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The map label for this gene is gyaR [H]

Identifier: 186475576

GI number: 186475576

Start: 909730

End: 910719

Strand: Direct

Name: gyaR [H]

Synonym: Bphy_0811

Alternate gene names: 186475576

Gene position: 909730-910719 (Clockwise)

Preceding gene: 186475575

Following gene: 186475577

Centisome position: 26.15

GC content: 65.15

Gene sequence:

>990_bases
ATGCAAAAAATTCTGGTCGCGCGTCCCATCTTTCCGGATGTGATCGAGCGCCTCAAGCAGTATTTCGACGTCGAATGGAA
TGACGGCGACGTGCTGCCCACGGATGAACTCAAGCGCCGGCTCGCCGACAAGGACGGCGCGCTGACGGCGGGCGACGTGA
TCGACGCATCGGTGCTCGCGGTCGCGCCGCGCCTGCGCGTGGTGTCGAACATGGCCGTCGGCTACAACAACTTCGACATG
GCTGCGTTCAACGCGTCGAACGTACTCGGCACGAATACGCCTGACGTGCTCAACGAATCGACGGCGGACTTCGGCTGGGC
GCTGATGATGGCGGCCGCACGCCGCATCGCCGAATCGGAACACTGGCTGCGCGCGGGAAAATGGGACAAGTGGTCGTATG
ACGGTTTTCTCGGCTCGGATCTGTACGGCTCGACGCTCGGCGTGATCGGCATGGGCCGCATCGGCCAGGCGCTGGCGCGC
CGCGCGCGCGGCTTCAATATGAATGTGATCTACCACAACCGTTCGCGCGTCGCGCCGGGCATCGAAGCCGAGCTGAACGC
GACGTATGTATCGAAGGAAGACTTGCTGCGCCGCGCCGATCATGTCGTGCTCGTGCTGCCGTACACGGCTGAAAGCCATC
ACACGATCGGCGCAGCCGAACTCGCCCTGATGAAGCCGACGGCCACGCTCACGAACATCGCGCGCGGCGGCATCGTCGAC
GACGCGGCGCTCGCCGTAGCACTGCGCGAAAAGCGCATCGCGGCTGCGGGCCTCGATGTGTTCGAGGGCGAGCCGAAGCT
CAATCCGGCGTTGCTGAGCGTGCCGAACGTGGTACTGACGCCGCACATCGCGAGCGCAACGGAAGCGACGCGCCGGGCGA
TGGCGAACCTCGCAGCCGACAATCTGATCGCCGCGCTGGGCGAAGGGCCGCGGGCAGGGCGTCCGCTGAATCCGATCAAC
CCCGATGTGAGCGGGAAGGCGCGTTCATGA

Upstream 100 bases:

>100_bases
CGTGCTGATACCGTTGTTCATCGCGACGTCGTTGATTTTCTTCTAATGCTGCGTGCGCGCCGAACGGCGTGCGCAGACGC
CTGATACTCGGAGAACGGCA

Downstream 100 bases:

>100_bases
CGTTGGTTTTGATTGCGGCCATCGCCGTACTGGCCGTCGCGCTCGTCATTGCGCTCGCGTTGTTGCTGCGCGGCGCGAAC
GCCGAGCAACAGCATGTCTA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKILVARPIFPDVIERLKQYFDVEWNDGDVLPTDELKRRLADKDGALTAGDVIDASVLAVAPRLRVVSNMAVGYNNFDM
AAFNASNVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGKWDKWSYDGFLGSDLYGSTLGVIGMGRIGQALAR
RARGFNMNVIYHNRSRVAPGIEAELNATYVSKEDLLRRADHVVLVLPYTAESHHTIGAAELALMKPTATLTNIARGGIVD
DAALAVALREKRIAAAGLDVFEGEPKLNPALLSVPNVVLTPHIASATEATRRAMANLAADNLIAALGEGPRAGRPLNPIN
PDVSGKARS

Sequences:

