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The map label for this gene is yeaE [H]

Identifier: 186475321

GI number: 186475321

Start: 625881

End: 626726

Strand: Direct

Name: yeaE [H]

Synonym: Bphy_0553

Alternate gene names: 186475321

Gene position: 625881-626726 (Clockwise)

Preceding gene: 186475319

Following gene: 186475322

Centisome position: 17.99

GC content: 65.13

Gene sequence:

>846_bases
ATGACGAACGACATCGCCAGCGTGACGCTGCCCGACGGCGAACGCATTCCGAAACTCGGGCAGGGCACGTGGGAGATGGG
CGAAAATCCGTCGCGCCGCAAGGCTGAAATCGACGCGCTGCGCGGCGGCATCGAACTCGGCATGACGCTCATCGACACAG
CCGAAATGTACGGCGAAGGCGCAACGGAATCGCTGCTCGGCGAAGCGTTGCATGGCCTGCGCGACGAGGTCTTTCTCGTC
AGCAAGGTGTATCCGCACAACGCGAGCCGGCGCGGCGTGCAGCATGCATGCGAGCAGTCGTTGAGGCGTCTGAAGACCGA
TCGCATTGATCTGTATCTGCTGCACTGGCGCGGCTCGGTGCCGCTCGAAGAGACGGTCGCGGGCTTCGAGGCGTTGCGCC
GCGACGGCAAGATCCGGCACTGGGGCGTGAGCAACTTCGACGTCGACGATATGGAAGAACTCGTCGGCGTGACGGACGGC
GATGCGTGTGCGACGAACCAGATTCTTTATAACGTCGCGCGGCGCGGCCCGGAGTTCGACCTGCTACCGTGGCTCGCGGC
CCGCAAGATGCCCGCGATGGCGTACAGCCCCGTCGATCACGCACGCCTGCCCAAGCGCTCGCCGCTCGACGATATCGCGG
GCAGGCTTGGCGTATCGGCGGTTCAGGTCGCGCTTGCATGGGTGCTGCGGCAGCCCGATGTGCTGGCCATTCCGAAGTCA
GGACGCATCGAGCACGTGCGAGACAACCGTCGCGCACTCGAACTGCCGCTTTCAGCCGACGACCTCGCCGCGATCGATGC
ACACTTTCGTGCGCCGCGCAGCAAGCGGCCGCTCGAGATGCTGTGA

Upstream 100 bases:

>100_bases
ATGCGCATCGACGTCCGGCGCTACACTCGCTGGTTGAGCCGCTGCATCGATCGTTGCCACGCAGCGTATCTTCATGCCAT
CACTAGCGAGGACCGCAACC

Downstream 100 bases:

>100_bases
GCGGCGCATGTGCCCGATGCTCCGCGGGAGCCGATCAGCCGATGATTCGCACGCGTGATGCATGTGCACCGAGCCGAGCA
CGGCGACTTCGGCGGGCGTG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTNDIASVTLPDGERIPKLGQGTWEMGENPSRRKAEIDALRGGIELGMTLIDTAEMYGEGATESLLGEALHGLRDEVFLV
SKVYPHNASRRGVQHACEQSLRRLKTDRIDLYLLHWRGSVPLEETVAGFEALRRDGKIRHWGVSNFDVDDMEELVGVTDG
DACATNQILYNVARRGPEFDLLPWLAARKMPAMAYSPVDHARLPKRSPLDDIAGRLGVSAVQVALAWVLRQPDVLAIPKS
GRIEHVRDNRRALELPLSADDLAAIDAHFRAPRSKRPLEML

Sequences:

