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The map label for this gene is yhfN [H]

Identifier: 186475542

GI number: 186475542

Start: 871899

End: 873158

Strand: Reverse

Name: yhfN [H]

Synonym: Bphy_0777

Alternate gene names: 186475542

Gene position: 873158-871899 (Counterclockwise)

Preceding gene: 186475544

Following gene: 186475541

Centisome position: 25.1

GC content: 64.44

Gene sequence:

>1260_bases
ATGCCTACTCTGTACTTCACCGTTCTGTTCGTGCTCGCCGTAGTGGCGATGGTCGTCACGAAGCTGTGGCTCGCGTCGCG
GCAAATCCGCTTCGTGGCAGCGCACCGCGAGAGCGTGCCGCAGCAGTTCACGGGCACGATCGCCCTCACGGCGCATCAGC
GCGCCGCCGACTACACCATCGAGCGCACGCGCCTCACCATGGCCGAAATCGTCGTGGGTGCGGCCGTGCTGATCGGGCTG
ACGCTGCTCGGCGGCGTGCAGGCGCTCGCGCTCGCCGTCGGCGACTGGCTCGGGCACGGCTATATCGGTCAGATCGCCCT
GGTGGCGGCTGTCATCGCGATCACGAGCGCGATCGAACTGCCCTTCGACTATTACCGTCAGTTCGTGGTCGAGCAGCGCT
TCGGCTTCAACCGGATGACGAAGCGCATCTTTGTCGTCGACCGCATCAAGGGCGTGCTGCTCGGTGCCGCGTTCGGGCTG
CCGCTACTCTTCGTCGTGCTGTGGCTGATGAATCAGGCGGGCACGTACTGGTGGTGGTGGACGTGGGTCGTCTGGGTCGT
GTTCCAGATGCTCGTGCTGATCTTGTACCCCACCTTCATCGCGCCGATGTTCAACAAGTTCGAGCCGCTGAAAGACGAGG
CGCTCGTGCAGCGTATCGACGCGCTGATGACGCGCTGCGGCTTCGCCGCCAAGGGTCTGTTCGTGATGGACGGCAGCCGC
CGCTCCGCGCATGGCAACGCGTATTTCACGGGCTTCGGGTCGTCAAAGCGGATCGTGTTCTTCGACACGCTGCTCTCGCG
TCTGTCGGGCAGCGAGATCGAAGCGGTGCTCGCGCACGAACTCGGCCACTTCAAGCGCCGCCATGTGATCAAGCGGATGA
TCGTCACCTTCCTGATCAGCCTCGCGATGCTCGCGCTGCTCGGCTGGCTCACGCAGCGCACATGGTTCTTCGAGGGTCTC
GGGGTGCGTCCGTCGATGACGGGCAGCAACGACGGCCTCGCGCTCGTGCTGTTCTTCCTCGCCGTACCCGTGTTCCTGTT
CTTCGTGACGCCGCTCGGCAGCCTCGCCTCGCGCAAGCACGAGTTCGAAGCCGACGCGTTCGCCGCGACGCAGACCGATG
CGAAGGATCTCGTCAACGCACTCGTCAAGCTGTATGAAGACAACGCATCGACGCTCACGCCCGACCCCATCTATACCGCG
TTCTACTATTCGCACCCGCCCGCCTCGCAGCGGATCGACCGGCTGCTGCGCCACGCATGA

Upstream 100 bases:

>100_bases
AATGTCAGTCATTGAAGGCAACCCTGATTTGGATGGCGCGCTCCCGCCCGCAAGCGGGAACAAACATATAATTCTCGCAT
AGAACCCACGGATTCCCCGG

Downstream 100 bases:

>100_bases
GCGGCCGTTCCCCGAAAGCGCTGCGCGCGGCGACTGCCAACGACCGCGCGCAGGATCGCGTGCGCGGCCTCGTGATCGCC
GCGCATGGCCGTCATTACAT

Product: Ste24 endopeptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPTLYFTVLFVLAVVAMVVTKLWLASRQIRFVAAHRESVPQQFTGTIALTAHQRAADYTIERTRLTMAEIVVGAAVLIGL
TLLGGVQALALAVGDWLGHGYIGQIALVAAVIAITSAIELPFDYYRQFVVEQRFGFNRMTKRIFVVDRIKGVLLGAAFGL
PLLFVVLWLMNQAGTYWWWWTWVVWVVFQMLVLILYPTFIAPMFNKFEPLKDEALVQRIDALMTRCGFAAKGLFVMDGSR
RSAHGNAYFTGFGSSKRIVFFDTLLSRLSGSEIEAVLAHELGHFKRRHVIKRMIVTFLISLAMLALLGWLTQRTWFFEGL
GVRPSMTGSNDGLALVLFFLAVPVFLFFVTPLGSLASRKHEFEADAFAATQTDAKDLVNALVKLYEDNASTLTPDPIYTA
FYYSHPPASQRIDRLLRHA

