Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 186475465

GI number: 186475465

Start: 787523

End: 788704

Strand: Direct

Name: fabF [H]

Synonym: Bphy_0700

Alternate gene names: 186475465

Gene position: 787523-788704 (Clockwise)

Preceding gene: 186475464

Following gene: 186475466

Centisome position: 22.64

GC content: 66.67

Gene sequence:

>1182_bases
ATGACCTTGCCACCCGTTTATCTGCATGCGCTCGGCATGGTCAACGCGCTCGGCGGCGACGTCGCTTCGATCGTGGCCGC
GCTCGGCGCCGCGCAATCGCCCGGCATGGGACTGATACATACGGGCATCGGCGATGCTTACGTGGGCCGCGTGGCGACGC
CGCTCGACATTGCGCCGCCCGCTGCGCTCAAGCGCTTCGATTGCCGCAACAACCGCATGCTGCTCGCTGCGCTCGAACAG
ATTCGCCCGGAACTCGAGGCCGCGCGCGAGCGTTATGGTTCGCACCGCATCGGCATCGTGCTCGGTACCAGCACCTCGGG
CATCGATGCGGCGGAAGTCGCGTTCGTGCATCAGGCGCAGGCAGGCCAGCTGCCGGAGAACTTCAACTACCGGCAGATGG
AAATCGGCACGGCCGCGCCGTTCGCGGCCGCCGCGCTGAATGTGCAGGGGCCGGCGTTCACAGTGTCGACGGCCTGCACG
TCGAGCGCTAAAGCCTTCGTGTCGGCGCGCCGTTTACTGCAGCTTGGACTGTGCGACGCGATGATCGTCGGCGGTGTGGA
TACGTTGTGCGAGCTGACGGTGCAGGGCTTCGCGTCGCTCGAATCGACGAGCGTCACGCGCACCAATCCGATGAGCCGCA
ATCGCAACGGCATCAATGTCGGCGAAGGCGCCGCCGTGTTCCTGATGACCCGCGAAGAAGGCGTGGTGCGGCTGGCGGGC
GCGGGCGAATCGAGCGACGCGCATCATGTGTCGGCGCCGGACCCGCAAGGCGTCGGCGGGGAGCTGGCGTTGCGCGAGGC
GCTCAAGGATGCGGGCGTCGAACCGTCGGCGATGGCGTATGTGAATCTGCATGCAACGGCCACGCGCAAGAACGACCACA
TGGAAGCGCATCTGATGTCGCGCGTGTTCGCGGACGGCGTGCCCGTCAGCGGCACCAAACCGCTCACGGGGCATCAGCTC
GGTGCGGCGGGCGCGACGGAATTGGGCTTCGCGTGGCTCACGCTCGCACGCGACGACATGGCGATACCGCGTCATCAGTG
GGATGGCGAGGCGGACCCGGCGTTGCCCGTGCTCGATCTCGTGCAGGACGAGCGGCGTATTCCACGCGGCGGCACGCAAT
ACGTAATGAGCAATTCGTTCGCGTTCGGCGGCAGCAACGTCAGCCTGATACTGGCGCGTTGA

Upstream 100 bases:

>100_bases
TGCCCGCCTTGAAGAGTTTCGGCGCCACACTGGCGCTCGGCATTCTCGTGTCGGTGTTGCTTGCACCGATCGGCATGCCG
CCTGGAAGAAGGAGAGTTGC

Downstream 100 bases:

>100_bases
CGCGCTCGAACGACGACGCAACAAACATAACGACATGAAGGCCACACCTGAGACCAGCGAAGGTTTTCCGCCCATCGAGA
CGATCCTGCCGCATCGCGGC

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTLPPVYLHALGMVNALGGDVASIVAALGAAQSPGMGLIHTGIGDAYVGRVATPLDIAPPAALKRFDCRNNRMLLAALEQ
IRPELEAARERYGSHRIGIVLGTSTSGIDAAEVAFVHQAQAGQLPENFNYRQMEIGTAAPFAAAALNVQGPAFTVSTACT
SSAKAFVSARRLLQLGLCDAMIVGGVDTLCELTVQGFASLESTSVTRTNPMSRNRNGINVGEGAAVFLMTREEGVVRLAG
AGESSDAHHVSAPDPQGVGGELALREALKDAGVEPSAMAYVNLHATATRKNDHMEAHLMSRVFADGVPVSGTKPLTGHQL
GAAGATELGFAWLTLARDDMAIPRHQWDGEADPALPVLDLVQDERRIPRGGTQYVMSNSFAFGGSNVSLILAR

Sequences:

>Translated_393_residues
MTLPPVYLHALGMVNALGGDVASIVAALGAAQSPGMGLIHTGIGDAYVGRVATPLDIAPPAALKRFDCRNNRMLLAALEQ
IRPELEAARERYGSHRIGIVLGTSTSGIDAAEVAFVHQAQAGQLPENFNYRQMEIGTAAPFAAAALNVQGPAFTVSTACT
SSAKAFVSARRLLQLGLCDAMIVGGVDTLCELTVQGFASLESTSVTRTNPMSRNRNGINVGEGAAVFLMTREEGVVRLAG
AGESSDAHHVSAPDPQGVGGELALREALKDAGVEPSAMAYVNLHATATRKNDHMEAHLMSRVFADGVPVSGTKPLTGHQL
GAAGATELGFAWLTLARDDMAIPRHQWDGEADPALPVLDLVQDERRIPRGGTQYVMSNSFAFGGSNVSLILAR
>Mature_392_residues
TLPPVYLHALGMVNALGGDVASIVAALGAAQSPGMGLIHTGIGDAYVGRVATPLDIAPPAALKRFDCRNNRMLLAALEQI
RPELEAARERYGSHRIGIVLGTSTSGIDAAEVAFVHQAQAGQLPENFNYRQMEIGTAAPFAAAALNVQGPAFTVSTACTS
SAKAFVSARRLLQLGLCDAMIVGGVDTLCELTVQGFASLESTSVTRTNPMSRNRNGINVGEGAAVFLMTREEGVVRLAGA
GESSDAHHVSAPDPQGVGGELALREALKDAGVEPSAMAYVNLHATATRKNDHMEAHLMSRVFADGVPVSGTKPLTGHQLG
AAGATELGFAWLTLARDDMAIPRHQWDGEADPALPVLDLVQDERRIPRGGTQYVMSNSFAFGGSNVSLILAR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=300, Percent_Identity=32.3333333333333, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI223972627, Length=151, Percent_Identity=37.0860927152318, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI41872631, Length=265, Percent_Identity=30.188679245283, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1787337, Length=264, Percent_Identity=35.9848484848485, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788663, Length=274, Percent_Identity=29.5620437956204, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71983541, Length=271, Percent_Identity=28.4132841328413, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=28.6259541984733, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=269, Percent_Identity=28.6245353159851, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=280, Percent_Identity=31.7857142857143, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644341, Length=266, Percent_Identity=33.8345864661654, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24581345, Length=268, Percent_Identity=27.2388059701493, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 41126; Mature: 40995

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPPVYLHALGMVNALGGDVASIVAALGAAQSPGMGLIHTGIGDAYVGRVATPLDIAPP
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCH
AALKRFDCRNNRMLLAALEQIRPELEAARERYGSHRIGIVLGTSTSGIDAAEVAFVHQAQ
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHH
AGQLPENFNYRQMEIGTAAPFAAAALNVQGPAFTVSTACTSSAKAFVSARRLLQLGLCDA
CCCCCCCCCEEEEECCCCCCHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
MIVGGVDTLCELTVQGFASLESTSVTRTNPMSRNRNGINVGEGAAVFLMTREEGVVRLAG
HHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEC
AGESSDAHHVSAPDPQGVGGELALREALKDAGVEPSAMAYVNLHATATRKNDHMEAHLMS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCHHHHHHHH
RVFADGVPVSGTKPLTGHQLGAAGATELGFAWLTLARDDMAIPRHQWDGEADPALPVLDL
HHHHCCCCCCCCCCCCCCCCCCCCCHHHCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
VQDERRIPRGGTQYVMSNSFAFGGSNVSLILAR
HHHHHCCCCCCCEEEEECCEEECCCCEEEEEEC
>Mature Secondary Structure 
TLPPVYLHALGMVNALGGDVASIVAALGAAQSPGMGLIHTGIGDAYVGRVATPLDIAPP
CCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCH
AALKRFDCRNNRMLLAALEQIRPELEAARERYGSHRIGIVLGTSTSGIDAAEVAFVHQAQ
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHH
AGQLPENFNYRQMEIGTAAPFAAAALNVQGPAFTVSTACTSSAKAFVSARRLLQLGLCDA
CCCCCCCCCEEEEECCCCCCHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
MIVGGVDTLCELTVQGFASLESTSVTRTNPMSRNRNGINVGEGAAVFLMTREEGVVRLAG
HHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEC
AGESSDAHHVSAPDPQGVGGELALREALKDAGVEPSAMAYVNLHATATRKNDHMEAHLMS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCHHHHHHHH
RVFADGVPVSGTKPLTGHQLGAAGATELGFAWLTLARDDMAIPRHQWDGEADPALPVLDL
HHHHCCCCCCCCCCCCCCCCCCCCCHHHCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
VQDERRIPRGGTQYVMSNSFAFGGSNVSLILAR
HHHHHCCCCCCCEEEEECCEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]