>Translated_329_residues
MQKILVARPIFPDVIERLKQYFDVEWNDGDVLPTDELKRRLADKDGALTAGDVIDASVLAVAPRLRVVSNMAVGYNNFDM
AAFNASNVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGKWDKWSYDGFLGSDLYGSTLGVIGMGRIGQALAR
RARGFNMNVIYHNRSRVAPGIEAELNATYVSKEDLLRRADHVVLVLPYTAESHHTIGAAELALMKPTATLTNIARGGIVD
DAALAVALREKRIAAAGLDVFEGEPKLNPALLSVPNVVLTPHIASATEATRRAMANLAADNLIAALGEGPRAGRPLNPIN
PDVSGKARS
>Mature_329_residues
MQKILVARPIFPDVIERLKQYFDVEWNDGDVLPTDELKRRLADKDGALTAGDVIDASVLAVAPRLRVVSNMAVGYNNFDM
AAFNASNVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGKWDKWSYDGFLGSDLYGSTLGVIGMGRIGQALAR
RARGFNMNVIYHNRSRVAPGIEAELNATYVSKEDLLRRADHVVLVLPYTAESHHTIGAAELALMKPTATLTNIARGGIVD
DAALAVALREKRIAAAGLDVFEGEPKLNPALLSVPNVVLTPHIASATEATRRAMANLAADNLIAALGEGPRAGRPLNPIN
PDVSGKARS

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=312, Percent_Identity=34.9358974358974, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI23308577, Length=302, Percent_Identity=29.4701986754967, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI4557497, Length=243, Percent_Identity=34.5679012345679, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI61743967, Length=246, Percent_Identity=34.1463414634146, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=34.9397590361446, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=34.9397590361446, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=34.9397590361446, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=40.3076923076923, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1789279, Length=313, Percent_Identity=29.7124600638978, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=27.7777777777778, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=30.8196721311475, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=28.7937743190661, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=34.1463414634146, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=310, Percent_Identity=27.741935483871, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=337, Percent_Identity=27.893175074184, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=29.7142857142857, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=169, Percent_Identity=30.1775147928994, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45552429, Length=320, Percent_Identity=37.5, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI28574284, Length=320, Percent_Identity=37.5, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45551003, Length=320, Percent_Identity=37.5, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24585514, Length=320, Percent_Identity=37.5, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574282, Length=320, Percent_Identity=37.5, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28571528, Length=310, Percent_Identity=37.4193548387097, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28574286, Length=268, Percent_Identity=39.9253731343284, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24585516, Length=319, Percent_Identity=31.974921630094, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19921140, Length=319, Percent_Identity=31.3479623824451, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646446, Length=249, Percent_Identity=34.5381526104418, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646448, Length=249, Percent_Identity=34.5381526104418, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646452, Length=249, Percent_Identity=34.5381526104418, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646450, Length=249, Percent_Identity=34.5381526104418, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI62472511, Length=249, Percent_Identity=34.5381526104418, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35443; Mature: 35443

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVARPIFPDVIERLKQYFDVEWNDGDVLPTDELKRRLADKDGALTAGDVIDASVLA
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEECHHHHHHHHH
VAPRLRVVSNMAVGYNNFDMAAFNASNVLGTNTPDVLNESTADFGWALMMAAARRIAESE
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
HWLRAGKWDKWSYDGFLGSDLYGSTLGVIGMGRIGQALARRARGFNMNVIYHNRSRVAPG
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCC
IEAELNATYVSKEDLLRRADHVVLVLPYTAESHHTIGAAELALMKPTATLTNIARGGIVD
CCCCCCEEEECHHHHHHHCCCEEEEEECCCCCCCCCCHHHHEEECCCHHHHHHHCCCCCC
DAALAVALREKRIAAAGLDVFEGEPKLNPALLSVPNVVLTPHIASATEATRRAMANLAAD
HHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHEECCCEEECCCCHHHHHHHHHHHHHHHHH
NLIAALGEGPRAGRPLNPINPDVSGKARS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKILVARPIFPDVIERLKQYFDVEWNDGDVLPTDELKRRLADKDGALTAGDVIDASVLA
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEECHHHHHHHHH
VAPRLRVVSNMAVGYNNFDMAAFNASNVLGTNTPDVLNESTADFGWALMMAAARRIAESE
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
HWLRAGKWDKWSYDGFLGSDLYGSTLGVIGMGRIGQALARRARGFNMNVIYHNRSRVAPG
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCC
IEAELNATYVSKEDLLRRADHVVLVLPYTAESHHTIGAAELALMKPTATLTNIARGGIVD
CCCCCCEEEECHHHHHHHCCCEEEEEECCCCCCCCCCHHHHEEECCCHHHHHHHCCCCCC
DAALAVALREKRIAAAGLDVFEGEPKLNPALLSVPNVVLTPHIASATEATRRAMANLAAD
HHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHEECCCEEECCCCHHHHHHHHHHHHHHHHH
NLIAALGEGPRAGRPLNPINPDVSGKARS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA