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The map label for this gene is czcD [H]

Identifier: 186475489

GI number: 186475489

Start: 816337

End: 817458

Strand: Direct

Name: czcD [H]

Synonym: Bphy_0724

Alternate gene names: 186475489

Gene position: 816337-817458 (Clockwise)

Preceding gene: 186475488

Following gene: 186475490

Centisome position: 23.46

GC content: 66.76

Gene sequence:

>1122_bases
ATGAAATACACCGCTCATCAGACGGACAGCGCCTCCGTGACGCATCAACCGAAGGCGCACGTGCACACCGATGCTTGCGA
CCACGCGGGTCACGACGACGCAGACCACGCGCATTCGCATGGCGACGGCCACACGCACGACCAGGCTCACGACCACGCTG
ACGCAAGCGGCGGCAAGGACGCGCATGCGCATCACGGGCACGGGCATGGTCACGGGCATCACCATCATCACCACGTGCCT
GCCGCCGGACACGGCCGCGCGTTTGCGATCGCCGTCGCACTGAACGTGGCGATCGTCGTCGTGCAGGGCATGTATGGCGT
GCTGGCCAATTCGACGGCGCTGCTCGCGGATGCCGGCCACAATCTCTCCGACGTGCTCGGCCTGCTGCTCGCGTGGGGCG
CAACGTGGCTCGCGACGCGCCGGCCATCCGCGCGCTACACGTTCGGACTCGGCGGCTCGTCGATTCTCGCGAGCCTGCTC
AATGCGGGGCTGCTGCTGTTCGCGTGTGGCGTGATCGTCGCGGAAGCGGTGGGGCGACTGATTCATCCTTCGCCAGTCGC
GGGATTCGACGTGTTCATCGTCGCCTGCGTGGGCATGGTGGTGAACGGCGTGTCGGCGTGGCTCTTCATGCGCGGCCAGG
GTGACGACCTGAACATCCGCGGCGCATTCCTGCATATGCTCGCCGACGCCGCCGTATCGGCCGCCGTCGCCGTCAGCGGC
CTCGCCATCGTGTTCACCGGCTGGACGTGGCTCGATCCCGTCATGAGCCTCGTCGTCGTCGCGGTGATCGTCTACGGCAC
GTGGGGTCTGTTGCGCGATTCTCTGAGCCTCGCATTGAACGGCGTGCCGCGCGGCGTCGACATGCAGAAGATTCGCGCCT
ACCTCGCCGCGCAGCCGGGCGTCACTGACGTGCACGACCTGCACGTCTGGGCGCTGTCGACTACGGGCAACGCGCTGTCC
GCGCATCTCGTGATTCCCGGCGGCCACCCTGGCGACCGCGTGATCGACGCAATCGTGGGCACGCTGCGCACCGAATTCGA
CATGCATCACGCGACGCTGCAGGTCGATATGGGCACGACGCAGCATCGCTGTTCGCTTGATCACACGCCGCACGTGCATT
GA

Upstream 100 bases:

>100_bases
TCGCCGCCGACGGACACATCAGCGGCATGCTGACCGACATGCTCGAACACGTCGATGAACCTGTCAGCGACGCTTCCGCC
GAATTCACGCAGGATCACGC

Downstream 100 bases:

>100_bases
AGTCGGCCGATCTTCCGATGACGCGTTGATGCGCTGCGTCGTCGGCCGCGCGGCAGCGACGCAAATGCTCGGCGTACACT
AGCGGACATGTCCGACTGCG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKYTAHQTDSASVTHQPKAHVHTDACDHAGHDDADHAHSHGDGHTHDQAHDHADASGGKDAHAHHGHGHGHGHHHHHHVP
AAGHGRAFAIAVALNVAIVVVQGMYGVLANSTALLADAGHNLSDVLGLLLAWGATWLATRRPSARYTFGLGGSSILASLL
NAGLLLFACGVIVAEAVGRLIHPSPVAGFDVFIVACVGMVVNGVSAWLFMRGQGDDLNIRGAFLHMLADAAVSAAVAVSG
LAIVFTGWTWLDPVMSLVVVAVIVYGTWGLLRDSLSLALNGVPRGVDMQKIRAYLAAQPGVTDVHDLHVWALSTTGNALS
AHLVIPGGHPGDRVIDAIVGTLRTEFDMHHATLQVDMGTTQHRCSLDHTPHVH

Sequences:

>Translated_373_residues
MKYTAHQTDSASVTHQPKAHVHTDACDHAGHDDADHAHSHGDGHTHDQAHDHADASGGKDAHAHHGHGHGHGHHHHHHVP
AAGHGRAFAIAVALNVAIVVVQGMYGVLANSTALLADAGHNLSDVLGLLLAWGATWLATRRPSARYTFGLGGSSILASLL
NAGLLLFACGVIVAEAVGRLIHPSPVAGFDVFIVACVGMVVNGVSAWLFMRGQGDDLNIRGAFLHMLADAAVSAAVAVSG
LAIVFTGWTWLDPVMSLVVVAVIVYGTWGLLRDSLSLALNGVPRGVDMQKIRAYLAAQPGVTDVHDLHVWALSTTGNALS
AHLVIPGGHPGDRVIDAIVGTLRTEFDMHHATLQVDMGTTQHRCSLDHTPHVH
>Mature_373_residues
MKYTAHQTDSASVTHQPKAHVHTDACDHAGHDDADHAHSHGDGHTHDQAHDHADASGGKDAHAHHGHGHGHGHHHHHHVP
AAGHGRAFAIAVALNVAIVVVQGMYGVLANSTALLADAGHNLSDVLGLLLAWGATWLATRRPSARYTFGLGGSSILASLL
NAGLLLFACGVIVAEAVGRLIHPSPVAGFDVFIVACVGMVVNGVSAWLFMRGQGDDLNIRGAFLHMLADAAVSAAVAVSG
LAIVFTGWTWLDPVMSLVVVAVIVYGTWGLLRDSLSLALNGVPRGVDMQKIRAYLAAQPGVTDVHDLHVWALSTTGNALS
AHLVIPGGHPGDRVIDAIVGTLRTEFDMHHATLQVDMGTTQHRCSLDHTPHVH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=322, Percent_Identity=25.4658385093168, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI21359890, Length=311, Percent_Identity=27.0096463022508, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI64762489, Length=281, Percent_Identity=29.1814946619217, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI289803013, Length=264, Percent_Identity=29.9242424242424, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI289803009, Length=264, Percent_Identity=29.9242424242424, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI289803007, Length=264, Percent_Identity=29.9242424242424, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI289803003, Length=264, Percent_Identity=29.9242424242424, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI21361112, Length=318, Percent_Identity=27.0440251572327, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=26.3888888888889, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI52351208, Length=158, Percent_Identity=27.8481012658228, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786966, Length=280, Percent_Identity=33.2142857142857, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193210990, Length=320, Percent_Identity=29.0625, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17555794, Length=331, Percent_Identity=26.8882175226586, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17555796, Length=283, Percent_Identity=27.5618374558304, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI32564488, Length=302, Percent_Identity=26.8211920529801, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320411, Length=176, Percent_Identity=35.2272727272727, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=120, Percent_Identity=34.1666666666667, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324892, Length=112, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583858, Length=329, Percent_Identity=23.1003039513678, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24656728, Length=328, Percent_Identity=25.3048780487805, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24656724, Length=328, Percent_Identity=25.3048780487805, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24656720, Length=328, Percent_Identity=25.3048780487805, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24656715, Length=328, Percent_Identity=25.3048780487805, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21357035, Length=328, Percent_Identity=25.3048780487805, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28574430, Length=153, Percent_Identity=27.4509803921569, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24584409, Length=156, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24585900, Length=149, Percent_Identity=27.5167785234899, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585898, Length=149, Percent_Identity=27.5167785234899, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585896, Length=149, Percent_Identity=27.5167785234899, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921672, Length=149, Percent_Identity=27.5167785234899, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24645863, Length=109, Percent_Identity=32.1100917431193, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 39155; Mature: 39155

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTAHQTDSASVTHQPKAHVHTDACDHAGHDDADHAHSHGDGHTHDQAHDHADASGGKD
CCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCC
AHAHHGHGHGHGHHHHHHVPAAGHGRAFAIAVALNVAIVVVQGMYGVLANSTALLADAGH
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
NLSDVLGLLLAWGATWLATRRPSARYTFGLGGSSILASLLNAGLLLFACGVIVAEAVGRL
CHHHHHHHHHHHCHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHPSPVAGFDVFIVACVGMVVNGVSAWLFMRGQGDDLNIRGAFLHMLADAAVSAAVAVSG
CCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHC
LAIVFTGWTWLDPVMSLVVVAVIVYGTWGLLRDSLSLALNGVPRGVDMQKIRAYLAAQPG
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCC
VTDVHDLHVWALSTTGNALSAHLVIPGGHPGDRVIDAIVGTLRTEFDMHHATLQVDMGTT
CCCCEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
QHRCSLDHTPHVH
CCCCCCCCCCCCC
>Mature Secondary Structure
MKYTAHQTDSASVTHQPKAHVHTDACDHAGHDDADHAHSHGDGHTHDQAHDHADASGGKD
CCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCC
AHAHHGHGHGHGHHHHHHVPAAGHGRAFAIAVALNVAIVVVQGMYGVLANSTALLADAGH
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
NLSDVLGLLLAWGATWLATRRPSARYTFGLGGSSILASLLNAGLLLFACGVIVAEAVGRL
CHHHHHHHHHHHCHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHPSPVAGFDVFIVACVGMVVNGVSAWLFMRGQGDDLNIRGAFLHMLADAAVSAAVAVSG
CCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHC
LAIVFTGWTWLDPVMSLVVVAVIVYGTWGLLRDSLSLALNGVPRGVDMQKIRAYLAAQPG
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCC
VTDVHDLHVWALSTTGNALSAHLVIPGGHPGDRVIDAIVGTLRTEFDMHHATLQVDMGTT
CCCCEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
QHRCSLDHTPHVH
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]