Sequences:

>Translated_419_residues
MPTLYFTVLFVLAVVAMVVTKLWLASRQIRFVAAHRESVPQQFTGTIALTAHQRAADYTIERTRLTMAEIVVGAAVLIGL
TLLGGVQALALAVGDWLGHGYIGQIALVAAVIAITSAIELPFDYYRQFVVEQRFGFNRMTKRIFVVDRIKGVLLGAAFGL
PLLFVVLWLMNQAGTYWWWWTWVVWVVFQMLVLILYPTFIAPMFNKFEPLKDEALVQRIDALMTRCGFAAKGLFVMDGSR
RSAHGNAYFTGFGSSKRIVFFDTLLSRLSGSEIEAVLAHELGHFKRRHVIKRMIVTFLISLAMLALLGWLTQRTWFFEGL
GVRPSMTGSNDGLALVLFFLAVPVFLFFVTPLGSLASRKHEFEADAFAATQTDAKDLVNALVKLYEDNASTLTPDPIYTA
FYYSHPPASQRIDRLLRHA
>Mature_418_residues
PTLYFTVLFVLAVVAMVVTKLWLASRQIRFVAAHRESVPQQFTGTIALTAHQRAADYTIERTRLTMAEIVVGAAVLIGLT
LLGGVQALALAVGDWLGHGYIGQIALVAAVIAITSAIELPFDYYRQFVVEQRFGFNRMTKRIFVVDRIKGVLLGAAFGLP
LLFVVLWLMNQAGTYWWWWTWVVWVVFQMLVLILYPTFIAPMFNKFEPLKDEALVQRIDALMTRCGFAAKGLFVMDGSRR
SAHGNAYFTGFGSSKRIVFFDTLLSRLSGSEIEAVLAHELGHFKRRHVIKRMIVTFLISLAMLALLGWLTQRTWFFEGLG
VRPSMTGSNDGLALVLFFLAVPVFLFFVTPLGSLASRKHEFEADAFAATQTDAKDLVNALVKLYEDNASTLTPDPIYTAF
YYSHPPASQRIDRLLRHA

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=443, Percent_Identity=28.8939051918736, Blast_Score=181, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17505484, Length=427, Percent_Identity=29.9765807962529, Blast_Score=184, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6322577, Length=307, Percent_Identity=39.0879478827362, Blast_Score=223, Evalue=4e-59,
Organism=Drosophila melanogaster, GI19922414, Length=437, Percent_Identity=31.1212814645309, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI78707252, Length=411, Percent_Identity=24.8175182481752, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI78707254, Length=411, Percent_Identity=24.8175182481752, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24654305, Length=445, Percent_Identity=25.1685393258427, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 47031; Mature: 46900

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PTLYFTVLFVLAVVAMVVTKLWLASRQIRFVAAHRESVPQQFTGTIALTAHQRAADYTI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEECHHHHCCHH
ERTRLTMAEIVVGAAVLIGLTLLGGVQALALAVGDWLGHGYIGQIALVAAVIAITSAIEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
PFDYYRQFVVEQRFGFNRMTKRIFVVDRIKGVLLGAAFGLPLLFVVLWLMNQAGTYWWWW
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TWVVWVVFQMLVLILYPTFIAPMFNKFEPLKDEALVQRIDALMTRCGFAAKGLFVMDGSR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHCCEEEECCCC
RSAHGNAYFTGFGSSKRIVFFDTLLSRLSGSEIEAVLAHELGHFKRRHVIKRMIVTFLIS
CCCCCCEEEEECCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMLALLGWLTQRTWFFEGLGVRPSMTGSNDGLALVLFFLAVPVFLFFVTPLGSLASRKH
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFEADAFAATQTDAKDLVNALVKLYEDNASTLTPDPIYTAFYYSHPPASQRIDRLLRHA
CCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]