Click here to switch to the map view.

The map label for this gene is rsbRA [H]

Identifier: 186474899

GI number: 186474899

Start: 138001

End: 138864

Strand: Direct

Name: rsbRA [H]

Synonym: Bphy_0129

Alternate gene names: 186474899

Gene position: 138001-138864 (Clockwise)

Preceding gene: 186474898

Following gene: 186474900

Centisome position: 3.97

GC content: 59.95

Gene sequence:

>864_bases
ATGAACGCATCGAAAAGCGCGGCTCTCGTCGAAGTACTGACGCGTCATCGCGATACGCTGCTGACCGAATGGTTGAATCA
GCATCTATCGATCGCGCTTCGCCGCGGCCTGACGACGGAAGCGGAAATGAACGATCAGTTCCGCAACTTCCTGAACGTGT
TCTCCGATACGCTCGCCAGATCCGATACGCTCGATGCAAGCCGTCCCGAATGGGAACCCGTGCGCGCATTTCTCACCGAC
ATGTCCACGCATCGCGCGCGCCAGGGCTTCACGCCCGTCGAGACGGCCACCTTCGTGTTCTCGCTGAAGCAGCCGTTGTA
CTCGCGTATGCGTGAAGAATTCGACAGCCAGCCGCTCGAACTCGCCGAAGTAAGCTGGACGGTCAACCTGCTGCTCGACG
CGCTCGGCCTCTTTACGACGGAAGTCTTCCAGCGCGCGCGCGAAGCGATCATCTCGCGTCAGCAGGAAGAACTGCTCGAA
CTGTCGACGCCCGTCGTGCAGTTGTGGGAAGGCATTCTCGCGCTGCCGTTGATCGGCACGCTCGACTCCGCACGCACGCA
GGTCGTGATGGAAAGTCTGCTGCAGAAGATCGTCGAAACGGGCGCCGCGATTTCGATCATCGACATCACGGGCGTTCCGA
CCGTCGACACACTGGTCGCGCAACATCTGCTCAAGACGGTTGCCGCCGCGCGTCTGATGGGGGCGGACTGCATCATTAGC
GGCATACGTCCACAGATTGCACAGACCATCGTGCATCTCGGCGTCGATCTCACGAACGTGATCACGAAGTCGACGCTCGC
CGACGCTTTCATCGTCGCGCTGCAAAAAAGCGGTTCGAGCATTTCGACTCGCATCGCGAGCTAA

Upstream 100 bases:

>100_bases
CAGGCGCCTTCCGGTAATGTTTGCGTGCATCGACTGTGCGCAAACGGTTTGCACGCAAACAGTCGCGCAATATTTACCTG
AACCGTTTCTGGGAGACCTT

Downstream 100 bases:

>100_bases
GGTGATCACATGGATCGCATTCCAATCCTGCGGATGGGCGATTGCCTGATCGTCGCGATTCAGGTCGATATGCACGACCG
TCTCGCCATCGCGCTTCAGG

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNASKSAALVEVLTRHRDTLLTEWLNQHLSIALRRGLTTEAEMNDQFRNFLNVFSDTLARSDTLDASRPEWEPVRAFLTD
MSTHRARQGFTPVETATFVFSLKQPLYSRMREEFDSQPLELAEVSWTVNLLLDALGLFTTEVFQRAREAIISRQQEELLE
LSTPVVQLWEGILALPLIGTLDSARTQVVMESLLQKIVETGAAISIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
GIRPQIAQTIVHLGVDLTNVITKSTLADAFIVALQKSGSSISTRIAS

Sequences:

>Translated_287_residues
MNASKSAALVEVLTRHRDTLLTEWLNQHLSIALRRGLTTEAEMNDQFRNFLNVFSDTLARSDTLDASRPEWEPVRAFLTD
MSTHRARQGFTPVETATFVFSLKQPLYSRMREEFDSQPLELAEVSWTVNLLLDALGLFTTEVFQRAREAIISRQQEELLE
LSTPVVQLWEGILALPLIGTLDSARTQVVMESLLQKIVETGAAISIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
GIRPQIAQTIVHLGVDLTNVITKSTLADAFIVALQKSGSSISTRIAS
>Mature_287_residues
MNASKSAALVEVLTRHRDTLLTEWLNQHLSIALRRGLTTEAEMNDQFRNFLNVFSDTLARSDTLDASRPEWEPVRAFLTD
MSTHRARQGFTPVETATFVFSLKQPLYSRMREEFDSQPLELAEVSWTVNLLLDALGLFTTEVFQRAREAIISRQQEELLE
LSTPVVQLWEGILALPLIGTLDSARTQVVMESLLQKIVETGAAISIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
GIRPQIAQTIVHLGVDLTNVITKSTLADAFIVALQKSGSSISTRIAS

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 31713; Mature: 31713

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASKSAALVEVLTRHRDTLLTEWLNQHLSIALRRGLTTEAEMNDQFRNFLNVFSDTLAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SDTLDASRPEWEPVRAFLTDMSTHRARQGFTPVETATFVFSLKQPLYSRMREEFDSQPLE
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LAEVSWTVNLLLDALGLFTTEVFQRAREAIISRQQEELLELSTPVVQLWEGILALPLIGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LDSARTQVVMESLLQKIVETGAAISIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIRPQIAQTIVHLGVDLTNVITKSTLADAFIVALQKSGSSISTRIAS
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MNASKSAALVEVLTRHRDTLLTEWLNQHLSIALRRGLTTEAEMNDQFRNFLNVFSDTLAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SDTLDASRPEWEPVRAFLTDMSTHRARQGFTPVETATFVFSLKQPLYSRMREEFDSQPLE
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LAEVSWTVNLLLDALGLFTTEVFQRAREAIISRQQEELLELSTPVVQLWEGILALPLIGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LDSARTQVVMESLLQKIVETGAAISIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIRPQIAQTIVHLGVDLTNVITKSTLADAFIVALQKSGSSISTRIAS
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]