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The map label for this gene is icd [H]

Identifier: 186475333

GI number: 186475333

Start: 639716

End: 640972

Strand: Direct

Name: icd [H]

Synonym: Bphy_0565

Alternate gene names: 186475333

Gene position: 639716-640972 (Clockwise)

Preceding gene: 186475331

Following gene: 186475335

Centisome position: 18.39

GC content: 59.43

Gene sequence:

>1257_bases
ATGGCGTATCAGCACATCACGGTTCCCGCTGACGGTGACAAGATCACTGTCAACGCGGATTTCTCGCTCAACGTTTCCGA
TCAGCCGATCATTCCTTACATCGAAGGTGACGGTACGGGTGTCGACATCACGCCTGTGATGATCAAGGTTGTCGATGCAG
CCGTTGAGAAGGCATACGGCGGCAAGAAGAAAATCCACTGGATGGAAATCTTCGCGGGCGAGAAGGCGACCCGGGTGTAC
GGTCCCGACGTGTGGTTGCCGGATGAGACGCTGGAAGTCGTGAAGGAATACATCGTGTCGATCAAGGGGCCGCTCACGAC
GCCAGTCGGCGGCGGCATCCGCTCGCTGAACGTCACGCTGCGCCAGGAGCTGGACCTTTACGTGTGCCTGCGTCCCGTGC
AGTATTTCAAGGGCGTGCCGTCGCCGCTGCGCGAGCCGGAGAAGGTCAACATGGTGATCTTCCGTGAGAACTCGGAAGAC
ATCTACGCCGGCATTGAATGGCCGGCGGGTTCACCTGAAGCGAAGAAGGTCATCCAGTTCCTGCGCGACGAAATGGGCGT
GAAGAAGATCCGCTTTCCGGACTCGTCGGGTATCGGCGTGAAGCCGGTGTCGCGCGAAGGCACGGAGCGTCTGGTGCGCA
AGGCGATTCAGTACGCGCTCGACAACGATCGACGCACGGTCACGCTTGTGCACAAGGGCAACATCATGAAGTACACGGAA
GGCGCGTTCCGTGACTACGGTTATGCACTCGCGCAGAAGGAGTTCAACGCGGAGCTGATCGACGGCGGTCCGTGGATGAA
GGTGAAGAATCCGAAGACGGGCAACGACGTCGTCGTGAAGGACGTGATCGCCGATGCGTTCCTGCAGCAGATCCTGTTGC
GTCCCGCCGAATACGATGTGATCGCGACGCTGAACCTGAACGGCGACTACATATCCGACGCACTCGCTGCGCAGGTCGGC
GGCATCGGCATCGCGCCGGGCGCGAACATGTCGGACTCCGTTGCGATGTTCGAAGCAACGCACGGTACCGCACCGAAGTA
CGCAGGCAAGGATTATGTGAATCCGGGTTCGGAGATCCTCTCGGCGGAAATGATGCTGCGGCACCTCGGCTGGACGGATG
CAGCCGATAGGATTCTGGCCTCGATGGAAAAGTCGATCCTGTCGAAGCGCGTCACGTACGACTTCGCACGTCTGATGGAA
GGCGCAACACAGGTGTCGTGCTCGGGCTTCGGGCAGGTGATGATCGAGAATATGTGA

Upstream 100 bases:

>100_bases
GCATTTGCATCGGCGTGGCGCTGCGTCGCGCGCAAGAGAAGCGCCCCGGTTTCGCATTTCCAACCTGTTCTCACGGTACA
GCTATCACTGGAGTCCGATC

Downstream 100 bases:

>100_bases
GCGCGCGTTTCGAGGTCCTTGTATCGTGACGAAACCCCCGGCGAGTGCGAACCTGTCGGGGTTTCATTTTTGAGCTTCCC
GTCATCGATGCAGCAGCCTG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MAYQHITVPADGDKITVNADFSLNVSDQPIIPYIEGDGTGVDITPVMIKVVDAAVEKAYGGKKKIHWMEIFAGEKATRVY
GPDVWLPDETLEVVKEYIVSIKGPLTTPVGGGIRSLNVTLRQELDLYVCLRPVQYFKGVPSPLREPEKVNMVIFRENSED
IYAGIEWPAGSPEAKKVIQFLRDEMGVKKIRFPDSSGIGVKPVSREGTERLVRKAIQYALDNDRRTVTLVHKGNIMKYTE
GAFRDYGYALAQKEFNAELIDGGPWMKVKNPKTGNDVVVKDVIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTDAADRILASMEKSILSKRVTYDFARLME
GATQVSCSGFGQVMIENM

Sequences:

>Translated_418_residues
MAYQHITVPADGDKITVNADFSLNVSDQPIIPYIEGDGTGVDITPVMIKVVDAAVEKAYGGKKKIHWMEIFAGEKATRVY
GPDVWLPDETLEVVKEYIVSIKGPLTTPVGGGIRSLNVTLRQELDLYVCLRPVQYFKGVPSPLREPEKVNMVIFRENSED
IYAGIEWPAGSPEAKKVIQFLRDEMGVKKIRFPDSSGIGVKPVSREGTERLVRKAIQYALDNDRRTVTLVHKGNIMKYTE
GAFRDYGYALAQKEFNAELIDGGPWMKVKNPKTGNDVVVKDVIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTDAADRILASMEKSILSKRVTYDFARLME
GATQVSCSGFGQVMIENM
>Mature_417_residues
AYQHITVPADGDKITVNADFSLNVSDQPIIPYIEGDGTGVDITPVMIKVVDAAVEKAYGGKKKIHWMEIFAGEKATRVYG
PDVWLPDETLEVVKEYIVSIKGPLTTPVGGGIRSLNVTLRQELDLYVCLRPVQYFKGVPSPLREPEKVNMVIFRENSEDI
YAGIEWPAGSPEAKKVIQFLRDEMGVKKIRFPDSSGIGVKPVSREGTERLVRKAIQYALDNDRRTVTLVHKGNIMKYTEG
AFRDYGYALAQKEFNAELIDGGPWMKVKNPKTGNDVVVKDVIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGG
IGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTDAADRILASMEKSILSKRVTYDFARLMEG
ATQVSCSGFGQVMIENM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=386, Percent_Identity=31.8652849740933, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI28178821, Length=343, Percent_Identity=28.8629737609329, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI28178816, Length=343, Percent_Identity=28.8629737609329, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4758582, Length=278, Percent_Identity=29.136690647482, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI28178838, Length=278, Percent_Identity=29.136690647482, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI28178819, Length=172, Percent_Identity=35.4651162790698, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787381, Length=413, Percent_Identity=73.365617433414, Blast_Score=641, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=370, Percent_Identity=29.7297297297297, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87081683, Length=398, Percent_Identity=24.8743718592965, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=377, Percent_Identity=30.7692307692308, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=31.1475409836066, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=312, Percent_Identity=29.4871794871795, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17550882, Length=362, Percent_Identity=25.414364640884, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324709, Length=398, Percent_Identity=29.3969849246231, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322097, Length=363, Percent_Identity=28.9256198347107, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324291, Length=372, Percent_Identity=28.7634408602151, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=24.3767313019391, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24643270, Length=354, Percent_Identity=33.6158192090396, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24643268, Length=354, Percent_Identity=33.6158192090396, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24661184, Length=391, Percent_Identity=31.2020460358056, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161078639, Length=308, Percent_Identity=27.9220779220779, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161078637, Length=305, Percent_Identity=28.1967213114754, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161078635, Length=305, Percent_Identity=28.1967213114754, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161078633, Length=305, Percent_Identity=28.1967213114754, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24650122, Length=305, Percent_Identity=28.1967213114754, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20130355, Length=296, Percent_Identity=25.3378378378378, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281362242, Length=327, Percent_Identity=27.5229357798165, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648872, Length=327, Percent_Identity=27.5229357798165, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45976; Mature: 45845

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYQHITVPADGDKITVNADFSLNVSDQPIIPYIEGDGTGVDITPVMIKVVDAAVEKAYG
CCCEEEEECCCCCEEEEEECEEECCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHCC
GKKKIHWMEIFAGEKATRVYGPDVWLPDETLEVVKEYIVSIKGPLTTPVGGGIRSLNVTL
CCCEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
RQELDLYVCLRPVQYFKGVPSPLREPEKVNMVIFRENSEDIYAGIEWPAGSPEAKKVIQF
HHCCCEEEEECHHHHHCCCCHHHCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHH
LRDEMGVKKIRFPDSSGIGVKPVSREGTERLVRKAIQYALDNDRRTVTLVHKGNIMKYTE
HHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECC
GAFRDYGYALAQKEFNAELIDGGPWMKVKNPKTGNDVVVKDVIADAFLQQILLRPAEYDV
CHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTDAADRILASMEKSILSKRVTYDFARLMEGATQVSCSGFGQVMIENM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECC
>Mature Secondary Structure 
AYQHITVPADGDKITVNADFSLNVSDQPIIPYIEGDGTGVDITPVMIKVVDAAVEKAYG
CCEEEEECCCCCEEEEEECEEECCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHCC
GKKKIHWMEIFAGEKATRVYGPDVWLPDETLEVVKEYIVSIKGPLTTPVGGGIRSLNVTL
CCCEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
RQELDLYVCLRPVQYFKGVPSPLREPEKVNMVIFRENSEDIYAGIEWPAGSPEAKKVIQF
HHCCCEEEEECHHHHHCCCCHHHCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHH
LRDEMGVKKIRFPDSSGIGVKPVSREGTERLVRKAIQYALDNDRRTVTLVHKGNIMKYTE
HHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECC
GAFRDYGYALAQKEFNAELIDGGPWMKVKNPKTGNDVVVKDVIADAFLQQILLRPAEYDV
CHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTDAADRILASMEKSILSKRVTYDFARLMEGATQVSCSGFGQVMIENM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]