLLVLATLEGDNKPPSNQMVDMRAVLRHLEDDAQSLSGGRHRIGFEADEALTVTGVETE
IMSAFGNLVTNAIRYTPDGGSIDVSWHAQGGQATFAVTDSGLGIPAADIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAQLEVKSEEGRGSTFTVRFPVARSARLQSTAA
>Mature_437_residues
MNIIWARSLVSLVLLAVLCVAIGIFVNTKTALALAVLALLAQGIFSTFHKQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKRWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAISEAHFGLDAKRDLRQHITHLVRHPDFVRYLNSHH
YEQMLIMRGMGDKRQNVLSVQVFPYGENRKLVLSQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMREIPLDES
ERVRYLDLMMQQAQRMQHIVSDLLVLATLEGDNKPPSNQMVDMRAVLRHLEDDAQSLSGGRHRIGFEADEALTVTGVETE
IMSAFGNLVTNAIRYTPDGGSIDVSWHAQGGQATFAVTDSGLGIPAADIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAQLEVKSEEGRGSTFTVRFPVARSARLQSTAA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=421, Percent_Identity=36.5795724465558, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI145693157, Length=344, Percent_Identity=28.1976744186047, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1788393, Length=265, Percent_Identity=30.5660377358491, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786783, Length=257, Percent_Identity=33.4630350194552, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI48994928, Length=374, Percent_Identity=27.0053475935829, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=30.5555555555556, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=29.5154185022026, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790436, Length=301, Percent_Identity=26.578073089701, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790346, Length=248, Percent_Identity=28.6290322580645, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=264, Percent_Identity=25.7575757575758, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=28.8135593220339, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=24.5535714285714, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=25.6410256410256, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=237, Percent_Identity=32.0675105485232, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=253, Percent_Identity=25.6916996047431, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=30.6666666666667, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789403, Length=229, Percent_Identity=30.5676855895196, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=24.5762711864407, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49111; Mature: 49111

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIWARSLVSLVLLAVLCVAIGIFVNTKTALALAVLALLAQGIFSTFHKQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKRWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHH
EWCNAISEAHFGLDAKRDLRQHITHLVRHPDFVRYLNSHHYEQMLIMRGMGDKRQNVLSV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
QVFPYGENRKLVLSQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMREIPLDES
EEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ERVRYLDLMMQQAQRMQHIVSDLLVLATLEGDNKPPSNQMVDMRAVLRHLEDDAQSLSGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
RHRIGFEADEALTVTGVETEIMSAFGNLVTNAIRYTPDGGSIDVSWHAQGGQATFAVTDS
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEECC
GLGIPAADIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAQLEVKSEEGRGSTF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEE
TVRFPVARSARLQSTAA
EEEECCCCCCCHHHCCC
>Mature Secondary Structure
MNIIWARSLVSLVLLAVLCVAIGIFVNTKTALALAVLALLAQGIFSTFHKQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKRWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHH
EWCNAISEAHFGLDAKRDLRQHITHLVRHPDFVRYLNSHHYEQMLIMRGMGDKRQNVLSV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
QVFPYGENRKLVLSQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMREIPLDES
EEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ERVRYLDLMMQQAQRMQHIVSDLLVLATLEGDNKPPSNQMVDMRAVLRHLEDDAQSLSGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
RHRIGFEADEALTVTGVETEIMSAFGNLVTNAIRYTPDGGSIDVSWHAQGGQATFAVTDS
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEECC
GLGIPAADIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAQLEVKSEEGRGSTF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEE
TVRFPVARSARLQSTAA
EEEECCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]