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The map label for this gene is moeA [H]

Identifier: 186475580

GI number: 186475580

Start: 913101

End: 914396

Strand: Reverse

Name: moeA [H]

Synonym: Bphy_0815

Alternate gene names: 186475580

Gene position: 914396-913101 (Counterclockwise)

Preceding gene: 186475581

Following gene: 186475579

Centisome position: 26.28

GC content: 67.9

Gene sequence:

>1296_bases
ATGACCGCGCTGAACGAAACCTCGAGTTGCGTCGACCAGTACGACGCTCAAGCCATGCCGGTGTCCGCTGTCCAGGCAAT
CGTCCGCGAGTGGGCGGCGCCCGTGACGACGGTCGAGCGCGTGCATCTGCGTGACGCGCTCAATCGCGTTCTCGCGCACG
ACATCGTGTCGCCCATCGACGTGCCCGCGCACGACAACTCCGCAATGGACGGCTACGCGTTTTCCGGCGCGGCGCTCGAA
GGTCGGACCGACGAAATCGCGCTGGGTGTTGCGGGCAAGGCGTTCGCCGGGCATCCGTTCGAAGGCCGCATCGACGTTAC
GCAGTGCGTGCGCGTGATGACGGGCGCGACGATGCCGCCCGGCTGCGACACCGTGGTTCCGCAAGAAGCCGTCACGCGCG
ACGGCGATACGGTCCGCTTCCATGCTGCGGCCTTGCGCACGGGCGCGAACCGGCGCCTCGCGGGCGAAGACCTTGCGAAC
GGCGCCGTCGCACTGAAGGCGGGCCGCATCGTGCGCGCCTCGGATCTCGGGCTGCTCGCGTCGCTCGGCATCGGCGAGGT
GTCGGTACGGCGCCGGCTGCGCGTCGCCTTCTTTTCGACGGGCGACGAACTGCGCTCGATCGGCGAGTCGCTCGATCCCG
GCTGCGTCTACGACAGCAACCGCTACACGCTCTTCGCGATGCTCAAGCGCCTCGATGTCGAGCCGATCGATCTCGGCGTG
ATTCGCGACGAACCGGCCGCGCTCGAAGAAGCGTTGCGGACGGCTGCCGCAAGCGCGGATGTCGTGATAACCTCCGGCGG
CGTTTCTGTCGGGGAAGCCGATCTGACGAAGCAGATGTTGCGTCTGCTCGGCGACGTCGCTCACTGGAGCCTCGCGATGC
GTCCCGGCCGGCCGCTAGCATTCGGGCGCATCTGGTCGGGCGGCAAACCGGGTGCGGGCGAGCCCGCCATCTTCTTCGGT
CTGCCGGGCAACCCTGTGGCCGTGATGGCCGCGTTCTACCAGATCGTGCGCGAAGTGCTGCTGCGGATGTCAGGTGCGAC
CACGCACCCGCTGCCGCTGGTCCGTGCCGCATCCGTCGAGCCGATCCGCAAGCGGCCGGGCCGGACCGAATTCCAGCGCG
GCGTTGCGCAGCGTGACGCGCAAGGCGCATGGCACGTTACGCCGACGGGCTCGCAAGGCTCGGGCGTGCTGAGTTCGATG
AGCGAAGCAAACTGCTTCATCGTGCTCGCCCACGAACAGGCCGATCTCGATCCGGGCGACCCCGTCGATATCATGCTGTT
CGACGGCCTGATCTGA

Upstream 100 bases:

>100_bases
CGACTTCGAGCGACGTTAATCGAATTCGGCATCAGCAGCCGCCATTTGCCGCGATCGCCCGGCCGCCGCCGCACCGCACC
CGTCGCGACGCTCCCCATTC

Downstream 100 bases:

>100_bases
GCGCACGAGACCACAGCTTTCACGCATCACGCATTCCACTACGACATACGGGTTTGACTTACATGAAAAAACAGATCTCG
TTCATTGCACCGGGGCAAAC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTALNETSSCVDQYDAQAMPVSAVQAIVREWAAPVTTVERVHLRDALNRVLAHDIVSPIDVPAHDNSAMDGYAFSGAALE
GRTDEIALGVAGKAFAGHPFEGRIDVTQCVRVMTGATMPPGCDTVVPQEAVTRDGDTVRFHAAALRTGANRRLAGEDLAN
GAVALKAGRIVRASDLGLLASLGIGEVSVRRRLRVAFFSTGDELRSIGESLDPGCVYDSNRYTLFAMLKRLDVEPIDLGV
IRDEPAALEEALRTAAASADVVITSGGVSVGEADLTKQMLRLLGDVAHWSLAMRPGRPLAFGRIWSGGKPGAGEPAIFFG
LPGNPVAVMAAFYQIVREVLLRMSGATTHPLPLVRAASVEPIRKRPGRTEFQRGVAQRDAQGAWHVTPTGSQGSGVLSSM
SEANCFIVLAHEQADLDPGDPVDIMLFDGLI

Sequences:

>Translated_431_residues
MTALNETSSCVDQYDAQAMPVSAVQAIVREWAAPVTTVERVHLRDALNRVLAHDIVSPIDVPAHDNSAMDGYAFSGAALE
GRTDEIALGVAGKAFAGHPFEGRIDVTQCVRVMTGATMPPGCDTVVPQEAVTRDGDTVRFHAAALRTGANRRLAGEDLAN
GAVALKAGRIVRASDLGLLASLGIGEVSVRRRLRVAFFSTGDELRSIGESLDPGCVYDSNRYTLFAMLKRLDVEPIDLGV
IRDEPAALEEALRTAAASADVVITSGGVSVGEADLTKQMLRLLGDVAHWSLAMRPGRPLAFGRIWSGGKPGAGEPAIFFG
LPGNPVAVMAAFYQIVREVLLRMSGATTHPLPLVRAASVEPIRKRPGRTEFQRGVAQRDAQGAWHVTPTGSQGSGVLSSM
SEANCFIVLAHEQADLDPGDPVDIMLFDGLI
>Mature_430_residues
TALNETSSCVDQYDAQAMPVSAVQAIVREWAAPVTTVERVHLRDALNRVLAHDIVSPIDVPAHDNSAMDGYAFSGAALEG
RTDEIALGVAGKAFAGHPFEGRIDVTQCVRVMTGATMPPGCDTVVPQEAVTRDGDTVRFHAAALRTGANRRLAGEDLANG
AVALKAGRIVRASDLGLLASLGIGEVSVRRRLRVAFFSTGDELRSIGESLDPGCVYDSNRYTLFAMLKRLDVEPIDLGVI
RDEPAALEEALRTAAASADVVITSGGVSVGEADLTKQMLRLLGDVAHWSLAMRPGRPLAFGRIWSGGKPGAGEPAIFFGL
PGNPVAVMAAFYQIVREVLLRMSGATTHPLPLVRAASVEPIRKRPGRTEFQRGVAQRDAQGAWHVTPTGSQGSGVLSSMS
EANCFIVLAHEQADLDPGDPVDIMLFDGLI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=415, Percent_Identity=33.7349397590361, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI10880983, Length=415, Percent_Identity=33.7349397590361, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1787049, Length=389, Percent_Identity=48.3290488431877, Blast_Score=337, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI25147659, Length=386, Percent_Identity=29.0155440414508, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=364, Percent_Identity=25.8241758241758, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136978, Length=325, Percent_Identity=28.3076923076923, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24638841, Length=325, Percent_Identity=28.3076923076923, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45693; Mature: 45561

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALNETSSCVDQYDAQAMPVSAVQAIVREWAAPVTTVERVHLRDALNRVLAHDIVSPID
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
VPAHDNSAMDGYAFSGAALEGRTDEIALGVAGKAFAGHPFEGRIDVTQCVRVMTGATMPP
CCCCCCCCCCCEEECCCEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
GCDTVVPQEAVTRDGDTVRFHAAALRTGANRRLAGEDLANGAVALKAGRIVRASDLGLLA
CCCCCCCHHHHHCCCCEEEEEHHHHHCCCCCCCCCCHHCCCEEEEECCCEEEECCCCHHH
SLGIGEVSVRRRLRVAFFSTGDELRSIGESLDPGCVYDSNRYTLFAMLKRLDVEPIDLGV
HCCCCHHHHHHHEEEEEECCCHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCCCEEEE
IRDEPAALEEALRTAAASADVVITSGGVSVGEADLTKQMLRLLGDVAHWSLAMRPGRPLA
ECCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEE
FGRIWSGGKPGAGEPAIFFGLPGNPVAVMAAFYQIVREVLLRMSGATTHPLPLVRAASVE
EEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCC
PIRKRPGRTEFQRGVAQRDAQGAWHVTPTGSQGSGVLSSMSEANCFIVLAHEQADLDPGD
HHHHCCCCCHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCC
PVDIMLFDGLI
CEEEEEECCCC
>Mature Secondary Structure 
TALNETSSCVDQYDAQAMPVSAVQAIVREWAAPVTTVERVHLRDALNRVLAHDIVSPID
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
VPAHDNSAMDGYAFSGAALEGRTDEIALGVAGKAFAGHPFEGRIDVTQCVRVMTGATMPP
CCCCCCCCCCCEEECCCEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
GCDTVVPQEAVTRDGDTVRFHAAALRTGANRRLAGEDLANGAVALKAGRIVRASDLGLLA
CCCCCCCHHHHHCCCCEEEEEHHHHHCCCCCCCCCCHHCCCEEEEECCCEEEECCCCHHH
SLGIGEVSVRRRLRVAFFSTGDELRSIGESLDPGCVYDSNRYTLFAMLKRLDVEPIDLGV
HCCCCHHHHHHHEEEEEECCCHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCCCEEEE
IRDEPAALEEALRTAAASADVVITSGGVSVGEADLTKQMLRLLGDVAHWSLAMRPGRPLA
ECCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEE
FGRIWSGGKPGAGEPAIFFGLPGNPVAVMAAFYQIVREVLLRMSGATTHPLPLVRAASVE
EEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCC
PIRKRPGRTEFQRGVAQRDAQGAWHVTPTGSQGSGVLSSMSEANCFIVLAHEQADLDPGD
HHHHCCCCCHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCC
PVDIMLFDGLI
CEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]