>Translated_281_residues
MTNDIASVTLPDGERIPKLGQGTWEMGENPSRRKAEIDALRGGIELGMTLIDTAEMYGEGATESLLGEALHGLRDEVFLV
SKVYPHNASRRGVQHACEQSLRRLKTDRIDLYLLHWRGSVPLEETVAGFEALRRDGKIRHWGVSNFDVDDMEELVGVTDG
DACATNQILYNVARRGPEFDLLPWLAARKMPAMAYSPVDHARLPKRSPLDDIAGRLGVSAVQVALAWVLRQPDVLAIPKS
GRIEHVRDNRRALELPLSADDLAAIDAHFRAPRSKRPLEML
>Mature_280_residues
TNDIASVTLPDGERIPKLGQGTWEMGENPSRRKAEIDALRGGIELGMTLIDTAEMYGEGATESLLGEALHGLRDEVFLVS
KVYPHNASRRGVQHACEQSLRRLKTDRIDLYLLHWRGSVPLEETVAGFEALRRDGKIRHWGVSNFDVDDMEELVGVTDGD
ACATNQILYNVARRGPEFDLLPWLAARKMPAMAYSPVDHARLPKRSPLDDIAGRLGVSAVQVALAWVLRQPDVLAIPKSG
RIEHVRDNRRALELPLSADDLAAIDAHFRAPRSKRPLEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24497577, Length=300, Percent_Identity=25.3333333333333, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI5174391, Length=300, Percent_Identity=25.3333333333333, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310109922, Length=290, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI5453543, Length=317, Percent_Identity=27.4447949526814, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI45446745, Length=317, Percent_Identity=27.4447949526814, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4503285, Length=317, Percent_Identity=27.4447949526814, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI223468663, Length=309, Percent_Identity=25.5663430420712, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI310109920, Length=317, Percent_Identity=27.4447949526814, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI24497585, Length=307, Percent_Identity=27.0358306188925, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI24497583, Length=310, Percent_Identity=27.0967741935484, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI223718702, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4502049, Length=298, Percent_Identity=26.510067114094, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788081, Length=271, Percent_Identity=54.2435424354244, Blast_Score=300, Evalue=6e-83,
Organism=Escherichia coli, GI1786400, Length=267, Percent_Identity=28.8389513108614, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787674, Length=279, Percent_Identity=27.5985663082437, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1788070, Length=304, Percent_Identity=27.6315789473684, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI87082198, Length=266, Percent_Identity=28.1954887218045, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87081735, Length=296, Percent_Identity=25, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789199, Length=325, Percent_Identity=28.6153846153846, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI48994888, Length=276, Percent_Identity=30.7971014492754, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561298, Length=297, Percent_Identity=29.6296296296296, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552492, Length=269, Percent_Identity=28.6245353159851, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71998625, Length=284, Percent_Identity=26.056338028169, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17564128, Length=310, Percent_Identity=26.7741935483871, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17566692, Length=174, Percent_Identity=28.735632183908, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17550248, Length=304, Percent_Identity=23.0263157894737, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=27.2058823529412, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538386, Length=282, Percent_Identity=26.241134751773, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320576, Length=314, Percent_Identity=27.7070063694268, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324694, Length=304, Percent_Identity=27.6315789473684, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320079, Length=284, Percent_Identity=25.7042253521127, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644950, Length=307, Percent_Identity=26.7100977198697, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24662789, Length=297, Percent_Identity=26.9360269360269, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24657054, Length=301, Percent_Identity=25.2491694352159, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45553081, Length=296, Percent_Identity=26.0135135135135, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129731, Length=313, Percent_Identity=24.2811501597444, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31252; Mature: 31121

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDIASVTLPDGERIPKLGQGTWEMGENPSRRKAEIDALRGGIELGMTLIDTAEMYGEG
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATESLLGEALHGLRDEVFLVSKVYPHNASRRGVQHACEQSLRRLKTDRIDLYLLHWRGSV
CHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
PLEETVAGFEALRRDGKIRHWGVSNFDVDDMEELVGVTDGDACATNQILYNVARRGPEFD
CHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
LLPWLAARKMPAMAYSPVDHARLPKRSPLDDIAGRLGVSAVQVALAWVLRQPDVLAIPKS
HHHHHHHHCCCCHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GRIEHVRDNRRALELPLSADDLAAIDAHFRAPRSKRPLEML
CCCHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TNDIASVTLPDGERIPKLGQGTWEMGENPSRRKAEIDALRGGIELGMTLIDTAEMYGEG
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATESLLGEALHGLRDEVFLVSKVYPHNASRRGVQHACEQSLRRLKTDRIDLYLLHWRGSV
CHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
PLEETVAGFEALRRDGKIRHWGVSNFDVDDMEELVGVTDGDACATNQILYNVARRGPEFD
CHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
LLPWLAARKMPAMAYSPVDHARLPKRSPLDDIAGRLGVSAVQVALAWVLRQPDVLAIPKS
HHHHHHHHCCCCHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GRIEHVRDNRRALELPLSADDLAAIDAHFRAPRSKRPLEML
CCCHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]